70 results about "Acetamido-CNU" patented technology

The invention discloses a tannic acid modified tungsten disulfide nanosheet and application thereof in treatment of acetaminophen acute liver injury, the nanosheet takes a tungsten disulfide nanosheet as a core, and the surface of the tungsten disulfide nanosheet is modified with electronegative tannic acid. The nanosheet disclosed by the invention has good stability and biocompatibility, can be used for preparing a nano-drug for treating acetaminophen acute liver injury, and specifically targets and removes active oxygen at a liver injury part through an electrostatic adsorption effect, so that inflammatory response is inhibited, and symptoms caused by the acute liver injury are effectively relieved.

The invention relates to the technical field of acetaminophen crystallization, in particular to a multi-stage continuous cooling crystallization device and method for acetaminophen. The invention provides a multi-stage continuous cooling crystallization method for acetaminophen, which comprises the following steps: S1, at least five stages of continuous cooling crystallization are adopted, and circulating water with a set temperature is injected into a jacket of a crystallization kettle during each stage of cooling crystallization; wherein during the first several stages of crystallization, the difference between the initial temperature of the material entering the crystallization kettle and the initial temperature of the circulating water is 13-25 DEG C; and during the last crystallization, the initial temperature of the material entering the crystallization kettle is 30-35 DEG C. According to the multi-stage continuous cooling crystallization method, different water temperatures are adopted to carry out gradient cooling on the materials, so that the problems of non-uniform grain size and low purity caused by crystal explosion due to large temperature difference between the materials and a refrigerant and high cooling rate in the early stage of cooling are avoided.

The utility model discloses a production device of 3-acetamino phthalic acid, and belongs to the technical field of chemical production devices. The device comprises an acylation reaction device, an acidification device and a solid-liquid filtering device. The acylation reaction device comprises an acylation reaction kettle with a stirring device, an acetic anhydride high-position metering tank with a first rotor flow meter, a solid feeding hole and a first conveying pump; the acidification device comprises an acidification reaction kettle with a stirring device, a hydrochloric acid high-position metering tank with a second rotor flow meter, an online pH meter and a second delivery pump; and the solid-liquid filtering device comprises solid-liquid separation equipment, a filtrate receiving tank and a product collecting tank. All the devices of the device are connected through pipelines and stop valves. According to the utility model, the dosage of hydrochloric acid is reduced by adjusting the dosage of acetic anhydride and controlling the acidification pH value, so that the production cost is reduced, and the quality and yield of the product 3-acetamino phthalic acid are improved.

The invention belongs to the technical field of fine chemical engineering, and relates to a method for recovering 5-acetoacetamidobenzimidazolone, which comprises the following steps: adding a stabilizer into AABI acylation wastewater, concentrating under reduced pressure, cooling to 25-30 DEG C, carrying out suction filtration, and taking a filter cake for later use; adding methanol into a filter cake, dispersing and stirring for 0.5 hour, adding corresponding sodium alkoxide, stirring for 0.5 hour, adding activated carbon, stirring for 0.5 hour, decolorizing, carrying out suction filtration, and concentrating filtrate until no fraction appears; and adding water into the concentrated filtrate for refining, dropwise adding acetic acid to adjust the pH value, stirring for 0.5 h, carrying out suction filtration, and washing and drying a filter cake to obtain an AABI product. The gallic acid is selected as a stabilizer, in the high-temperature concentration process, the AABI structure cannot be damaged, water-soluble salts are filtered out after concentration, impurities are removed through alcohol dispersion and alkali adjustment through sodium alcoholate, then a qualified product is obtained through aqueous phase inversion, the purity is larger than or equal to 99.60%, operation is simpler, conversion is easier, and application and popularization are facilitated.

The invention provides a marker for predicting caries occurrence based on saliva metabolites, which is characterized by comprising 4-acetaminobutyric acid, adipic acid, pantetheine and palmitoyl ethanolamide, and the marker is used for preparing a kit for detecting the caries occurrence risk of a subject. The invention provides four markers in saliva metabolites, and early warning of future caries can be realized in a non-invasive and low-cost manner; according to the basis of detection numerical values of the markers, the morbidity state of the constant dentition caries can be reflected, so that accurate prevention and control of the caries can be realized, and finally the purposes of reducing the morbidity of the caries, helping disease pathological typing and researching drug action targets, accurate medication and pathogenesis can be achieved.

The application provides a production method of 2-amino-4-acetylamino anisole, relates to the technical field of organic chemical synthesis, and comprises the following steps: continuously acetylating p-aminoanisole in a tubular reactor, neutralizing, crystallizing and drying to obtain an intermediate. The intermediate, concentrated sulfuric acid and a specific auxiliary A are mixed to form a substrate liquid, and the substrate liquid is subjected to a nitration reaction with a nitration mixed acid in a three-stage continuous reaction kettle. The auxiliary A is composed of perfluoropolyether oil, boron nitride nanosheet, polyethylene glycol perfluorooctyl ether block copolymer and lipophilic fumed silica. The nitration liquid is quenched, extracted and crystallized to obtain a nitration product. The nitration product is dissolved in ethanol, and catalytic hydrogenation is carried out in a fixed bed reactor. The hydrogenation product is subjected to post-treatment to obtain 2-amino-4-acetylamino anisole. The application remarkably improves the reaction selectivity, yield and product purity through the cooperation of the continuous process and the specific auxiliary, and the by-products are few, so that the method is suitable for industrial production.

The utility model discloses an acetaminophen refined mother liquor recovery processing device which comprises a rack, a barrel shell is installed in the rack, filter screens are arranged in the barrel shell at intervals, the filter screens are clamped in a screen ring, a protruding tongue of the screen ring is rotationally connected to the barrel shell through a hinged support, an arc groove is formed in the side wall of one side of the barrel shell in a penetrating mode, and an arc plate is arranged on the outer side of the arc groove. The arc plate is connected to the outer curved surface of the net ring through an arc pad, the arc pad is clamped in the arc groove, a pressing rod mechanism is arranged on the outer side of the arc plate, and a seat plate of the pressing rod mechanism is connected to the outer wall of the barrel shell; the device is simple in structure, reasonable in design and novel and unique in thought, the adsorption layer is placed on the filter screen, the baffle ring limits the adsorption layer (particulate matter, a pad and the like), the adsorption layer adsorbs and filters mother liquor, the arc plate shields the arc groove in the barrel shell, and the arc pad on the inner side of the arc plate seals the arc groove, so that the mother liquor entering the barrel shell is prevented from leaking, and the service life of the mother liquor is prolonged. In addition, the arc plate is pressed and contacted through the pressing rod mechanism, so that the arc plate is prevented from accidentally driving the net ring and the filter net to rotate out.

The present invention provides a salt of a triazine compound which has an inhibitory action against aldosterone synthase and is useful as a drug, and especially as a drug for preventing or treating primary aldosteronism and the like, a crystal thereof, and a method for producing the same. Specifically, the present invention provides a pharmaceutically acceptable salt of 3-[4-[[trans-4-(acetamino)cyclohexyl]carbamoylmethyl]piperazin-1-yl]-5-(p-tolyl)-1,2,4-triazine, wherein the salt is hydrobromide, sulfate, succinate, or tosylate, and the like.

The invention belongs to the field of organic synthesis, and discloses a novel pymetrozine intermediate and a preparation method thereof. The structure of the novel pymetrozine intermediate is as shown in a formula I. The preparation method comprises the following steps: (1) reacting propionyl hydrazine, butyrylhydrazine or isobutyrylhydrazine with phosgene or solid phosgene in a solvent to obtain corresponding ethyl oxadiazolone, n-propyl oxadiazolone or isopropyl oxadiazolone, and then removing hydrogen chloride gas to obtain a uniform reaction solution; (2) adding an inorganic base, a phase transfer catalyst and chloroacetone into the reaction liquid obtained in the step (1) to react, and then sequentially desalting, distilling and concentrating to obtain a corresponding acetonyl intermediate; and (3) adding alcohol and hydrazine hydrate into the acetone-based intermediate obtained in the step (2), and sequentially cooling, crystallizing and separating after reaction. Compared with traditional acetamido triazinone, the acetamido triazinone is easier to synthesize, lower in cost, good in thermal stability and capable of remarkably reducing the cost of pymetrozine, and in the formula I, R is ethyl, propyl or isopropyl. Formula I.

The present disclosure relates to PI3Kα inhibitors, their crystalline forms, solvates, compositions, and methods of use. For example, the present disclosure describes solid forms of compounds including the crystalline solid form of the following compounds: N-((1S,2R,4S)-4-(((S)-(3-chloro-2,6-difluorophenyl)(4-fluorobicyclo[2.2.1]heptane-1-yl)methyl)carbamoyl)-2-hydroxycyclopentyl)pyrimidine-5-carboxamide; and (1S,3S,4R)-3-acetamido-N-((S)-(3-chloro-2,6-difluorophenyl)(4-fluorobicyclo[2.2.1]heptane-1-yl)methyl)-4-hydroxycyclopentane-1-carboxamide.

The invention belongs to the field of pharmaceutical reagents, and provides a preparation method of an intermediate containing an acetylfuran structure. According to the invention, N-acetyl-D-glucosamine is used as a raw material, a La2O3 catalyst with a nanoscale sheet-shaped wrinkle structure is used for catalytic dehydration reaction, and the design of segmented temperature control and a multi-step cascade recrystallization process is combined; according to the method, the total purity of the target products N-3-furyl-acetamide and N-(5-acetyl-3-furyl)-acetamide reaches 97.5-99.5%, the product is in a needle-like crystal form, the high quality performance is achieved, the problems that an existing intermediate containing an acetylfuran structure is low in catalytic activity and product purity are solved, the catalyst can be repeatedly used for 4-6 times, the activity retention rate is larger than or equal to 90%, and the method is suitable for industrial production. The intermediate can be used for preparing key intermediates of bioactive molecules such as antitumor drugs and antibiotics, and has wide application value.

The utility model relates to the technical field of centrifugal equipment, in particular to a centrifugal machine for separating acetaminophen mother liquor, which comprises a centrifugal machine body, the centrifugal machine body comprises an outer barrel and a centrifugal filter barrel, a cleaning mechanism is arranged at the upper end of the inner side of the outer barrel and comprises a second motor, and the lower end of the second motor is connected with a supporting shaft. Two first mounting holes which are vertically distributed are formed in the supporting shaft, a first supporting rod and a second supporting rod are arranged in the two first mounting holes in a penetrating mode correspondingly, and a first connecting block and a second connecting block are arranged at one end of the first supporting rod and one end of the second supporting rod correspondingly; the cleaning mechanism in the centrifugal machine can be suitable for cleaning various centrifugal filter barrels with different diameters and depths and outer barrels on the outer sides of the centrifugal filter barrels, the application range of the cleaning mechanism is widened, the utilization rate of the cleaning mechanism is increased, and the cleaning efficiency of the centrifugal machine is improved. The limitation of the cleaning mechanism is reduced.

The invention discloses an acetamido abamectin injection and a preparation method thereof, and belongs to the technical field of veterinary drug preparations. The injection comprises the following components in percentage by weight: 1%-10% of acetamido abamectin, 5%-20% of a sustained-release material, 0.1%-1% of an antioxidant, 5%-15% of a cosolvent and the balance of oil for injection. Wherein the sustained-release material is a polylactic acid-glycolic acid copolymer or polycaprolactone with a specific proportion and molecular weight, the antioxidant is selected from an efficient antioxidant such as tert-butylhydroquinone, the cosolvent is common cosolvent such as propylene glycol, and the oil for injection is soybean oil, sesame oil or corn oil and the like which meet the standard of veterinary drug poeia. The preparation method comprises the steps of oil phase preparation, medicine dissolution, mixing, antioxidant addition, filtration, filling and the like. The injection provided by the invention has the characteristics of long-acting slow release and high stability, can effectively prolong the plasma concentration duration time and reduce the administration frequency, and is simple in preparation process and suitable for large-scale industrial production.

The invention belongs to the technical field of acetaminophen medicine synthesis, and particularly relates to a preparation method of acetaminophen, which is characterized in that acetaminophen and glacial acetic acid are subjected to one-step amidation reaction in a negative-pressure low-temperature reaction system to synthesize acetaminophen. The method solves the problems of high acetaminophen preparation temperature, easy raw material oxidation, low crude product quality, high cost and environmental protection potential safety hazard.

Presented herein are methods for making, isolating, and purifying N-acetylcysteine amide, (2R,2R′)-3,3′-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: alternatively contacting cystine with methanol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine, and an alcohol.

This invention discloses a method for degrading acetaminophen in water using PCN-224-activated persulfate. The method utilizes the PCN-224 photocatalyst to activate persulfate and degrade acetaminophen-containing water. The PCN-224 photocatalyst is prepared from tetrakis(4-carboxyphenyl)porphyrin and zirconium oxychloride through a hydrothermal reaction at 65℃–80℃. The PCN-224 photocatalyst of this invention possesses abundant microporous and mesoporous structures and numerous functional groups, which not only facilitates the rapid adsorption of acetaminophen and the rapid activation of persulfate but also enhances the activation effect of persulfate, ultimately achieving efficient and complete degradation of acetaminophen. The method of this invention has advantages such as simple process, convenient operation, good removal effect, wide applicability, and no risk of secondary pollution, making it of practical significance for the treatment of acetaminophen wastewater in the environment.

The present invention provides a process for preparing a composition having a low dissolved oxygen content comprising acetaminophen and optionally one or more NSAIDs wherein the composition has a dissolved oxygen of at most 1.0 ppm in a closed container, said process comprising flushing the mixing container at least once with water at a temperature of at least 80 DEG C, and the composition obtained therefrom, thereby heating the container and creating a hypoxic environment in the container; and dissolving the acetaminophen in water for injection in the flushed container, the water for injection having a temperature of at least 80 DEG C wherein one or more NSAIDs are optionally added before or after dissolving the acetaminophen. The method of the present invention can produce a stable, intravenously administered aqueous composition without the need to deoxidize the composition.

The present application relates to a kind of preparation methods of 4-acetamido-5-chloro-2-methoxybenzoic acid methyl ester, steps include: S1, m-amino phenol is reacted with acetic anhydride to generate m-acetylamino phenol;S2, the m-acetylamino phenol is reacted with carbon dioxide to generate 4-acetylamino salicylic acid;S3, the 4-acetylamino salicylic acid is reacted with dimethyl sulfate to generate 2-methoxy-4-acetylamino benzoic acid methyl ester;S4, the 2-methoxy-4-acetylamino benzoic acid methyl ester is reacted with hydrochloric acid to generate 4-acetamido-5-chloro-2-methoxybenzoic acid methyl ester.The preparation method of the present application not only improves product quality and production efficiency, but also reduces cost, simplifies operation, and is friendly to environment, with significant industrial application prospect and market competitiveness.

The present invention provides a salt of a triazine compound which has an inhibitory action against aldosterone synthase and is useful as a drug, and especially as a drug for preventing or treating primary aldosteronism and the like, a crystal thereof, and a method for producing the same. Specifically, the present invention provides a pharmaceutically acceptable salt of 3-[4-[[trans-4-(acetamino)cyclohexyl]carbamoylmethyl]piperazin-1-yl]-5-(p-tolyl)-1,2,4-triazine, wherein the salt is hydrobromide, sulfate, succinate, or tosylate, and the like.

The present invention provides an N-(tert-butyl)-2-(N-acetylamino)formamide compound and a 3CL derivative of the N-(tert-butyl)-2-(N-acetylamino)formamide compound. pro The experimental results show that the compound synthesized by the present invention has an inhibitory effect on 3CL pro The compounds 1, 8, 13, 16 and 20 showed the strongest inhibitory activity against 3CL protease, with IC 50 The concentrations of compound 1 and its derivatives were all below 200 nM, and the in vitro toxicity test showed that compound 1 was safer than the positive controls PF-07321332 and S-217622, indicating that it can be developed and applied as an anti-coronavirus drug.

The invention provides a preparation method of 3-acetamido-5-acetylfuran. The preparation method comprises the following steps: preparing 3-acetamido-5-acetylfuran; the chitin and / or crustacean waste are / is subjected to ball milling treatment under the assistance of sulfuric acid, so that the crystal structure of the chitin is broken, the molecular weight is reduced, the accessibility of a substrate is remarkably improved, and the conversion bottleneck caused by a compact three-dimensional structure of a high-molecular polymer is solved; then, in a DMAc / LiCl solvent, hydrolysis and dehydration reactions of chitin are connected in series, and the yield of 3A5AF of 68.3 mol% is obtained from chitin, or the yield of 3A5AF of 52.45 mol% is directly obtained from shrimp shells; according to the method, an extensible efficient path is opened up, the 3-acetamido-5-acetylfuran can be directly prepared from the crustacean waste biomass, tedious separation and purification steps are avoided, and a new path is opened up for economical and efficient biomass refining.

The present invention provides a salt of a triazine compound which has an inhibitory action against aldosterone synthase and is useful as a drug, and especially as a drug for preventing or treating primary aldosteronism and the like, a crystal thereof, and a method for producing the same. Specifically, the present invention provides a pharmaceutically acceptable salt of 3-[4-[[trans-4-(acetamino)cyclohexyl]carbamoylmethyl]piperazin-1-yl]-5-(p-tolyl)-1,2,4-triazine, wherein the salt is hydrobromide, sulfate, succinate, or tosilate, and the like.

The utility model relates to the field of medicine, discloses a drying device for acetaminophen production, and solves the problems that acetaminophen closer to the inner wall of a drying cylinder is dried faster, acetaminophen far away from the inner wall of the drying cylinder is dried slowly, some acetaminophen is still dried after being dried, some acetaminophen is not dried, and the drying efficiency is low. The drying device for acetaminophen production comprises a base, a drying cylinder arranged above the middle of the base and a drying layer arranged in the drying cylinder, a reciprocating mechanism is arranged above one side of the base, and a rotating mechanism is arranged above the reciprocating mechanism. The reciprocating mechanism is started to drive the drying cylinder to swing up and down, the drying cylinder swings in a reciprocating mode to enable the rotating mechanism to rotate in a reciprocating mode, acetaminophen on the inner side of the drying cylinder swings and rotates, and therefore the drying effect is better.

The utility model provides a crushing device for acetaminophen raw material production, and relates to the technical field of acetaminophen raw material production, the crushing device comprises a support and a shell, the upper surface of the shell is provided with a feed hopper, the lower surface of the shell is provided with a discharge port, and the interior of the shell is rotatably connected with a crushing roller A and a crushing roller B. The screening plate is arranged in the shell, raw materials obtained after preliminary smashing can be screened out, the raw materials which do not meet the smashing requirement are screened out, the motor B is started to drive the threaded rod to rotate, the threaded rod is in threaded connection with the moving block, and the moving block is in sliding connection with the sliding rod; the movable block can drive the crushing roller to horizontally move, then raw materials which do not meet the crushing requirement can be crushed again, workers do not need to manually take out the raw materials which are not completely crushed to manually add the raw materials for secondary crushing, manpower is saved, and meanwhile the crushing quality and the flexibility and crushing effect of the device are improved.

The invention relates to an application of a 5-selenoquinoline amide compound in preparation of an anti-osteoporosis medicine. The 5-selenoquinoline amide compound is 5-(4-bromophenylseleno)-8-acetamidoquinoline (3w), and the structural formula of the 5-selenoquinoline amide compound is shown in the description. Anti-osteoporosis activity evaluation is carried out on 5-(4-bromophenylseleno)-8-acetaminoquinoline (3w), and it is found for the first time that 5-(4-bromophenylseleno)-8-acetaminoquinoline (3w) has obvious anti-osteoporosis activity, osteoclast differentiation and bone resorption activity can be effectively inhibited, in-vivo bone loss is inhibited, and osteoporosis is inhibited. The compound can be used for preparing the anti-osteoporosis medicine, provides a novel anti-osteoporosis medicine for clinic, and has good clinical application value and wide application prospect.

The invention discloses a treatment method for the production wastewater of 5-acetylacetamido benzimidazolone, mainly solving the technical problems of high investment and operation costs of enterprises producing wastewater of 5-acetylacetamido benzimidazolone, secondary pollution generation and unstable effluent indexes. The wastewater of the invention is successively passed through a high-concentration wastewater AO process, an oxidation process, an activated sludge AO process and a denitrification process, and most of the pollutants in the wastewater are degraded through a biochemical section, realizing the up-to-standard discharge of the wastewater at low cost.

The invention discloses an industrial preparation method of 4-acetaminobutyrate, which comprises the following steps: adding water and an organic phase into a ton kettle, sequentially adding 4-aminobutyric acid and inorganic alkali, dropwise adding an acylating agent, heating to react, evaporating to remove an organic solvent after the reaction is finished, adding ethanol, cooling to crystallize, carrying out suction filtration, leaching and drying to obtain the 4-acetaminobutyrate. The three steps of acylation, salification and crystallization are completed through a one-pot method, solvent loss caused by intermediate purification due to conventional step-by-step synthesis is avoided, the reaction time is shortened, the cost is reduced, the raw materials are cheap and easy to obtain, the molar yield of the product is 90% or above, and the method has wide market application prospects.

1. Name of the designed product: medicine packing box (compound paracetamol tablet (II)). 2. Use of the designed product: medicine packing box. 3. Design points of the designed product: the pattern. 4. Picture or photo best indicating the design points: front view.

N-(4-fluoro-5-(((2S,4R)-4-((6-methoxypyrimidin-4-yl)oxy)-2-methylpyrrolidin-1-yl)methyl)thiazol-2-yl)acetamide, Compound (I): Described herein are solid forms of JPEG2023536911000013.jpg53125, and processes for making such solid forms of Compound (I). The invention further relates to pharmaceutical compositions comprising crystalline Forms A and B of Compound (I), and methods of using such forms and pharmaceutical compositions in the treatment and prevention of Alzheimer's disease and related neurological disorders.

The present disclosure provides lyophilates comprising (S)-isopropyl 2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo-5-oxohexanoate: and pharmaceutical compositions, pharmaceutical formulations, and uses thereof.