Chemical modified adefovir and tynofovir
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- LIANYUNGANG RUNZHONG PHARMA CO LTD
- Publication Date
- 2007-04-18
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Abstract
Description
technical field
[0001] The present invention relates to the chemical modification of drug molecules to improve the deficiencies of existing drugs, specifically the combination of Adefovir (Adefovir, PMEA) or tenofovir (tenofovir, PMPA) and polyethylene glycol, Adefovir (PMEA) The combination of defovir or tenofovir and glycosylated polyethylene glycol also relates to their preparation method and antiviral application. Background technique
[0002] Adefovir and Tenofovir are nucleoside analogues with similar structures and have broad-spectrum antiviral activity. Their structural formulas are:
[0003]
[0004] Where A can choose H or CH 3 , when A represents H, it is adefovir; when A represents CH 3 At that time, it was tenofovir.
[0005] Clinical trials have found that both adefovir and tenofovir have good anti-AIDS virus (HIV) and hepatitis B virus (HBV) activities. Experiments have confirmed that adefovir and tenofovir have significant inhibitory effects on the rep...