20 results about "Motor coordination" patented technology

The invention provides an intelligent cognitive movement rehabilitation task generation method based on knowledge graph dynamic adaptation, and the method comprises the steps: collecting the behavior response data of a patient in real time through a multi-modal sensor array, and inputting a pre-trained state evaluation neural network model after preprocessing; outputting a four-dimensional ability state vector representing cognitive load, motion coordination, attention and fatigue degree, taking the vector as a dynamic query condition, starting multi-hop semantic reasoning in the cognitive motion rehabilitation knowledge graph, screening a candidate task set matched with the current state of a patient and associated with a rehabilitation target, and performing task selection on the candidate task set; according to the matching relation between the capability state and the task difficulty, execution parameters such as task presentation duration and action amplitude are dynamically adjusted, task sequence sorting is optimized based on the path distance, and finally generated personalized rehabilitation tasks are presented in a three-dimensional virtual scene mode through an interaction terminal. A closed-loop control process of real-time data acquisition, state evaluation, task generation and execution is formed, and dynamic personalized adaptation of the rehabilitation training process is realized.

The invention discloses a strain of lactobacillus acidophilus for treating chronic cerebral ischemia, which is preserved in the China Center for Type Culture Collection (CCTCC) and has the preservation number of CCTCC NO: M 20251505. Animal experiments show that the strain can reduce the death rate of chronic cerebral ischemia model mice and improve neurological impairment, motion coordination and spatial learning and memory ability of the chronic cerebral ischemia model mice. Mechanism research shows that the strain can increase histone acetylation and BDNF secretion by inhibiting the activity of astrocyte HDAC1, and meanwhile, can inhibit an NF-kappa B signal channel and reduce inflammatory factor release by activating a microglial cell GPR120 receptor, so that a neuroprotective effect is achieved through an'intestine-brain axis'. The invention provides a new candidate strain for the development of microbial preparations for preventing and / or treating chronic cerebral ischemia and related cognitive impairment.

The utility model discloses a combined type rotating wheel fatigue instrument which comprises a fatigue instrument body, a test area is divided into a plurality of channels on the fatigue instrument body through partition plates, through holes are formed in the partition plates respectively, and a rotating rod penetrating through the through holes in sequence is transversely installed on the fatigue instrument body. The rotating rod is sleeved with a detachable sleeve wheel, and the sleeve wheel is provided with a structure used for increasing animal movement coordination, balance feeling and endurance difficulty. The rotating rod is reasonable in structural design, the sleeve wheel structure is additionally arranged on the rotating rod in a sleeving mode, sole perception of an animal in different motion states is enhanced, formation of muscle memory is promoted, leap-type improvement of motion coordination is achieved, the animal can complete various complex actions more efficiently, and therefore the motion coordination is improved; and meanwhile, additional stability support is provided when the animal performs complex actions, the balance sensing ability is enhanced, and experimental movement conditions in more states are more prominently completed.

The invention relates to the technical field of early screening of osteoporotic compression fracture, and provides an osteoporotic compression fracture screening method based on a multi-modal large language model. A multi-modal large language model is introduced to carry out quantitative evaluation on key functions such as posture alignment, motion coordination and pain-related reactions of a patient from images and videos, and the key functions are output in a standardized scoring form, so that structural features with clear clinical significance are automatically extracted. And constructing a machine learning model based on the above structured features, evaluating the OVCF occurrence risk, and determining key discriminant factors and the action direction thereof in combination with an SHAP feature contribution analysis and decision tree visualization method, so as to realize interpretable expression of the prediction process. The technical scheme which is safe, low in cost, explainable and easy to popularize is provided for early screening of the OVCF, and the method is suitable for various application scenes such as community and home screening.

The invention discloses an application of sunitinib in preparation of a medicine for treating secondary injury caused by intracranial hemorrhage. It is found for the first time that sunitinib can act on a CSF-1R / PI3K / Akt axis, pathological activation and pro-inflammatory response of microglial cells are effectively inhibited, the normal phagocytic function and lipid metabolism balance of the microglial cells are remarkably recovered, myelin sheath damage around hematoma is effectively relieved, and the neurological function score, the movement coordination ability and the exploration behavior of ICH mice are remarkably improved; the progress of secondary injury caused by intracranial hemorrhage is hindered from multiple dimensions, the curative effect is superior to that of a positive control drug pecetinib (PLX3397), and a brand new molecular target and an interference strategy are provided for comprehensive treatment of ICH.

The invention discloses application of C-176 in preparation of a medicine for treating Parkinson's disease, belongs to the technical field of medicines, and particularly relates to a medicine for treating Parkinson's disease, which comprises C-176 or a pharmaceutical salt thereof. As an STING inhibitor C-176 is adopted as a medicine for treating Parkinson's disease, 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is utilized to construct an animal model of Parkinson's disease, and animal experiments prove that the expression of STING protein in striatum of a mouse in the model is increased, and the expression of tyrosine hydroxylase (TH) is reduced at the same time. The C-176 can improve the expression level of TH in striatum of a Parkinson model mouse. A behavioral experiment result proves that the C-176 can improve the movement and movement coordination ability of a model mouse and relieve the anxiety behavior of the model mouse.

The invention discloses an application of picrogenin A in preparation of a medicine for treating ischemia-reperfusion injury. The invention proposes and verifies that the kuichnogenin A can inhibit ferroptosis to prevent and treat cerebral ischemia reperfusion injury for the first time, including greatly reducing the volume of cerebral infarction caused by cerebral ischemia reperfusion; the invention provides a plant-derived natural medicine for treating cerebral ischemia reperfusion injury, which has great application potential, and can be used for remarkably improving neurological function injury symptoms such as autonomous activity reduction, sensory motor function damage and motor coordination reduction caused by cerebral ischemia reperfusion, and the invention provides a plant-derived natural medicine for treating cerebral ischemia reperfusion injury.

The invention relates to the technical field of animal behavioral research, in particular to a behavioral detection device for detecting the motion coordination ability of a mouse. The device comprises a transverse ladder runway, a rectangular baffle, a cuboid support, a cuboid camera obscura, a rectangular tray, a supporting rod, a camera and a lamp. The transverse ladder runway is composed of metal bars and metal wires, and is convenient for mice to climb. The rectangular baffles are arranged on the two sides of the runway and are beneficial to limiting the mice from climbing towards the side faces and guiding the mice to climb along the runway, the cuboid supports are installed below the two ends of the runway to enhance the stability of the runway, the cuboid camera obscura and the lamp are placed on the supports at the two ends of the runway respectively, and the mice are guided to move unidirectionally through the darkness tendency instinct of the mice. The camera is placed on the side of the runway and records mouse movement images for subsequent analysis. The device is simple in structure, sensitive and effective in mouse movement coordination ability determination, and capable of detecting multiple behavior indexes, so that the experiment efficiency is remarkably improved.

This utility model relates to the field of rehabilitation exercise technology and proposes a four-limb coordinated health training vehicle. It includes two linkage plates that swing back and forth on the left and right sides of the front of the frame, with the two linkage plates swinging alternately. Two handles are respectively located on the upper ends of the two linkage plates. A linkage rod has linkage parts on both sides, with the middle of the linkage rod rotatably mounted on the frame. The linkage parts on both sides are movably connected to the linkage plates on their respective sides. Swinging one linkage plate drives the linkage rod to swing, and the swinging linkage rod drives the linkage plate on the other side to swing. Two pedals are movably located on the left and right sides of the front of the frame. Each linkage plate has a hinged linkage component for transmission between the linkage plate and the pedal. This technical solution solves the problem that existing exercise equipment lacks four-limb coordinated function, cannot meet the health needs of most patients, is not conducive to enhancing limb muscle strength and motor coordination, and has poor rehabilitation and fitness effects.

The application discloses application of bupropion hydrochloride tablets (75mg) in preparation of a medicine for treating stroke, and belongs to the technical field of new purposes of medicines. The core verifies the efficacy and safety of the medicine of the specification through systematic animal tests, aims at the problems of post-stroke neural function defect, motor dysfunction and insufficient neural plasticity, adopts a line plug method to prepare a rat focal cerebral ischemia (MCAO) model, sets multiple control tests, and explores the dosing effect of an equivalent dose of the bupropion hydrochloride tablets (75mg). The test results show that the medicine can significantly reduce the neural function defect score of the model animals, improve the motor coordination ability and the limb usage rate, increase the content of brain-derived neurotrophic factor (BDNF) in the brain, promote the repair of neural plasticity, and is safer than a high-dose scheme and has no obvious adverse reactions. Through complete animal test data, the application proves the effectiveness and safety of the bupropion hydrochloride tablets (75mg) in treating stroke, provides solid test basis for clinical conversion and application of the bupropion hydrochloride tablets (75mg), and has important medical application value.

The application discloses a tail suspension test device and method for evaluating the behavioral despair of mice after stroke, wherein a slope plate is arranged below the hanging piece for hanging the mice in the hanging chamber, so as to prevent the mice from struggling due to movement coordination disorders, to help the suspended mice keep balance, and to prevent the mice from shaking even if the movement ability of the mice is impaired, and the application is particularly suitable for evaluating the despair of the mice with impaired movement coordination after stroke. The application supports part of the body weight of the mice through the slope plate, the pain caused during the test is slight, and the application can also be used for rats once the size of the device is adapted to the rats. The application is a modified detection method (mTST for short) of TST, and is used for evaluating the behavioral despair of the mice after stroke. The application can be applied to the evaluation of the curative effect of antidepressant drugs on the model mice of chronic mild stress (CMS) and post-stroke depression (PSD), and is favorable to the basic research of diseases such as PSD and the clinical transformation of drugs.

The application provides a method for establishing a subacute cerebellar ataxia animal model and application. Specifically, a method for establishing a subacute cerebellar ataxia animal model based on a low-dose staged increasing administration mode of a compound preparation of talipexole and application thereof are provided. The application induces mice to have pathological characteristics such as movement coordination disorders, cerebellar volume atrophy and Purkinje cell loss under the premise of ensuring the survival rate of animals by intraperitoneal injection of Zoletil 50 for several weeks. The model has high stability, good repeatability and controllable damage degree, and can be used for anti-ataxia drug screening and neuroprotective mechanism research.

The walking acupressure fascia massage mechanism comprises a shell and a massage driving unit, a fluted disc is fixed in the shell, and a rotatable rotating frame is arranged in the shell; the massage driving unit comprises a driving motor, an eccentric transmission assembly driven by the motor, a walking gear in transmission connection with the eccentric transmission assembly and a massage head in linkage with the eccentric transmission assembly. And the walking gear is meshed with the fixed fluted disc. The walking gear and the massage head are simultaneously driven by the eccentric transmission assembly, so that the single driving motor can synchronously realize the circumferential walking of the rotating frame along the fluted disc and the lifting finger-pressing movement of the massage head relative to the rotating frame. According to the mechanism, rotation driving and finger pressing driving are integrated, the mechanism has the advantages of being compact in structure, low in cost and reliable in movement coordination, and automatic and bionic massage experience is provided.

The application discloses a plant lactobacillus and application of the plant lactobacillus in a composition for preventing or treating a tic disorder, and belongs to the technical field of microorganisms. The technical problem to be solved is to provide a plant lactobacillus LP496 isolated from healthy breast milk, wherein the plant lactobacillus LP496 can significantly reduce a tic behavior, improve a stereotypic symptom, improve motor coordination and repair muscle strength damage, realize double neurotransmitter regulation by down-regulating dopamine and up-regulating serotonin, and has a significant protective effect on brain neuron damage. A technical solution point is that the plant lactobacillus LP496 has a preservation number of CGMCC No. 33499. The application further discloses a microbial agent containing the strain or a preparation of the strain, and application of the strain and the microbial agent in preparation of a composition for preventing or treating a tic disorder and related compositions, and provides a safe, effective and mild new microecological intervention scheme for the tic disorder.

The present application provides the application of dendrobium polysaccharide in the preparation of medicine for preventing and / or treating alcohol-induced neuroinflammation and a dendrobium polysaccharide liqueur, belonging to the field of biological medicine. The present application prepares dendrobium polysaccharide into a liqueur, and applies it to a mouse model exposed to alcohol for a long time, and finds that the dendrobium polysaccharide liqueur can improve the cognitive dysfunction, the decrease of motor coordination ability and the anxiety-like behavior and other neurofunctional abnormalities caused by long-term drinking; can intervene in the neuroinflammation of long-term drinking mice. It is shown that the dendrobium polysaccharide has a significant intervention effect on the neurodegenerative diseases caused by excessive drinking of alcohol, including Alzheimer's disease, Parkinson's disease and the like. It provides a new way for the development and utilization of dendrobium resources, and helps to promote the modernization of traditional Chinese medicine and the development of the health industry.

The present application relates to the technical field of early screening of osteoporotic vertebral compression fractures, and proposes an osteoporotic compression fracture screening method based on a multi-modal large language model, which takes patient posture images and action videos and other unstructured visual data as input, introduces a multi-modal large language model to quantitatively evaluate key functions such as patient posture alignment, motion coordination and pain-related responses from images and videos, and outputs in the form of standardized scores, automatically extracting structured features with clear clinical significance. Based on the above structured features, a machine learning model is constructed to assess the risk of OVCF, and combined with SHAP feature contribution analysis and decision tree visualization methods, the key discriminant factors and their action directions are clarified, realizing the interpretable expression of the prediction process. A safe, low-cost, interpretable and easy-to-promote technical solution is provided for the early screening of OVCF, which is suitable for various application scenarios such as community and home screening.

The invention discloses a sleep hypopnea type automatic discrimination method and system based on a multi-modal signal, and aims to solve the technical bottlenecks of strong subjectivity, poor consistency and limited single signal feature discrimination capability of the existing visual scoring method. The method comprises the following steps: collecting multi-modal signals in a polysleep pattern (PSG), wherein the multi-modal signals comprise nasal ventilation airflow, thoracico-abdominal breathing movement, blood oxygen saturation and other signals; extracting multi-dimensional features related to hypopnea typing, wherein the multi-dimensional features comprise an inspiration flow limited index, thoracico-abdominal movement coordination, an event termination mode, an awakening sequential relationship and a sleep stage associated feature; the features are fused and optimized based on a machine learning algorithm, a high-precision classification model is constructed, and automatic discrimination of obstructive and central hypoventilation is realized. According to the method, the key problems that a traditional method depends on manpower in hypopnea typing, feature utilization is not comprehensive, and judgment precision is insufficient are solved, and a reliable basis is provided for accurate diagnosis, typing and treatment strategy formulation of sleep breathing disorder.

The invention discloses an application of white datura in preparation of a medicine for preventing and treating cerebral ischemia-reperfusion injury. The invention proposes and verifies that white datura can effectively prevent and treat ischemia reperfusion injury for the first time, including greatly reducing the volume of cerebral infarction caused by cerebral ischemia reperfusion; meanwhile, the neurological function impairment symptoms such as motor coordination and balance ability reduction, spatial learning and reference memory impairment and depression-like behaviors caused by cerebral ischemia reperfusion are remarkably improved, and a natural medicine with great application potential is provided for mechanism research, prevention and treatment of cerebral ischemia reperfusion injury.

This invention relates to a rehabilitation training method, apparatus, equipment, medium, and program product. The method includes acquiring initial state data of a target subject, obtaining impedance configuration parameters from a rehabilitation training institution based on the initial state data, and controlling the rehabilitation training institution to perform passive limb training on the target subject based on the impedance configuration parameters. During the passive training phase, real-time state data and real-time torque data of the target subject are collected, and an active force characterization value is calculated based on the real-time torque data. A bilateral movement deviation value is also calculated based on the real-time state data. The real-time state data collected during the passive training phase is used to assess the degree of motor completion. When the assessment result reaches the stage transition standard, the rehabilitation training institution is switched to an active assisted training mode to continue training until a training end command is received. This invention enables the matching of training resistance and movement trajectory with the patient's real-time force exertion ability and motor coordination.

Methods and apparatuses for sensory electrical stimulation of the peripheral nervous system to improve human motor function and performance are described. Methods and devices may be used to enhance physical performance of athletes, professionals, and gamers or improve motor function (hand, finger and limb movement) in patients rehabilitating from neurological deficits and impairments caused by stroke, traumatic brain injury and other neurologic or non-neurologic conditions. These apparatuses and methods may be used for physical training and mental training (to improve memory and functional performance including motor coordination, limb-eye coordination, occupational and recreational skills) through periodic or sustained sensory electrical stimulation. Treatment plans may be based on biomarkers and may be used alone or in combination with other apparatuses. Learning and feedback techniques individualize treatment parameters depending on the subject's neurologic and motor function in diseased patients and healthy users.