66 results about "Implanted electrodes" patented technology

The invention discloses a patient improvement effect analysis method for controlling spinal cord electrical stimulation through an implantable brain-computer interface, and relates to the technical field of medical rehabilitation, and the method comprises the steps: multi-dimensional collaborative data collection: implanting electrodes in a target brain region and below a spinal cord injury segment, installing a detection element at an exoskeleton key part, and carrying out multi-dimensional collaborative data collection; a sensor is attached to a lower limb preset muscle group, electroencephalogram signals, SCS stimulation parameters, EXS motion data and neuromuscular response data are synchronously collected, and time correlation marks are embedded; according to the method, the reliability of motion intention decoding is remarkably improved by adopting a mode of combining multi-source signal preprocessing and a multi-mode intention recognition model, and in the signal preprocessing stage, the self-adaptive filtering algorithm combining Kalman filtering and wavelet threshold denoising is applied, so that the motion intention decoding efficiency is improved. SCS electrical stimulation interference, EXS motor noise and physiological noise in the electroencephalogram signals are effectively removed.

The invention relates to the technical field of nerve regulation and control, and provides a closed-loop ultrasonic brain-computer interface regulation and control method for improving post-stroke dysfunction, which comprises the following steps: S1, constructing integrated closed-loop ultrasonic brain-computer interface equipment which comprises a behavior control unit, a signal generator unit, a power amplifier unit and an electrophysiological signal monitoring unit; s2, constructing a mouse model, and embedding an electrode provided for the electrophysiological signal monitoring unit for monitoring; s3, dividing the mouse model into a random stimulation group and a brain-computer interface treatment group, and simultaneously performing closed-loop ultrasonic stimulation for preset time; s4, after closed-loop ultrasonic stimulation for a preset time, performing various behavioral test evaluations including representation of a sensory movement function and representation of an emotional emotion function; and S5, carrying out neural circuit remodeling evaluation, and observing the projection change of the high-order thalamus PO nuclei region of the mouse to the primary cortex. In the aspects of targeting, closed-loop control and integrated design, the method is expected to become a novel and effective post-stroke dysfunction treatment method.

This document discusses a neurostimulation device to monitor electrical neural activity when connected to implantable electrodes. The neurostimulation device includes a sensing circuit configured to sense sensing a local field potential (LFP) signal of a patient when connected to implantable electrodes and signal processing circuitry operatively coupled to the sensing circuit. The signal processing circuitry is configured to compute a power spectral density (PSD) of the sensed LFP signal, compute a slope of the PSD of the sensed LFP signal, and determine a physiological state of the patient using the computed slope of the PSD of the sensed LFP signal.

The present disclosure relates to an interventional device for implanting an electrode into the brain through a blood vessel, the blood vessel having a blood vessel channel and a blood vessel wall, characterized in that the interventional device comprises: a first guide, the distal end of which is movable distally within the blood vessel channel and establishes a first support point within the blood vessel channel; a second guide, the distal end of the second guide being movable distally through the first guide in the vascular channel and establishing a second support point in the vascular channel such that the second guide extends in an arcuate manner between the first support point and the second support point; the puncture suite is used for carrying an electrode, and the far end of the puncture suite can penetrate through the first guiding piece to move towards the far side in the blood vessel channel and pierce the blood vessel wall in a target puncture area between the first supporting point and the second supporting point, so that the carried electrode is implanted into the brain. Furthermore, the present disclosure relates to a medical device.

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

An implantable electrode system includes a controller device to treat apply electric field therapy (EFT) to a target structure according to specific anatomical properties of the target structure. The system enables selective association of contacts of the implantable electrode system with one or more target locations of varying tissue types within the body for application and measurement of EFT. The one or more target locations are associated with one or more anticipated tissue parameters that the implantable electrode system uses to apply and update waveform parameters to modulate EFT application from each respective contact to the one or more target locations.

The invention discloses a multi-brain-region electrode integral component and a manufacturing and implanting method thereof, the component comprises a multi-brain-region electrode support, the support is provided with multi-brain-region electrode jacks, and the multi-brain-region electrode jacks are through holes penetrating through the multi-brain-region electrode support and are parallel to each other; the clamping rod is fixed on the multi-brain-region electrode bracket; the multi-brain-region electrode vertically penetrates through the multi-brain-region electrode jack, and the multi-brain-region electrode is matched with the multi-brain-region electrode jack and is firmly adhered and fixed by glue; the multi-brain-region electrode jacks are used for fixing the relative positions of the electrodes on the horizontal plane of the support. According to the invention, electrodes can be implanted into a plurality of brain areas at the same time, and the operation difficulty of electrode manufacturing and electrode implantation is effectively reduced.

A method of treating obstructive sleep apnea in a patient includes measuring, with electrodes, thoracic impedance of the patient, and stimulating, with a nerve stimulation device implanted in the patient, a nerve of patient based on the thoracic impedance. The nerve is associated with sleep apnea, such as the hypoglossal nerve and / or the ansa cervicalis nerve. The electrodes may be either surface electrodes or implanted electrodes, and the thoracic impedance may be trans-thoracic impedance or intra-thoracic impedance.

The present disclosure relates to an interventional device for implanting an electrode into the brain via a blood vessel, the blood vessel having a blood vessel channel and a blood vessel wall, characterized in that the interventional device comprises: a first guide member, the distal end of which can move distally in the blood vessel channel and establish a first support point in the blood vessel channel; a second guide member, the distal end of which can pass through the first guide member to move distally in the blood vessel channel and establish a second support point in the blood vessel channel, so that the second guide member extends in an arc shape between the first support point and the second support point; and a puncture kit, the puncture kit being used to carry the electrode, and the distal end of the puncture kit being able to pass through the first guide member to move distally in the blood vessel channel and puncture the blood vessel wall in a target puncture area between the first support point and the second support point, thereby implanting the carried electrode into the brain. Furthermore, the present disclosure relates to a medical apparatus.

A method includes receiving a user input first signal configured to trigger a device to perform a measurement procedure utilizing at least one electrode implanted within a recipient's body. The method further includes, in response to said receiving the user input first signal, performing an evaluation of whether performing a conditioning procedure of the at least one electrode is potentially warranted prior to performing the measurement procedure. The method further includes generating and communicating a user output signal indicative of a result of the evaluation to the user. The method further includes receiving a user input second signal configured to trigger the device either to perform the conditioning procedure prior to performing the measurement procedure or to perform the measurement procedure without performing the conditioning procedure prior to performing the measurement procedure.

The present disclosure relates to a system (100) for providing stimulation to a patient, in particular stimulation to a left bundle branch area of the heart (701) of the patient, the system comprising: a stimulation pulse generator (10, 610); at least one electrode (30, 620, 800) having a distal end (31) for being engaged with the patient and a proximal end for being engaged with the generator (10, 610), the electrode (30, 620, 800) being configured to be implanted at least partially in the septum (713) of the heart (701) of the patient, and to provide stimulation to the patient, wherein the distal end (31) comprises a fixing portion configured to facilitate implanting in the septum (713); a sheath (50) having a three- dimensional opening for guiding the at least one electrode (30, 620, 800) for implanting of the electrode (30, 620, 800); wherein the generator (10, 610), the electrode (30, 620, 800) and the sheath (50) are adapted for use in combination with each other.

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

The present disclosure relates to an interventional device for implanting an electrode into a brain through a blood vessel having a blood vessel passage and a blood vessel wall, characterized in that the interventional device comprises: a first guide, a distal end of which is movable distally within the blood vessel passage and establishes a first support point in the blood vessel passage; a second guide, a distal end of which is movable distally within the blood vessel passage through the first guide and establishes a second support point in the blood vessel passage, such that the second guide extends arcuately between the first support point and the second support point; and a puncture set for carrying the electrode, and a distal end of which is movable distally within the blood vessel passage through the first guide and punctures the blood vessel wall in a target puncture region between the first support point and the second support point, thereby implanting the carried electrode into the brain. Furthermore, the present disclosure relates to a medical device.

The application belongs to the technical field of neuroelectrophysiology and brain stereotaxy, and provides an implantable electrode pushing and protecting device. The device is provided with a separable electrode protecting assembly and a base assembly fixed on the skull. The electrode does not need to be preformed before leaving the factory, and the electrode can be flexibly driven or replaced in the operation of the electrode protecting assembly without involving the base assembly in contact with the skull. The adjustment and use of the implanted electrode are more flexible and convenient.

An implantable medical device includes processing circuitry, the computing apparatus configured to communicate with a plurality of implantable electrodes to sense and pace a patient's heart. The plurality of electrodes include a conduction system pacing electrode positioned in a myocardium of the patient's heart. The computing apparatus is configured to monitor local muscle impedance of the patient's heart using the cardiac conduction system electrode and adapt cardiac therapy deliverable by the implantable device based on the local muscle impedance.

The invention provides an obsessive-compulsive disorder animal model and a construction method and application thereof, and relates to the technical field of animal models. A construction method of an obsessive-compulsive disorder animal model comprises the following steps: S1, injecting a quantel solution into a rat according to a standard of 0.5 mg / kg, carrying out neck subcutaneous injection twice a week, and continuously injecting for 5 weeks; s2, detecting behavior characteristics of the rats after administration to obtain a basic animal model; and S3, implanting an electrode into the brain of the basic animal model to obtain a target animal model. According to the method, the neurotransmitter activity condition of the corresponding brain region under the disease state can be completely displayed, and an important foundation is laid for exploring the OCD pathogenesis. According to the animal model and the application thereof, the pathophysiological mechanism of OCD and the treatment mechanism of NAc-DBS can be explored from multiple aspects of animal behavioristics, neuroelectrophysiology, histopathology, molecular biology and the like, and a theoretical basis is laid for clarification of OCD pathogenesis and development of new treatment means.

The present invention relates to a deep sEEG electrode for brain intracranial neuronal electrical stimulation, the electrode comprising a temperature sensor to protect brain tissue from undesired local temperature increase due to sustained / chronic intracranial neuronal electrical stimulation, and further comprising a humidity sensor to detect a deviation from a baseline liquid volume and / or pressure value in brain parenchyma. In the stimulation process through the electrode, if one or more temperature values rise to exceed a preset safety limit value, the nerve stimulation / sEEG device can immediately interrupt the ongoing nerve stimulation to protect brain tissue from adverse heat side effects. The detected fluid volume and / or pressure values may be transmitted to a neurostimulation / sEEG device that presents data to a physician / neurosurgeon responsible for sEEG operations for assessing whether the implantable electrode is located at a predetermined location, or partially / fully located in the cerebrospinal fluid space within or outside of the brain parenchyma, and assessing the risk of intracranial bleeding.

The present disclosure relates to an interventional device for implanting an electrode into the brain via a blood vessel, the blood vessel having a vascular channel and a vascular wall. The interventional device comprises: a first guide, the distal end of which is capable of distally moving within the vascular channel and establishing a first support point in the vascular channel; a second guide, the distal end of which is capable of passing through the first guide, distally moving within the vascular channel, and establishing a second support point in the vascular channel, such that the second guide extends in an arcuate manner between the first and second support points; and a puncture kit for carrying an electrode, the distal end of which is capable of passing through the first guide, distally moving within the vascular channel, and puncturing the vascular wall in a target puncture area between the first and second support points, thereby implanting the carried electrode into the brain. The present disclosure also relates to a medical device.

The invention discloses a modular positioning and assembling type artificial cochlea implant and an assembling method thereof. A modular positioning assembly type artificial cochlea implant comprises a decoding stimulator, the decoding stimulator comprises a middle titanium shell and an electrode feed-through welded and fixedly connected with the middle titanium shell, a first PIN and a second PIN are arranged on the electrode feed-through, and a receiving antenna part comprises a receiving antenna and an insulated antenna prefabricated part. The leading-out end of the receiving antenna extends out of the antenna prefabricated part and is pressed into a flat antenna leading-out end; the implanted electrode part comprises an implanted electrode and an insulated electrode prefabricated part, and the electrode prefabricated part is provided with a feed-through channel used for exposing electrode feed-through, an electrode channel used for exposing an electrode wire and an antenna channel bent in an arc shape; the first PINs are in one-to-one correspondence with the end parts of the electrode wires and are in welded connection with the end parts; and the end part of the second PIN is welded and connected with the antenna leading-out end. Due to the modular component composition, the difficulty of the assembly process is reduced.

The application provides a cochlear implant, which comprises an implanted electrode, a decoder, a receiving coil, an implanted magnet, an auxiliary coil, an elastic buckle and encapsulating silica gel; the implanted electrode, the decoder and the receiving coil are connected in series in sequence, the receiving coil covers the auxiliary coil, the implanted magnet is installed inside the auxiliary coil, the encapsulating silica gel is wrapped outside the implanted magnet 11, and the elastic buckle holds the implanted magnet in the cochlear implant; the auxiliary coil is provided with a via hole, a stop edge one and a stop edge two; the elastic buckle comprises a buckle encapsulating silica gel and a clamping jaw; the clamping jaw is provided with a stopper, a limit and a supporting leg, and the limit is arranged on the inner side of the supporting leg; the stopper holds the stop edge, and the stopper abuts against the flange side edge. The application has good biological safety and good mechanical strength, the receiving coil is provided with the auxiliary coil, the implanted magnet is rotationally held on the auxiliary coil and is provided with the elastic buckle, the impact resistance of the implanted magnet is improved, the application has the anti-disengagement function, and the firmness and reliability of the implant are ensured.

Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrode assemblies that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Also disclosed are various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.

The invention relates to the technical field of implanted electrodes, in particular to a multi-mode composite neural electrode body, an electrode system and a preparation method. Comprising an insulating substrate, a plurality of electrical detection sites are arranged at the tip of the insulating substrate, and a leading-out bonding pad is arranged at the tail of the insulating substrate; a metal wiring layer; the fluid structure comprises a flow channel inlet, a first flow channel outlet and a second flow channel outlet, the flow channel inlet is a medicine inlet, and the first flow channel outlet is a medicine outlet; and the optical fiber penetrates in from the second flow channel outlet and extends to the first flow channel outlet, and an optical fiber light emitting position is formed at the front end of the optical fiber and penetrates out from the first flow channel outlet. By integrating the leading-out bonding pad, the metal wiring layer and the flow channel structure on the base body, electrical detection, electrical stimulation, optical detection, optical stimulation and drug delivery can be carried out after the slender piercing part pierces the human tissue, the freedom degree of a biological experiment is greatly improved, and a complex experiment scene can be dealt with.

Presented herein are techniques for monitoring a physical state (e.g., surface area) of one or more implantable electrodes of an implantable medical device / implantable component and using the physical state to adjust operation of the implantable component. More specifically, an exemplary implantable medical device includes one or more electrodes that are used to deliver electrical stimulation (current signals) to a recipient.

The invention provides an experimental method for verifying the curative effect of retinoic acid on schizophrenia, which comprises the following steps: step 1, selecting two groups of pregnant SD rats, injecting Poly I: C into tail veins of one group of SD rats after 9.5 days of pregnancy according to the standard of 10 mg / kg, and taking male offspring rats as schizophrenia model group rats; the other group of SD rats are intravenously injected with equal-volume normal saline at the tail after pregnancy 9.5 days, and the male offspring rats are the control group; 2, the model components are divided into two groups, retinoic acid is fed to one group 45 days after birth according to the standard of 3 mg / kg / day, an equal amount of placebo is injected to the other group, and an equal amount of placebo is injected to the control group; step 3, carrying out behavioral detection experiments on the three groups of rats in the step 2; and 4, implanting electrodes into hippocampal CA1 regions of the three groups of rats in the step 2, and recording and analyzing electroencephalogram activities of the three groups of rats. The experimental method provided by the invention proves that the retinoic acid has good application value in preparation of the schizophrenia medicine.

Provided herein are systems for treating a paralysis patient in need of controlled motion to improve quality of life, and related methods. The systems comprise an implantable system formed from a hub, various electrodes, such as spinal cord (upstream) electrode, periphery nerve (downstream) electrode and an external system formed of communication pod implanted just under the skin, a computing core, and a plurality of motion sensors. A software system, providing AI compatibility are used to supply the computing core, and thereby implanted electrodes, with signal. In this manner, the specially positioned electrodes, upstream of the spinal cord injury and downstream of the spinal cord injury, can provide safe and reliable patient motion.

The present application describes various implementations of devices, systems, and methods for electrical treatment of cancer in the brain. The systems can include an implanted component with a hub and two flexible electrodes, wirelessly connectable to an external retriever for transmission of power and data. The systems may provide stimulation to and / or recording from the target brain tissue. Systems and methods for implantation of one or more components are also described. Such systems can include a center stylet, a hollow insertion needle, and an outer tube for releasably retaining the implanted electrode and hub during an insertion procedure.

The application discloses a brain electric wire fixing band after intracranial electrode implantation, which effectively solves the problem of inconvenient wire fixation after operation of the patient with implanted electrodes; the brain electric wire fixing band comprises a winding band, a fixing ring is arranged at the left free end of the winding band, the winding band is in a circular ring shape and the right free end of the winding band penetrates through the fixing ring, a positioning air bag is fixed to the inner side of the winding band, connecting rings are respectively fixed to the left and right sides of the upper end of the winding band, a pressing band in the up-down direction is fixed to the middle part of the winding band, two anti-pressure air bags are fixed to the upper end of the winding band and are located between the two connecting rings, the pressing band is located between the two anti-pressure air bags, an inflation device is fixed to the right end of the winding band, the left end of the inflation device is communicated with the positioning air bag through a main air pipe, the upper side of the inflation device is communicated with the right anti-pressure air bag through a secondary air pipe, and the two anti-pressure air bags are communicated through a connecting pipe; the structure is simple, convenient to operate, novel in design and high in practicability.

The present invention discloses a drug-loaded cochlear implant electrode. A flexible electrode head is arranged at the forefront, n electrode contacts and m air bags are both arranged on a silica gel body. The air bags are V-shaped, and the m air bags are arranged at several electrode contacts among the n electrode contacts close to the flexible electrode head, and the air bags and the electrode contacts are arranged at intervals; a second catheter is connected to a first catheter through a check valve, the second catheter is connected to a drug reservoir through a pressure regulating valve, a spring part is arranged in the drug reservoir, and by pressing the spring part, the drug in the drug reservoir enters the air bags through the second catheter, the check valve and the first catheter. In the present invention, V-shaped air bags are arranged in the electrode part of the cochlear implant. When filled, the electrode part of the cochlear implant is in a bent shape consistent with the shape of the cochlea, which can make the implanted electrode better fit the inner wall of the cochlea. Moreover, the water gel with ear drugs is filled into the air bags, achieving a better hearing and treatment effect.

VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue-piercing electrode implanted in the basal and / or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be implanted completely within the patient's heart or may use one or more leads to implant electrodes in the patient's heart. The device may be used to provide cardiac therapy, including single or multiple chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A separate medical device may be used to provide some functionality for cardiac therapy, such as sensing, pacing, or shock therapy.

The utility model relates to a spiral electrode implanting device, belong to medical instrument technology or the field of neuroscientific research, spiral electrode implanting device is located on the intracranial blood vessel wall, including a spiral support, electrode wire and developing object, the body of spiral support is a spiral shape, the electrode wire that is provided with on the support body is a spiral shape, the both ends of spiral support are equipped with developing object, the utility model can adopt the way of through blood vessel intervention, implants the electrode, gathers the electric signal, simple structure can realize high degree, electrode and blood vessel wall good adhesion, electrode gathers signal effect good, the cross section is small, can be transported through the small sheath, can reach the far end small blood vessel far end, satisfy brain deep position electrode collection and the electrode implanting requirement of intracranial multiple point (brain area).