44 results about "Motor coordination" patented technology

The invention provides application of scEMC10 in treatment and diagnosis of cerebral vascular endothelial cell senescence, and relates to the technical field of biomedicine. The research of the inventor finds that brain microvascular endothelial cell senescence is caused by the lack of scEMC10; after the brain microvascular endothelial cells are treated by scEMC10, beta-galactosidase, SASP and classic senescence markers related to senescence can be down-regulated; after scEmc10 is supplemented to old mice and Alzheimer's disease 5XFAD model mice, the motion coordination ability and the spatial cognitive ability of the mice can be obviously improved, the relative content of a marker phosphorylated alpha-synuclein of the Parkinson's disease of the old mice can be obviously reduced, and the content of tyrosine hydroxylase phosphorylated active forms can be increased. Therefore, the scEMC10 can be used for treating brain microvascular endothelial cell senescence, improving Alzheimer's disease and Parkinson's disease and detecting brain microvascular endothelial cell senescence as a marker.

The invention provides an intelligent cognitive movement rehabilitation task generation method based on knowledge graph dynamic adaptation, and the method comprises the steps: collecting the behavior response data of a patient in real time through a multi-modal sensor array, and inputting a pre-trained state evaluation neural network model after preprocessing; outputting a four-dimensional ability state vector representing cognitive load, motion coordination, attention and fatigue degree, taking the vector as a dynamic query condition, starting multi-hop semantic reasoning in the cognitive motion rehabilitation knowledge graph, screening a candidate task set matched with the current state of a patient and associated with a rehabilitation target, and performing task selection on the candidate task set; according to the matching relation between the capability state and the task difficulty, execution parameters such as task presentation duration and action amplitude are dynamically adjusted, task sequence sorting is optimized based on the path distance, and finally generated personalized rehabilitation tasks are presented in a three-dimensional virtual scene mode through an interaction terminal. A closed-loop control process of real-time data acquisition, state evaluation, task generation and execution is formed, and dynamic personalized adaptation of the rehabilitation training process is realized.

The invention belongs to the technical field of power-assisted robots, and particularly relates to a pneumatic muscle four-bar linkage variable instantaneous center lower limb rehabilitation exoskeleton and an impedance training method. The exoskeleton comprises a waist fixing piece, a hip joint assembly, a knee joint assembly and a sole assembly. The knee joint assembly comprises a four-connecting-rod variable instantaneous center structure, first to fourth connecting rods and the like form a parallelogram mechanism, and the parallelogram mechanism is matched with the thigh pneumatic muscle assembly for driving, so that the instantaneous center track of the knee joint is matched with the physiological track of a human body, and man-machine slippage is reduced. The hip joint assembly is hinged through a hip-leg plate and driven by a hip joint pneumatic muscle assembly, and the sole assembly comprises an elastic connecting structure. The invention further provides a variable instantaneous center knee joint track obtaining method, and the structure size matched with the human body is obtained by establishing a kinematics system and optimizing parameters. According to the impedance training method, safe and effective flexion and extension impedance training is achieved based on pneumatic muscle pressure dynamic adjustment. The exoskeleton has good motion coordination and safety, and has wide applicability.

The invention relates to the technical field of medicines, in particular to application of ginkgo terpene lactones in preparation of medicines for preventing and / or treating Parkinson's disease. The bilobalide and the composition or extract thereof can improve the motion coordination of Parkinson's disease model mice, have a treatment effect on Parkinson's disease, and can be used for preparing drugs for treating Parkinson's disease.

The invention discloses a strain of lactobacillus acidophilus for treating chronic cerebral ischemia, which is preserved in the China Center for Type Culture Collection (CCTCC) and has the preservation number of CCTCC NO: M 20251505. Animal experiments show that the strain can reduce the death rate of chronic cerebral ischemia model mice and improve neurological impairment, motion coordination and spatial learning and memory ability of the chronic cerebral ischemia model mice. Mechanism research shows that the strain can increase histone acetylation and BDNF secretion by inhibiting the activity of astrocyte HDAC1, and meanwhile, can inhibit an NF-kappa B signal channel and reduce inflammatory factor release by activating a microglial cell GPR120 receptor, so that a neuroprotective effect is achieved through an'intestine-brain axis'. The invention provides a new candidate strain for the development of microbial preparations for preventing and / or treating chronic cerebral ischemia and related cognitive impairment.

The utility model discloses a combined type rotating wheel fatigue instrument which comprises a fatigue instrument body, a test area is divided into a plurality of channels on the fatigue instrument body through partition plates, through holes are formed in the partition plates respectively, and a rotating rod penetrating through the through holes in sequence is transversely installed on the fatigue instrument body. The rotating rod is sleeved with a detachable sleeve wheel, and the sleeve wheel is provided with a structure used for increasing animal movement coordination, balance feeling and endurance difficulty. The rotating rod is reasonable in structural design, the sleeve wheel structure is additionally arranged on the rotating rod in a sleeving mode, sole perception of an animal in different motion states is enhanced, formation of muscle memory is promoted, leap-type improvement of motion coordination is achieved, the animal can complete various complex actions more efficiently, and therefore the motion coordination is improved; and meanwhile, additional stability support is provided when the animal performs complex actions, the balance sensing ability is enhanced, and experimental movement conditions in more states are more prominently completed.

A computer-based education system and method for teaching a user with fine motor coordination impairment to recognize characters. Software residing on a user computing device includes first code containing characters displayable on the display and second code containing sounds playable on the speaker, each of the sounds corresponding to at least one of the characters. The software causes the user computing device to: display at least a portion of the characters in a spaced-apart arrangement each at least at a minimum size with at least a minimum space provided between the displayed characters, the minimum size and the minimum space being large enough to enable user selection by the user with fine motor coordination impairment of one of the characters using substantially only gross motor movements; and play on the speaker the sound that corresponds to the character selected by the user.

The present invention relates to a method for measuring binocular motricity parameters and postural parameters in ecologic conditions (both eye viewing targets displaced in the real 3D space) for individuals suffering from vertigo comprising at least two REMOBI tests of eye movements and a posture test, wherein the REMOBI tests are performed using a device physically stimulating vergences or saccades in the real world in three dimensions and contain multiple trials for each type of stimulation, vergences or saccades. The REMOBI eye movement tests are performed once with the individual in seated position and the other time with the individual in standing position. In the latter case, posture is measured simultaneously. It further relates to a method for detecting intrinsic binocular motor abnormalities and / or postural control abnormalities in an individual suffering from vertigo using the same vergence and posture tests. It also relates to a method for improving binocular motor coordination and postural control in an individual suffering from vertigo.

The double-joint continuously variable transmission ratio structure comprises an artificial limb hip joint, a continuously variable transmission power mechanism and an artificial limb knee joint, wherein one end of the continuously variable transmission power mechanism is connected with the artificial limb hip joint, and the other end of the continuously variable transmission power mechanism is connected with the artificial limb knee joint; the continuous variable transmission power mechanism is driven by a power motor to transmit power to the prosthetic hip joint and the prosthetic knee joint at the same time, the prosthetic hip joint is driven to complete hip bending action, the prosthetic knee joint is driven to complete knee bending action, and hip and knee movement coordination is conducted through a speed adjusting motor. Under the action of a single power source, through the structure, the transmission ratio can be changed according to the hip and knee joint movement relation in the gait cycle, the hip and knee cooperation rule in the human body movement process is simulated, and therefore the movement collaboration between artificial leg joints is improved, and the energy conversion efficiency is improved.

The invention discloses a lactobacillus reuteri source extracellular vesicle for preventing and relieving senescence syndrome by relieving immune cell senescence, and belongs to the technical field of microorganisms and the technical field of medicines. The extracellular vesicle provided by the invention can improve learning, memory and cognitive abilities; the muscle strength capability is enhanced; the exercise coordination ability is improved; the motion balance capability is enhanced; the blood inflammatory factor level is obviously reduced, and the anti-inflammatory factor level is improved; the enzyme activity of the senescence-related enzyme SA-beta-Gal in the brain tissue is obviously reduced; the expression levels of brain-derived neurotrophic factors and neurotransmitters are obviously up-regulated; the collagen content and the collagen synthesis capability in skin tissues are obviously improved. The lactobacillus reuteri CCFM1471 source extracellular vesicles do not generate toxic and side effects in a host body, can be used for preparing functional foods and / or dietary supplements and related beauty products with the effects of preventing and relieving senescence syndromes, and have huge application prospects.

The invention relates to the technical field of early screening of osteoporotic compression fracture, and provides an osteoporotic compression fracture screening method based on a multi-modal large language model. A multi-modal large language model is introduced to carry out quantitative evaluation on key functions such as posture alignment, motion coordination and pain-related reactions of a patient from images and videos, and the key functions are output in a standardized scoring form, so that structural features with clear clinical significance are automatically extracted. And constructing a machine learning model based on the above structured features, evaluating the OVCF occurrence risk, and determining key discriminant factors and the action direction thereof in combination with an SHAP feature contribution analysis and decision tree visualization method, so as to realize interpretable expression of the prediction process. The technical scheme which is safe, low in cost, explainable and easy to popularize is provided for early screening of the OVCF, and the method is suitable for various application scenes such as community and home screening.

The invention discloses an application of sunitinib in preparation of a medicine for treating secondary injury caused by intracranial hemorrhage. It is found for the first time that sunitinib can act on a CSF-1R / PI3K / Akt axis, pathological activation and pro-inflammatory response of microglial cells are effectively inhibited, the normal phagocytic function and lipid metabolism balance of the microglial cells are remarkably recovered, myelin sheath damage around hematoma is effectively relieved, and the neurological function score, the movement coordination ability and the exploration behavior of ICH mice are remarkably improved; the progress of secondary injury caused by intracranial hemorrhage is hindered from multiple dimensions, the curative effect is superior to that of a positive control drug pecetinib (PLX3397), and a brand new molecular target and an interference strategy are provided for comprehensive treatment of ICH.

The invention discloses application of C-176 in preparation of a medicine for treating Parkinson's disease, belongs to the technical field of medicines, and particularly relates to a medicine for treating Parkinson's disease, which comprises C-176 or a pharmaceutical salt thereof. As an STING inhibitor C-176 is adopted as a medicine for treating Parkinson's disease, 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is utilized to construct an animal model of Parkinson's disease, and animal experiments prove that the expression of STING protein in striatum of a mouse in the model is increased, and the expression of tyrosine hydroxylase (TH) is reduced at the same time. The C-176 can improve the expression level of TH in striatum of a Parkinson model mouse. A behavioral experiment result proves that the C-176 can improve the movement and movement coordination ability of a model mouse and relieve the anxiety behavior of the model mouse.

The invention relates to the technical field of limb movement nursing, and particularly discloses a limb movement nursing device for neurosurgery department, comprising: a support mechanism comprising a support assembly, a backrest assembly rotatably clamped and embedded on the support assembly, and a hydraulic cylinder I for driving the backrest assembly to rotate; the upper limb training mechanism comprises an upper limb training assembly mounted on the backrest assembly; a second motor is started, a first belt wheel is driven to rotate, power is transmitted through a belt, a second belt wheel and a rotating shaft rotate synchronously, a gear on the rotating shaft is meshed with a rack, a sliding plate is pushed to slide along a shaft rod, and then a bevel push plate is driven to move; the bending and stretching actions of the legs during natural walking of the human body are simulated, the movement coordination and muscle control ability of the lower limbs of the patient can be recovered, and powerful support is provided for walking function rehabilitation of the patient.

The present invention relates to uses of cyclo(his-pro) (CHP) for enhancing exercise performance, improving muscle function, or preventing, alleviating, or treating muscle diseases and, more specifically, provides a pharmaceutical composition, a food composition, a feed additive, a method for enhancing exercise performance, a method for improving muscle function or for preventing, alleviating, or treating muscle diseases, and a method for enhancing muscle strength, each using cyclo(his-pro) as an active ingredient, wherein the cyclo(his-pro) can be used not only in enhancing exercise performance and strengthening muscle strength by exhibiting effects of increasing muscle strength, movement coordination, resistance to muscle fatigue, sense of balance, and muscle energy production, but also in enhancing muscle function or preventing, alleviating, or treating muscle diseases by exhibiting effects of increasing muscle mass and muscle fiber size, inhibiting muscle loss, muscle atrophy, and improving muscle energy production.

The invention provides application of a salidroside derivative in preparation of a medicine for preventing and / or treating cognitive impairment caused by cerebrovascular lesion, and belongs to the technical field of biological medicine. The invention discloses application of a salidroside derivative SHPL-49 in preparation of a medicine for preventing and / or treating cognitive impairment caused by cerebrovascular lesion. The SHPL-49 can effectively improve the learning and memory functions after brain injury, recover the exercise coordination ability, relieve corpus callosum region myelin sheath loss above the hippocampus region and further protect the brain-sea horse region synapses. The SHPL-49 has the efficacy of treating the vascular cognitive impairment and the vascular dementia. According to the application, the medical application of the SHPL-49 is widened, and a new way is provided for treating cognitive impairment diseases caused by cerebrovascular lesion.

The invention discloses an application of picrogenin A in preparation of a medicine for treating ischemia-reperfusion injury. The invention proposes and verifies that the kuichnogenin A can inhibit ferroptosis to prevent and treat cerebral ischemia reperfusion injury for the first time, including greatly reducing the volume of cerebral infarction caused by cerebral ischemia reperfusion; the invention provides a plant-derived natural medicine for treating cerebral ischemia reperfusion injury, which has great application potential, and can be used for remarkably improving neurological function injury symptoms such as autonomous activity reduction, sensory motor function damage and motor coordination reduction caused by cerebral ischemia reperfusion, and the invention provides a plant-derived natural medicine for treating cerebral ischemia reperfusion injury.

The invention relates to the technical field of animal behavioral research, in particular to a behavioral detection device for detecting the motion coordination ability of a mouse. The device comprises a transverse ladder runway, a rectangular baffle, a cuboid support, a cuboid camera obscura, a rectangular tray, a supporting rod, a camera and a lamp. The transverse ladder runway is composed of metal bars and metal wires, and is convenient for mice to climb. The rectangular baffles are arranged on the two sides of the runway and are beneficial to limiting the mice from climbing towards the side faces and guiding the mice to climb along the runway, the cuboid supports are installed below the two ends of the runway to enhance the stability of the runway, the cuboid camera obscura and the lamp are placed on the supports at the two ends of the runway respectively, and the mice are guided to move unidirectionally through the darkness tendency instinct of the mice. The camera is placed on the side of the runway and records mouse movement images for subsequent analysis. The device is simple in structure, sensitive and effective in mouse movement coordination ability determination, and capable of detecting multiple behavior indexes, so that the experiment efficiency is remarkably improved.

This utility model relates to the field of rehabilitation exercise technology and proposes a four-limb coordinated health training vehicle. It includes two linkage plates that swing back and forth on the left and right sides of the front of the frame, with the two linkage plates swinging alternately. Two handles are respectively located on the upper ends of the two linkage plates. A linkage rod has linkage parts on both sides, with the middle of the linkage rod rotatably mounted on the frame. The linkage parts on both sides are movably connected to the linkage plates on their respective sides. Swinging one linkage plate drives the linkage rod to swing, and the swinging linkage rod drives the linkage plate on the other side to swing. Two pedals are movably located on the left and right sides of the front of the frame. Each linkage plate has a hinged linkage component for transmission between the linkage plate and the pedal. This technical solution solves the problem that existing exercise equipment lacks four-limb coordinated function, cannot meet the health needs of most patients, is not conducive to enhancing limb muscle strength and motor coordination, and has poor rehabilitation and fitness effects.

The invention relates to a nanogold-loaded NS9283 targeted long-acting analgesic drug and a preparation method thereof. The preparation method comprises the following steps: loading NS9283 on the surfaces of gold nanoparticles coated with sodium citrate by virtue of a ligand exchange method, and then constructing the amphiphilic Janus AuNPs self-assembled microcapsule by virtue of a Pickering emulsion method. The medicine has the advantages that the stability is improved, and long-term activity is kept at room temperature; targeted controlled release and in-vivo fluorescence imaging show that the drug is continuously enriched at the nerve injury part for more than 7 days; long-acting analgesia: after local administration, the analgesic effect lasts for 28 days and is improved by at least 4 times compared with free NS9283; safety guarantee: neurotoxicity is not caused after continuous administration for 14 days, and the body weight, the movement coordination and the main organ function of the mouse are not obviously different from those of a control group. The medicine provides a safe and efficient treatment scheme for chronic pain.

The application discloses application of bupropion hydrochloride tablets (75mg) in preparation of a medicine for treating stroke, and belongs to the technical field of new purposes of medicines. The core verifies the efficacy and safety of the medicine of the specification through systematic animal tests, aims at the problems of post-stroke neural function defect, motor dysfunction and insufficient neural plasticity, adopts a line plug method to prepare a rat focal cerebral ischemia (MCAO) model, sets multiple control tests, and explores the dosing effect of an equivalent dose of the bupropion hydrochloride tablets (75mg). The test results show that the medicine can significantly reduce the neural function defect score of the model animals, improve the motor coordination ability and the limb usage rate, increase the content of brain-derived neurotrophic factor (BDNF) in the brain, promote the repair of neural plasticity, and is safer than a high-dose scheme and has no obvious adverse reactions. Through complete animal test data, the application proves the effectiveness and safety of the bupropion hydrochloride tablets (75mg) in treating stroke, provides solid test basis for clinical conversion and application of the bupropion hydrochloride tablets (75mg), and has important medical application value.

The application discloses a tail suspension test device and method for evaluating the behavioral despair of mice after stroke, wherein a slope plate is arranged below the hanging piece for hanging the mice in the hanging chamber, so as to prevent the mice from struggling due to movement coordination disorders, to help the suspended mice keep balance, and to prevent the mice from shaking even if the movement ability of the mice is impaired, and the application is particularly suitable for evaluating the despair of the mice with impaired movement coordination after stroke. The application supports part of the body weight of the mice through the slope plate, the pain caused during the test is slight, and the application can also be used for rats once the size of the device is adapted to the rats. The application is a modified detection method (mTST for short) of TST, and is used for evaluating the behavioral despair of the mice after stroke. The application can be applied to the evaluation of the curative effect of antidepressant drugs on the model mice of chronic mild stress (CMS) and post-stroke depression (PSD), and is favorable to the basic research of diseases such as PSD and the clinical transformation of drugs.

The application provides a method for establishing a subacute cerebellar ataxia animal model and application. Specifically, a method for establishing a subacute cerebellar ataxia animal model based on a low-dose staged increasing administration mode of a compound preparation of talipexole and application thereof are provided. The application induces mice to have pathological characteristics such as movement coordination disorders, cerebellar volume atrophy and Purkinje cell loss under the premise of ensuring the survival rate of animals by intraperitoneal injection of Zoletil 50 for several weeks. The model has high stability, good repeatability and controllable damage degree, and can be used for anti-ataxia drug screening and neuroprotective mechanism research.

The walking acupressure fascia massage mechanism comprises a shell and a massage driving unit, a fluted disc is fixed in the shell, and a rotatable rotating frame is arranged in the shell; the massage driving unit comprises a driving motor, an eccentric transmission assembly driven by the motor, a walking gear in transmission connection with the eccentric transmission assembly and a massage head in linkage with the eccentric transmission assembly. And the walking gear is meshed with the fixed fluted disc. The walking gear and the massage head are simultaneously driven by the eccentric transmission assembly, so that the single driving motor can synchronously realize the circumferential walking of the rotating frame along the fluted disc and the lifting finger-pressing movement of the massage head relative to the rotating frame. According to the mechanism, rotation driving and finger pressing driving are integrated, the mechanism has the advantages of being compact in structure, low in cost and reliable in movement coordination, and automatic and bionic massage experience is provided.

The invention belongs to the technical field of animal model establishment, and discloses an establishment method and application of a chronic oral ferric citrate induced Parkinson mouse model, C57BL / 6 mice are fed with mouse maintenance food (high-iron feed) added with 2.25% ferric citrate for 22 weeks, and then a 5% ferric citrate solution is used for intragastric administration for 4 weeks. Finally, behavioral evaluation is carried out through behavioral tests such as an open field test, a rotating rod test, a pole climbing test, a holding power test and a Y labyrinth test, and the tests such as the rotating rod test, the pole climbing test and the holding power test show that the PD model mouse has remarkable motor function impairment such as reduction of motor coordination, muscular tension and balance force; open field tests and Y maze show that learning and memory functions of mice are impaired, and cognitive impairments such as anxiety mood occur. Clinical chronic disease conditions of Parkinson's disease are simulated, and the chronic model is more suitable for monitoring early changes and screening early diagnosis indexes of Parkinson's disease; the method has the characteristics that the behavioral disorder can be quantified, and DA energy neuron degeneration loss characteristic lesion is realized.

The application discloses a plant lactobacillus and application of the plant lactobacillus in a composition for preventing or treating a tic disorder, and belongs to the technical field of microorganisms. The technical problem to be solved is to provide a plant lactobacillus LP496 isolated from healthy breast milk, wherein the plant lactobacillus LP496 can significantly reduce a tic behavior, improve a stereotypic symptom, improve motor coordination and repair muscle strength damage, realize double neurotransmitter regulation by down-regulating dopamine and up-regulating serotonin, and has a significant protective effect on brain neuron damage. A technical solution point is that the plant lactobacillus LP496 has a preservation number of CGMCC No. 33499. The application further discloses a microbial agent containing the strain or a preparation of the strain, and application of the strain and the microbial agent in preparation of a composition for preventing or treating a tic disorder and related compositions, and provides a safe, effective and mild new microecological intervention scheme for the tic disorder.

The present invention is in the field of learning disorders such as dyslexia, and more particularly to the functional exploration and rehabilitation of ocular motor coordination in such individuals. It relates to a method for measuring binocular motricity parameters in an individual suffering from a learning disorder comprising based on ocular motor tests comprising at least a reading test, a vergence test and a saccade test, wherein the vergence test and the saccade test are performed using a device physically stimulating vergences or saccades in the real world in three dimensions and contain multiple trials of vergence or saccade stimulation. It further relates to a method for detecting intrinsic ocular motor abnormalities in an individual suffering from a learning disorder based on previously recorded eye movements in ocular motor tests, and to a method for treating intrinsic ocular motor abnormalities in an individual suffering from a learning disorder.

A three-dimensional finger-to-finger movement-based Parkinson's disease artificial intelligence classification method, including three-dimensional finger-to-finger segmentation, three-dimensional mode feature extraction and automatic diagnosis discrimination, based on the collected three-dimensional finger-to-finger movement, through three-dimensional finger-to-finger segmentation, the problem that the thumb and index finger do not reach the closing point and opening point at the same time in the finger-to-finger movement process is solved, and through three-dimensional mode feature extraction, the movement coordination, damaged inconsistency and modal energy entropy related features in the finger-to-finger movement process are extracted, and finally through automatic classification discrimination, whether the user has Parkinson's disease is comprehensively analyzed and discriminated by combining three-dimensional mode features and traditional features such as slowness, amplitude reduction and fatigue. And provide the system realized by the method. The present application does not need invasive detection, and can effectively assist in distinguishing Parkinson's disease patients and healthy people.

The present application provides the application of dendrobium polysaccharide in the preparation of medicine for preventing and / or treating alcohol-induced neuroinflammation and a dendrobium polysaccharide liqueur, belonging to the field of biological medicine. The present application prepares dendrobium polysaccharide into a liqueur, and applies it to a mouse model exposed to alcohol for a long time, and finds that the dendrobium polysaccharide liqueur can improve the cognitive dysfunction, the decrease of motor coordination ability and the anxiety-like behavior and other neurofunctional abnormalities caused by long-term drinking; can intervene in the neuroinflammation of long-term drinking mice. It is shown that the dendrobium polysaccharide has a significant intervention effect on the neurodegenerative diseases caused by excessive drinking of alcohol, including Alzheimer's disease, Parkinson's disease and the like. It provides a new way for the development and utilization of dendrobium resources, and helps to promote the modernization of traditional Chinese medicine and the development of the health industry.