15results about How to "Improve motor function" patented technology

The invention discloses a silk fibroin-hyaluronic acid temperature-sensitive bioactive hydrogel scaffold, a preparation method thereof and application of the silk fibroin-hyaluronic acid temperature-sensitive bioactive hydrogel scaffold in TBI treatment, hyaluronic acid, silk fibroin and N-isopropylacrylamide are used as raw materials to construct temperature-sensitive hydrogel, and bone marrow mesenchymal stem cells (BMSCs) and paeoniflorin (PF) are loaded to form a treatment unit. Hyaluronic acid is one of components of an extracellular matrix (ECM), has high affinity to cells, and can promote proliferation of stem cells. Silk fibroin has high biocompatibility and biodegradability and good mechanical strength and ductility / toughness, and can promote tissue repair and stem cell attachment and proliferation. N-isopropylacrylamide endows the hydrogel with the characteristic of in-situ temperature-sensitive gelling. Therefore, the bioactive hydrogel stent has the advantages of components, combines the BMSCs and the PF, overcomes the obstacle that the medicine is limited by BBB to be transferred into the brain, and is implanted into a brain injury part after a TBI surgical operation to be used for repairing and treating nerve injury.

The present application relates to the field of cell therapy and regenerative medicine, and in particular to a kind of old age adipose tissue-derived mesenchymal stem cells pretreated by MK8722, its preparation method and application.The method comprises the following steps: the old age adipose tissue-derived mesenchymal stem cells are inoculated in culture solution containing MK8722 to carry out in vitro treatment, and first cells are obtained;The culture solution containing MK8722 is removed, and the first cells are washed to obtain second cells;Second cells are cultured using culture solution without MK8722, and the old age adipose tissue-derived mesenchymal stem cells pretreated by MK8722 are obtained.The cells obtained by the method, relative to the old age adipose tissue-derived mesenchymal stem cells without the in vitro treatment, show at least one improvement in proliferation capacity, continuous passage amplification capacity, adipogenic differentiation capacity or chondrogenic differentiation capacity, and can be used to prepare products for treating or alleviating osteoarthritis.

The invention relates to the technical field of rehabilitation medicine, in particular to a gait training system assisted by virtual reality. Comprising a virtual reality module, a data acquisition module, a data processing module and a data analysis and evaluation module, and the virtual reality module is used for simulating a multi-scene gait training environment; the data acquisition module is used for acquiring environmental parameters and response data of an experiencer; the reaction data comprises physiological data and motion parameter data; the data processing module is used for processing the environmental parameters and the reaction data; and the data analysis and evaluation module is used for analyzing whether the gait training of the experiencer is valid or not according to the environmental parameters and the reaction data, and forming an evaluation report according to the analysis data. By providing a personalized, efficient and safe training scheme, the rehabilitation process of the patient can be accelerated. The patient can be trained at home or in a hospital and other places and does not need to frequently go to a rehabilitation center, and rehabilitation convenience and efficiency are improved.

The utility model discloses a safe hand joint movement trainer, which belongs to the field of hand joint training and comprises a mirror glove, a training glove and a hand joint air bag fixedly mounted in the mirror glove and the training glove. A rolling box is arranged between the mirror image glove and the training glove. The safe hand joint movement trainer is simple in structure and convenient to use, the movement precision and coordination of the hand joint on the affected side can be effectively improved by arranging the hand joint air bag and the electric puncture instrument in a mirror image mode, a patient can be helped to more accurately simulate the movement of the hand on the healthy side, and therefore the rehabilitation process is accelerated, muscle movement can be stimulated through intermediate-frequency electrical stimulation, and the rehabilitation effect is improved. The muscle strength is increased, the movement function of the hand joint on the affected side is improved, the mirror image mode and the electrical stimulation function can be individually set according to the specific illness state and rehabilitation requirements of a patient, the pertinence is higher, and the treatment effect is more remarkable.

This invention discloses the application of Polygonatum oligosaccharides in the preparation of products that improve sperm motility. The molecular weight of the Polygonatum oligosaccharides is 1 × 10⁻⁶. 4 ~5×10 4 This oligosaccharide, Da, can be prepared through steps including ethanol defatting, water extraction, 30%-50% ethanol precipitation, and protein removal. Experiments show that this oligosaccharide can significantly improve sperm motility, particularly restoring the forward sperm motility rate in asthenospermia model mice to over 32%, reaching the clinical treatment threshold; it can also effectively alleviate cyclophosphamide-induced reproductive damage and improve testicular tissue pathological damage. Furthermore, this oligosaccharide can upregulate the expression of sperm motility-related genes such as Crisp2 and Catsper, downregulate miR-27 expression, and has multiple effects including reducing oxidative stress, inhibiting inflammation, and improving reproductive hormone levels. Therefore, this oligosaccharide can be used to prepare products that improve sperm motility, prevent and / or treat asthenospermia, and alleviate chemotherapy-related reproductive damage.

The invention provides a pathogenic factor for neurodegenerative diseases and application of the pathogenic factor. The pathogenic factor for the neurodegenerative diseases is a PASP-GPR37-IL-6 signal axis. According to the application, the action mechanism of the PASP-GPR37-IL-6 signal axis serving as a neurodegenerative disease (especially Parkinson's disease) pathogenic factor is defined for the first time, the molecular path of neuroinflammation and neurodegenerative diseases regulated and controlled by the oligodendroglia through the signal axis is disclosed, and the research blank of participation of the oligodendroglia in PD pathogenesis in the prior art is filled.

The present invention relates to the field of human bioelectric signal measurement, and in particular to a self-adaptive functional electrical stimulation rehabilitation training method and device, the self-adaptive functional electrical stimulation rehabilitation training method comprising the following steps: obtaining joint parameters and target angles; constructing a world coordinate system, the origin of the world coordinate system is represented as a joint end; constructing a dynamic coordinate system, the origin of the dynamic coordinate system is represented as the joint end, the dynamic coordinate system is obtained by translating the world coordinate system or the previous dynamic coordinate system along the coordinate axis, and the joint rotation center is used as a stationary point in the dynamic coordinate system; calculating the coordinates of the stationary point in the dynamic coordinate system in the world coordinate system; constructing a vector through the stationary point, and calculating the vector angle; calculating the difference between the target angle and the actual rotation angle, and calculating the electrical stimulation intensity required for further rotation of the joint by using the difference through a control algorithm; outputting electrical stimulation. The present invention has the effect of enabling patients to better participate in treatment and improve rehabilitation effects.

The application relates to the technical field of stroke rehabilitation, in particular to a multifunctional auxiliary appliance for ischemic stroke rehabilitation training, which comprises a rehabilitation chair, an adjusting training mechanism and a fixing mechanism. The rehabilitation chair is convenient for ischemic stroke patients to train, the adjusting training mechanism can adjust the body position of the patient, and the patient can properly perform strength training when performing stroke rehabilitation training, so that muscle atrophy and adhesion of soft tissues around joints are avoided, muscle strength and motor function are enhanced, nerve function recovery is promoted, metabolism and cardiopulmonary function are improved, and balance and coordination ability is enhanced. The fixing mechanism can enable the patient suffering from severe ischemic stroke to independently use the training instrument at home, and the independent use of the patient is improved.

The present application belongs to the technical field of biological materials, and particularly relates to a microemulsion hydrogel as well as a preparation method and application thereof. The microemulsion hydrogel has a network structure hydrogel, and the network structure hydrogel can improve the solubility of hydrophobic drugs, thereby improving the drug loading capacity of the hydrogel. The drug-loaded hydrogel can slowly and continuously release the drugs at the site of spinal cord injury for repair treatment, avoid side effects caused by excessively high local concentration, and help the repair of movement and nerve function at the injury site. The hydrogel itself can provide a structural scaffold for axon and neuron regeneration for tissue regeneration, and further improve the therapeutic effect of the hydrophobic drugs. Moreover, the preparation method of the microemulsion hydrogel is simple, raw materials are cheap and easy to obtain, and the method is suitable for large-scale production.

The utility model relates to a multifunctional waist twisting machine, and relates to the field of physical exercise apparatus, including front support frame, rear support frame and frame, the frame is connected between front support frame and rear support frame, the front end of frame is equipped with two handrails that are arranged left and right, the rear end top surface of frame is equipped with two swing rods that can swing left and right, two swing rods are arranged left and right, the rear end of two swing rods is connected with kneel pad, and the detachable connecting pin is arranged between two swing rods, and the connecting pin is used for connecting two swing rods. Two swing rods can swing left and right relative to the frame, when the connecting pin is connected with two swing rods, two swing rods can swing simultaneously in the same direction, the user's both knees are knelt on the kneel pad of two swing rods respectively, and both hands hold two handrails respectively, at this time, the user can twist the body left and right to make waist twisting movement, when the connecting pin is removed, two swing rods can rotate independently, at this time, the user can make split leg movement of double legs opening and closing to exercise the leg.

The invention discloses an application of alpha ketoglutaric acid ferric salt in preparation of a health product for improving exercise function and / or improving exercise fatigue. Animal tests show that the alpha ketoglutaric acid ferric salt can remarkably improve exercise tolerance and gripping power of mice, can reduce the lactic acid level of serum of the mice, can also improve some enzyme activities in the metabolic process and enhance the metabolic effect of the body, and has the effect remarkably superior to that of pure use of alpha ketoglutaric acid sodium salt. The alpha ketoglutarate ferric salt is applied to enhancing muscle strength, improving the metabolic capacity of the body and reducing factors adverse to the body in the metabolic process, so that the alpha ketoglutarate ferric salt has wide prospects in medicines or health care products for relieving body fatigue and improving exercise ability.

The invention belongs to the technical field of ischemic stroke treatment, and discloses application of ULK1 possibly serving as a target spot for treating ischemic stroke. According to the invention, a photothrombotic stroke model is established, a ULK1 inhibitor SBI-0206965 (SBI), LYN1604 hydrochloride (LYN) and a ULK1 agonist are administered, and the ULK1 agonist is used for regulating the activity of ULK1 in vivo. Examples assess the outcome of sensory motor deficits, neuronal apoptosis, and microglia / macrophage activated neurological function. Immunofluorescence detection results show that ULK1 is mainly located in microglial cells in a post-ischemic infarction area of China. Upregulated ULK1 is treated by LYN, so that the infarct volume is remarkably reduced, the motor function is improved, and the increase of inflammatory microglial cells is promoted. In conclusion, the ULK1 promotes the repair of neurons and promotes the formation of 13 paths of anti-inflammatory microglial cell paths after ischemic injury.

The application discloses a traditional Chinese medicine composition for treating Parkinson's disease and a traditional Chinese medicine preparation and application thereof. The traditional Chinese medicine composition comprises, in terms of weight parts, 9-20 parts of Schisandra chinensis, 10-30 parts of Ophiopogon japonicus, 3-15 parts of Radix ginseng rubra, 10-30 parts of Uncaria, 10-30 parts of Cuscuta chinensis, 10-30 parts of Semen ecliptae prostratae, 3-5 parts of ginger and 5-15 parts of Jujube. The application further discloses a preparation of the traditional Chinese medicine composition. The traditional Chinese medicine composition and the preparation thereof can effectively improve the motor function of Parkinson's disease patients, reduce the dosage of Madopa, and thus reduce the related side effects caused by dopamine replacement therapy.

The present application provides the use of aucubin or the combination of aucubin and ACA in the preparation of a medicament for treating ischemic brain injury, in particular acute cerebral ischemia-reperfusion injury. The present application first discovers that aucubin or the combination of aucubin and ACA can increase the blood flow of the ischemic side after ischemic brain injury in mice; significantly reduce the cerebral infarction volume; improve the cognitive and motor function of mice after ischemic brain injury; reduce the degree of injury caused by cerebral ischemia, significantly improve the degree of neuronal necrosis of brain tissue after ischemia; significantly increase the survival rate of HT22 cells after oxygen-glucose deprivation and reperfusion injury, reduce intracellular Ca 2+ fluorescence intensity, and inhibit cell apoptosis.

The invention relates to the technical field of medicines, and particularly discloses a pharmaceutical composition containing a cistanche deserticola extract and a microbial preparation. The pharmaceutical composition containing the cistanche deserticola extract is prepared from the following raw materials in parts by mass: 1 to 3 parts of the cistanche deserticola extract, 0.1 to 0.5 part of glutathione, 1 to 2 parts of dopamine hydrochloride and 2 to 6 parts of montmorillonite. The microbial preparation comprises the following raw materials in parts by mass: 5-12 parts of the pharmaceutical composition containing the cistanche extract, 1-2 parts of compound microorganisms, 10-20 parts of starch and 1-2 parts of superfine silica powder. The invention also discloses application of the pharmaceutical composition containing the cistanche deserticola extract or / and the microbial preparation in preparation of drugs for treating Parkinson's disease. The traditional Chinese medicine composition not only can effectively improve the motor function of Parkinson's disease patients and delay the progress of Parkinson's disease, but also is remarkable in effect, high in safety, simple in preparation method and suitable for large-scale popularization and application.