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3 results about "Leucine zipper" patented technology
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A leucine zipper (or leucine scissors) is a common three-dimensional structural motif in proteins. They were first described by Landschulz and collaborators in 1988 when they found that an enhancer binding protein had a very characteristic 30-amino acid segment and the display of these amino acid sequences on an idealized alpha helix revealed a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. The polypeptide segments containing these periodic arrays of leucine residues were proposed to exist in an alpha-helical conformation and the leucine side chains from one alpha helix interdigitate with those from the alpha helix of a second polypeptide, facilitating dimerization.
Conjugate and use thereof
PCT designated stageWO2026108716A1Peptide preparation methodsImmunoglobulinsAntigenAntigen Binding Fragment
The present invention relates to a conjugate. The conjugate comprises a chimeric immunoglobulin and a conjugation partner, wherein the chimeric immunoglobulin comprises an antigen-binding fragment and a leucine zipper, and the leucine zipper is linked to the terminus of the antigen-binding fragment.
Owner:GUANGDONG FAPON BIOTECH CO LTD
Truncated transposase, transposome system and applications thereof
The application provides a truncated transposase, a transposon system and application thereof. Compared with a wild-type PS transposase, the truncated transposase lacks 1-50 amino acids at the C terminal of the wild-type PS transposase, preferably 44 amino acids. By deleting the amino acids at the C terminal of the transposase which have less influence on transposition, the length of the transposase is shortened, which is beneficial to the expression of the transposase and the preparation of a fusion protein, so that a transposase or a fusion protein thereof with higher catalytic activity and smaller size is obtained. The application also provides a fusion protein of the transposase, which is preferably fused with a leucine zipper through a linker, and a transposon system comprising the transposase and the transposon, which has great application value in the transgenic industry.
Owner:MAXIRNA (SHANGHAI) PHARM CO LTD +2