5 results about "Capecitabine" patented technology

The application provides a cattail extract capable of preventing and treating breast cancer and an application thereof, and belongs to the technical field of biological medicine. The cattail extract is prepared by the following steps: peeling cattails, drying and crushing cattail flesh to obtain cattail flesh powder; mixing the cattail flesh powder with water to extract, filtering to obtain filtrate and residue; concentrating the filtrate to obtain a concentrate, mixing the concentrate with an ethanol solution, standing, taking the precipitate and drying to obtain dry powder 1; mixing the residue with an ethanol solution, ultrasonic extraction, taking the extract and drying to obtain dry powder 2; and mixing the dry powder 1 and the dry powder 2 to obtain the cattail extract. The cattail extract has the advantages of sufficient extraction of active ingredients, various effective components and strong overall anti-tumor effect, and can achieve an ideal effect of preventing and treating breast cancer. The cattail extract is combined with capecitabine, which can synergistically enhance the anti-breast cancer effect, reverse drug resistance, reduce toxic side effects, and greatly improve the treatment tolerance and safety.

The application discloses application of a pharmaceutical composition with GL-V9 and a chemotherapeutic drug as active ingredients in treatment of tumors, and the GL-V9 can obviously achieve a drug synergistic effect when the GL-V9 is combined with a classical chemotherapeutic drug to treat tumors, and the effect is obviously superior to combination of similar drugs and the chemotherapeutic drug. The chemotherapeutic drugs include PARP1 inhibitors, capecitabine, irinotecan, sorafenib, cisplatin or 5-fluorouracil; and the tumor types include leukemia, colorectal cancer and lung cancer.

The present application relates to methods of treating ocular diseases. In particular, the present application provides the use of a combination therapy of administering a thymidylate synthetase inhibitor and a vascular endothelial growth factor inhibitor and a monotherapy of administering capecitabine in ocular diseases. The diseases have one or more of the following characteristics: ocular vascular leakage, ocular vascular pathology, retinal fibrosis, scarring, and retinal inflammation. Representative diseases include neovascular age-related macular degeneration, diabetic retinopathy, and retinal vein occlusion.

This invention provides a purification method for compound I, a key intermediate of capecitabine. The crude compound I is dissolved in an organic solvent, stirred at a first temperature, and primary tar is removed. Water is added at room temperature, and the pH is adjusted to alkaline with alkali to remove secondary tar. The organic phase is then concentrated and recrystallized. Compared to existing technologies or traditional column chromatography processes, the purification method provided by this invention significantly improves product purity, removes tar-like substances and impurities of similar polarity generated during preparation, ensuring that the content of the toxic impurity methyl methanesulfonate in the intermediate is less than 1.0 ppm, yielding a white solid compound I with a purity ≥99%. This method is suitable for large-scale industrial production, avoids column chromatography separation, is low-cost, and environmentally friendly.

This invention discloses the application of a pharmaceutical composition with GL-V9 and chemotherapeutic drugs as active ingredients in the treatment of tumors. When GL-V9 is combined with classic chemotherapeutic drugs to treat tumors, it can achieve a significant synergistic effect, and its effect is significantly better than the combination of similar drugs and chemotherapeutic agents. These chemotherapeutic drugs include capecitabine; the tumor types include leukemia, colorectal cancer, and lung cancer.