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OX2 receptor homolog

A technology of antibodies and compounds, applied in the field of compositions for immune system function

Inactive Publication Date: 2008-09-03
MEDICAL RESEARCH COUNCIL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Nevertheless, identification of OX2R on mouse macrophages by blocking antibody OX89 has not been successful

Method used

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  • OX2 receptor homolog
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Experimental program
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Embodiment

[0894] I. General approach

[0895]Some standard methods are described and referenced, e.g., Maniatis et al. (1982) Molecular Cloning, A Laboratory Manual , Cold Spring Harbor Laboratory, Cold Spring Harbor Press; Sambrook et al. (1989) Molecular Cloning: A Laboratory Manual , (2d.ed.), vols.1-3, CSH Press, NY; or Ausubel et al. (1987 and suppl.) Current Protocols in Molecular Biology , Greene / Wiley, New York. Protein purification methods include ammonium sulfate precipitation, column chromatography, electrophoresis, centrifugation, crystallization, and others. See, eg, Ausubel et al. (1987 and Suppl); Coligan et al. (ed. 1996) and Suppl, Current Protocols In Protein Science Greene / Wiley, New York; Deutscher (1990) "Guide to Protein Purification" in Methods in Enzymology , vol. 182, and other volumes in this series; and manufacturers' literature utilizing protein purification products, eg, Pharmacia, Piscataway, N.J., or Bio-Rad, Richmond, CA. Fused to appr...

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Abstract

The present invention provides OX2 receptor homologs. The present invention also provides nucleic acids encoding mammalian, e.g., primate, receptors of OX2, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Method of using the compositions for both diagnostic and therapeutic utilities are described.

Description

[0001] This application is a divisional application of an invention patent application with an application date of May 11, 2000, an application number of 00810289.9, and an invention title of "Homologue of OX2 Receptor". field of invention [0002] The present invention relates to compositions and methods for affecting the physiology of mammals, including the function of the immune system. In particular, it provides agents or methods that can modulate the developmental and / or immune system. Diagnostic and therapeutic uses of these materials are also described. Background of the invention [0003] OX2 antigen (OX2) is a cell surface protein identified on various cells, including thymocytes, B lymphocytes, activated T lymphocytes, neurons, endothelial cells, and follicular dendritic cells. Barclay (1981) Immunology 44: 727-736. Sequence analysis revealed that it is a transmembrane protein comprising two extracellular immunoglobulin-like (Ig-like) regions and a short cytopla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/12C12N15/63C07K14/705C07K16/28A61K38/17A61K39/395A61P37/02A61P31/04A61KC07KC12NG01N
Inventor A·N·巴克莱M·H·布朗D·M·戈尔曼L·L·拉尼尔G·J·赖特H·切尔温斯基J·H·菲利普斯R·M·赫克J·D·塞德维克
Owner MEDICAL RESEARCH COUNCIL
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