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Ibuprofen nanoparticle with low renal toxicity and preparation method thereof

A technology of nephrotoxicity and nanoparticles, which is applied in the direction of pharmaceutical formulations, organic active ingredients, non-central analgesics, etc., can solve the problems of chronic nephrotoxicity and low bioavailability, achieve low nephrotoxicity, high preparation efficiency, and production low cost effect

Active Publication Date: 2021-06-04
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the problems of low bioavailability and chronic nephrotoxicity in existing non-steroidal anti-inflammatory drug ibuprofen preparations, the present invention aims to provide a nanoparticle for reducing nephrotoxicity of non-steroidal anti-inflammatory drug ibuprofen and its preparation method, and the use of organic solvents is avoided in the preparation, which meets the requirements of green environmental protection

Method used

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  • Ibuprofen nanoparticle with low renal toxicity and preparation method thereof
  • Ibuprofen nanoparticle with low renal toxicity and preparation method thereof
  • Ibuprofen nanoparticle with low renal toxicity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Add 1.0 g of ibuprofen, 10 g of polygonatum polysaccharide, 0.02 g of micropowdered silica gel, and 64 stainless steel ball milling beads with a diameter of 15 mm into a 330 mL polytetrafluoroethylene ball milling tank, and grind for 4 hours at 100 rpm. After ball milling, the compound powder is taken out, Obtain ibuprofen nanoparticles.

Embodiment 2

[0028] Add 1.0 g of ibuprofen, 10 g of arabinogalactan, 0.02 g of micropowdered silica gel, and 64 stainless steel ball milling beads with a diameter of 15 mm into a 330 mL polytetrafluoroethylene ball milling jar, and grind at 100 rpm for 4 hours. After ball milling, take out the compound powder to obtain ibuprofen nanoparticles.

Embodiment 3

[0030] Add 1.0 g of ibuprofen, 10 g of glycyrrhizic acid, 0.02 g of micropowdered silica gel, and 64 stainless steel ball milling beads with a diameter of 15 mm into a 330 mL polytetrafluoroethylene ball mill jar, and grind for 4 hours at 100 rpm. After ball milling, the compound powder is taken out. Obtain ibuprofen nanoparticles.

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Abstract

The invention relates to an ibuprofen nanoparticle with low renal toxicity and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The nanoparticle is prepared by placing ibuprofen, a plant-derived functional natural product auxiliary material, a flow aid and ball-milling beads in a ball-milling tank and carrying out a co-grinding reaction at a certain rotating speed, and the ibuprofen is uniformly entrapped in a carrier under the action of mechanical force, so that an ibuprofen nanoparticle product with low renal toxicity is obtained. According to the ibuprofen nanoparticle and the method, the nanoparticle is prepared through a limited preparation method, the operation is simple, the use of an organic solvent is avoided, the problems about raw material loss, thermal decomposition and the like caused by solvent residues and a solvent thermal removal process are prevented, and the advantages of high preparation efficiency, safe and reliable production, low production cost, less pollution and the like are achieved; and meanwhile, a plant-derived macromolecule is adopted as the carrier, so that the renal toxicity of the ibuprofen is reduced while solubilization and synergism are achieved, and the macromolecule is of great importance to safe medication of a non-steroidal anti-inflammatory drug.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a low-nephrotoxic ibuprofen nanoparticle and a preparation method thereof, which have low nephrotoxicity and improve its bioavailability. Background technique [0002] Ibuprofen (Ibuprofen, IBU), whose chemical name is 2-methyl-4-(2-methylpropyl) phenylacetic acid, is a clinically widely used non-steroidal antiinflammatory drug (non-steroidal antiinflammatory drugs, NSAIDs). IBU inhibits cyclooxygenase (COX), reduces the synthesis of prostaglandins, produces analgesic and anti-inflammatory effects, and plays an antipyretic effect through the hypothalamic thermoregulatory center. Compared with other types of antipyretic and analgesic drugs, ibuprofen has the characteristics of good antipyretic effect, less acute adverse reactions and shorter course of disease, and is widely used to relieve mild to moderate pain such as headache, joint pain, toothac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/36A61K47/28A61K31/192A61P29/00
CPCA61K9/146A61K9/145A61K31/192A61P29/00
Inventor 许文灏杨进利苏为科
Owner ZHEJIANG UNIV OF TECH
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