5 results about "Subtilisins" patented technology

Disclosed are, inter alia, double stranded RNAi (dsRNAi) agents inhibiting expression of proprotein convertase subtilisin kexin 9 (PCSK9), for example, human PCSK9, compositions including the same, and methods of treatment using the same.

Disclosed are, inter alia, combinations comprising a first antisense (e.g., first double stranded RNAi (dsRNAi)) agent for inhibiting expression of proprotein convertase subtilisin kexin 9 (PCSK9), for example, human PCSK9, and a second antisense agent (e.g., second dsRNAi agent) for inhibiting expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR); pharmaceutical compositions including the same, and methods of treatment using the same.

Disclosed are, inter alia, double stranded RNAi (dsRNAi) agents inhibiting expression of proprotein convertase subtilisin kexin 9 (PCSK9), for example, human PCSK9, compositions including the same, and methods of treatment using the same.

The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant subtilisins suitable for laundry cleaning applications.

This invention discloses a formulation for pet oral cleaning and softening of dental plaque and tartar, and its preparation method, belonging to the technical field of pet oral cleaning formulations. The formulation comprises the following components: 0.5%-2.0% complex protease, 0.3%-1.2% repair agent, 0.05%-0.2% antibacterial agent, 0.2%-0.8% probiotic active liquid, 0.03%-0.3% metal chelating agent, 0.1%-2% emulsifier, 5%-15% humectant, 0.01%-0.3% breath freshener, 0.1%-0.5% pH adjuster, and the balance purified water. The complex protease is composed of subtilisin, bromelain, and papain. This invention, through the combination of a multi-enzyme synergistic system and active components, achieves effective removal of pet dental plaque and a significant softening and peeling effect on dental tartar. The resulting formulation is compatible with the pet's oral physiological environment, and long-term use can effectively prevent the occurrence of oral diseases.