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9 results about "Leucine-rich repeat" patented technology
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A leucine-rich repeat (LRR) is a protein structural motif that forms an α/β horseshoe fold. It is composed of repeating 20–30 amino acid stretches that are unusually rich in the hydrophobic amino acid leucine. These tandem repeats commonly fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Typically, each repeat unit has beta strand-turn-alpha helix structure, and the assembled domain, composed of many such repeats, has a horseshoe shape with an interior parallel beta sheet and an exterior array of helices. One face of the beta sheet and one side of the helix array are exposed to solvent and are therefore dominated by hydrophilic residues. The region between the helices and sheets is the protein's hydrophobic core and is tightly sterically packed with leucine residues.
Leucine rich repeat kinase 2 (LRRK2) degrading compounds and associated methods of use
PendingUS20260085066A1Organic active ingredientsNervous disorderLeucine-rich repeatPharmaceutical drug
The present disclosure relates to bifunctional compounds that cause the degradation of LRRK2; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with LRRK2, including Parkinson's Disease.
Owner:ARVINAS OPERATIONS INC
Benzimidazole and benzimidazolone based protac compounds for the targeted degradation of leucine rich repeat kinase 2 (LRRK2)
ActiveUS12589156B2Organic active ingredientsNervous disorderProteasome degradationLeucine-rich repeat
Owner:ARVINAS OPERATIONS INC
Use of an aberrant leucine-rich repeat receptor-like kinase gene in cotton
The application discloses an application of a leucine-rich repeat receptor-like kinase gene of Gossypium anomalum, which is composed of 3885 bases, wherein the first base from the 5' end is a transcription start site, and the 3885th base is a transcription termination site. Expression of the gene can cause a lethal phenotype of a single segment introgression line CSSL11-9 of the Gossypium anomalum. The lethal phenotype is inhibited by silencing the gene expression in the single segment introgression line CSSL11-9 of the Gossypium anomalum, and the single segment introgression line CSSL11-9 can survive normally. In addition, the gene can also endow cotton with resistance to verticillium wilt and fusarium wilt, and the resistance of the CSSL11-9 plant with the silenced gene to the cotton verticillium wilt and fusarium wilt is significantly reduced, thereby providing an important gene resource for cotton breeding against the verticillium wilt and the fusarium wilt.
Owner:JIANGSU ACAD OF AGRI SCI
Oligonucleotide for reducing the expression of leucine-rich repeat kinase 2 (LRRK2) and its use for preventing and / or treating human diseases
The present invention refers to an oligonucleotide comprising 10 to 25 nucleotides, at least one nucleotide having a modification, wherein the oligonucleotide hybridizes with a transcript or an mRNA of leucine-rich repeat kinase 2 (LRRK2) of SEQ ID NO. 1 and / or with pre-mRNA of LRRK2 of SEQ ID NO. 2 and / or a fragment thereof. The invention further refers to a pharmaceutical composition comprising such oligonucleotide, and the use of the oligonucleotide and pharmaceutical composition, respectively, for use in method of preventing and / or treating a human disease.
Owner:SCINEURO THERAPEUTICS INC +1
PROTAC compounds based on benzimidazole and benzimidazole for the targeted degradation of leucine-rich repeat kinase 2 (LRRK2).
PendingCN122319142AProteasome degradationLeucine-rich repeat
This article provides compounds (e.g., compounds of formula (la)) that recruit LRRK2 protein or its mutant form to E3 ubiquitin ligases for targeting ubiquitination and subsequent proteasome degradation.
Owner:ARVINAS OPERATIONS INC
Indazole based compounds and associated methods of use
Bifunctional compounds, which find utility as modulators of leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation / inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
Owner:ARVINAS OPERATIONS INC
Methods for controlling meristem size for crop improvement
This invention relates to compositions and methods for modifying a Leucine Rich Repeat Receptor Like Protein Kinase (LRR-RLK) gene in plants to increase kernel row number. The invention further relates to plants having increased kernel row number produced using the methods and compositions of the invention.
Owner:PAIRWISE PLANTS SERVICES INC
Receptor-like kinase MaHPCA1 and application thereof in relieving banana cold injury
The invention discloses receptor-like kinase MaHPCA1 and application thereof in relieving banana cold injury, and relates to the field of plant genetic engineering. According to the application disclosed by the invention, homologous genes MaHPCA1-1 and MaHPCA1-3 in two leucine-rich repeat receptor-like kinase gene families are found from bananas, and the generation of hydrogen peroxide, superoxide anions and malondialdehyde can be inhibited by overexpressing the MaHPCA1-1 and MaHPCA1-3 in banana peels, so that the cold injury symptom of the banana fruits is relieved; the cold resistance of the banana fruits under the postharvest low-temperature storage condition is improved, and the storage period of the banana fruits is prolonged.
Owner:HAINAN UNIV
Receptor-like kinase MaHPCA1 and application thereof in relieving banana chilling injury
The application discloses a receptor-like kinase MaHPCA1 and application thereof in relieving banana chilling injury, and relates to the field of plant genetic engineering. Two homologous genes MaHPCA1-1 and MaHPCA1-3 in a leucine-rich repeat receptor-like kinase gene family are found from banana, and overexpression of MaHPCA1-1 and MaHPCA1-3 in banana peel can inhibit the generation of hydrogen peroxide, superoxide anion and malondialdehyde, and further relieve banana fruit chilling injury symptoms, improve the cold resistance of banana fruit under postharvest low-temperature storage conditions, and prolong the storage period of banana fruit.
Owner:HAINAN UNIV