Chemical modified adefovir and tynofovir

A technology of compounds and derivatives, applied in the field of chemically modified adefovir or tenofovir, can solve the problems of not reaching effective concentration, slow phosphorylation of host cells, etc.
CN1947796BActive Publication Date: 2010-11-24LIANYUNGANG RUNZHONG PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LIANYUNGANG RUNZHONG PHARMA CO LTD
Publication Date
2010-11-24

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Abstract

A chemically modified adefovir and tenofovir is prepared through the combination of adefovir (or tenofovir) with polyethanediol (or glycosylated polyethanediol). Their preparing process and their antiviral application are also disclosed.
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Description

Chemically modified adefovir or tenofovir technical field The present invention relates to the chemical modification of drug molecules to improve the deficiencies of existing drugs, specifically the combination of Adefovir (Adefovir, PMEA) or tenofovir (tenofovir, PMPA) and polyethylene glycol, Adefovir (PMEA) The combination of defovir or tenofovir and glycosylated polyethylene glycol also relates to their preparation method and antiviral application. Background technique Adefovir and Tenofovir are nucleoside analogues with similar structures and have broad-spectrum antiviral activity. Their structural formulas are: Among them, A can choose H or CH3. When A represents H, it is adefovir; when A represents CH3, it is tenofovir. Clinical trials have found that both adefovir and tenofovir have good anti-AIDS virus (HIV) and hepatitis B virus (HBV) activities. Experiments have confirmed that adefovir and tenofovir have significant inhibitory effects on the replication an...

Claims

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