91results about How to "Loss of function" patented technology

Described herein are compositions and methods for treating or preventing nervous system injury. In particular, the methods and compositions relate to the use of at least one neuroprotective steroid, such as progesterone, and vitamin D.

Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.

Provided is a microfluidic control device and method for controlling the microfluid, and a fine amount of fluid is controlled even with natural fluid flow and solution injection, wherein a pressure barrier of a capillary is removed by a surface tension change resulted from the solution injection to thereby obtain transport, interflow, mixing, and time delay of the microfluid, and to detail this, solution is injected to meet the boundary surface of the stopped fluid when the fluid is stopped by the stop valve, so that a function of the stop valve is removed to obtain the transport, interflow, and mixing of the fluid, and the method for controlling the microfluid may be applied to the microfluidic control device for biochemical reaction, and it uses only the capillary force change resulted from solution injection to thereby have its structure simplified.

The present invention is a natural, cell-free tissue replacement that does not require difficult or extensive preparation made by washing tissue replacement in a solution including one or more sulfobetaines and an anionic surface-active detergent and washing the tissue replacement in serial solutions of the buffered salt to remove excess detergent. The natural, cell-free tissue replacement may be a nerve graft that supports axonal regeneration, guides the axons toward the distal nerve end and / or is immunologically tolerated. Other forms of the invention are a composition and kit prepared by the method of making a native, cell-free tissue replacement. The present invention may be modified for use in diagnostic, therapeutic, and prophylactic applications.

The invention discloses establishment and application of a CHO cell line for producing a fucose-free monoclonal antibody. A CRISPR / Cas9 technology is utilized to encode an FUT8 gene of a CHO cell to obtain the FUT8 gene silenced CHO cell line for stabilizing FUT8 gene deletion (hereinafter referred to as FUT8- / -cell line). By adopting physicochemical property and bioactivity detection of an FUT8- / -cell expressed antibody, a glycoform detection result indicates that fucose of the FUT8- / -cell expressed monoclonal antibody is completely eliminated, a fucose-containing monoclonal antibody expressed by a wild CHO cell serves as a contrast, the affinity with a Fcgamma RIIIa antigen of the fucose-free monoclonal antibody is improved by 7 times, and the ADCC effect is improved by 25 times.

The present invention is a method for treating anxiety or mood disorders in elderly subjects comprising administering to the subject exhibiting an anxiety or mood disorder an effective amount of an agent that modulates Aβ in the subject.

In a semiconductor device, a circuit unit is formed in an inside portion, and seal rings that enclose the inside portion that are composed of walls of metal layers are formed around the periphery. In the corners, the seal rings include linear parts that extend inwardly in addition to the linear parts that extend along the periphery, whereby the seal rings are formed in a planar pattern having small rectangular planar patterns in each corner.

A method for treating a patient suffering from loss of muscle control and / or function in a body region after a stroke includes epidurally applying electrical stimulation to a spinocerebellar tract of the patient (e.g., at or above the vertebral level of the spinal cord where the sensory and motor mapping for the body region are located), thereby increasing cortical excitability and facilitating the patient regaining muscle control and / or function in the body region. The method may include using cortical mapping to determine a cortical region having a residual motor response in or near the body region, implanting an electrode in a lateral epidural space, and applying the electrical stimulation in a manner that causes excitability in the cortical region having the residual motor response, wherein the stimulation is applied by the implanted electrode. The method may include exercising the body region while simultaneously applying the electrical stimulation.

An insert for a breast-receiving funnel of a breast pump includes an elongate inflatable bladder which defines a pressure chamber. The elongate inflatable bladder is configured to fit in a teat receiving space of the breast receiving funnel so that the bladder extends from an inner end of the funnel towards an outer end of the funnel. The bladder lies between a user's teat and the funnel when a breast is inserted in the funnel, such that the elongate inflatable bladder is configured to deform towards a user's teat located in the teat receiving space in a predetermined manner when a pressure difference is applied between the teat receiving space and the pressure chamber such that a peristaltic action is applied to the user's teat, to aid the expression of milk therefrom.

A tire condition acquisition device located in a tire and that transmits at least tire internal air pressure information includes: a housing that allows outside air to enter in only through a ventilation hole; an air pressure detecting element disposed in the housing and that detects an air pressure of air that enters in through the ventilation hole, and converts the detected air pressure to an electric signal which is then output; and a transmission circuit disposed in the housing and that transmits the detected air pressure information via electromagnetic waves based on the electric signal output from the air pressure detecting element; wherein at least the ventilation hole and an area peripheral thereto are treated so as to be water repellent.

Provided are methods and compositions for maintaining the viability of photoreceptor cells and / or retinal pigment epithelial cells in a subject with an ocular disorder including, for example, age-related macular degeneration (AMD) (e.g., dry or neovascular AMD), retinitis pigmentosa (RP), or a retinal detachment. The viability of the photoreceptor cells and / or the retinal pigment epithelial cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

The invention relates to a fire extinguishing system for a marine vessel comprising an engine room (1) and a fuel cell arrangement. In order to improve the fire extinguishing system with respect to the fuel cell arrangement comprising at least one fuel cell module (2), the fuel cell module (2) is provided with at least one fire detection sensor (9) and at least one internal nozzle (10) for releasing a fire extinguishing medium into the fuel cell module.

Provided are methods and compositions for maintaining the viability of retinal ganglion cells in a subject with an ocular disorder including, for example, glaucoma and optic nerve injury. The viability of the retinal ganglion cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells and / or promote axon regeneration, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

Provided is a microfluidic control device and method for controlling the microfluid, and a fine amount of fluid is controlled even with natural fluid flow and solution injection, wherein a pressure barrier of a capillary is removed by a surface tension change resulted from the solution injection to thereby obtain transport, interflow, mixing, and time delay of the microfluid, and to detail this, solution is injected to meet the boundary surface of the stopped fluid when the fluid is stopped by the stop valve, so that a function of the stop valve is removed to obtain the transport, interflow, and mixing of the fluid, and the method for controlling the microfluid may be applied to the microfluidic control device for biochemical reaction, and it uses only the capillary force change resulted from solution injection to thereby have its structure simplified.

The invention discloses an integrated immersed pipe section, an installing method thereof and an installing and closure method of the immersed pipe section. The integrated immersed pipe section comprises a standard immersed pipe section, and extension-type water joints in a closed ring shape are arranged at the two ends of the standard immersed pipe section. By using the integrated immersed pipe section, the immersed pipe section closed finally is still the standard immersed pipe section and needs the same foundation as a common pipe section, stiffness difference is avoided, the risk of differential settlement of pipe sections during operation of a subsea tunnel can be effectively reduced, the same installing equipment is used for installing the closed immersed pipe sections and the otherimmersed pipe sections, and a floating crane and other equipment do not need to be arranged additionally. Compared with the existing method, installation of a specially-made final joint is omitted, the construction process is simplified, and engineering risks are reduced; on-sea special construction equipment ship rent is very high, cost is reduced substantially by using the integrated immersed pipe section, and various resources are saved.

A method and / or a composition relates to cleaning and reprocessing a hemodialysis filtration membrane assembly that employs polyvinylpyrrolidone-containing membranes. The method includes the step of treating the assembly with an aqueous mixture or a gas-liquid mixture having an inorganic base and from 100 to 1,000 ppm of a hypochlorite salt, wherein the mixture has a pH between about 12.0 and about 12.5, an oxidation reduction potential of less than 0.5 volts, a temperature of 40° to 55° C. and wherein the mole % of hypochlorous acid, HOCl, relative to the sum of hypochlorous acid plus hypochlorite anion, —OCl, is less than 0.004%. The composition may be used in such a method.

The present invention provides methods for regulating the growth and / or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem / progenitor cells, for producing differentiated cells and for isolating / purifying differentiated cells, including neural cells. Also provided are differentiated cells, cell populations and transgenic animals comprising same and uses of same. The present invention further provides methods for treating nervous tissue degeneration and for identifying an agent for use in treating nervous tissue degeneration. Methods for promoting apoptosis in neoplastic cells and for treating or preventing tumors, and identifying agents for use in treating or preventing tumors are also provided by the present invention. The present invention further provides methods for identifying agents that inhibit ATF5, agents identified by these methods. Also provided are methods for diagnosing tumors, for assessing the efficacy of therapy to treat tumors and for assessing the prognosis of a subject who has a neural tumor. Finally, the present invention provides a kits for use in detecting and treating tumors.

Sperm, oocyte, and embryo survival and function is improved in vivo or in vitro by the use of a polysaccharide containing arabinose, galactose and / or hexuronic acid. In particular, a nonspermicidal lubricant containing such a polysaccharide (e.g., gum arabic, pectin, or galacturonic acid) increases the fertilization potential of the sperm during coitus, artificial insemination or sperm collection. Similarly, a freezing medium containing a polysaccharide containing arabinose, galactose and / or hexuronic acid enhances sperm, oocyte, or embryo viability.

Provided are methods and compositions for maintaining the viability of photoreceptor cells and / or retinal pigment epithelial cells in a subject with an ocular disorder including, for example, age-related macular degeneration (AMD) (e.g., dry or neovascular AMD), retinitis pigmentosa (RP), or a retinal detachment. The viability of the photoreceptor cells and / or the retinal pigment epithelial cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells, thereby minimizing the loss of vision or visual function associated with the ocular disorder.

An engine valve is provided with a valve head, a cap disposed opposite of the valve head; and a stem interposed between the valve head and the cap. The stem has a cylindrically shaped surface and at least one helical section embedded in the stem. The helical section includes alternating crests and roots in which the roots depend inwardly in a direction of a centerline of the valve such that the surface area of the stem is periodically interrupted by the helical section. The introduction of the valve with helical section in an engine increases engine efficiency and reduces fuel consumption. Methods of making and using the engine valve are also provided.

Method for producing a circular minimalist expression construct closed in an annular manner, from a double-strand DNA, an expression construct produced according to said method, and the use of the same in gene therapy and vaccination. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

The invention relates to an intelligent direct-buried integrated prefabricated pump station long in service life and belongs to the technical field of water supply and drainage. The pump station comprises a tank body provided with a base, and the tank body is provided with an inverted-Y-shaped hole and a controller and divided into a lower water containing region and an upper operation region through a service platform. The intelligent direct-buried integrated prefabricated pump station is further provided with a water inlet pipe and a water outlet pipe, the water inlet pipe is located outside the water containing region, and the water outlet pipe is located outside the operation region. The bottom of the tank body is provided with a water pumping device with the output end connected with the water outlet pipe. The tank body is internally provided with a personnel ascending and descending channel and a garbage lifting system, the garbage lifting system comprises a vertical ascending and descending rail, a garbage basket and a garbage basket seat. The operation region is internally provided with a temperature sensor and a harmful gas sensor for monitoring the temperature and the gas. The bottom of the service platform is provided with a set of spraying devices for cooling or fire prevention or attenuation of harmful gas. The water containing region is provided with a water level detection device, the bottom of the water containing region is provided with a stirring device and a lifting guide rail of the stirring device. Equipment in the tank body is integrally controlled through a control cabinet.

The invention provides an absorption type heat pump, which prevents crystallization of concentrated absorption solution due to partial load in the heating operation. A heat source water pump is disposed on the upper stream side of the heat conductive pipe through the evaporator, a flow detection mechanism is disposed on the lower stream side, a refrigerating temperature sensor is disposed on the bottom of the evaporator. When the flow of the heat water is reduced below the set value, or the heat pump stops, the operation is not immediately stopped for dilution operation of the absorbent liquid, so that crystallization of the concentrated absorption solution is prevented. Moreover, when the heat water is likely to freeze, the refrigerating temperature sensor measures the temperature of the refrigerant liquid accumulated at the bottom of the evaporator; when the temperature of the refrigerant liquid exceeds the set temperature, dilution of the absorbent liquid is carried out, which is stopped when the temperature turns below the set temperature.

A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from conditions such as Parkinson's disease or Alzheimer's which can exhibit themselves as progressive loss of central nervous system function. The compounds can arrest or slow the progressive loss of function.

A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from conditions such as Parkinson's disease which can exhibit themselves as progressive loss of central nervous system function. The compounds can arrest or slow the progressive loss of function.

The present invention relates to identification and isolation of zinc finger transcription factor in tomato that specifically expresses in glandular trichomes of Solanum lycopersicum cultivar Moneymaker and binds to the promoters of the genes encoding Terpene Synthase 5 (also known as Monoterpene Synthase 1) and Terpene Synthase 11 (also known as Sesquiterpene Synthase 1). The invention provides the isolated, recombinant or synthetic polynucleotides encoding the polypeptide sequences of SEQ ID NO:2 and variants and fragments thereof. The invention also provides constructs, vectors, host cells and plants genetically modified to contain the polynucleotides of the invention. The methods for producing plants with altered levels of terpenes, including transformed and mutant plants, are also provided.

Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.

An insert for a breast-receiving funnel (10) of a breast pump comprising an elongate inflatable bladder (23) which defines a pressure chamber (26), the elongate inflatable bladder (23) being adapted to fit in a teat receiving space (11) of said breast receiving funnel (10) so that the bladder extends from an inner end of said funnel towards an outer end of said funnel, and lie between a user's teat and the funnel when a breast is inserted in the funnel, such that the elongate inflatable bladder is configured to deform towards a user's teat located in the teat receiving space in a predetermined manner when a pressure difference is applied between the teat receiving space and the pressure chamber such that a peristaltic action is applied to said user's teat, to aid the expression of milk therefrom.

A method for error handling for a control device for a passenger protection system and a corresponding control device are provided, the error handling being implemented by switching off at least one function of the control device as a function of an error detection. The switching off takes place immediately after the error detection, the error qualification taking place after the switching off.