Tanshinon IIA sulfonic acid sodium glucose injection liquid and its preparing method
A technology of glucose injection and sodium sulfonate, applied in pharmaceutical formulations, cardiovascular system diseases, drug combinations, etc., can solve the problems of affecting the stability of injections, the influence of therapeutic effects, and difficulty in grasping the dose, and solve the problem of discoloration and instability. Sexuality, better therapeutic effect, less impurity effect
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[0019] Tanshinone IIA sodium sulfonate 0.4g, glucose 250g, antioxidant sodium bisulfite 5.0g, cysteine hydrochloride 1.0g, water for injection 5000ml.
[0020] Add 4000ml of water for injection into 0.4g of tanshinone IIA sodium sulfonate, and dissolve; then add glucose, sodium bisulfite and cysteine hydrochloride, and adjust the Ph value to 4.5 with 0.1mol / L sodium hydroxide; 0.1% volume of activated carbon for needles was incubated and stirred at 80°C for about 30 minutes, filtered and decarbonized; after cooling, the remaining water for injection was added to a sufficient amount, and after the content was determined to pass, filter with a 0.45μ microporous membrane; Fill the filtrate into a 500ml infusion bottle, put a polyester film on it, cover with a rubber stopper and press the cap, and sterilize under circulating steam at 115°C for 30 minutes to obtain the final product.
[0021] Since antioxidants are added to this product to make the product more stable, an alkal...
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