75 results about "Kidney Toxicity" patented technology

The invention relates to the technical field of traditional Chinese medicines, and provides application of quercetin in preparing a medicine for treating polycystic ovarian syndrome. A test is performed on a rat model with polycystic ovarian syndrome by adopting quercetin, and discovers that the quercetin has a remarkable treatment effect and can remarkably reverse insulin resistance. Quercetin does not have liver or kidney toxicity, is small in side effect, has a good clinical application prospect, does not have drug resistance, can avoid operative wounds, and obtains an excellent clinical effect in PCOS (polycystic ovary syndrome) treatment.

The invention discloses an allogeneic bone cement for bone defect repair, which is composed of a component A and a component B, wherein the component A is prepared by mixing allogeneic muscle tendon collagen fibers and allogeneic bone particles according to a ratio of 1:(2-8); the component B is a colorless, transparent and viscous sodium hyaluronate solution of which the pH value is 6-7 and the concentration is 5-20mg / ml; and the component A and the component B are mixed according to a ratio of 1g:(1.5-3.5)ml. The allogeneic bone cement has good biological activity and biodegradability, has no kidney toxicity, has fine osteoinduction and osteophony effects, and is convenient to use, thereby being widely used in the field of bone defect repair.

The invention relates to the use of schisandra fruit in preparing medicament for prevention and abatement of toxic and side effects of antineoplastic drugs including cardiovascular toxicity, liver toxicity, kidney toxicity, or bone marrow depression, or immunological suppression or trichomadesis.

The invention discloses a honeybee pupae extract and application in protecting against cisplatin induced kidney injury, and relates to the technical field of honeybee pupae and application. Accordingto the invention, the honeybee pupae extract is firstly prepared and then a product of the honeybee pupae extract is applied to treat the cisplatin induced kidney injury, and has the effects of treating the cisplatin induced kidney injury. An experiment finds that the honeybee pupae extract has extremely-high free radical scavenging activity and can improve the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in an organism. By inhibiting a molecular mechanism of inducing by cisplatin to form superoxide free radicals, the effect of reducing renal toxicity is achieved; meanwhile, the honeybee pupae extract has extremely-high nutritional value, so that animal physique can be improved and the immunity is enhanced; in addition, because the honeybee pupae extract isderived from active ingredients in the organism, the honeybee pupae extract has medicine and food dual-purpose function, and no toxic or side effects, can be obtained through ingestion and is expectedto be further developed as a safe and reliable treatment drug.

The invention discloses a low-renal-toxicity protein-ferric oxide composite nano magnetic resonance contrast agent as well as a preparation method and application thereof, and belongs to the technical field of medical materials. The preparation method of the magnetic resonance contrast agent comprises the following steps: mixing functional protein with a ferric salt solution formed by mixing Fe < 2 + > and Fe < 3 + >, and adding a NaOH solution into the mixed solution or sequentially adding the NaOH solution and an excessive hydrogen peroxide solution, so that the protein-ferric oxide composite nano magnetic resonance contrast agent can be prepared by a one-pot in-situ method. The contrast agent takes ferric oxide as a core, and the functionalized protein is wrapped on the core, so that the contrast agent has high uniformity, hydrophilicity and monodispersity, low renal toxicity and good biocompatibility, and can be used as a safe magnetic resonance contrast agent.

Six-ingredient rehmannia pill is a famous ancient medicine which is applied for almost a thousand years, and is also a popular drug which is often taken by people for a long term in pursuit of health care and body building, however, alisma in the raw material medicine can cause gastroenteritis, nausea, vomiting, dizziness, eye faint, abdominal pain, diarrhea, limb weakness, loss of appetite, itching, angioedema, allergic skin rashes or even respiratory paralysis and other poisoning symptoms. The ancient and modern medical literature points out that the alisma can not be taken for a long term or with a large amount at early time, or else, the long-term taking of the alisma can also cause sever side effects such as kidney toxicity and thus resulting in acute tubular necrosis and the like. The traditional Chinese medicine phellodendron has the function of reducing renal fire of the alisma in the six-ingredient rehmannia pill. The six-ingredient rehmannia pill is used to replace the alisma, is improved into a new six-ingredient rehmannia pill, not only can maintain the functions of nourishing yin and tonifying the kidney of the ancient six-ingredient rehmannia pill, but also can avoid adverse reactions caused by the use of the alisma, thereby being conducive to improving the safety of the medicine and being capable of obtaining a considerable amount of market share in the competition with the original six-ingredient rehmannia pill.

The invention discloses a pharmaceutical composition for treating acute kidney failure, which comprises (by weight ratio) 10.0-25.0 of Xiangdan injection, 1.0-5.0 of glycine, and 70.0-88.0 of physiological saline solution. The composition can be prepared into various dosage forms including injection, powder preparation, tablet, and capsule.

The invention discloses food suitable for acid-base equilibrium of uric acid, which relates to the technical field of a homologous formula of medicine and food and novel resource food. According to the formula, by considering constitutive characters of a patient with high uric acid, various traditional Chinese medicines of the homology of medicine and food are reasonably combined according to the quintessence theory of the traditional Chinese medicine, by adopting a traditional Chinese medicine extraction and special storage and natural fermentation principle, the food is produced by combining active molecules such as deep sea oligopeptide, spirulina and the like and mixing oil with a healthcare function, various vitamins and minerals, when eating the food, people do not need to avoid certain food, active ingredients can eliminate kidney toxicity in the human body, the taste is good, and the food can be eaten for a long time, meets the requirement of modern life, not only can be used as a single nutritional source to meet the nutritional need of the patient with high uric acid, but also has functions of inducing diuresis to alleviate edema, clearing away the heat, inducing dieresis, excreting dampness, checking diarrhea, nourishing and activating the blood, invigorating the spleen, reinforcing stomach, dispelling the humidity and improving the immunity. The preparation process is reasonable, simple, environmentally-friendly and easy for realizing the industrialized mass production.

The invention discloses a novel nano sustained-release drug-loaded material for inhibiting antibody-mediated rejection reaction in a targeted immune hair growth center, a preparation method and application. The novel nano drug-loaded material has targeting property, can slowly release drugs, can be used for treating inflammatory infiltration of transplanted organs, and is low in toxicity (low in neurotoxicity and renal toxicity) and small in side effect.