9results about How to "Improve motor function" patented technology

The present application relates to the field of cell therapy and regenerative medicine, and in particular to a kind of old age adipose tissue-derived mesenchymal stem cells pretreated by MK8722, its preparation method and application.The method comprises the following steps: the old age adipose tissue-derived mesenchymal stem cells are inoculated in culture solution containing MK8722 to carry out in vitro treatment, and first cells are obtained;The culture solution containing MK8722 is removed, and the first cells are washed to obtain second cells;Second cells are cultured using culture solution without MK8722, and the old age adipose tissue-derived mesenchymal stem cells pretreated by MK8722 are obtained.The cells obtained by the method, relative to the old age adipose tissue-derived mesenchymal stem cells without the in vitro treatment, show at least one improvement in proliferation capacity, continuous passage amplification capacity, adipogenic differentiation capacity or chondrogenic differentiation capacity, and can be used to prepare products for treating or alleviating osteoarthritis.

This invention discloses the application of Polygonatum oligosaccharides in the preparation of products that improve sperm motility. The molecular weight of the Polygonatum oligosaccharides is 1 × 10⁻⁶. 4 ~5×10 4 This oligosaccharide, Da, can be prepared through steps including ethanol defatting, water extraction, 30%-50% ethanol precipitation, and protein removal. Experiments show that this oligosaccharide can significantly improve sperm motility, particularly restoring the forward sperm motility rate in asthenospermia model mice to over 32%, reaching the clinical treatment threshold; it can also effectively alleviate cyclophosphamide-induced reproductive damage and improve testicular tissue pathological damage. Furthermore, this oligosaccharide can upregulate the expression of sperm motility-related genes such as Crisp2 and Catsper, downregulate miR-27 expression, and has multiple effects including reducing oxidative stress, inhibiting inflammation, and improving reproductive hormone levels. Therefore, this oligosaccharide can be used to prepare products that improve sperm motility, prevent and / or treat asthenospermia, and alleviate chemotherapy-related reproductive damage.

The invention provides a pathogenic factor for neurodegenerative diseases and application of the pathogenic factor. The pathogenic factor for the neurodegenerative diseases is a PASP-GPR37-IL-6 signal axis. According to the application, the action mechanism of the PASP-GPR37-IL-6 signal axis serving as a neurodegenerative disease (especially Parkinson's disease) pathogenic factor is defined for the first time, the molecular path of neuroinflammation and neurodegenerative diseases regulated and controlled by the oligodendroglia through the signal axis is disclosed, and the research blank of participation of the oligodendroglia in PD pathogenesis in the prior art is filled.

The application relates to the technical field of stroke rehabilitation, in particular to a multifunctional auxiliary appliance for ischemic stroke rehabilitation training, which comprises a rehabilitation chair, an adjusting training mechanism and a fixing mechanism. The rehabilitation chair is convenient for ischemic stroke patients to train, the adjusting training mechanism can adjust the body position of the patient, and the patient can properly perform strength training when performing stroke rehabilitation training, so that muscle atrophy and adhesion of soft tissues around joints are avoided, muscle strength and motor function are enhanced, nerve function recovery is promoted, metabolism and cardiopulmonary function are improved, and balance and coordination ability is enhanced. The fixing mechanism can enable the patient suffering from severe ischemic stroke to independently use the training instrument at home, and the independent use of the patient is improved.

The present application belongs to the technical field of biological materials, and particularly relates to a microemulsion hydrogel as well as a preparation method and application thereof. The microemulsion hydrogel has a network structure hydrogel, and the network structure hydrogel can improve the solubility of hydrophobic drugs, thereby improving the drug loading capacity of the hydrogel. The drug-loaded hydrogel can slowly and continuously release the drugs at the site of spinal cord injury for repair treatment, avoid side effects caused by excessively high local concentration, and help the repair of movement and nerve function at the injury site. The hydrogel itself can provide a structural scaffold for axon and neuron regeneration for tissue regeneration, and further improve the therapeutic effect of the hydrophobic drugs. Moreover, the preparation method of the microemulsion hydrogel is simple, raw materials are cheap and easy to obtain, and the method is suitable for large-scale production.

The utility model relates to a multifunctional waist twisting machine, and relates to the field of physical exercise apparatus, including front support frame, rear support frame and frame, the frame is connected between front support frame and rear support frame, the front end of frame is equipped with two handrails that are arranged left and right, the rear end top surface of frame is equipped with two swing rods that can swing left and right, two swing rods are arranged left and right, the rear end of two swing rods is connected with kneel pad, and the detachable connecting pin is arranged between two swing rods, and the connecting pin is used for connecting two swing rods. Two swing rods can swing left and right relative to the frame, when the connecting pin is connected with two swing rods, two swing rods can swing simultaneously in the same direction, the user's both knees are knelt on the kneel pad of two swing rods respectively, and both hands hold two handrails respectively, at this time, the user can twist the body left and right to make waist twisting movement, when the connecting pin is removed, two swing rods can rotate independently, at this time, the user can make split leg movement of double legs opening and closing to exercise the leg.

The invention belongs to the technical field of ischemic stroke treatment, and discloses application of ULK1 possibly serving as a target spot for treating ischemic stroke. According to the invention, a photothrombotic stroke model is established, a ULK1 inhibitor SBI-0206965 (SBI), LYN1604 hydrochloride (LYN) and a ULK1 agonist are administered, and the ULK1 agonist is used for regulating the activity of ULK1 in vivo. Examples assess the outcome of sensory motor deficits, neuronal apoptosis, and microglia / macrophage activated neurological function. Immunofluorescence detection results show that ULK1 is mainly located in microglial cells in a post-ischemic infarction area of China. Upregulated ULK1 is treated by LYN, so that the infarct volume is remarkably reduced, the motor function is improved, and the increase of inflammatory microglial cells is promoted. In conclusion, the ULK1 promotes the repair of neurons and promotes the formation of 13 paths of anti-inflammatory microglial cell paths after ischemic injury.

The application discloses a traditional Chinese medicine composition for treating Parkinson's disease and a traditional Chinese medicine preparation and application thereof. The traditional Chinese medicine composition comprises, in terms of weight parts, 9-20 parts of Schisandra chinensis, 10-30 parts of Ophiopogon japonicus, 3-15 parts of Radix ginseng rubra, 10-30 parts of Uncaria, 10-30 parts of Cuscuta chinensis, 10-30 parts of Semen ecliptae prostratae, 3-5 parts of ginger and 5-15 parts of Jujube. The application further discloses a preparation of the traditional Chinese medicine composition. The traditional Chinese medicine composition and the preparation thereof can effectively improve the motor function of Parkinson's disease patients, reduce the dosage of Madopa, and thus reduce the related side effects caused by dopamine replacement therapy.

The present application provides the use of aucubin or the combination of aucubin and ACA in the preparation of a medicament for treating ischemic brain injury, in particular acute cerebral ischemia-reperfusion injury. The present application first discovers that aucubin or the combination of aucubin and ACA can increase the blood flow of the ischemic side after ischemic brain injury in mice; significantly reduce the cerebral infarction volume; improve the cognitive and motor function of mice after ischemic brain injury; reduce the degree of injury caused by cerebral ischemia, significantly improve the degree of neuronal necrosis of brain tissue after ischemia; significantly increase the survival rate of HT22 cells after oxygen-glucose deprivation and reperfusion injury, reduce intracellular Ca 2+ fluorescence intensity, and inhibit cell apoptosis.