19results about How to "Safe preparation" patented technology

The invention discloses high-purity oxamide with concentrated particle size and spherical morphology, a preparation method of the high-purity oxamide and application of the high-purity oxamide in preparation of a slow-release fertilizer, and belongs to the technical field of oxamide synthesis and application. The method comprises the following steps: mixing an ammonia-alcohol solution and an alcohol ester solution, conveying the mixed solution into a series tubular reactor for reaction, and then conveying the mixed solution into a parallel tubular reactor for reaction after pressure stabilization and flow equalization to obtain a reaction solution containing oxamide; performing flash evaporation on the reaction liquid to obtain flash evaporation liquid and flash evaporation gas, and performing solid-liquid separation on the flash evaporation liquid to obtain solid oxamide and filtrate; and drying the solid oxamide to obtain the oxamide. The method realizes high conversion rate and high purity, and the product has ultrafine particle size distribution. The purity of the prepared oxamide is greater than or equal to 99%, the D50 particle size is concentrated to 50 + / -15 microns, the spherical morphology is uniform, the release is stable, and the oxamide has a very good effect in preparation of long-acting slow-release fertilizers and combustion inhibitors and research on the nitrogen utilization rate.

This invention relates to a mesoporous platinum@platinum-nickel core-shell framework nanowire and its preparation method, comprising the following steps: (1) uniformly mixing platinum precursor, nickel precursor, structure directing agent, and reducing agent with a first solvent, and performing a hydrothermal reaction to obtain Pt@Pt-Ni core-shell nanowires; (2) uniformly mixing the Pt@Pt-Ni core-shell nanowires with a second solvent and acetic acid, and performing an etching reaction to obtain etched mesoporous platinum@platinum-nickel core-shell framework nanowires. This invention employs a hydrothermal method, which is simple, reproducible, and allows for batch production with safety. Compared with traditional commercial platinum-carbon catalysts, the catalytic activity is greatly improved, the stability is greatly enhanced, and the production cost is reduced.

The application discloses a method for preparing fluorine-containing diphenylmethane compounds by using sulfur hexafluoride as a fluorination reagent, and belongs to the technical field of organic chemical synthesis. The preparation method comprises the following steps: (1) mixing a photocatalyst, a solvent and a reducing agent, and performing ultrasonic treatment to obtain solution A; mixing a reaction substrate and the solvent to obtain solution B; the photocatalyst is one or more of 4CzIPN, Ir[dF(CF3)ppy]2(dtbpy))PF6, 9-thioxanthone and 10-phenylphenothiazine; the reaction substrate is a compound with a structural formula of R1 and R2 are both H, alkoxy or halogen; (2) mixing the obtained solution A and solution B in a sulfur hexafluoride gas atmosphere, and performing reaction under blue light illumination, and the fluorine-containing diphenylmethane compounds are obtained. The method has the beneficial effects that the fluorine-containing diphenylmethane compounds are efficiently prepared by using sulfur hexafluoride as the fluorination reagent, and by selecting raw materials and catalysts with certain proportions; the reaction raw materials are cheap; the preparation process is safe, mild, has good substrate compatibility and high preparation efficiency.

The container manufacturing method is a method for manufacturing a composite container by making a film (FL) tightly adhered to the inner surface of a container (10) having a flange portion protruding outward from the periphery of the opening. The method includes the following steps: a step of receiving the container (10) in a concave first forming mold (20); a step of moving a second forming mold (30) to the first forming mold (20), the second forming mold (30) being configured to face the first forming mold (20) and having a protrusion (34) disposed on the outer periphery of the flange portion when the container (10) is received in the first forming mold (20); a step of holding the film (FL) between the first forming mold (20) and the second forming mold (30); a step of making the held film (FL) tightly adhered to the inner surface of the container (10) by means of a pressure difference; and a step of melting the film (FL) by means of the protrusion (34).

The present application relates to a kind of reversible immunomagnetic beads for quickly separating target cells and its preparation method. Specifically, the present application provides a kind of reversible immunomagnetic beads, which includes magnetic carrier, affinity ligand and the connecting arm of the connection between the two, wherein the connecting arm contains a nucleotide sequence that can be specifically recognized by enzyme cutting, preferably containing deoxyinosine (dI) base.The present application also provides a kit comprising the magnetic beads and specific cleavage enzyme (such as endonuclease V).The magnetic beads of the present application can be cleaved by enzyme to achieve mild and rapid dissociation of the magnetic beads and target cells, with high separation efficiency and good cell viability, solving the problem of cell damage caused by irreversible binding of traditional immunomagnetic beads.The present application is simple to operate, does not require complex equipment, and the separated cells can be directly used for in vitro expansion, differentiation or cell therapy, and has wide research and clinical application prospects.

The invention discloses equipment for preparing glass fibers from waste glass, and relates to the field of glass fiber preparation, and the equipment for preparing the glass fibers from the waste glass comprises a cleaning mechanism, a fiber clamping mechanism, a fiber winding mechanism and a discharging hole; the cleaning mechanism can automatically clean the fiber outlet hole, firstly, manual operation is avoided, secondly, the manual operation cannot clean the fiber outlet hole before yarn outlet every time like the mechanism, and the cleaning of the mechanism can enable the cleaning of the fiber outlet hole to achieve a better yarn outlet effect. The cellosilk clamping mechanism can automatically complete the action of drawing the cellosilk, manpower is saved, the working efficiency is improved, the cellosilk winding mechanism can be matched with the former two mechanisms to autonomously clamp the cellosilk and wind the cellosilk, the overall efficiency of the equipment is high, the two mechanisms are linked with each other, the previous imperfect operation is changed, and the working efficiency and the product quality are improved.

The application discloses a key amino acid induced new crystal form of linagliptin based on protein-drug interaction structure mining and a preparation method thereof; and the technical scheme is that key amino acids are introduced into a solvent crystallization system of linagliptin to induce five new crystal forms of linagliptin; the preparation method does not need to use a large amount of organic solvents, has the characteristics of being simple, precise and efficient, has strong crystal form regulation capacity, is energy-saving, environment-friendly and safe, and is easy to realize green industrial production.

Disclosed is a production method of a p-toluenesulfonic acid salt of a compound represented by the following formula (I), the method including: a step of converting an N,N-dimethylacetamide compound of a compound represented by the following formula (I) into a p-toluenesulfonic acid salt of a compound represented by the following formula (I).

The invention discloses a method for preparing MXene through fluoride-free etching of an ultrasonic-assisted supercritical carbon dioxide flash explosion technology, and relates to the field of MXene preparation, MXene is prepared through a one-pot method by utilizing the synergistic effect of a high-frequency power ultrasonic technology, a flash explosion technology and a supercritical carbon dioxide fluid medium, and the MXene is prepared through a high-frequency power ultrasonic technology, a flash explosion technology and a supercritical carbon dioxide fluid medium. Putting the fluoride-free etching agent and the MAX phase into a supercritical reaction kettle; introducing carbon dioxide to enable the carbon dioxide to reach a supercritical state, and applying continuous or discontinuous high-frequency power ultrasonic treatment to carry out supercritical state etching reaction; after the reaction is finished, carrying out instantaneous supercritical flash explosion treatment; releasing the pressure of the flash explosion area and the buffer area, collecting the product, centrifuging, washing and drying to obtain an MXene product; according to the method, the production of fluorine-containing waste liquid is avoided, the etching efficiency and the product yield are remarkably improved by virtue of high permeability and mass transfer characteristics of supercritical carbon dioxide, and a new way is provided for large-scale preparation of various MXene materials.

The invention relates to the technical field of medical biological materials, and discloses mussel mucoprotein-agarose composite hydrogel and a preparation method and application thereof.The preparation method comprises the steps that agarose powder is dispersed in an aqueous solvent and heated to 80-100 DEG C to be completely dissolved, and a clear agarose solution is obtained; cooling the agarose solution to 40-60 DEG C, and keeping the agarose solution in a liquid state; the preparation method comprises the following steps: dissolving mussel mucin powder in an aqueous solvent or a buffer solution to prepare a mussel mucin solution, and slightly heating (1t, 40 DEG C) to promote dissolution; uniformly mixing the agarose solution obtained in the step S2 and the mussel mucoprotein solution obtained in the step S3 at 40-60 DEG C, and avoiding introducing bubbles to obtain a mixture; cooling the mixture to room temperature or body temperature to form composite hydrogel; carrying out irradiation sterilization on the composite hydrogel; the hydrogel is simple to prepare, has the thermal reversible gel characteristic, has good tissue adhesion and biocompatibility, and can effectively maintain the biological activity of the two natural components.

The application relates to the field of synthesis of selenide, and aims at the technical problems of complicated operation steps and slow reaction process in the implementation of the existing method, and provides an alkali metal selenide compound based on a direct preheating method, a preparation method and application thereof, which comprises the following steps: in a glove box in an inert gas atmosphere, heating alkali metal elements until the alkali metal elements are in a liquid state; mixing selenium elements with the liquid alkali metal elements and reacting for 1-3 seconds to form a molten state, after the molten substance is solidified, standing and cooling, and grinding to obtain an alkali metal selenide compound; the molar mass ratio of the selenium elements to the alkali metal elements is 1:0.5-2. x Se y The precursor compound can simplify a precursor synthesis process, reduce a synthesis condition threshold, reduce synthesis time cost and money cost, and improve precursor product synthesis efficiency.

The application relates to a linear negative temperature coefficient thermistor material. The material takes graphene oxide and a manganese-cobalt-nickel system transition metal oxide as a base material, is doped with urea, melamine, dicyandiamide, thiourea, boric acid or sodium borohydride, and is obtained by hydrothermal synthesis to have the linear negative temperature coefficient thermistor material. The material has obvious NTC performance, and the resistance value thereof changes with temperature in a linear manner. The preparation steps are simple, the process is safe, the cost is low, the performance is stable, and the material is easy to popularize in the industrial field. The material overcomes the process of realizing the compensation of electrical parameters from nonlinearity to linearity by complicated design of a circuit part in the application process of an existing nonlinear thermistor device, and has a larger TCR value compared to a linear negative temperature coefficient thermistor material obtained by only doping modification, and has a good application prospect in the temperature sensing field.

The application provides a method and system for natural evaporation crystallization of rare earth chlorides, and relates to the technical field of rare earth chlorides, which comprises the following steps: adjusting the pH value of a rare earth chloride solution to 5.0-7.5, and filtering and removing impurities after clarification; performing natural evaporation concentration on the rare earth chloride solution after impurity removal at the pH value to obtain a saturated rare earth chloride solution; and performing natural crystallization on the saturated rare earth chloride solution to precipitate rare earth chloride crystals. By using the method provided by the application, high-quality rare earth chloride crystals can be prepared in a relatively safe and environmentally friendly manner under the premise of greatly reducing evaporation energy consumption.

The invention discloses a small organic molecule modified composite photocatalyst as well as a preparation method and application thereof. The composite photocatalyst comprises small organic molecules and a photocatalyst containing active vacancies, wherein the small organic molecules can interact with the active vacancies and are embedded into the active vacancies; the active vacancies are generated by carrying out chemical etching treatment on the surface of the photocatalyst; the photocatalyst is an oxide, a sulfide or a nitride, and the composite photocatalyst enhances CO2 adsorption and electron transfer efficiency and improves separation efficiency, so that the catalyst can perform photocatalytic CO2 reduction under sunlight, and shows good catalytic stability under long-term continuous illumination.

The invention relates to a method for preparing an electronic-grade hydroxylamine aqueous solution by using an industrial-grade 50% hydroxylamine aqueous solution as a raw material through a microfiltration, ion exchange and nanofiltration combined technology. The method comprises the following steps: firstly, removing suspended particles and colloidal substances by microfiltration pretreatment; removing ion impurities through a specially modified ion exchange resin combined bed; and finally, deeply purifying by utilizing a nanofiltration technology to obtain a high-purity product. The method is short in process route, safe to operate and low in cost, the electronic-grade hydroxylamine aqueous solution can be stably produced, the metal ion content is lower than 10 ppt, the particle size of particles is controlled to be larger than 0.1 micrometer and smaller than 50 particles / ml, the resistivity reaches 18.2 M omega.cm, and the industrial requirements of semiconductor manufacturing, integrated circuits and display panels are met.

The present application relates to the technical field of interventional medical instruments, in particular to a pressure-controllable super-high-oxygen myocardial perfusion device and a pressure control method. The device comprises a normal-pressure oxygenation cavity, a heat exchange cavity and a high-pressure oxygenation cavity connected in sequence, and a main circulation loop and a static high-pressure oxygenation bypass; the inlet and outlet of the high-pressure oxygenation cavity are both provided with a blockage type peristaltic pump with pumping and sealing functions, the peristaltic pump is internally provided with an oxygenation membrane, and is configured with a pressurizing mechanism for simultaneously pressurizing liquid sides and oxygen sides on both sides of the oxygenation membrane, and a heat exchange mechanism for cooling the perfusion liquid to about 14 DEG C. The present application can prepare super-high-oxygen myocardial protective liquid with oxygen partial pressure higher than 700 mmHg through static, low-temperature and high-pressure oxygenation while maintaining extracorporeal circulation continuous perfusion, significantly improve the myocardial protection effect, and has the advantages of compact structure, precise control and safe operation.

This invention relates to the field of organic synthesis technology, specifically, providing a 1-methyl-2-nitro-3-(1,4-naphthoquinone-2-yl)indole with the following structural formula: It also provides a method for preparing 1-methyl-2-nitro-3-(1,4-naphthoquinone-2-yl)indole, comprising the following steps: using 1-methyl-3-(1,4-naphthoquinone-2-yl)indole as a raw material, adding a solvent, adding a nitrate after temperature control, then slowly adding an acid anhydride solution, reacting at controlled temperature for a period of time, and then processing to obtain 1-methyl-2-nitro-3-... (1,4-Naphthoquinone-2-yl)indole crude product, purified to obtain pure 1-methyl-2-nitro-3-(1,4-naphthoquinone-2-yl)indole; This invention uses 1-methyl-3-(1,4-naphthoquinone-2-yl)indole as the starting material to prepare the target product. A one-step electrophilic nitration reaction efficiently and safely prepares 1-methyl-2-nitro-3-(1,4-naphthoquinone-2-yl)indole. The synthesis method is easy to operate, environmentally friendly, low in cost, high in yield, and produces few byproducts, making it suitable for large-scale commercial preparation and production.

The application provides a fluorine-containing polymer for spleen-selective nucleic acid delivery, a polymer-lipid hybrid nanoparticle and a preparation method and application thereof. The preparation method of the fluorine-containing polymer for spleen-selective nucleic acid delivery comprises the following steps: preparing the fluorine-containing polymer through ring-opening addition reaction of alkylene oxide, fluorine-substituted alkylene oxide and polyethylene imine. The preparation method of the fluorine-containing polymer is simple, the conditions are mild, and the yield of the finished product is high; the obtained fluorine-containing polymer is used for preparing the polymer-lipid hybrid nanoparticle, nucleic acid can be specifically delivered to the spleen and play a role, the polymer-lipid hybrid nanoparticle has a good transfection effect on spleen dendritic cells, and has good biological safety.