13 results about "Leucine-rich repeat" patented technology

The present disclosure relates to bifunctional compounds that cause the degradation of LRRK2; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with LRRK2, including Parkinson's Disease.

The present disclosure relates to compounds and methods for inhibiting Leucine-Rich Repeat Kinase 2 (LRRK2), the methods comprising administering to the subject a compound of Formula (I). In some embodiments, the disclosure provides compounds and methods for treating cancer.

Provided herein are compounds (e.g., compounds of Formula (Ia)) that function to recruit LRRK2 protein or a mutated version thereof to an E3 ubiquitin ligase for targeted ubiquitination and subsequent proteasomal degradation.

The application discloses an application of a leucine-rich repeat receptor-like kinase gene of Gossypium anomalum, which is composed of 3885 bases, wherein the first base from the 5' end is a transcription start site, and the 3885th base is a transcription termination site. Expression of the gene can cause a lethal phenotype of a single segment introgression line CSSL11-9 of the Gossypium anomalum. The lethal phenotype is inhibited by silencing the gene expression in the single segment introgression line CSSL11-9 of the Gossypium anomalum, and the single segment introgression line CSSL11-9 can survive normally. In addition, the gene can also endow cotton with resistance to verticillium wilt and fusarium wilt, and the resistance of the CSSL11-9 plant with the silenced gene to the cotton verticillium wilt and fusarium wilt is significantly reduced, thereby providing an important gene resource for cotton breeding against the verticillium wilt and the fusarium wilt.

Bifunctional compounds, which find utility as modulators of non-receptor Leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation / inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

The invention discloses an InDel marker related to the browning resistance character of pear pulp, a primer and a detection kit, the InDel marker is located at the 22496111-22496306 bp position of a chromosome 2 of a red fragrant pear genome, the overall length is 196 bp, the InDel marker is a deletion or insertion polymorphic site located in a pear Ras related leucine-rich repeat protein coding gene PbrPIRL promoter region, and the InDel marker is located at the deletion or insertion polymorphic site of the pear Ras related leucine-rich repeat protein coding gene PbrPIRL promoter region. The InDel marker is closely linked with the anti-browning character of pear pulp, a pear pulp single plant prone to browning shows that an InDel marker sequence is deleted, and a pear pulp anti-browning single plant shows that the InDel marker sequence is inserted. Based on the molecular marker and the method disclosed by the invention, the anti-browning variety can be quickly and accurately identified through a conventional molecular experiment. Besides, the detection method has the characteristics of simplicity and convenience in operation, high specificity and high accuracy, is not interfered by external factors such as climate and environment, provides reliable technical support for breeding of anti-browning pear varieties, and has important economic value and wide application prospect.

This invention relates to compositions and methods for modifying a Leucine Rich Repeat Receptor Like Protein Kinase (LRR-RLK) gene in plants to increase kernel row number. The invention further relates to plants having increased kemel row number produced using the methods and compositions of the invention.

The present invention refers to an oligonucleotide comprising 10 to 25 nucleotides, at least one nucleotide having a modification, wherein the oligonucleotide hybridizes with a transcript or an mRNA of leucine-rich repeat kinase 2 (LRRK2) of SEQ ID NO. 1 and / or with pre-mRNA of LRRK2 of SEQ ID NO. 2 and / or a fragment thereof. The invention further refers to a pharmaceutical composition comprising such oligonucleotide, and the use of the oligonucleotide and pharmaceutical composition, respectively, for use in method of preventing and / or treating a human disease.

This article provides compounds (e.g., compounds of formula (la)) that recruit LRRK2 protein or its mutant form to E3 ubiquitin ligases for targeting ubiquitination and subsequent proteasome degradation.

Bifunctional compounds, which find utility as modulators of leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation / inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

This invention relates to compositions and methods for modifying a Leucine Rich Repeat Receptor Like Protein Kinase (LRR-RLK) gene in plants to increase kernel row number. The invention further relates to plants having increased kernel row number produced using the methods and compositions of the invention.

The invention discloses receptor-like kinase MaHPCA1 and application thereof in relieving banana cold injury, and relates to the field of plant genetic engineering. According to the application disclosed by the invention, homologous genes MaHPCA1-1 and MaHPCA1-3 in two leucine-rich repeat receptor-like kinase gene families are found from bananas, and the generation of hydrogen peroxide, superoxide anions and malondialdehyde can be inhibited by overexpressing the MaHPCA1-1 and MaHPCA1-3 in banana peels, so that the cold injury symptom of the banana fruits is relieved; the cold resistance of the banana fruits under the postharvest low-temperature storage condition is improved, and the storage period of the banana fruits is prolonged.

The application discloses a receptor-like kinase MaHPCA1 and application thereof in relieving banana chilling injury, and relates to the field of plant genetic engineering. Two homologous genes MaHPCA1-1 and MaHPCA1-3 in a leucine-rich repeat receptor-like kinase gene family are found from banana, and overexpression of MaHPCA1-1 and MaHPCA1-3 in banana peel can inhibit the generation of hydrogen peroxide, superoxide anion and malondialdehyde, and further relieve banana fruit chilling injury symptoms, improve the cold resistance of banana fruit under postharvest low-temperature storage conditions, and prolong the storage period of banana fruit.