26 results about "Biological regulation" patented technology

The invention discloses a neural network calculation method and device for gene expression regulation and control analysis, and relates to the technical field of bioinformatics, and the method comprises the steps: obtaining first feature data and second feature data; constructing an input feature comprising a plurality of regulation and control hierarchies; and inputting the input features of the plurality of regulation levels and the second feature data into the target neural network model, and outputting a prediction result of the gene expression state. According to the neural network calculation method provided by the invention, chromatin accessibility and three-dimensional space interaction data are deeply fused through a dynamic routing module, so that the problem of'black box 'which is inaccurate in prediction and difficult to explain in a traditional deep learning model is solved in a mode of explicitly simulating a real biological regulation mechanism; and a key gene regulatory pathway can be accurately identified.

The application discloses an application method of a Transformer architecture based on a biological regulation mechanism, S1, original data is divided into basic units token, and then each discrete token is mapped into a continuous high-dimensional vector through a word embedding layer; S2, a prototype activation unit identifies an initial semantic core from the input embedded token, and scores an activation value based on the embedded vector of the token; S3, a multi-scale prototype aggregation module performs multi-scale pattern aggregation on the prototype candidate, and forms a prototype vector across tokens; S4, a regulation path diverter determines a main / auxiliary path distribution strategy of each token according to the context semantic weight and the prototype responsiveness of the token; S5, the main path performs a standard QKV calculation process; S6, a biological regulation loop module performs feedback regulation on the auxiliary path token by using the aggregated prototype vector in the S3 step; S7, two token expression streams generated by the main path and the auxiliary path are integrated, so that the final output of the Transformer layer is generated.

This invention discloses NtBRL2 The application of genes in regulating potassium content in plants belongs to the field of plant genetic engineering technology. This invention provides a gene that can effectively regulate potassium content in plant leaves, a feature of existing technologies. NtBRL2 This invention first discovered through Real-time PCR. NtBRL2 The gene was expressed at the highest level in tobacco roots; then, a silenced gene was constructed using virus-induced gene silencing (VIGS) technology. NtBRL2 The VIGS vector of the gene was transformed into Nicotiana benthamiana, and repression was successfully achieved. NtBRL2 Silent plants, obtained by silencing gene expression, exhibit a specific phenotype with significantly lower potassium ion content compared to control plants, indicating that silencing this gene can significantly reduce potassium ion content in plants. This invention lays the foundation for elucidating the biological regulation mechanism of potassium ions and provides precise regulatory sites for the regulation of potassium ion content in plants.

The present application relates to the technical field of biological medicine materials, and particularly relates to a magnesium chelated vitamin C nanomaterial, a preparation method and application thereof. The preparation raw material of the nanomaterial comprises VCMg, a lipid modification material and a solvent I. The preparation raw material of the VCMg comprises an oil phase emulsion and an aqueous phase emulsion. The oil phase emulsion contains a magnesium source, a non-ionic surfactant, a stabilizer and a solvent II. The aqueous phase emulsion contains vitamin C, a dispersing agent and water. The research results of the present application establish that the VMNP is a unique nanometer platform integrating coordination chemistry and biological regulation, reveal a new biochemical mechanism of stabilizing unstable nutrients through materials, promote the anti-fibrosis treatment based on vitamin C, and provide a new technical idea for the cross research of nanotherapy and molecular biology mechanism.

The invention provides a lake water ecological system restoration method based on staged biological regulation and control, and belongs to the field of water environment treatment and water ecological restoration. According to the method, directional putting and regulation of aquatic animal communities are performed in three stages according to the recovery process of submerged plants: in the early regulation stage, carnivorous fishes are put to inhibit breeding of benthic omnivorous fishes; a middle-stage regulation and control stage: introducing benthonic animals to cooperatively control the quality of algae biomass and improve the transparency of the water body; in the later regulation and control stage, herbivorous fishes are put to promote plant tillering, lateral branch development and root system downward growth and expansion, and the substrate fixing capacity is enhanced; according to the method, the aquatic animals with the specific function class groups are sequentially put in stages, directional regulation and control of the aquatic animal community structure are effectively achieved, the planting success rate of the submerged plants is increased, growth of the aquatic plants is promoted, water transparency is improved, and a stable water ecosystem with the self-purification capacity is constructed.

The invention provides a COPD (chronic obstructive pulmonary disease) target protein based on plasma proteomics. The target protein comprises one or more of the following four proteins: HLA-DRA (human leukocyte antigen-DRA), CXCL9, TNFRSF8 and RNASET2. The invention not only highlights the important value of longitudinal proteomics analysis in revealing the early biological change of COPD, but also opens up a new path for the development of personalized treatment schemes. In view of the complex function of protein in the biological regulation and control process, the research result of the invention provides an important framework for understanding the pathological mechanism of COPD, and lays a foundation for developing a treatment strategy based on proteomics in the future. The invention also provides an application based on the COPD target protein and a medicine for treating COPD.

The embodiment of the present application provides a method for preparing a biological adaptation functional medium, a biological adaptation functional medium product, a storage slow-release biological regulation device and a biological regulation system, and relates to the technical field of biological regulation. The method applies a periodic electric signal with a preset frequency to a basic medium body to obtain a biological adaptation functional medium. The dielectric loss factor of the biological adaptation functional medium is increased by at least 50% compared to that of the basic medium body at the preset frequency. The basic medium body is a carbon-based mineral material naturally produced, and the carbon component exists in a multi-level fractal structure formed by step-by-step aggregation of reduced graphene oxide nanosheets. Thus, the solid medium body can obtain the biological adaptation without relying on external energy supply, and the biological regulation effect in the power-off state is realized.

The invention belongs to the technical field of biomedical composite materials, and discloses a copper-based MOF modified small-caliber polyurethane artificial blood vessel and a preparation method. The copper-based metal organic framework is used as a functional carrier to be compounded with polyurethane, the artificial blood vessel with the inner diameter smaller than or equal to 6 mm is prepared through the electrostatic spinning technology, and synergistic release of copper ions, nitric oxide and medicine molecules is achieved; the preparation process comprises the steps of synthesis of the copper-based metal organic framework, preparation of a polyurethane solution, drug loading, electrostatic spinning forming and the like. According to the invention, a mechanical adaptation-biological regulation synergistic system is innovatively constructed, so that proliferation of endothelial cells is effectively promoted, excessive proliferation of smooth muscle cells is inhibited, and an ideal microenvironment is provided for vascular repair; the clinical problems of mechanical property mismatch, thrombosis, intimal hyperplasia and the like of the small-caliber artificial blood vessel are solved, and the preparation method is stable in process and low in cost and has important clinical application value.

The application discloses a neural network calculation method and device for gene expression regulation analysis, and relates to the technical field of bioinformatics.The method comprises the following steps: obtaining first feature data and second feature data; constructing input features containing multiple regulation levels; inputting the input features of the multiple regulation levels and the second feature data into a target neural network model, and outputting a prediction result of a gene expression state.The neural network calculation method provided by the application can deeply integrate chromatin accessibility and three-dimensional spatial interaction data through a dynamic routing module, can solve the "black box" problem that a traditional deep learning model is inaccurate and difficult to explain, and can accurately identify key gene regulation pathways in a manner of explicitly simulating real biological regulation mechanisms.

To find out a useful living body-regulating function in a treated product of Abelmoschus manihot and to provide a functional use thereof.SOLUTION: An intestinal environment-improving agent comprising a processed product of Abutilon striata as an active ingredient, wherein the intestinal environment-improving agent increases bacteria of the genus Lactobacillusmurinus and / or the genus Parabacteroides.SELECTED DRAWING: Figure 5

The present application relates to the technical field of gene expression process regulation, in particular to a gene expression process optimization regulation method, system and computer storage medium, the method comprising: constructing a biological regulation circuit of a regulated gene expression process to obtain a mathematical relationship of the gene expression process; designing a controller model for capturing dynamic changes in the gene expression process in a space with a curvature not constant as 0; based on the controller model, establishing a matrix equation for solving the regulation input, and according to the matrix equation, obtaining the regulation input that makes the expression product GFP concentration of the regulated gene stable; and controlling the expression process of the regulated gene through the regulation input, so that the gene expression product concentration can be kept stable under the condition of ribosome quantity fluctuation in the cell. According to the difference between the ribosome disturbance degree and the GFP product concentration under different situations, the required regulation input is calculated, and the efficiency, universality and stability of the gene expression process are improved.

1. Name of the product in this design: Care Patch (Optical Biomodulation). 2. Purpose of this product design: a nursing patch for the care of women's intimate areas. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The invention belongs to the technical field of biological medicine, and particularly relates to gradient centrifugation leukocyte extraction equipment and method for inhibiting release of inflammatory factors, the equipment comprises a centrifugal cavity with a cover body, a placing cavity is arranged in the cavity body, the placing cavity is equipped with an illuminating lamp, an image sensor, a temperature sensor, a cooling assembly and a heating assembly, and the bottom is connected with a centrifugal driving assembly; the supporting frame at the top end of the placement cavity is matched with the supporting block, and the equipment stability and the sample treatment effect are improved by combining microfiltration membranes and other structures. According to the extraction method, the equipment is utilized, through the four steps of equipment pre-adjustment, sample preparation and placement, centrifugal process synchronous adjustment (including photo-biological adjustment, precise temperature control, gas signal molecule intervention and dynamic monitoring feedback) and leukocyte extraction, inflammatory factor release is effectively inhibited while gradient centrifugal separation is performed, the leukocyte extraction quality and activity are improved, and the leukocyte extraction efficiency is improved. The method is suitable for efficient extraction and subsequent research application of leukocytes in clinical blood samples.

The invention relates to the technical field of agricultural biology, and discloses a high-glucan rice planting method based on microbial enzymes, which comprises the following steps: carrying out aerated fermentation on barley flour, mushroom mycelium powder and other raw materials to prepare a composite enzyme solution containing beta-amylase and glucose polymerase with a specific activity ratio, the enzyme stock solution prepared in the step S1 is used for treating the whole process from seeds to maturity of rice, in the whole growth period of the rice, a composite enzyme solution is used for biological regulation and control, and in the filling period, the starting opportunity of spike spraying is determined by monitoring the trend that the relative chlorophyll content of rice flag leaves is converted into a stable decreasing trend from a peak value. According to the method, through accurate coupling of an enzymatic reaction system and a plant endogenous substance transport rhythm, under the condition of not applying chemical synthesis investments, the content of glucan in the finally harvested rice is remarkably increased, taste quality indexes such as chalky grain rate are improved, and meanwhile the crop yield is maintained.

The invention relates to a preparation method of a metal ion activated soil indigenous enzyme bacterium composition, and belongs to the field of agricultural microbial technologies and novel fertilizers, the composition is prepared from a powder water-soluble fertilizer with the zinc content of 10.0-20.0% and a special activator accounting for 0.5-1.0% of the total mass of the composition through a low-temperature chelation compounding process. Through the triple mechanisms of zinc nutrition starting, activating agent biological regulation and control and slow release synergy, soil aboriginal beneficial microbial communities can be efficiently and directionally activated and optimized, soil enzyme activity and microbial biomass are remarkably improved, continuous cropping obstacle soil is improved, crop stress resistance is effectively enhanced, growth is promoted, and finally yield increase and quality improvement of crops are achieved.

The invention discloses a single-cell multi-omics dimension reduction method based on a Gaussian process hidden variable model, and aims to solve the problems that single-omics and multi-omics data analysis requirements are difficult to consider and high sparsity and technical noise of single-cell data cannot be effectively handled in the prior art. According to the method, a shared potential space probability generation framework is constructed, variational inference and a sparse Gaussian regression strategy are combined, data of different modalities are non-linearly mapped to a unified low-dimensional space, and meanwhile, an adjustable modal weight is introduced, so that the model can perform efficient dimensionality reduction on single-cell transcriptome and multi-omics data. When the method is used for carrying out dimension reduction on single cell sequencing data, low-dimensional representation learned by the model can be used for completing downstream tasks such as cell clustering, visualization and differential expression analysis, cell heterogeneity and potential biological regulation signals are accurately revealed, and the method has a good application prospect.

The invention relates to the technical field of bioinformatics, in particular to a method for constructing a gene network based on two-stage Granger causality and application, and the method comprises the following steps: firstly, carrying out global Granger causality test based on gene expression time sequence data, and constructing an initial candidate network containing all potential regulation and control relationships; and then, refining the candidate network by adopting a dynamic pruning strategy based on event driving. And before the target gene expression has significant fluctuation, detecting whether the candidate regulatory gene has synchronous significant expression change or not, and verifying the causal driving force of the candidate regulatory gene. And only the regulation and control relationship passing the verification is reserved, so that wrong causal association is effectively removed, and optimization of the network structure is realized. The network constructed by the invention better conforms to a real biological regulation rule, and can better reflect the dynamics and directivity of a regulation relationship in a biological system; the method is especially suitable for the research fields of plant stress response, development regulation and control, system biology and the like, and has wide application prospects and practical values.

The invention discloses a membrane-mediated THz biological regulation mineral ion water composition and a preparation method thereof, and relates to the technical field of soft substance dielectric regulation and weak-field THz biophysics, the composition comprises an aqueous phase medium and an ion component, the aqueous phase medium is purified water, deionized water or low-salinity base water, or is directly taken from a predetermined water source; the ion component comprises monovalent cations, divalent cations, monovalent anions and / or polyatomic anions; the mineral ion water composition can form stable terahertz dielectric response under the cooperation of a membrane structure; the method is suitable for engineering application of physiotherapy products and related health regulation and control products. A terahertz regulation and control environment can be constructed without an active terahertz emission device; the method is suitable for engineering application of physiotherapy products and related health regulation and control products; the adjustability of terahertz response can be realized by adjusting ion function parameters and membrane structure parameters.

The invention is applicable to the technical field of biological medicine, and provides a preparation method and application of a uracil modified gold nano conjugate, the method comprises the following steps: in the presence of a reducing agent, slowly adding a uracil ligand solution into a gold precursor solution for controlled reduction reaction to form a gold nano conjugate with the average particle size less than or equal to 2 nm; and adding a sulfhydrylation uracil derivative into the obtained dispersion liquid of the gold nano conjugate, adjusting the pH value of a reaction system to be alkaline, and enabling the sulfhydrylation uracil derivative to be combined with the surface of the gold nano conjugate through an Au-S bond to obtain the uracil modified gold nano conjugate. The material has the characteristics of ultra-small size, pH-responsive surface and selective uptake of pathogenic bacteria, can efficiently penetrate through a periodontal biological membrane, and realizes efficient removal and toxicity blocking of periodontal pathogenic bacteria by interfering bacterial proton dynamic potential and inhibiting toxicity factor secretion.

The invention relates to the technical field of livestock manure treatment, and particularly discloses a compound microorganism composition and application thereof. The composition comprises immobilized tannic acid and paenibacillus mucilaginosus thalli, tannic acid and capsular polysaccharide secreted by strains are subjected to in-situ crosslinking to form a dynamic enhanced biological flocculation network, and the feces solid-liquid separation efficiency is remarkably improved; meanwhile, through the synergistic effect of chemical inhibition of tannic acid on urease activity and biological regulation and control of strains on methanogens and nitrification / denitrification flora, synchronous inhibition of methane and nitrous oxide in the excrement storage process is achieved for the first time. All the components of the composition are derived from natural materials or environmental functional microorganisms, the risk of secondary pollution is avoided, strains surviving after the treated manure is returned to the field can continuously play the probiotic functions of improving soil and promoting crop growth, and the composition has multiple benefits of efficient emission reduction, ecological safety and resource value increase and has wide application prospects. The method has a wide application prospect in the fields of livestock and poultry manure harmless treatment and agricultural green low-carbon development.

The invention discloses a self-assembled nano composite material as well as a preparation method and application thereof, and belongs to the technical field of preparation of novel nano materials. The self-assembled nano composite material comprises a copper-based metal organic framework, an exosome wrapped inside the copper-based metal organic framework, polydopamine wrapped outside the copper-based metal organic framework, and an ASGR1 antibody modified on the surface of the polydopamine. According to the invention, catalytic treatment of nano-enzyme, biological regulation and control of exosome and a molecular targeting function of an antibody are ingeniously integrated, and a complex pathological network of MASLD is coped with through a multi-mechanism synergistic effect. The invention not only provides an effective candidate treatment material, but also provides multiple omics perspectives for understanding a combined treatment mechanism based on the exosome and the nano-enzyme, and has important theoretical significance and transformation application potential.

The invention discloses an application method of a Transform architecture based on a biological-like regulation mechanism, which comprises the following steps of: S1, segmenting original data into basic unit tokens, and mapping each discrete token into a continuous high-dimensional vector through a word embedding layer; s2, identifying an initial semantic core from the input embedded token by a prototype activation unit, and performing activation value scoring based on an embedded vector of the token; s3, a multi-scale prototype aggregation module performs multi-scale pattern aggregation on the prototype candidates to form a cross-token prototype vector; s4, the adjusting path branching device determines a main / auxiliary path distribution strategy of each token according to the context semantic weight and the prototype responsivity of the token; s5, the main path executes a standard QKV calculation process; s6, the biological regulation loop module performs feedback regulation on the secondary path token by using the prototype vector aggregated in the step S3; and S7, integrating the two token expression streams generated by the main path and the auxiliary path so as to generate the final output of the Transform layer.

The invention discloses a stem cell exosome immune regulation function improving system based on synthetic biological regulation, and particularly relates to the technical field of biological medicine and cell engineering. Comprising a port synthetic gene loop module, a dynamic parameter culture parameter regulation and control module, a controlled promoter subsystem module, a stem cell exosome collection and purification module, a stem cell exosome quality and function detection module and a stem cell exosome quality and function detection feedback module. The synthetic gene loop module is used for introducing a miRNA module capable of inducing regulation expression, designing a synthetic promoter module for expressing miR-146a, and combining the synthetic promoter module with a transcription factor to regulate and transfect human umbilical cord mesenchymal stem cells; on the basis of a cell synthesis flux optimization theory, a brand new dynamic culture parameter regulation and control system is established, a plurality of key culture parameters are precisely regulated and controlled, the secretion amount of the exosome is greatly multiplied, the problem that the secretion amount is limited is solved, and the clinical dosage requirement can be better met.

1. Name of the product in this design: Disinfection Box (Optical Biological Regulation). 2. Purpose of this design: A sterilization box for disinfecting feminine hygiene pads. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.