A kind of gelatin porous material prepared with high internal phase emulsion as a template and its preparation method

A technology of high internal phase emulsion and porous material, applied in the field of gelatin porous material and preparation, can solve problems such as complex preparation process, achieve the effects of simple preparation method, reduced toxicity risk and short production cycle

Active Publication Date: 2016-02-03
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of this material is too complicated, and at the same time, small molecule surfactants, initiators, chemical cross-linking agents and other substances are used in the synthesis process, which makes the material have potential biological toxicity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Dissolve 0.5g of gelatin and 5mg of genipin in 5mL of water to form an aqueous phase, add 5mL of the aqueous phase into 20mL of n-hexane, and form a high internal phase emulsion under stirring at 9000rpm, react the obtained sample at room temperature for 24 hours, then water and The ethanol was extracted separately for 24 hours, and finally the sample was freeze-dried to obtain a gelatin porous material.

Embodiment 2

[0018] Example 2 Dissolve 0.25g of gelatin and 4mg of genipin in 5mL of water to form a water phase, add 5mL of the water phase into 20mL of toluene, form a high internal phase emulsion under stirring at 13500rpm, react the resulting sample at room temperature for 36 hours, then water and ethanol respectively They were extracted for 24 hours respectively, and finally the samples were freeze-dried to obtain gelatin porous materials.

Embodiment 3

[0019] Example 3 Dissolve 0.5g of gelatin and 4mg of genipin in 5mL of water to form a water phase, add 5mL of the water phase into 45mL of p-xylene, form a high internal phase emulsion under stirring at 15000rpm, react the obtained sample at room temperature for 40 hours, then water and ethanol were extracted for 24 hours, and finally the sample was freeze-dried to obtain a gelatin porous material.

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PUM

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Abstract

The invention discloses a gelatin porous material prepared by using a high internal phase emulsion as a template and a preparation method. Using high-speed stirring to mix gelatin aqueous solution and organic solvent to form an oil-in-water (O / W) high internal phase emulsion, and use genipin to cross-link the continuous phase to form a three-dimensional network structure, and freeze-dry to obtain a pore size of 10-100 μm. Porous materials with a porosity greater than 70%. The material prepared by the invention is easy to form, has good biocompatibility, and can be widely used in tissue engineering materials.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a gelatin porous material prepared with a high internal phase emulsion as a template and a preparation method. Background technique [0002] Porous materials can provide three-dimensional space for cell attachment, growth and reproduction in tissue engineering applications. Porous materials with high porosity can provide more space for cell growth, and its connectivity can promote cell proliferation, migration and communication between cells. Therefore, the improvement of the structure and the optimization of the function of porous materials have aroused the interest of many researchers in recent years. [0003] A high internal phase emulsion is an emulsion with 74% or more internal phase, sometimes as high as 99%. By immobilizing the continuous phase of such emulsions by crosslinking and then removing the internal phase, porous materials with high porosity can be obtained. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/28C08J3/24C08L89/00C08K5/1545
Inventor 林炜谭欢魏涛穆畅道
Owner SICHUAN UNIV
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