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34 results about "HomoloGene" patented technology

HomoloGene, a tool of the United States National Center for Biotechnology Information (NCBI), is a system for automated detection of homologs (similarity attributable to descent from a common ancestor) among the annotated genes of several completely sequenced eukaryotic genomes.

Method for quantitatively detecting target protein yield of cell-free protein synthesis system and method for screening zymoprotein with high catalytic activity

The invention discloses a method for quantitatively detecting the target protein yield of a cell-free protein synthesis system and screening zymoprotein with high catalytic activity. According to the method for quantitatively detecting the yield of the target protein in the CFPS system, the expression quantity of the target protein in the CFPS system can be rapidly analyzed by segmenting the intensity value of fluorescence emitted by spontaneous binding of fluorescent protein, and rapid detection of the expression quantity of the target protein in the CFPS system is facilitated; meanwhile, based on the method, the enzyme homologues with high catalytic activity can be quickly screened by calculating the ratio of the quantity of products obtained by catalysis of each enzyme protein to the fluorescence intensity value after spontaneous binding of segmented fluorescent protein, and a conventional large intestine transformation-expression-purification process is not needed, so that the time and the material cost are greatly saved, the screening speed is increased, and moreover, the screening leakage risk of the high-catalytic-activity protein caused by too low protein expression quantity is avoided, and rapid and accurate screening of the high-catalytic-activity zymoprotein is facilitated.
Owner:林影 +1

Regulation of gene expression through manipulation of mRNA splicing and its uses

A cis-acting nucleotide sequence which is capable of rendering the removal of introns from a precursor transcript encoded by a gene, which gene harbors at least one such cis-acting nucleotide sequence, occurring during the production of mRNA of a gene, dependent upon activation of a trans-acting factor. The trans-acting factor is an RNA-activated protein kinase which is capable of phosphorylating the α-subunit of eukaryotic initiation factor 2. The trans-acting factor is preferably, the RNA-activated protein kinase (PKR). The cis-acting nucleotide sequence can be derived from the 3′ untranslated region of the human tumor necrosis factor α gene (TNF-α3′-UTR) and may comprise the nucleotide sequence as denoted by SEQ ID NO:1 or biologically functional fragments, derivatives, mutants and homologues thereof.
Owner:YISSUM RES DEV CO OF THE HEBREW UNIV OF JERUSALEM LTD

Live, Oral Vaccine for Protection Against Shigella Dysenteriae Serotype 1

ActiveUS20080193486A1Antibacterial agentsBiocideO antigen biosynthesisDna encoding
The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae type 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding S. dysenteriae polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.
Owner:US DEPT OF HEALTH & HUMAN SERVICES

Chordin-like homologs

The present invention concerns several splice variants of a Chordin like homologues (CHL2) and depicts their nucleic acid and amino acid sequences, vectors and host cells containing said nucleic acid sequences and antibodies reactive with the amino acid sequences. The invention also concerns pharmaceutical compositions for the treatment of a plurality of diseases, comprising nucleic acid sequences, amino acid sequences, expression vectors and antibodies. The invention also concerns methods for detecting the above nucleic acid or amino acid sequences or antibodies in a biological sample.
Owner:COMPUGEN

Plants with altered root architecture, related constructs and methods involving genes encoding protein phophatase 2c (PP2C) polypeptides and homologs thereof

Isolated polynucleotides and polypeptides and recombinant DNA constructs particularly useful for altering root structure of plants, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter functional in a plant, wherein said polynucleotide encodes a polypeptide useful for altering plant root architecture.
Owner:EI DU PONT DE NEMOURS & CO +1
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