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370 results about "Gene family" patented technology

A gene family is a set of several similar genes, formed by duplication of a single original gene, and generally with similar biochemical functions. One such family are the genes for human hemoglobin subunits; the ten genes are in two clusters on different chromosomes, called the α-globin and β-globin loci. These two gene clusters are thought to have arisen as a result of a precursor gene being duplicated approximately 500 million years ago.

Cysteine variants of erythropoietin

The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby.
Owner:BOLDER BIOTECH

Markers for detection of gastric cancer

Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and / or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.
Owner:PACIFIC EDGE

Hybrid antibodies

Hybrid antibodies and / or hybrid antibody fragments and methods of making them are provided. In one embodiment the hybrid antibodies and / or hybrid antibody fragments contain heavy and / or light variable regions that contain two or more framework regions derived from at least two antibodies. In another embodiment, at least two of the framework regions are classified in the same germline gene family. In one embodiment, at least two framework regions are classified in the same germline gene family member. The hybrid antibodies or hybrid antibody fragments may contain human framework regions and nonhuman CDRs.
Owner:ALEXION PHARMA INC

Homologous 28-kilodalton immunodominant protein genes of Ehrlicha canis and uses thereof

The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family of Ehrlichia canis. Further disclosed is a multigene locus encoding all nine homologous 28-kDa protein genes of Ehrlichia canis. Recombinant Ehrlichia canis 28-kDa proteins react with convalescent phase antiserum from an E. canis-infected dog, and may be useful in the development of vaccines and serodiagnostics that are particularly effective for disease prevention and serodiagnosis.
Owner:RES DEVMENT FOUND

Regulatory sequences for expressing gene products in plant reproductive tissue

Expression cassettes causing specific regulatory control of transgene expression in plants, wherein the expression cassettes include regulatory sequences from the MADS gene family for expression of recombinant gene products in the reproductive tissue of plants for the purpose of generating abiotic stress tolerant plants.
Owner:SYNGENTA PARTICIPATIONS AG

Methods and compositions for monitoring t cell receptor diversity

The present invention provides an array for use in a method of monitoring T cell diversity. The array comprises a substrate having a plurality of capture probes that can specifically bind to a nucleic acid molecule corresponding to a T cell receptor (TCR) gene family selected from the group consisting of the TCR gene families listed in Table 1. In one format, the system has one or more oligonucleotide capture probes wherein each probe is selected from the group consisting of SEQ ID NO: 1-41. Further provided are methods for monitoring T cell diversity in a subject following, for example, allogeneic hematopoietic stem cell transplantation, or other treatment or therapy that contributes to an alteration in T cell population and / or diversity. Compositions of the invention include arrays, computer readable media, and kits for use in the methods of the invention.
Owner:ST JUDE CHILDRENS RES HOSPITAL INC

Brown planthopper resistant rice gene Bph9 as well as molecular marker and application thereof

The invention provides a brown planthopper resistant rice gene Bph9 as well as a molecular marker and application thereof. The brown planthopper resistant rice gene Bph9 has a nucleotide sequence as shown in SEQ ID No.1 and a cDNA (complementary Desoxvribose Nucleic Acid) sequence as shown in SEQ ID No.2. The Bph9 gene is located between molecular markers InD2 and RM28466. The molecular markers closely linked with the gene also includes one of RM28438, InD28450, InD28453, InD14, InD28432, RM28481 and RM28486 which can be used for sieving the rice containing the brown planthopper resistant gene Bph9. The Bph9 gene belongs to the NBS-LRR (Nucleotide Binding Site-Leucine Rich Repeat) gene family; the encoded protein is related to the plant disease resistance; the Bph9 gene is transferred into common rice by virtue of genetic transformation and hybridization, and thus the resistance of rice to brown planthopper can be improved, so that the damage of brown planthopper is decreased, and the purposes of yield increase and yield stabilization are realized.
Owner:WUHAN UNIV

Gene expression profiling in primary ovarian serous papillary tumors and normal ovarian epithelium

InactiveUS20060078941A1Highligthing the divergence of gene expressionMicrobiological testing/measurementBiological testingKallikrein-10Gene family
Gene expression profiling and hierarchial clustering analysis readily distinguish normal ovarian epithelial cells from primary ovarian serous papillary carcinomas. Laminin, tumor-associated calcium signal transducer 1 and 2 (TROP-1 / Ep-CAM; TROP-2), claudin 3, claudin 4, ladinin 1, S100A2, SERPIN2 (PAI-2), CD24, lipocalin 2, osteopontin, kallikrein 6 (protease M), kallikrein 10, matriptase and stratifin were found among the most highly overexpressed genes in ovarian serous papillary carcinomas, whereas transforming growth factor beta receptor III, platelet-derived growth factor receptor alpha, SEMACAP3, ras homolog gene family, member I (ARHI), thrombospondin 2 and disabled-2 / differentially expressed in ovarian carcinoma 2 (Dab2 / DOC2) were significantly down-regulated. Therapeutic strategy targeting TROP-1 / Ep-CAM by monoclonal chimeric / humanized antibodies may be beneficial in patients harboring chemotherapy-resistant ovarian serous papillary carcinomas. Claudin-3 and claudin-4 being receptors for Clostridium Perfringens enterotoxin, this toxin may be used as a novel therapeutic agent to treat ovarian serous papillary tumors.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ARKANSAS

Use of interfering RNA in the production of transgenic animals

The invention provides cells and animals, as well as methods of producing cells and animals, that express at least one interfering RNA molecule to regulate the expression of a specific gene or family of genes. The invention further provides novel iRNA molecules, as well as DNA templates for producing iRNA molecules.
Owner:REVIVICOR INC

Mutations of the pik3ca gene in human cancers

Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the P13K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the P13K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE

Cysteine variants of alpha interferon-2

The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby. Also disclosed are therapeutic methods for using the cysteine variants of the invention.
Owner:BOLDER BIOTECH

Rice blast resistance gene Pi7 and application thereof

The invention discloses a rice blast resistance gene Pi7 and application thereof, and provides a nucleotide sequence of the rice blast resistance gene Pi7 and an amino acid polypeptide sequence coded thereby. The nucleotide sequence comprises two genes which belong to members of a coiled-coil nucleotide binding site leucine-rich repeat (CC-NBS-LRR) resistance gene family and are constitutive expression genes. The invention also provides application of the gene to the aspect of transforming rice or breeding disease-resistant varieties of other plants and application of a molecular marker produced according to the gene sequence to breeding.
Owner:SOUTH CHINA AGRI UNIV

Brown planthopper resistant gene in rice and use thereof

The invention provides a brown planthopper resistance gene Bph14 in rice. The gene has a nucleotide sequence shown in SEQ ID No. 1 and a cDNA sequence thereof is shown in SEQ ID No.2. The gene Bph14 of the invention belongs to CC-NBS-LRR gene family, and coded protein is related to plant disease resistance. The gene Bph14 has function of resisting the brown planthopper. Through genetic transformation and hybridization, the gene Bph14 is transferred into normal rice varieties, which can improve the resistance of the rice to the brown planthopper, thus reducing the damage caused by the brown planthopper and achieving the purposes of increasing and stabilizing the production of rice.
Owner:WUHAN UNIV

Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof

The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby. Also disclosed are therapeutic methods for using the cysteine variants of the invention.
Owner:BOLDER BIOTECH

Analysis of gene family expression

InactiveUS6232065B1Eliminates the cumbersome cloning and sequencing strategiesOvercomes shortcomingSugar derivativesMicrobiological testing/measurementIndividual geneGene expression profiling
The present invention relates to methods and compositions for characterizing the expression patterns of genes and gene families. Specifically, the present invention provides means to generate and monitor gene expression profiles resulting from cellular and physiological changes such that the expression patterns of individual genes or groups of genes can be readily identified and characterized.
Owner:CASE WESTERN RESERVE UNIV

Mutations of the PIK3CA gene in human cancers

Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the P13K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the P13K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE

Inositol polyphosphate kinase genes and uses thereof

This invention relates to newly identified polynucleotides and polypeptides in the phytic acid biosynthetic pathway, variants and derivatives of same; methods for making the polynucleotides, polypeptides, variants, derivatives and antagonists. In particular the invention relates to polynucleotides and polypeptides of the inositol polyphosphate kinase gene family. In particular this invention relates to using the newly identified polynucleotides and polypeptides to modulate the phytic acid biosynthesis in such a way as to decrease phytate and / or increase non-phytate phosphorous, especially in corn or soy animal feedstuffs.
Owner:PIONEER HI BRED INT INC +1

Rice blast resistance gene Pi1 and application thereof

InactiveCN101906427ADoes not create linkage problems with bad genesNo cascading problemsMicrobiological testing/measurementPlant peptidesBiotechnologyDisease
The invention discloses clone and application of rice blast resistance gene Pi1. The rice blast resistance gene Pi1 comprises gene Pi1-1, or Pi1-2, or tandem sequence of the Pi1-1 and the Pi1-2, the nucleotide sequence of the Pi1-1 is shown as SEQIDNO:1, the nucleotide sequence of the Pi1-2 is shown as SEQIDNO:2, and the nucleotide sequence of the tandem sequence is shown as SEQIDNO:3. The two genes of Pi1-1 and Pi1-2 belong to members of CC-NBS-LRR resistance gene family and are constitutive expression genes. The rice blast resistance gene Pi1 can endue plants with specific disease resistance response to disease caused by rice blast fungus (Magnaporthe oryzae), and is suitable for the plants sensitive to pathogens. By connecting the Pi1 gene sequence with plants transformation carriers to be introduced to plant cells, genetically modified resistant varieties can be obtained so as to be applied to farm production.
Owner:SOUTH CHINA AGRI UNIV

Gene markers for chronic mucosal injury

The invention provides gene markers for chronic mucosal injury and ulcerative colitis. Expression products of the REG gene family can be used to detect the presence of chronic mucosal injury in a body sample of a human. The expression products of a gene represented by a Hs.111244 polynucleotide can be used to detect ulcerative colitis in a body sample of a human. Further, these markers can be used to differentiate humans with chronic mucosal injury from humans with common acute inflammatory colon disorder, common non-inflammatory benign colon disorder, and healthy colons. The degree of injury to the colon from chronic mucosal injury can be determined and the efficacy of therapy for chronic mucosal injury can be monitored. A method of screening compounds for anti-chronic mucosal injury and anti-ulcerative activity is also provided by these gene markers.
Owner:WASHINGTON UNIV IN SAINT LOUIS

High throughput discovery of new genes from complex mixtures of environmental microbes

Compositions and methods for isolating new variants of known gene sequences are provided. The methods find use in identifying variants, particularly homologs, in complex mixtures. Compositions comprise hybridization baits that hybridize to gene families of interest, particularly agricultural interest, in order to selectively enrich the polynucleotides of interest from complex mixtures. Bait sequences may be specific for a number of genes from distinct gene families of interest and may be designed to cover each gene of interest by at least 2-fold. Thus methods disclosed herein are drawn to an oligonucleotide hybridization gene capture approach for identification of new genes of interest from environmental samples. This approach bypasses the need for labor-intensive microbial strain isolation, permits simultaneous discovery of genes from multiple gene families of interest, and increases the potential to discover genes from low-abundance and unculturable organisms present in complex mixtures of environmental microbes.
Owner:AGBIOME INC

Malaria Vaccines

Transcript profiles for irradiated and non-irradiated P. falciparum sporozoites were compared in an attempt to identify transcripts that are reproducibly perturbed by irradiation. Four loci were identified with high confidence. Three of these transcripts were derived from 3 different known gene families, and the fourth from a gene encoding a conserved hypothetical protein of unknown function. All four loci are up-regulated in radiation attenuated sporozoites which have been shown to be very effective in establishing protective immunity against malaria. Up-regulation of these transcripts contributes directly to protective immunity. The polypeptides encoded by the transcripts, individually and / or in combination, are incorporated into subunit vaccines, useful for the prevention of malaria and the establishment of protective immunity against malaria.
Owner:SANARIA INC

Brassica napus, parent species Chinese cabbage, cabbage MYBL2 (v-myb avian myeloblastosis viral oncogene homolog-like 2) gene family and application thereof

InactiveCN102226193AReduced seed coat pigmentSeed coat thinningFermentationVector-based foreign material introductionBrassicaHigh homology
The invention discloses a Brassica napus, parent species Chinese cabbage, cabbage MYBL2 (v-myb avian myeloblastosis viral oncogene homolog-like 2) gene family. The Chinese cabbage MYBL2 gene family comprises a BrMYBL2-1 gene and a BrMYBL2-2 gene. The cabbage MYBL2 gene family comprises a BoMYBL2-1 gene and a BoMYBL2-2 gene. The Brassica napus MYBL2 gene family comprises a BnMYBL2-1 gene, a BnMYBL2-2 gene, a BnMYBL2-3 gene, a BnMYBL2-4 gene. Eight MYBL2 genes have higher homology. The invention also discloses the application of the above gene families in molecular breeding with characters, such as plant seed coat color, seed coat thickness and the like. After a just overexpression plant carrier is built and double 10 number in the black Brassica napus variety, the Brassica napus is compared with the contrast of the explant of a non-transgenosis, transgenosis plants normally grow and develop, pigments such as Proanthocyanidins in the seed coat are reduced, and meanwhile the seed coat becomes thin to form the transgenosis yellow seed character.
Owner:SOUTHWEST UNIVERSITY

Derivatives of growth hormone and related proteins, and methods of use thereof

The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby. Also disclosed are therapeutic methods for using the cysteine variants of the invention.
Owner:BOLDER BIOTECH

Application of osa-MIR167a gene for regulating and controlling plant type of paddy rice

The invention relates to the field of plant genetic engineering and specifically relates to an application of an osa-MIR167a gene for regulating and controlling plant type of paddy rice. The osa-MIR167a gene has several homologous genes in paddy rice genome and belongs to a same gene family MIR167 as an arabidopsis thaliana ath-MIR167 gene. The osa-MIR167a gene has a function of regulating and controlling the plant type of paddy rice and the nucleotide sequence thereof is shown in the sequence table SEQ ID NO:1 while the core sequence formed by transcription and splicing is shown in the sequence table SEQ ID NO:3. An ideal plant type and increased yield are achieved by changing the expression models of the osa-MIR167a gene or other members in the osa-MIR167a gene family through gene engineering and regulating and controlling the tillering angle, the height and the effective tillering number of the plant. The invention discloses the application of the osa-MIR167a gene for regulating and controlling the plant type of paddy rice.
Owner:HUAZHONG AGRI UNIV

Plant cytoplasmic male sterile recovering gene and its use

The present invention provides the nucleotide sequence and encoded amino acid polypeptide sequence of one cytoplamis male sterile restoring gene OsRf1 originating from rice. The gene is member of PPR gene family, and is one constitutive expression gene. The present invention also relates to the application of utilizing the gene in transforming rice and other plant breeding restorer and the application of the molecular label produced based on the gene sequence in breeding.
Owner:SOUTH CHINA AGRI UNIV
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