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Anti-bacterial compositions

A kind of composition, technology of antibacterial agent, applied in the field of antibacterial composition, can solve the problem to be determined etc.

Inactive Publication Date: 2011-04-27
NOVARTIS AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unlike Nod2, Nod1 is not related to Grim19 (Barnich N et al., 2005), suggesting that the mechanism by which Nod proteins prevent cellular infection remains to be determined

Method used

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Examples

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Embodiment Construction

[0058]According to the present invention there is thus provided an isolated protein comprising multiple LRR (leucine rich repeat) domains for use as an antimicrobial agent. In use of the present invention such as described below, these proteins have been found to be effective in killing a wide variety of bacteria with potency comparable to known antibiotics.

[0059] In a preferred embodiment of the invention there are LRRs at the C-terminus of the protein. This has been found to increase the antimicrobial activity of the protein.

[0060] Further preferably, each LRR domain independently comprises or essentially consists of an amino acid sequence of formula (I):

[0061] (F1LxxLxL(xxZ) Y F2) (I)

[0062] in:

[0063] F1 and F2 are independently contiguous amino acid sequences of 1 to 30 residues;

[0064] x can be any amino acid;

[0065] L can be Leu, Ile, Val or Phe;

[0066] Z can be NxL or CxxL;

[0067] N is Asn, Thr, Ser or Cys;

[0068] C is Cys or Ser; and

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PUM

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Abstract

An isolated protein for use as an antimicrobial agent comprises a plurality of LRR (leucine rich repeat) domains, each LRR domain independently comprising an amino acid sequence of formula (I): (F1LxxLxL(xxZ)YF2) wherein: F1 and F2 are independently, a contiguous amino acid sequence of between 1 and 30 residues; x can be any amino acid; L can be Leu, Ile, VaI or Phe; Z can be NxL or CxxL; N is Asn, Thr, Ser or Cys; C is Cys or Ser; and Y = 0 or 1.

Description

1. Field of invention [0001] The present invention relates to antibacterial compositions and methods for treating or preventing pathogenic bacterial infections. More specifically, the present invention relates to antibacterial pharmaceutical compositions useful in the treatment or prevention of bacterial infections and diseases associated therewith. Other aspects, objects and advantages of the invention will be apparent from the following description. 2. Background of the invention [0002] The intestinal epithelium encloses bacteria in the gut lumen, allowing the host to harvest prokaryotic metabolites that it cannot synthesize itself, while protecting the host from infection. Because epithelial cells are frequently exposed to the microbiota of the gastrointestinal tract, they are also a major entry point for many pathogens. To protect against host infection, epithelial cells express various pattern recognition receptors (PRRs) such as Nod2 to provide the first line of de...

Claims

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Application Information

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IPC IPC(8): C07K7/00C07K14/435A61K38/00A61P31/04
CPCA61K38/00C07K14/435A61P1/00A61P31/00A61P31/04Y02A50/30
Inventor S·帕金森L-H·佩雷兹
Owner NOVARTIS AG
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