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Tanshinon IIA sulfonic acid sodium glucose injection liquid and its preparing method

A technology of glucose injection and sodium sulfonate, applied in pharmaceutical formulations, cardiovascular system diseases, drug combinations, etc., can solve the problems of affecting the stability of injections, the influence of therapeutic effects, and difficulty in grasping the dose, and solve the problem of discoloration and instability. Sexuality, better therapeutic effect, less impurity effect

Inactive Publication Date: 2005-07-20
昆明希捷医药研发有限公司
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  • Summary
  • Abstract
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AI Technical Summary

Problems solved by technology

The injection will become darker when exposed to light and high temperature, and the glucose will also oxidize and change color after being placed for a long time, thus affecting the stability of the injection, making its potency decrease or uncertain, and it is difficult to determine the dosage in clinical application. Healing will also be affected by

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0019] Tanshinone IIA sodium sulfonate 0.4g, glucose 250g, antioxidant sodium bisulfite 5.0g, cysteine ​​hydrochloride 1.0g, water for injection 5000ml.

[0020] Add 4000ml of water for injection into 0.4g of tanshinone IIA sodium sulfonate, and dissolve; then add glucose, sodium bisulfite and cysteine ​​hydrochloride, and adjust the Ph value to 4.5 with 0.1mol / L sodium hydroxide; 0.1% volume of activated carbon for needles was incubated and stirred at 80°C for about 30 minutes, filtered and decarbonized; after cooling, the remaining water for injection was added to a sufficient amount, and after the content was determined to pass, filter with a 0.45μ microporous membrane; Fill the filtrate into a 500ml infusion bottle, put a polyester film on it, cover with a rubber stopper and press the cap, and sterilize under circulating steam at 115°C for 30 minutes to obtain the final product.

[0021] Since antioxidants are added to this product to make the product more stable, an alkal...

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PUM

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Abstract

The persent invention relates to a sodium tanshinon IIA sulfonate glucose injection and its preparation method. Said injection contains (by wt%) 0.002-0.016% of sodium tanshinon IIA sulfonate, 5-25% of glucose, 0.05-0.2% of antioxidant and the rest is injection water. Said injection can obtain good therapeutic effect, and its preparation method is simple.

Description

technical field [0001] The invention relates to a tanshinone IIA sulfonate sodium glucose injection and a preparation method thereof. Background technique [0002] Before the present invention was made, there was a small injection of tanshinone IIA sodium sulfonate injection, which was produced by Shanghai No. 1 Biochemical Pharmaceutical Co., Ltd., and the trade name was Nuoxinkang. When in use, 40-80 mg is added to 500 ml of 5% glucose injection and diluted intravenously. The injection will become darker when exposed to light and high temperature, and the glucose will also oxidize and change color after being placed for a long time, thus affecting the stability of the injection, making its potency decrease or uncertain, and it is difficult to determine the dosage in clinical application. Healing effects are also affected. Contents of the invention [0003] The object of the present invention is to overcome the above-mentioned defects and provide a Tanshinone IIA Sodium...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/343A61P9/10
Inventor 秦引林颜培玲何龙其
Owner 昆明希捷医药研发有限公司
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