50 results about "Implanted electrodes" patented technology

The invention discloses a patient improvement effect analysis method for controlling spinal cord electrical stimulation through an implantable brain-computer interface, and relates to the technical field of medical rehabilitation, and the method comprises the steps: multi-dimensional collaborative data collection: implanting electrodes in a target brain region and below a spinal cord injury segment, installing a detection element at an exoskeleton key part, and carrying out multi-dimensional collaborative data collection; a sensor is attached to a lower limb preset muscle group, electroencephalogram signals, SCS stimulation parameters, EXS motion data and neuromuscular response data are synchronously collected, and time correlation marks are embedded; according to the method, the reliability of motion intention decoding is remarkably improved by adopting a mode of combining multi-source signal preprocessing and a multi-mode intention recognition model, and in the signal preprocessing stage, the self-adaptive filtering algorithm combining Kalman filtering and wavelet threshold denoising is applied, so that the motion intention decoding efficiency is improved. SCS electrical stimulation interference, EXS motor noise and physiological noise in the electroencephalogram signals are effectively removed.

The invention relates to the technical field of nerve regulation and control, and provides a closed-loop ultrasonic brain-computer interface regulation and control method for improving post-stroke dysfunction, which comprises the following steps: S1, constructing integrated closed-loop ultrasonic brain-computer interface equipment which comprises a behavior control unit, a signal generator unit, a power amplifier unit and an electrophysiological signal monitoring unit; s2, constructing a mouse model, and embedding an electrode provided for the electrophysiological signal monitoring unit for monitoring; s3, dividing the mouse model into a random stimulation group and a brain-computer interface treatment group, and simultaneously performing closed-loop ultrasonic stimulation for preset time; s4, after closed-loop ultrasonic stimulation for a preset time, performing various behavioral test evaluations including representation of a sensory movement function and representation of an emotional emotion function; and S5, carrying out neural circuit remodeling evaluation, and observing the projection change of the high-order thalamus PO nuclei region of the mouse to the primary cortex. In the aspects of targeting, closed-loop control and integrated design, the method is expected to become a novel and effective post-stroke dysfunction treatment method.

The present disclosure relates to an interventional device for implanting an electrode into the brain through a blood vessel, the blood vessel having a blood vessel channel and a blood vessel wall, characterized in that the interventional device comprises: a first guide, the distal end of which is movable distally within the blood vessel channel and establishes a first support point within the blood vessel channel; a second guide, the distal end of the second guide being movable distally through the first guide in the vascular channel and establishing a second support point in the vascular channel such that the second guide extends in an arcuate manner between the first support point and the second support point; the puncture suite is used for carrying an electrode, and the far end of the puncture suite can penetrate through the first guiding piece to move towards the far side in the blood vessel channel and pierce the blood vessel wall in a target puncture area between the first supporting point and the second supporting point, so that the carried electrode is implanted into the brain. Furthermore, the present disclosure relates to a medical device.

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

The invention discloses a multi-brain-region electrode integral component and a manufacturing and implanting method thereof, the component comprises a multi-brain-region electrode support, the support is provided with multi-brain-region electrode jacks, and the multi-brain-region electrode jacks are through holes penetrating through the multi-brain-region electrode support and are parallel to each other; the clamping rod is fixed on the multi-brain-region electrode bracket; the multi-brain-region electrode vertically penetrates through the multi-brain-region electrode jack, and the multi-brain-region electrode is matched with the multi-brain-region electrode jack and is firmly adhered and fixed by glue; the multi-brain-region electrode jacks are used for fixing the relative positions of the electrodes on the horizontal plane of the support. According to the invention, electrodes can be implanted into a plurality of brain areas at the same time, and the operation difficulty of electrode manufacturing and electrode implantation is effectively reduced.

The present disclosure relates to a system (100) for providing stimulation to a patient, in particular stimulation to a left bundle branch area of the heart (701) of the patient, the system comprising: a stimulation pulse generator (10, 610); at least one electrode (30, 620, 800) having a distal end (31) for being engaged with the patient and a proximal end for being engaged with the generator (10, 610), the electrode (30, 620, 800) being configured to be implanted at least partially in the septum (713) of the heart (701) of the patient, and to provide stimulation to the patient, wherein the distal end (31) comprises a fixing portion configured to facilitate implanting in the septum (713); a sheath (50) having a three- dimensional opening for guiding the at least one electrode (30, 620, 800) for implanting of the electrode (30, 620, 800); wherein the generator (10, 610), the electrode (30, 620, 800) and the sheath (50) are adapted for use in combination with each other.

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

The present disclosure relates to an interventional device for implanting an electrode into a brain through a blood vessel having a blood vessel passage and a blood vessel wall, characterized in that the interventional device comprises: a first guide, a distal end of which is movable distally within the blood vessel passage and establishes a first support point in the blood vessel passage; a second guide, a distal end of which is movable distally within the blood vessel passage through the first guide and establishes a second support point in the blood vessel passage, such that the second guide extends arcuately between the first support point and the second support point; and a puncture set for carrying the electrode, and a distal end of which is movable distally within the blood vessel passage through the first guide and punctures the blood vessel wall in a target puncture region between the first support point and the second support point, thereby implanting the carried electrode into the brain. Furthermore, the present disclosure relates to a medical device.

The application belongs to the technical field of neuroelectrophysiology and brain stereotaxy, and provides an implantable electrode pushing and protecting device. The device is provided with a separable electrode protecting assembly and a base assembly fixed on the skull. The electrode does not need to be preformed before leaving the factory, and the electrode can be flexibly driven or replaced in the operation of the electrode protecting assembly without involving the base assembly in contact with the skull. The adjustment and use of the implanted electrode are more flexible and convenient.

An implantable medical device includes processing circuitry, the computing apparatus configured to communicate with a plurality of implantable electrodes to sense and pace a patient's heart. The plurality of electrodes include a conduction system pacing electrode positioned in a myocardium of the patient's heart. The computing apparatus is configured to monitor local muscle impedance of the patient's heart using the cardiac conduction system electrode and adapt cardiac therapy deliverable by the implantable device based on the local muscle impedance.

The invention provides an obsessive-compulsive disorder animal model and a construction method and application thereof, and relates to the technical field of animal models. A construction method of an obsessive-compulsive disorder animal model comprises the following steps: S1, injecting a quantel solution into a rat according to a standard of 0.5 mg / kg, carrying out neck subcutaneous injection twice a week, and continuously injecting for 5 weeks; s2, detecting behavior characteristics of the rats after administration to obtain a basic animal model; and S3, implanting an electrode into the brain of the basic animal model to obtain a target animal model. According to the method, the neurotransmitter activity condition of the corresponding brain region under the disease state can be completely displayed, and an important foundation is laid for exploring the OCD pathogenesis. According to the animal model and the application thereof, the pathophysiological mechanism of OCD and the treatment mechanism of NAc-DBS can be explored from multiple aspects of animal behavioristics, neuroelectrophysiology, histopathology, molecular biology and the like, and a theoretical basis is laid for clarification of OCD pathogenesis and development of new treatment means.

The present invention relates to a deep sEEG electrode for brain intracranial neuronal electrical stimulation, the electrode comprising a temperature sensor to protect brain tissue from undesired local temperature increase due to sustained / chronic intracranial neuronal electrical stimulation, and further comprising a humidity sensor to detect a deviation from a baseline liquid volume and / or pressure value in brain parenchyma. In the stimulation process through the electrode, if one or more temperature values rise to exceed a preset safety limit value, the nerve stimulation / sEEG device can immediately interrupt the ongoing nerve stimulation to protect brain tissue from adverse heat side effects. The detected fluid volume and / or pressure values may be transmitted to a neurostimulation / sEEG device that presents data to a physician / neurosurgeon responsible for sEEG operations for assessing whether the implantable electrode is located at a predetermined location, or partially / fully located in the cerebrospinal fluid space within or outside of the brain parenchyma, and assessing the risk of intracranial bleeding.

The present disclosure relates to an interventional device for implanting an electrode into the brain via a blood vessel, the blood vessel having a vascular channel and a vascular wall. The interventional device comprises: a first guide, the distal end of which is capable of distally moving within the vascular channel and establishing a first support point in the vascular channel; a second guide, the distal end of which is capable of passing through the first guide, distally moving within the vascular channel, and establishing a second support point in the vascular channel, such that the second guide extends in an arcuate manner between the first and second support points; and a puncture kit for carrying an electrode, the distal end of which is capable of passing through the first guide, distally moving within the vascular channel, and puncturing the vascular wall in a target puncture area between the first and second support points, thereby implanting the carried electrode into the brain. The present disclosure also relates to a medical device.

The application provides a cochlear implant, which comprises an implanted electrode, a decoder, a receiving coil, an implanted magnet, an auxiliary coil, an elastic buckle and encapsulating silica gel; the implanted electrode, the decoder and the receiving coil are connected in series in sequence, the receiving coil covers the auxiliary coil, the implanted magnet is installed inside the auxiliary coil, the encapsulating silica gel is wrapped outside the implanted magnet 11, and the elastic buckle holds the implanted magnet in the cochlear implant; the auxiliary coil is provided with a via hole, a stop edge one and a stop edge two; the elastic buckle comprises a buckle encapsulating silica gel and a clamping jaw; the clamping jaw is provided with a stopper, a limit and a supporting leg, and the limit is arranged on the inner side of the supporting leg; the stopper holds the stop edge, and the stopper abuts against the flange side edge. The application has good biological safety and good mechanical strength, the receiving coil is provided with the auxiliary coil, the implanted magnet is rotationally held on the auxiliary coil and is provided with the elastic buckle, the impact resistance of the implanted magnet is improved, the application has the anti-disengagement function, and the firmness and reliability of the implant are ensured.

The invention relates to the technical field of implanted electrodes, in particular to a multi-mode composite neural electrode body, an electrode system and a preparation method. Comprising an insulating substrate, a plurality of electrical detection sites are arranged at the tip of the insulating substrate, and a leading-out bonding pad is arranged at the tail of the insulating substrate; a metal wiring layer; the fluid structure comprises a flow channel inlet, a first flow channel outlet and a second flow channel outlet, the flow channel inlet is a medicine inlet, and the first flow channel outlet is a medicine outlet; and the optical fiber penetrates in from the second flow channel outlet and extends to the first flow channel outlet, and an optical fiber light emitting position is formed at the front end of the optical fiber and penetrates out from the first flow channel outlet. By integrating the leading-out bonding pad, the metal wiring layer and the flow channel structure on the base body, electrical detection, electrical stimulation, optical detection, optical stimulation and drug delivery can be carried out after the slender piercing part pierces the human tissue, the freedom degree of a biological experiment is greatly improved, and a complex experiment scene can be dealt with.

Provided herein are systems for treating a paralysis patient in need of controlled motion to improve quality of life, and related methods. The systems comprise an implantable system formed from a hub, various electrodes, such as spinal cord (upstream) electrode, periphery nerve (downstream) electrode and an external system formed of communication pod implanted just under the skin, a computing core, and a plurality of motion sensors. A software system, providing AI compatibility are used to supply the computing core, and thereby implanted electrodes, with signal. In this manner, the specially positioned electrodes, upstream of the spinal cord injury and downstream of the spinal cord injury, can provide safe and reliable patient motion.

The present application describes various implementations of devices, systems, and methods for electrical treatment of cancer in the brain. The systems can include an implanted component with a hub and two flexible electrodes, wirelessly connectable to an external retriever for transmission of power and data. The systems may provide stimulation to and / or recording from the target brain tissue. Systems and methods for implantation of one or more components are also described. Such systems can include a center stylet, a hollow insertion needle, and an outer tube for releasably retaining the implanted electrode and hub during an insertion procedure.

The application discloses a brain electric wire fixing band after intracranial electrode implantation, which effectively solves the problem of inconvenient wire fixation after operation of the patient with implanted electrodes; the brain electric wire fixing band comprises a winding band, a fixing ring is arranged at the left free end of the winding band, the winding band is in a circular ring shape and the right free end of the winding band penetrates through the fixing ring, a positioning air bag is fixed to the inner side of the winding band, connecting rings are respectively fixed to the left and right sides of the upper end of the winding band, a pressing band in the up-down direction is fixed to the middle part of the winding band, two anti-pressure air bags are fixed to the upper end of the winding band and are located between the two connecting rings, the pressing band is located between the two anti-pressure air bags, an inflation device is fixed to the right end of the winding band, the left end of the inflation device is communicated with the positioning air bag through a main air pipe, the upper side of the inflation device is communicated with the right anti-pressure air bag through a secondary air pipe, and the two anti-pressure air bags are communicated through a connecting pipe; the structure is simple, convenient to operate, novel in design and high in practicability.

VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue-piercing electrode implanted in the basal and / or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be implanted completely within the patient's heart or may use one or more leads to implant electrodes in the patient's heart. The device may be used to provide cardiac therapy, including single or multiple chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A separate medical device may be used to provide some functionality for cardiac therapy, such as sensing, pacing, or shock therapy.

The utility model relates to a spiral electrode implanting device, belong to medical instrument technology or the field of neuroscientific research, spiral electrode implanting device is located on the intracranial blood vessel wall, including a spiral support, electrode wire and developing object, the body of spiral support is a spiral shape, the electrode wire that is provided with on the support body is a spiral shape, the both ends of spiral support are equipped with developing object, the utility model can adopt the way of through blood vessel intervention, implants the electrode, gathers the electric signal, simple structure can realize high degree, electrode and blood vessel wall good adhesion, electrode gathers signal effect good, the cross section is small, can be transported through the small sheath, can reach the far end small blood vessel far end, satisfy brain deep position electrode collection and the electrode implanting requirement of intracranial multiple point (brain area).

A method of controlling an implanted electrode includes receiving information from an external device; calculating a first region in a body in which the electrode is to be implanted and a second region in which electrode implantation is prohibited, based on the received information; and calculating a plurality of predicted paths through which an electrode is moved based on the first region or the second region, and outputting the plurality of predicted paths.

Implantable electrode assemblies, including implantable electrode assemblies for the brain, and associated systems, devices and methods are disclosed herein. In one embodiment, an electrode shank comprises (i) a plurality of electrodes and (ii) a body extending between a proximal end region and a distal end region opposite the proximal end region. The body can include a plurality of non-conductive layers arranged in a stack. The body can further include a plurality of conductive traces formed on each of the plurality of non-conductive layers. The plurality of electrodes can be disposed on the body, and each of the plurality of conductive traces can extend from the proximal end region to a corresponding one of the plurality of electrodes.

Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. An implantable baroreflex activation system includes a control system having an implantable housing, an electrical lead, attachable to the control system, and an electrode structure. The electrode structure is near one end of the electrical lead, and includes a monopolar electrode, a backing material having an effective surface area larger than the electrode, and a releasable pivotable interface to mate with an implant tool. The electrode is configured for implantation on an outer surface of a blood vessel and the control system is programmed to deliver a baroreflex therapy via the monopolar electrode to a baroreceptor within a wall of the blood vessel.

Implant electrode insertion system (1) for inserting an implant electrode into the cochlea (99), comprising an oct device (2) comprising an oct probe (3) defining an optical axis (A) and configured to be held in a measurement position outside of the cochlea and configured to provide an orientation signal representative for an orientation of the oct probe with respect to a cochlea, measured using optical coherence tomography of light emitted from the probe in the measurement position along the optical axis (A); an implant electrode insertion module (4) connected to the oct device, and configured to be arranged in an insertion position on the basis of the orientation signal; and an alignment unit (5) configured to assist in positioning of the implant electrode insertion module (4) in the insertion position on the basis of the orientation signal; wherein the implant electrode insertion module (4) comprises an electrode guide that defines a guide axis (G), and is configured to, in the insertion position, guide a cochlear implant electrode along the guide axis towards the cochlea, wherein the guide axis (G) is coaxial with the optical axis (A) of the oct device.

The invention relates to the technical field of intracranial electroencephalogram signal processing, in particular to an intracranial electroencephalogram multivariable decoding method and system based on sparse logistic regression, and the method comprises the steps: obtaining an intracranial electroencephalogram original signal collected by an implantable electrode, and sequentially carrying out the filtering, power frequency interference removal, bad contact removal and re-reference preprocessing of the intracranial electroencephalogram original signal; calculating energy measurement of a whole brain electrode through time-frequency analysis, and forming three-dimensional feature tensors of a space domain M, a time domain T and a frequency domain F; expanding the three-dimensional feature tensor into a feature matrix based on a multivariate analysis method, and selecting an acceleration path of matrix operation according to a ratio of a dimension D to a sample number N; and performing feature subset selection based on sparse logistic regression, inputting the selected feature subset into a classifier, and generating a neural decoding instruction, thereby solving the problems of large data volume, calculation delay, dimension disaster and low scene generalization in the prior art.

Provided herein are lead and stylet systems and methods of implanting a lead into the brain using a stylet. The lead may be used for deep brain stimulation (DBS) and may be connected to a skull-mounted implantable pulse generator (IPG) of a deep brain stimulation system. The lead may include a lumen configured to removably receive a stylet to assist in implanting an electrode disposed on the lead into the brain. The lead and stylet systems described herein may allow for a minimum of excess lead length between an implantation site of the lead in the brain and an implantable pulse generator (e.g., implanted in the skull).

This disclosure provides a method for selecting parameters for stimulation of the thalamus using a deep brain stimulator to treat a motor disorder in a subject, such as paralysis of the upper limb and face muscles. Also provided are methods for treating motor disorder in a subject. Also provided is an implantable electrode lead for neuromodulation and recording, configured to provide targeted stimulation and / or recording to multiple anatomically distinct neural structures, specifically the thalamus, the motor cortex, and optionally, the corona radiata, using a single continuous elongate lead body.

This invention relates to the field of intracranial electroencephalogram (EEG) signal processing technology, and particularly to an intracranial EEG multivariate decoding method and system based on sparse logistic regression. The method includes: acquiring raw intracranial EEG signals collected by implanted electrodes; sequentially preprocessing the raw intracranial EEG signals by filtering, removing power frequency interference, removing bad contacts, and rereferencing; calculating the energy metric of the whole-brain electrodes through time-frequency analysis to form a three-dimensional feature tensor with spatial domain M, time domain T, and frequency domain F; expanding the three-dimensional feature tensor into a feature matrix based on multivariate analysis, and selecting an acceleration path for matrix operations based on the ratio of dimension D to the number of samples N; performing feature subset selection based on sparse logistic regression, inputting the selected feature subset into a classifier, and generating neural decoding instructions. This invention solves the problems of large data volume, computational latency, curse of dimensionality, and low scene generalization in existing technologies.

Arrangements are described for fitting an implanted patient and a hearing implant system having an implanted electrode array of electrode contacts. Objective response measurements are performed following delivery of preliminary electrical stimulation signals to the electrode contacts to determine a preliminary fit map that characterizes preliminary patient-specific operating parameters for the hearing implant system. Then an adjusted fit map is produced that characterizes adjusted patient-specific operating parameters for the hearing implant system based on using the preliminary fit map to constrain an implant neural response model to best fit a normal hearing neural response model.

This invention discloses an electromagnetic modulation method for improving the formation of glial scars around implanted electrodes. The method selects at least two electrode channels in an implanted brain-computer interface electrode array as stimulation channels and connects them to an external stimulation driving circuit. By outputting a charge-balanced low-frequency pulse stimulation current, it implements staged modulation of the local tissue around the electrodes at different stages after implantation. Simultaneously, it continuously monitors the electrode-tissue interface impedance and / or the signal-to-noise ratio of neural signals, and performs closed-loop switching between different stimulation parameters based on the monitoring results. This method is drug-free and can utilize bipolar or tripolar current-guided stimulation configurations to regulate the spatial distribution of the local electric field. Combined with the accompanying near-field electromagnetic effect, it provides electromagnetic parameter-dependent long-term modulation of the inflammatory response of microglia and astrocytes at the implantation interface, thereby improving the long-term electrical stability of the implantation interface and extending the lifespan of the implanted electrodes.