100 results about "Implanted electrodes" patented technology

An interventional device for a tubular body, comprising: a stent switchable between a first state and a second state, the diameter of the stent in the second state being greater than the diameter of the stent in the first state; the at least one puncture part is arranged on the stent, and the puncture part is used for puncturing the wall of the tubular body when the stent is in the second state; the at least one electrode is arranged on the at least one puncture part, and the electrode is used for extending out of the tubular body from the area, punctured by the puncture part, of the wall. By means of the scheme, effective implantation of the electrode can be achieved based on the intervention device, the implanted electrode can make direct contact with the biological tissue target area outside the tubular body, direct and non-barrier signal interaction is achieved, and the signal collecting and stimulation applying effects of the electrode are greatly improved.

At least some embodiments of the present disclosure are directed to systems and methods for managing sleep disordered breathing (e.g., obstructive sleep apnea) for a patient. A first implantable electrode delivers a first stimulation signal proximate to a first nerve of the patient to stimulate the first nerve and activate at least one first muscle for an upper airway dilation of the person. A second implantable electrode delivers a second stimulation signal proximate to a second nerve to stimulate the second nerve and activate at least one second muscle for a caudal tracheal traction for an upper airway of the person. A stimulation signal generator generates the first and second stimulation signals and coordinates the delivery of the first stimulation signal with the delivery of the second stimulation signal.

The invention discloses a patient improvement effect analysis method for controlling spinal cord electrical stimulation through an implantable brain-computer interface, and relates to the technical field of medical rehabilitation, and the method comprises the steps: multi-dimensional collaborative data collection: implanting electrodes in a target brain region and below a spinal cord injury segment, installing a detection element at an exoskeleton key part, and carrying out multi-dimensional collaborative data collection; a sensor is attached to a lower limb preset muscle group, electroencephalogram signals, SCS stimulation parameters, EXS motion data and neuromuscular response data are synchronously collected, and time correlation marks are embedded; according to the method, the reliability of motion intention decoding is remarkably improved by adopting a mode of combining multi-source signal preprocessing and a multi-mode intention recognition model, and in the signal preprocessing stage, the self-adaptive filtering algorithm combining Kalman filtering and wavelet threshold denoising is applied, so that the motion intention decoding efficiency is improved. SCS electrical stimulation interference, EXS motor noise and physiological noise in the electroencephalogram signals are effectively removed.

The invention discloses an olfactory navigation rat robot based on a brain-computer interface technology and a navigation method. The olfactory navigation rat robot comprises a biological rat body, a signal acquisition stimulation backpack and a host, an invasive cortex array electrode is implanted in a rat olfactory bulb area, a field potential signal is accurately recorded, and motion control and respiration signal recording are achieved through the implanted electrode; the signal acquisition stimulation knapsack acquires electrophysiological signals of the rat in the movement process, and an online odor classification model is constructed by combining acquired respiratory signals or a neural network respiratory signal fitting model; based on a multi-normal form olfactory bulb signal database of rat individuals, a transfer learning technology is adopted to adapt to odor decoding tasks under different experimental conditions. The natural olfactory capability of the rat is utilized to construct an autologous neural signal closed-loop system, so that the accurate control of efficient site traversal and specific smell search on the rat robot is realized, and the accuracy and adaptability of olfactory navigation tasks are remarkably improved.

The invention provides a three-dimensional flexible neural microelectrode and an array and a preparation method thereof. The three-dimensional flexible neural microelectrode comprises a cortical electrode part which comprises a first electrode site, and the first electrode site is used for recording a cortical electroencephalogram signal of a to-be-detected body when the cortical electrode part is attached to the cerebral cortical surface of the to-be-detected body; the implanted electrode part comprises a second electrode site, and the second electrode site is used for recording a single neuron discharge signal of the to-be-detected body when the implanted electrode part is implanted into the cerebral cortex of the to-be-detected body; wherein the cortical electrode part is located in an area defined by the implanted electrode part, so that when the implanted electrode part is implanted into the cerebral cortex, the relative position of the cortical electrode part and the surface of the cerebral cortex is kept fixed.

The invention relates to the technical field of nerve regulation and control, and provides a closed-loop ultrasonic brain-computer interface regulation and control method for improving post-stroke dysfunction, which comprises the following steps: S1, constructing integrated closed-loop ultrasonic brain-computer interface equipment which comprises a behavior control unit, a signal generator unit, a power amplifier unit and an electrophysiological signal monitoring unit; s2, constructing a mouse model, and embedding an electrode provided for the electrophysiological signal monitoring unit for monitoring; s3, dividing the mouse model into a random stimulation group and a brain-computer interface treatment group, and simultaneously performing closed-loop ultrasonic stimulation for preset time; s4, after closed-loop ultrasonic stimulation for a preset time, performing various behavioral test evaluations including representation of a sensory movement function and representation of an emotional emotion function; and S5, carrying out neural circuit remodeling evaluation, and observing the projection change of the high-order thalamus PO nuclei region of the mouse to the primary cortex. In the aspects of targeting, closed-loop control and integrated design, the method is expected to become a novel and effective post-stroke dysfunction treatment method.

The invention discloses an auxiliary device for armless disabled people, and relates to the technical field of brain-computer interfaces. In order to solve the problems that in the prior art, an invasive type and a semi-invasive type of existing wearable auxiliary devices for providing life assistance for people with upper limb disability need surgical operation, electrodes are implanted into the cerebral cortex, but the surgical risk is large, complications such as infection and bleeding are possibly caused, and long-term maintenance is needed after implantation; in order to solve the technical problems that a non-invasive interbrain interface is relatively small in risk, convenient to use, simple to operate, low in cost and relatively low in control precision, the technical scheme provided by the invention is as follows: the auxiliary system for the armless disabled person comprises a brain signal acquisition module for acquiring an electroencephalogram signal of a user in a non-invasive manner; the visual control module is used for collecting target object positioning information; and the main control module is used for generating grabbing action group signals according to the signals acquired by the brain signal acquisition module and the visual control module. The auxiliary grabbing device is suitable for being applied to auxiliary grabbing work of the arm-free handicapped.

The implantation assembly is used for implanting an electrode wire and specifically comprises a puncture component, the puncture component is provided with a first end and a second end which are opposite to each other in the axial direction of the puncture component, the puncture component is provided with at least one built-in channel, and the first end is provided with an opening corresponding to the built-in channel; and the at least one guide component is accommodated in the at least one built-in channel and can move relative to the puncture component along the extension direction of the built-in channel so as to extend out or retract from the opening. By the adoption of the technical scheme, the electrode wire can be implanted into different depths and positions of the brain area from multiple directions and positions, so that a wider brain area can be covered, and higher implantation possibility and flexibility can be provided.

The invention belongs to the technical field of medical experimental instruments, and provides an electrode device for subcutaneous implantation, comprising: an electrode comprising a cylinder structure and a barb structure arranged at one end of the cylinder structure; one end of the wire is connected with the cylinder structure; and the interface is connected to the other end of the wire. The section width of the electrode can be increased through the cylinder structure, the electrode can be stably implanted subcutaneously, and electrode displacement or damage caused by animal activity or tissue growth can be reduced. The barb structure enables the electrode to be better fixed subcutaneously, so that the electrode can be accurately positioned, the accuracy of an experimental result and the repeatability of an experiment are improved, and the complexity of surgical operation is also reduced.

The invention discloses an intracranial electrode lead track generation method, device and system, a medium and a product. The method comprises the following steps: acquiring medical image data of the brain of a patient after an electrode lead is implanted into the intracranial of the patient; extracting a feature point set corresponding to the electrode lead from the medical image data; according to trajectory features of the electrode lead in the cranium of the patient, a target feature point set implanted into the cranium of the patient is screened out from the feature point set, and the trajectory features at least represent that the bending degree of the electrode lead in the cranium of the patient does not exceed a preset bending value; and according to the target feature point set, simulating to obtain an intracranial electrode lead track of the patient. According to the method, the intracranial electrode lead wire part can be accurately identified by utilizing the intracranial trend of the electrode lead wire, and accurate three-dimensional visual rendering is performed on the intracranial electrode lead wire through the point corresponding to the intracranial electrode lead wire part, so that a doctor can better understand the position relationship between the intracranial electrode lead wire and the surrounding nerve fiber bundle, and the accuracy and the reliability of the system are improved. Doctors can optimize program control parameters, and the treatment effect is improved.

This document discusses a neurostimulation device to monitor electrical neural activity when connected to implantable electrodes. The neurostimulation device includes a sensing circuit configured to sense sensing a local field potential (LFP) signal of a patient when connected to implantable electrodes and signal processing circuitry operatively coupled to the sensing circuit. The signal processing circuitry is configured to compute a power spectral density (PSD) of the sensed LFP signal, compute a slope of the PSD of the sensed LFP signal, and determine a physiological state of the patient using the computed slope of the PSD of the sensed LFP signal.

The invention relates to the technical field of biomedical engineering, and provides an integrated microneedle which comprises a first electrode used for positioning the position of a target part and a second electrode used for regulating and controlling the target part, the second electrode is arranged on the first electrode, and after the first electrode is implanted in place, the second electrode is arranged on the first electrode. And the second electrode is implanted at the target part along the first electrode. The invention further provides an electrode regulation and control device which comprises the integrated microneedle. The invention further provides an implantation method of the integrated microneedle. The integrated microneedle is adopted to detect, regulate and control the deep target part of the brain, damage caused by repeated implantation of the electrodes can be avoided, damage to the body is reduced, meanwhile, the first electrode of the integrated microneedle can also play a detection role in the process of implanting the second electrode, the second electrode can accurately reach the target part, and the detection precision is improved. Deviation is avoided, and the regulation and control effect is improved.

Disclosed herein are compositions and methods for preventing or attenuating the development of fibrosis and scarring, or for treating fibrosis and scarring that have resulted from implantation trauma, implantation and maintenance of a foreign body in the inner ear, such as a cochlear or vestibular implant, or from damage resulting from other injury to the inner ear, such as, for example, from electrical stimulation from an implant electrode.

The present disclosure relates to an interventional device for implanting an electrode into the brain via a blood vessel, the blood vessel having a blood vessel channel and a blood vessel wall, characterized in that the interventional device comprises: a first guide member, the distal end of which can move distally in the blood vessel channel and establish a first support point in the blood vessel channel; a second guide member, the distal end of which can pass through the first guide member to move distally in the blood vessel channel and establish a second support point in the blood vessel channel, so that the second guide member extends in an arc shape between the first support point and the second support point; and a puncture kit, the puncture kit being used to carry the electrode, and the distal end of the puncture kit being able to pass through the first guide member to move distally in the blood vessel channel and puncture the blood vessel wall in a target puncture area between the first support point and the second support point, thereby implanting the carried electrode into the brain. Furthermore, the present disclosure relates to a medical apparatus.

The invention discloses an electrode for neurochemical detection of a deep brain region and a preparation method thereof, and relates to the technical field of electrochemical analysis, and the key point of the technical scheme is that the electrode comprises carbon fibers, a fused quartz capillary tube and a glass capillary tube; the carbon fiber penetrates into the fused quartz capillary tube, and one end of the fused quartz capillary tube penetrates into the glass capillary tube. The low-damage implantable cranial nerve chemical electrode provided by the invention has the advantages of small implantation cross section, good biocompatibility and the like, greatly reduces the damage of the implanted electrode to brain tissues and possible inflammatory reactions, is beneficial to realizing long-term implantation, supports electrochemical analysis methods such as cyclic voltammetry, oxidation-reduction potential method and the like, and has good application prospects. In-situ high-sensitivity detection of neurochemical substances such as ascorbic acid and dopamine can be realized, and the method has a relatively good application value in the research field of various neurophysiology and pathology processes.

The present disclosure relates to an interventional device for implanting an electrode into the brain through a blood vessel, the blood vessel having a blood vessel channel and a blood vessel wall, characterized in that the interventional device comprises: a first guide, the distal end of which is movable distally within the blood vessel channel and establishes a first support point within the blood vessel channel; a second guide, the distal end of the second guide being movable distally through the first guide in the vascular channel and establishing a second support point in the vascular channel such that the second guide extends in an arcuate manner between the first support point and the second support point; the puncture suite is used for carrying an electrode, and the far end of the puncture suite can penetrate through the first guiding piece to move towards the far side in the blood vessel channel and pierce the blood vessel wall in a target puncture area between the first supporting point and the second supporting point, so that the carried electrode is implanted into the brain. Furthermore, the present disclosure relates to a medical device.

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

An implantable electrode system includes a controller device to treat apply electric field therapy (EFT) to a target structure according to specific anatomical properties of the target structure. The system enables selective association of contacts of the implantable electrode system with one or more target locations of varying tissue types within the body for application and measurement of EFT. The one or more target locations are associated with one or more anticipated tissue parameters that the implantable electrode system uses to apply and update waveform parameters to modulate EFT application from each respective contact to the one or more target locations.

The invention discloses a multi-brain-region electrode integral component and a manufacturing and implanting method thereof, the component comprises a multi-brain-region electrode support, the support is provided with multi-brain-region electrode jacks, and the multi-brain-region electrode jacks are through holes penetrating through the multi-brain-region electrode support and are parallel to each other; the clamping rod is fixed on the multi-brain-region electrode bracket; the multi-brain-region electrode vertically penetrates through the multi-brain-region electrode jack, and the multi-brain-region electrode is matched with the multi-brain-region electrode jack and is firmly adhered and fixed by glue; the multi-brain-region electrode jacks are used for fixing the relative positions of the electrodes on the horizontal plane of the support. According to the invention, electrodes can be implanted into a plurality of brain areas at the same time, and the operation difficulty of electrode manufacturing and electrode implantation is effectively reduced.

A method of treating obstructive sleep apnea in a patient includes measuring, with electrodes, thoracic impedance of the patient, and stimulating, with a nerve stimulation device implanted in the patient, a nerve of patient based on the thoracic impedance. The nerve is associated with sleep apnea, such as the hypoglossal nerve and / or the ansa cervicalis nerve. The electrodes may be either surface electrodes or implanted electrodes, and the thoracic impedance may be trans-thoracic impedance or intra-thoracic impedance.

The present disclosure relates to an interventional device for implanting an electrode into the brain via a blood vessel, the blood vessel having a blood vessel channel and a blood vessel wall, characterized in that the interventional device comprises: a first guide member, the distal end of which can move distally in the blood vessel channel and establish a first support point in the blood vessel channel; a second guide member, the distal end of which can pass through the first guide member to move distally in the blood vessel channel and establish a second support point in the blood vessel channel, so that the second guide member extends in an arc shape between the first support point and the second support point; and a puncture kit, the puncture kit being used to carry the electrode, and the distal end of the puncture kit being able to pass through the first guide member to move distally in the blood vessel channel and puncture the blood vessel wall in a target puncture area between the first support point and the second support point, thereby implanting the carried electrode into the brain. Furthermore, the present disclosure relates to a medical apparatus.

A method includes receiving a user input first signal configured to trigger a device to perform a measurement procedure utilizing at least one electrode implanted within a recipient's body. The method further includes, in response to said receiving the user input first signal, performing an evaluation of whether performing a conditioning procedure of the at least one electrode is potentially warranted prior to performing the measurement procedure. The method further includes generating and communicating a user output signal indicative of a result of the evaluation to the user. The method further includes receiving a user input second signal configured to trigger the device either to perform the conditioning procedure prior to performing the measurement procedure or to perform the measurement procedure without performing the conditioning procedure prior to performing the measurement procedure.

The present disclosure relates to a system (100) for providing stimulation to a patient, in particular stimulation to a left bundle branch area of the heart (701) of the patient, the system comprising: a stimulation pulse generator (10, 610); at least one electrode (30, 620, 800) having a distal end (31) for being engaged with the patient and a proximal end for being engaged with the generator (10, 610), the electrode (30, 620, 800) being configured to be implanted at least partially in the septum (713) of the heart (701) of the patient, and to provide stimulation to the patient, wherein the distal end (31) comprises a fixing portion configured to facilitate implanting in the septum (713); a sheath (50) having a three- dimensional opening for guiding the at least one electrode (30, 620, 800) for implanting of the electrode (30, 620, 800); wherein the generator (10, 610), the electrode (30, 620, 800) and the sheath (50) are adapted for use in combination with each other.

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

In one example, a method includes selecting, by one or more processors and based on a sensed electrical signal representation for a particular patient and a plurality of sensed electrical signal representations for a plurality of other patients, an electrode combination from a plurality of combinations of one or more implantable electrodes for delivering electrical stimulation to the particular patient.

The present disclosure generally relates to the field of treatment of neurological disease, and in particular to devices for treating neurological diseases based on adaptive stimulation and to methods for controlling such devices. In detail, the present disclosure generally relates to a device (10) for adaptive treatment of neurological diseases comprising an implantable electrode (11) configured to sense neural activity signals and apply electrical stimulation signals, and a processing and stimulation unit (14) connected to the implantable electrode (11), wherein the processing and stimulation unit at least comprises: a stimulation module (16) configured to generate a stimulation signal to be carried at the implantable electrode (11), the stimulation signal being characterized by at least one stimulation parameter; an acquisition module (20) configured to record neural activity signal records of neural activity signals sensed by the implantable electrode; and a processing module (18) configured to process the neural activity signal records recorded by the acquisition module (20) based on a control logic (22) and to tune the at least one stimulation parameter (A) based on at least one neural activity signal record processed according to the control logic (22), the control logic being a function depending on at least one signal feature (Fi) of the neural activity signal records, being based on at least one control parameter (Cj) and being made of a plurality of function pieces, wherein each function piece of the plurality of function pieces is related to a respective range of the at least one signal feature (Fi), wherein the processing module (18) is further configured to process the neural activity signal records recorded by the acquisition module (20) based on an initializing logic (23,23') and / or to receive at least one neural activity signal record processed according to the initialization logic (23,23') and to initialize the at least one control parameter (Cj) of the control logic (22) based on at least one neural activity signal record processed according to the initializing logic (23); and wherein the initializing logic (23,23') is configured to extract at least one signal feature (Fi) form the neural activity signal records and to determine a distribution of the least one extracted signal feature (Fi) based on the number of times that the extracted signal feature (Fi) substantially reaches a given value of a plurality of given values or is comprised in a given range of a plurality of given ranges.

The present disclosure relates to an interventional device for implanting an electrode into a brain through a blood vessel having a blood vessel passage and a blood vessel wall, characterized in that the interventional device comprises: a first guide, a distal end of which is movable distally within the blood vessel passage and establishes a first support point in the blood vessel passage; a second guide, a distal end of which is movable distally within the blood vessel passage through the first guide and establishes a second support point in the blood vessel passage, such that the second guide extends arcuately between the first support point and the second support point; and a puncture set for carrying the electrode, and a distal end of which is movable distally within the blood vessel passage through the first guide and punctures the blood vessel wall in a target puncture region between the first support point and the second support point, thereby implanting the carried electrode into the brain. Furthermore, the present disclosure relates to a medical device.

The application belongs to the technical field of neuroelectrophysiology and brain stereotaxy, and provides an implantable electrode pushing and protecting device. The device is provided with a separable electrode protecting assembly and a base assembly fixed on the skull. The electrode does not need to be preformed before leaving the factory, and the electrode can be flexibly driven or replaced in the operation of the electrode protecting assembly without involving the base assembly in contact with the skull. The adjustment and use of the implanted electrode are more flexible and convenient.

An implantable medical device includes processing circuitry, the computing apparatus configured to communicate with a plurality of implantable electrodes to sense and pace a patient's heart. The plurality of electrodes include a conduction system pacing electrode positioned in a myocardium of the patient's heart. The computing apparatus is configured to monitor local muscle impedance of the patient's heart using the cardiac conduction system electrode and adapt cardiac therapy deliverable by the implantable device based on the local muscle impedance.

The invention provides an obsessive-compulsive disorder animal model and a construction method and application thereof, and relates to the technical field of animal models. A construction method of an obsessive-compulsive disorder animal model comprises the following steps: S1, injecting a quantel solution into a rat according to a standard of 0.5 mg / kg, carrying out neck subcutaneous injection twice a week, and continuously injecting for 5 weeks; s2, detecting behavior characteristics of the rats after administration to obtain a basic animal model; and S3, implanting an electrode into the brain of the basic animal model to obtain a target animal model. According to the method, the neurotransmitter activity condition of the corresponding brain region under the disease state can be completely displayed, and an important foundation is laid for exploring the OCD pathogenesis. According to the animal model and the application thereof, the pathophysiological mechanism of OCD and the treatment mechanism of NAc-DBS can be explored from multiple aspects of animal behavioristics, neuroelectrophysiology, histopathology, molecular biology and the like, and a theoretical basis is laid for clarification of OCD pathogenesis and development of new treatment means.