5 results about "Tensin" patented technology

The present invention discloses a method for constructing and using an animal model of dementia with Lewy bodies, and belongs to the technical field of animal model construction. The construction method comprises: obtaining a phosphatase and tensin homologous gene-induced kinase 1 gene knockout experimental animal A using gene editing technology, and crossbreeding with an Alzheimer's disease model experimental animal B simulating β-amyloid protein (Aβ) pathology, and screening offspring containing both Alzheimer's disease-related mutations and pink1 gene knockout. The model constructed by the present invention is to deposit β-amyloid protein on the basis of pink1 gene knockout, induce α-synuclein protein aggregation using β-amyloid plaques (Aβ), widely produce Lewy bodies in the cortex and hippocampus, simulate the occurrence and development process of DLB, and provide a reliable animal model for disease mechanism research and therapeutic drug screening and development.

The invention discloses a preeclampsia marker as well as application and a kit thereof. Comprising phosphatase and tension protein (PTEN), and the marker can be used for preparing a serological detection preeclampsia diagnostic reagent or diagnostic tool to perform early screening on preeclampsia risk population and fill the blank of current preeclampsia serological diagnosis. The invention belongs to the technical field of medicine. Furthermore, the invention also provides an ELISA kit for detecting preeclampsia, the sampling means is non-invasive and non-invasive, high-precision endoscope equipment is not needed, the kit can be applied to primary medical institutions, the early diagnosis of preeclampsia and the adoption of prevention means for intervention are facilitated, and the kit has good application value.

Implantable polymers that release a therapeutic agent near a tumor in a patient are disclosed. In some embodiments, a polyethylene glycol hydrogel can release a small molecule, such as a STING agonist, near a phosphatase and tensin homolog (PTEN)-null triple negative breast cancer (TNBC) in the patient.

Implantable polymers that release a therapeutic agent near a tumor in a patient are disclosed. In some embodiments, a polyethylene glycol hydrogel can release a STING agonist and / or CAR-T cells near a phosphatase and tensin homolog (PTEN)-deficient triple negative breast cancer (TNBC) in the patient.

The present invention relates to a compound of the formula (I) wherein the substituents R1, R2, R3 and R4 are as defined in the disclosure of this invention. Said compounds are for treating brain cancer, wherein brain cancer is glioblastoma and such glioblastoma is Phosphatase and Tensin Homolog deleted on Chromosome 10 or PTEN.