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159 results about "Quality enhancement" patented technology

Quality enhancement is therefore seen as an aspect of institutional quality management that is designed to secure, in the context of the constraints within which individual institutions operate, steady, reliable and demonstrable improvements in the quality of learning opportunities” (QAA 2006).

Product quality enhancement in mammalian cell culture processes for protein production

The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-galactose, preferably with feed medium containing D-galactose, preferably daily, to sustain a sialylation effective level of D-galactose in the culture for its duration, thus increasing sialylation of the produced proteins. The methods can also comprise at least two temperature shifts performed during the culturing period, in which the temperature is lower at the end of the culturing period than at the time of initial cell culture. The cell culture processes of the invention involving two or more temperature shifts sustain a high cell viability, and can allow for an extended protein production phase. The methods can also comprise the delayed addition of polyanionic compound at a time after innoculation. Supplementation of the cultures with D-galactose, preferably in a feed medium, to sustain galactose at sialylation effective levels in the cultures until the end of a culture run reverses a decline in sialylation that accompanies culture scale up, and is advantageous for large scale culturing processes.
Owner:BRISTOL MYERS SQUIBB CO

Product quality enhancement in mammalian cell culture processes for protein production

The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-galactose, preferably with feed medium containing D-galactose, preferably daily, to sustain a sialylation effective level of D-galactose in the culture for its duration, thus increasing sialylation of the produced proteins. The methods can also comprise at least two temperature shifts performed during the culturing period, in which the temperature is lower at the end of the culturing period than at the time of initial cell culture. The cell culture processes of the invention involving two or more temperature shifts sustain a high cell viability, and can allow for an extended protein production phase. The methods can also comprise the delayed addition of polyanionic compound at a time after innoculation. Supplementation of the cultures with D-galactose, preferably in a feed medium, to sustain galactose at sialylation effective levels in the cultures until the end of a culture run reverses a decline in sialylation that accompanies culture scale up, and is advantageous for large scale culturing processes.
Owner:BRISTOL MYERS SQUIBB CO

Method and device for drying and quality enhancement of lignite

The invention provides a method and a device for the drying and the quality enhancement of lignite. The device comprises a drying/sieving device, a preheating and drying/sieving device, a hot blast heater, a drying drum, a vibration fluidized bed, a cyclone separator, a defogger and a dust remover. The hot blast heater is respectively connected to the drying drum and the vibration fluidized bed, and an outlet of the preheating and drying/sieving device is respectively connected with the drying drum and the vibration fluidized bed. The preheating and drying/sieving device divides the lignite into two stages of big particle diameter and small particle diameter, high-temperature flue gas generated by the hot blast heater is used as a heating medium, the temperature of the flue gas is regulated by the residual low-oxygen gas after oxygen gas is separated by using an air separation system, the drying drum and the vibration fluidized bed are used for producing the quality-enhanced lignite with the big particle diameter and the small particle diameter, different production requirements are met, and part of exhausted tail gas is circularly used for preheating the raw materials of the lignite after being defogged. The invention respectively carries out drying and quality enhancement on the lignite according to the sizes of the particle diameters by grading equipment, eliminates the problem of uneven drying caused by different particle diameters, realizes the effective quality enhancement and the comprehensive utilization of coal resources, and is used for the large-scale process of drying and quality enhancement of the lignite.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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