Rna interference mediated inhibition of btb and cnc homology 1, basic leucine zipper transcription factor 1 (bach 1) gene expression using short interfering nucleic acid (sina) sequence listing

A technology for interfering nucleic acids, nucleotides, applied in the field of RNA interference-mediated inhibition of BTB and CNC homolog 1, basic leucine zipper transcription factor 1 (Bach1) gene expression using short interfering nucleic acid (siNA) , able to address issues such as Nrf2-dependent antioxidant loss
CN102439151AInactive Publication Date: 2012-05-02SCHERING AG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SCHERING AG
Publication Date
2012-05-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of Bach1 gene expression and / or activity, and / or modulate a Bach1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against Bach1 gene expression.
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Description

[0001] This application claims the benefit of US Provisional Application No. 61 / 161,699, filed March 19, 2009. The applications listed above, including the drawings, are hereby incorporated by reference in their entirety.

[0002] sequence listing

[0003] Pursuant to 37 CFR §1.52(e)(5), the sequence listing submitted via EFS is incorporated herein by reference. Sequence Listing text files submitted via EFS include file "SequenceListing75WPCT" created on February 25, 2010, which is 109,874 bytes in size. Background of the invention

[0004] Bach1 is a transcriptional repressor of heme oxygenase-1 (HO-1) and other Nrf2-dependent phase II genes. The transcription factor Bach1 belongs to the cap'n'collar (CNC) and basic region leucine zipper superfamily of transcriptional regulators (termed CNC-bZip). Furthermore, Bach1 represents in its N-terminal region the so-called broad complex, tram-track, bric-a-brac (BTB) domain (also known as poxvirus and zinc finger (POZ) domain). ...

Claims

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