Methods of making bioadapted functional media, bioadapted functional media products, depot biological modulation devices and biological modulation systems

Abstract

The embodiment of the present application provides a method for preparing a biological adaptation functional medium, a biological adaptation functional medium product, a storage slow-release biological regulation device and a biological regulation system, and relates to the technical field of biological regulation. The method applies a periodic electric signal with a preset frequency to a basic medium body to obtain a biological adaptation functional medium. The dielectric loss factor of the biological adaptation functional medium is increased by at least 50% compared to that of the basic medium body at the preset frequency. The basic medium body is a carbon-based mineral material naturally produced, and the carbon component exists in a multi-level fractal structure formed by step-by-step aggregation of reduced graphene oxide nanosheets. Thus, the solid medium body can obtain the biological adaptation without relying on external energy supply, and the biological regulation effect in the power-off state is realized.

Description

Technical Field

[0001] This invention relates to the field of bioregulation technology, and more specifically, to a method for preparing bioadaptive functional media, bioadaptive functional media products, storage-slow-release bioregulation devices, and bioregulation systems. Background Technology

[0002] Currently, mainstream contact-based energy modulation technologies (such as transcranial direct current stimulation, functional electrical stimulation, and ultrasound physical therapy devices) all rely on the 'real-time driven by exogenous energy' paradigm. That is, external devices continuously output electrical, magnetic, acoustic, or thermal energy, which is forcibly applied to biological tissues through the body surface interface to induce an immediate physiological response. This paradigm is mature in engineering implementation, but it has inherent structural defects: its biological effects are strictly coupled to the power supply status of the device. Once the power is cut off, the energy field disappears instantly, and it is impossible to form a mechanism for retaining and slowly releasing energy information detached from the device. Summary of the Invention

[0003] In view of this, the purpose of this invention is to provide a method for preparing bioadaptive functional media, a bioadaptive functional media product, a storage-slow-release bioregulatory device, and a bioregulatory system to at least partially improve the above-mentioned problems.

[0004] To achieve the above objectives, the technical solutions adopted in the embodiments of the present invention are as follows: In a first aspect, embodiments of the present invention provide a method for preparing biocompatible functional mediators, comprising: A biologically adapted functional medium is obtained by applying a periodic electrical signal of a preset frequency to the basic medium. The bio-adaptive functional medium has a dielectric loss factor that is at least 50% higher than that of the basic medium at the preset frequency; The basic medium is a naturally occurring carbon-based mineral material, whose carbon component exists in a multi-level fractal structure formed by the gradual aggregation of reduced graphene oxide nanosheets.

[0005] Optionally, the current intensity of the periodic electrical signal does not exceed 100 μA.

[0006] Optionally, the preset frequency is in the range of 0.5Hz to 30Hz.

[0007] Optionally, the base medium is sub-graphite, or a natural carbon-based mineral material having the same reduced graphene oxide nanosheet multi-level fractal structure as sub-graphite.

[0008] Secondly, embodiments of the present invention provide a biocompatible functional media product, which is prepared by the method described in any one of the first aspects.

[0009] Thirdly, embodiments of the present invention provide a storage-slow-release bioregulation device, comprising at least two bioadaptive functional media products as described in the second aspect; The storage-release biomodulation device is configured to contact the human body surface in a completely power-off operating mode.

[0010] Fourthly, embodiments of the present invention provide a bioregulation system, including at least one bioadaptive functional medium product as described in the second aspect and a safe real-time excitation module; the safe real-time excitation module includes a low-power power supply, electrodes, and a safety control unit; The safe real-time excitation module is configured to output a periodic electrical signal with a preset frequency and a preset current intensity. The operating modes of the bio-regulatory system include a storage-slow-release mode and a real-time activation mode; The storage slow-release mode is as follows: the safe real-time excitation module is in a closed or standby state, and only the functional medium product comes into contact with the human body surface, and the regulatory effect is generated by the slow-released bioadaptation field inside it. The real-time excitation mode is as follows: the safe real-time excitation module is activated, and the periodic electrical signal is applied to the human body through the functional medium product, which generates a synergistic enhancement effect with the bioadaptation field of the functional medium product itself. The safety control unit is configured to: when the functional medium product is detected to be in contact with the palms or precordial region of a human body, prevent the safety real-time excitation module from outputting the periodic electrical signal and force the system to operate in the storage slow-release mode.

[0011] This invention provides a method for preparing bioadaptive functional media, a bioadaptive functional media product, a storage-slow-release bioregulatory device, and a bioregulatory system. By applying periodic electrical excitation with a clear biological rhythm correspondence to a basic medium with a microampere current within a preset frequency, a novel functional state with long-term stability, repeatable characterization, and specific biological response is obtained. This state can achieve long-term, mild, and non-invasive physiological homeostasis regulation without external power supply when in contact with the human body through extremely weak but time-coded electric field perturbation.

[0012] To make the above-mentioned objectives, features and advantages of this application more apparent and understandable, preferred embodiments are described below in detail with reference to the accompanying drawings. Attached Figure Description

[0013] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0014] Figure 1 This is a schematic flowchart of a method for preparing biocompatible functional media provided in an embodiment of the present invention; Figure 2 A schematic structural block diagram of a storage-controlled slow-release bioregulation device provided in an embodiment of the present invention; Figure 3 A schematic structural block diagram of a biological regulatory system provided in an embodiment of the present invention; Figure 4 This is a schematic structural block diagram of a secure real-time excitation module provided in an embodiment of the present invention.

[0015] Icons: 200 - Bio-adaptive functional media products; 300 - Storage-type slow-release bio-regulation devices; 400 - Bio-regulation systems; 410 - Safe real-time excitation modules; 411 - Low-power power supplies; 412 - Electrodes; 413 - Safety control units. Detailed Implementation

[0016] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0017] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0018] It should be noted that similar reference numerals and letters in the following figures indicate similar items; therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures. Furthermore, in the description of this invention, terms such as "first," "second," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0019] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0020] In existing technologies, it is generally believed that "if a solid medium is excited by an electrical signal but is not continuously powered, its effect will decay rapidly and it will be unable to form a stable and sustainable functional state." However, the effect of contact energy regulation technology is strictly dependent on the continuous power supply of the device, and it will terminate when the power is cut off. Its interface (electrodes, transducers, etc.) is a stateless passive channel that cannot store, encode, or selectively release biological regulatory information. Its safety boundary is unidirectionally defined by the physical energy intensity, which means that "high efficiency" and "safety" cannot be achieved at the same time, and it is forced to disable highly sensitive and high-throughput energy interaction interfaces such as the palms of the hands.

[0021] Based on the above, embodiments of the present invention provide a method for preparing bioadaptive functional media, a bioadaptive functional media product, a storage-controlled release bioregulatory device, and a bioregulatory system. By using an inseparable closed-loop process of spectrum-adaptive energy programming and environmentally controllable relaxation solidification, the dielectric structure inside the basic medium undergoes non-equilibrium directional recombination.

[0022] In this embodiment of the invention, "bioadapted state" refers to a solid state that, compared to the basic dielectric body, has a dielectric loss factor that increases by at least 50% at a preset frequency and can generate a measurable physiological response (optionally, the physiological response is manifested as a change in high-frequency power of heart rate variability preceding a change in alpha waves of brainwaves) without the need for external power supply when in contact with the human body.

[0023] The method for preparing biocompatible functional media provided in this invention will be described below by way of example. See [link to relevant documentation]. Figure 1 The method includes, for example Figure 1 The following steps are described: S110: Apply a periodic electrical signal of a preset frequency to the basic medium to obtain a biocompatible functional medium.

[0024] Among them, the bio-adaptive functional medium has a dielectric loss factor that is at least 50% higher than that of the basic medium at the preset frequency.

[0025] The basic medium is a naturally occurring carbon-based mineral material, whose carbon component exists in a multi-level fractal structure formed by the gradual aggregation of reduced graphene oxide nanosheets.

[0026] This method disrupts the original energy distribution within the basic medium by applying a periodic electrical signal at a preset frequency. Even after being removed from external electrical signal excitation, the medium can still generate physical field effects that specifically interact with biological systems. These effects do not depend on current flow, heat release, or electromagnetic radiation emission; they can be triggered simply through direct contact between the medium and biological tissue. This provides a fundamental material-level support for constructing passive, long-lasting, and non-invasive bioregulatory technologies.

[0027] By applying periodic electrical signals, energy perturbations with a defined time structure are input into the basic medium, thereby exciting energy responses across multiple scales within the medium, including but not limited to non-equilibrium processes such as dipole orientation oscillations, interface charge accumulation / dissipation, and carrier local state transitions.

[0028] Specifically, the bio-adaptive functional medium needs to have a dielectric loss factor that is at least 50% higher than that of the basic medium at a preset frequency.

[0029] The dielectric loss factor characterizes a material's ability to irreversibly convert electrical energy into heat energy under an alternating electric field. Its value directly reflects the activity level of energy dissipation mechanisms within the material, such as dipole reversal, interfacial charge migration, and ionic conductivity. For a given material system, the measured values ​​of its dielectric loss factor at a specific frequency point exhibit good repeatability under specific test conditions. Therefore, when an increase of more than 50% in the dielectric loss factor is observed at the same characteristic frequency point under the same test conditions, this change significantly exceeds the scope that can be explained by conventional measurement errors, environmental perturbations, and intrinsic material fluctuations. This indicates that a fundamental, long-range ordered reorganization of the energy dissipation structure has occurred within the dielectric.

[0030] The basic medium is a naturally occurring carbon-based mineral material. Its essential structural feature is that carbon does not exist in the form of graphite single crystals, amorphous carbon, or fullerene clusters. Instead, it uses reduced graphene oxide nanosheets as the basic building blocks. Through van der Waals forces and hydrogen bonding mediated by residual oxygen-containing functional groups, it self-assembles step by step to form a multi-level fractal structure with statistical self-similarity.

[0031] In one alternative implementation, the current intensity of the periodic electrical signal does not exceed 100 μA.

[0032] The periodic electrical signal applied in step S110 is configured as a microampere-level excitation, with an upper limit of current intensity set at 100 μA. This intensity level is sufficient to effectively excite the coordinated oscillation behavior of the dielectric response units without inducing significant transitions in the macroscopic conductivity of the dielectric, without generating Joule heating effects, or causing interfacial electrolytic reactions, thereby ensuring the safety and biocompatibility of the process.

[0033] Optionally, the preset frequency is in the range of 0.5 Hz to 30 Hz.

[0034] The frequency of the periodic electrical signal applied by S110 is limited to the low-frequency range of 0.5Hz to 30Hz. This frequency band covers the fundamental and harmonic frequencies of key physiological rhythms such as human autonomic nervous system regulation (e.g., the high-frequency range of heart rate variability (HRV) 0.15–0.4Hz, vagal nerve discharge rhythm), EEG alpha waves (8–13Hz), and delta / theta waves, providing a spectral matching basis for establishing cross-scale energy information coupling between the medium state and the biological system.

[0035] It should be noted that the typical representative of the basic medium described in the embodiments of the present invention is shungite. Studies have shown that the carbon composition of shungite exhibits a multi-level fractal structure of nanoscale reduced graphene oxide fragments (see: Sheka, EF, Rozhkova, NN Shungite as the natural pantry of nanoscale reduced graphene oxide[J]. International Journal of Smart and Nano Materials,2014, 5(1): 1-16). This structure can be objectively characterized and identified by means of neutron scattering, X-ray diffraction, Raman spectroscopy, etc. The inventors have discovered that this specific multi-level fractal structure is the key to enabling the basic medium to form a biocompatible state under the excitation of the method of the present invention. Any natural carbon-based mineral material with this structure can be used as the basic medium of the present invention. Optionally, the basic medium is shungite, or a natural carbon-based mineral material with the same multi-level fractal structure of reduced graphene oxide nanosheets as shungite.

[0036] Take the same original sub-graphite sample as in this embodiment, and directly perform dielectric loss factor testing and physiological effect verification without applying any electrical signal excitation.

[0037] Test results showed that the dielectric loss factor of the original subgraphite at the preset frequency was the baseline value. In the physiological effect verification, no temporal characteristic was observed where high-frequency power changes in heart rate variability preceded changes in EEG alpha waves.

[0038] The above comparative examples demonstrate that applying a periodic electrical signal of a preset frequency to the basic dielectric body for excitation is a key step in significantly increasing its dielectric loss factor and obtaining the aforementioned temporal physiological effect.

[0039] In one implementation, high-purity natural sub-graphite is used as the base medium to verify the feasibility and implementability of the method of the present invention.

[0040] Take a piece of high-purity (>99%) natural sub-graphite raw material, process and clean it to obtain a clean, dry, and structurally stable basic medium.

[0041] The obtained base medium is connected to a low-frequency electrical signal generator. This generator is configured to output a sinusoidal periodic electrical signal with a frequency ranging from 0.5 Hz to 30 Hz and a current intensity on the order of microamps. In this embodiment, the signal frequency is set to 10 Hz and the effective current to 50 μA, and the signal is applied continuously for 30 minutes. This parameter combination constitutes a complete "spectrum-adaptive energy programming" process, causing the sub-graphite internal interface polarization domain and the localized carrier states to generate a coordinated oscillating response coupled with 10 Hz resonance, thus obtaining a biocompatible functional medium.

[0042] Broadband dielectric spectrometry was used to compare the pre- and post-treatment graphite samples. The dielectric loss factor of the treated sample at 10 Hz increased by more than 50% compared to the untreated original graphite under the same testing conditions. This result confirms that the graphite, after the S110 process, has successfully formed a biocompatible state with an objective physical fingerprint.

[0043] To verify the actual bioregulatory capacity of the bioadaptive functional medium under power-off conditions, this invention constructs a preliminary verification model: two sub-graphite media prepared as described above and confirmed to meet the requirement of ≥50% dielectric loss increase are taken; they are fixed on the palms of the subject's left and right hands respectively (skin is clean and undamaged), and kept completely powered off and without external wiring; electrocardiogram (ECG) and prefrontal single-lead electroencephalogram (EEG) signals are simultaneously collected from the subject at rest for 15 minutes.

[0044] Simultaneous monitoring of heart rate variability and prefrontal EEG revealed a measurable first change in the high-frequency power of heart rate variability, which time-series clearly preceded the measurable second change in the prefrontal alpha wave power. This temporal physiological effect is unique to the product of this invention, indicating that the physiological response exhibits a temporal characteristic of signal transmission from the autonomic nervous system to the central nervous system, distinguishing it from the effect pattern induced by exogenous forced intervention in existing technologies.

[0045] Furthermore, this embodiment of the invention also provides a bioadaptive functional media product, which is prepared by a method for preparing bioadaptive functional media.

[0046] This product is not obtained by changing the chemical composition, crystal structure, or macroscopic geometry of the base medium, but is defined entirely and uniquely by the above-mentioned preparation method. That is, its existence, functional state, and identifiability are all rooted in the closed loop of the "spectrum-adaptive energy programming" and "environmentally controlled relaxation curing" process contained in this method, as well as the objectively measurable and verifiable physical state transformation results that are inevitably caused by this process.

[0047] In other words, this product is a process-dependent functional material carrier: the same basic medium (such as sub-graphite), without S110 processing, is merely a conventional material; once processed by this method and successfully formed into a biocompatible state, it acquires a novel energy information expression capability that is distinct from the original material and possesses long-term stability. This capability is not manifested as a significant change in traditional physical quantities such as resistivity, hardness, or color, but rather as a reproducible enhanced dielectric response characteristic at specific frequency points within a wide dielectric spectrum of 0.1Hz–100Hz.

[0048] Furthermore, embodiments of the present invention also provide a storage-type sustained-release bioregulation device, see [link to previous document]. Figure 2 The storage-release biomodulation device 300 includes at least two bioadaptive functional media products 200. The storage-release biomodulation device is configured to contact the human body surface in a completely power-off operating mode.

[0049] The device consists of at least two bioadaptive functional media products, each of which is independent of the others, with no electrical connection, no line coupling, and no energy exchange path. The whole device is configured to contact the human body surface and function only in a completely power-off working mode. That is, the device itself does not contain any power source, is not connected to external circuits, does not generate active electromagnetic radiation, and does not output current or voltage. All its regulatory effects come from the physical field effect of the bioadaptive state that has been solidified inside each media product.

[0050] When two media products with the same structure and physical state are placed in the left and right palms respectively, the bilateral vagus nerve afferent pathways can be activated simultaneously, forming a spatially symmetrical and temporally coordinated neural signal input, thereby enhancing the stability and signal-to-noise ratio of autonomic nervous regulation.

[0051] Since the entire device does not involve any form of external energy input or real-time energy conversion during operation, it fundamentally avoids the inherent safety risks of electrolysis, tissue thermal damage, and electrophysiological interference faced by traditional electrical stimulation techniques. More importantly, its mechanism of action does not rely on a current circuit, thus completely eliminating the clinical contraindication in existing regulations that "electrodes should not be placed in the palms of the hands to prevent current from flowing through the heart." For the first time, the palm, a natural energy interaction interface with a high density of nerve endings, a high surface area-to-volume ratio, and strong autonomic nerve reflex sensitivity, can safely, directly, and continuously participate in systemic physiological regulation.

[0052] Furthermore, embodiments of the present invention also provide a biological regulatory system, see [link to previous document]. Figure 3 The bioregulation system 400 includes at least one bioadaptive functional media product 200 and a safe real-time excitation module 410.

[0053] See Figure 4 The safe real-time excitation module 410 includes a low-power power supply 411, an electrode 412, and a safety control unit 413, and is configured to output a periodic electrical signal with a preset frequency and a preset current intensity.

[0054] The working modes of biological regulatory systems include storage-slow release mode and real-time activation mode.

[0055] The storage slow-release mode is as follows: the safe real-time excitation module is in a closed or standby state, and it only comes into contact with the human body surface through the functional medium product, and the regulatory effect is generated by the slow-released bioadaptation field inside it. The real-time excitation mode is as follows: the safe real-time excitation module is activated, and periodic electrical signals are applied to the human body through the functional medium product, which generates a synergistic enhancement effect with the bioadaptation field of the functional medium product itself.

[0056] The safety control unit is configured to prevent the safety real-time excitation module from outputting periodic electrical signals and force the system to operate in storage slow-release mode when the functional medium product is detected to be in contact with the palms or precordial region of the human body.

[0057] In the storage-release mode, the safety real-time excitation module is in a closed or standby state, and the device as a whole does not output any electrical signals. The regulatory effect comes entirely and exclusively from the bioadaptive field released by the bioadaptive functional medium itself, which is achieved through direct contact between the medium and the human body surface. In this mode, the device is equivalent to the above-mentioned storage-release bioregulatory device and has all the safety characteristics of complete power-off, zero current, and passive long-term operation.

[0058] In real-time excitation mode, the safe real-time excitation module is activated, and its output periodic electrical signal is coupled to the biocompatible functional medium product via electrodes, and then applied to human tissue through the medium product. In this mode, the exogenous microcurrent and the inherent biocompatible field within the medium superimpose and resonate in both spatial and temporal dimensions, resulting in a stronger bioregulatory effect compared to a single mode. This effect is not a simple superposition, but rather stems from the medium's specific response to low-frequency electrical signals. Its physical basis lies in the fact that the solidified dielectric structure within the medium acts as an "energy information amplifier" and a "rhythm synchronizer," enhancing the bioavailability of exogenous signals.

[0059] To ensure safe operation, this system, through hardware logic and / or software configuration, forcibly prohibits the use of real-time excitation mode in the palms and precordial anatomical locations of both hands. This prohibition is an inherent safety operating rule of the device, not a user prompt: when the electrode detects that the contact area has fallen into the aforementioned prohibited anatomical area, the system automatically cuts off the low-power power output and switches to the storage-release mode. This design directly embeds clinical safety guidelines into the functional architecture of the device, achieving a paradigm shift from human adherence to contraindications to system-level physical avoidance.

[0060] In summary, the present invention provides a method for preparing bioadaptive functional media, bioadaptive functional media products, a storage-and-release bioregulatory device, and a bioregulatory system. These technologies achieve a bioadaptive functional state at the solid media level that requires no chemical modification, does not rely on external energy supply, is objectively characterizable, and is stable over a long period. Compared to existing contact-based energy regulation technologies, which suffer from structural defects such as reliance on external real-time driving, instantaneous effect loss, and limited interface, the present invention offers the following substantial advancements: it abandons the device-dominated, energy-imposed approach, shifting to a new paradigm of media-based, information-released regulation, making the functional media itself an energy information carrier with biorhythm encoding capabilities, achieving physiological homeostasis regulation under power-off conditions; because the storage-and-release mode is completely free of current, voltage, and electromagnetic radiation, it completely avoids the risks of electrolytic reactions, tissue thermal damage, and electrophysiological interference; and, most importantly, it overcomes clinical contraindications, achieving for the first time safe, direct, and symmetrical application to highly sensitive anatomical sites such as the palms of both hands, significantly improving the signal-to-noise ratio and stability of autonomic nervous system regulation.

[0061] In the embodiments provided by this invention, it should be understood that the disclosed apparatus and methods can also be implemented in other ways. The apparatus embodiments described above are merely illustrative; for example, the flowcharts and block diagrams in the accompanying drawings illustrate the architecture, functionality, and operation of possible implementations of apparatus, methods, and computer program products according to various embodiments of the present invention. In this regard, each block in a flowchart or block diagram may represent a module, segment, or portion of code, which contains one or more executable instructions for implementing a specified logical function. It should also be noted that in some alternative implementations, the functions marked in the blocks may occur in a different order than those marked in the drawings. For example, two consecutive blocks may actually be executed substantially in parallel, and they may sometimes be executed in reverse order, depending on the functions involved. It should also be noted that each block in a block diagram and / or flowchart, and combinations of blocks in block diagrams and / or flowcharts, can be implemented using a dedicated hardware-based system that performs the specified function or action, or using a combination of dedicated hardware and computer instructions.

[0062] In addition, the functional modules in the various embodiments of the present invention can be integrated together to form an independent part, or each module can exist independently, or two or more modules can be integrated to form an independent part.

[0063] If the functionality is implemented as a software module and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of this invention, or the part that contributes to the prior art, or a part of the technical solution, can be embodied in the form of a software product. This computer software product is stored in a computer-readable storage medium and includes several instructions to cause a computer device (which may be a personal computer, server, or network device, etc.) to execute all or part of the steps of the methods of the various embodiments of this invention. The aforementioned storage medium includes various media capable of storing program code, such as USB flash drives, portable hard drives, read-only memory (ROM), random access memory (RAM), magnetic disks, or optical disks.

[0064] The above are merely preferred embodiments of the present invention and are not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

[0065] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A method for preparing biocompatible functional mediators, characterized in that, include: A biologically adapted functional medium is obtained by applying a periodic electrical signal of a preset frequency to the basic medium. The bio-adaptive functional medium has a dielectric loss factor that is at least 50% higher than that of the basic medium at the preset frequency; The basic medium is a naturally occurring carbon-based mineral material, whose carbon component exists in a multi-level fractal structure formed by the gradual aggregation of reduced graphene oxide nanosheets.

2. The method according to claim 1, characterized in that, The current intensity of the periodic electrical signal does not exceed 100 μA.

3. The method according to claim 1, characterized in that, The preset frequency is in the range of 0.5Hz to 30Hz.

4. The method according to claim 1, characterized in that, The underlying medium is sub-graphite, or a natural carbon-based mineral material with the same reduced graphene oxide nanosheet multi-level fractal structure as sub-graphite.

5. A biocompatible functional media product, characterized in that, Prepared by the method as described in any one of claims 1 to 4.

6. A storage-type slow-release bioregulation device, characterized in that, Includes at least two bioadaptive functional media products as described in claim 5; The storage-release biomodulation device is configured to contact the human body surface in a completely power-off operating mode.

7. A biological regulatory system, characterized in that, It includes at least one bio-adaptive functional medium product as described in claim 5 and a safe real-time excitation module; the safe real-time excitation module includes a low-power power supply, electrodes, and a safety control unit; The safe real-time excitation module is configured to output a periodic electrical signal with a preset frequency and a preset current intensity. The operating modes of the bio-regulatory system include a storage-slow-release mode and a real-time activation mode; The storage slow-release mode is as follows: the safe real-time excitation module is in a closed or standby state, and only the functional medium product comes into contact with the human body surface, and the regulatory effect is generated by the slow-released bioadaptation field inside it. The real-time excitation mode is as follows: the safe real-time excitation module is activated, and the periodic electrical signal is applied to the human body through the functional medium product, which generates a synergistic enhancement effect with the bioadaptation field of the functional medium product itself. The safety control unit is configured to: when the functional medium product is detected to be in contact with the palms or precordial region of a human body, prevent the safety real-time excitation module from outputting the periodic electrical signal and force the system to operate in the storage slow-release mode.

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