49 results about "Acetamido-CNU" patented technology

The utility model discloses a production device of 3-acetamino phthalic acid, and belongs to the technical field of chemical production devices. The device comprises an acylation reaction device, an acidification device and a solid-liquid filtering device. The acylation reaction device comprises an acylation reaction kettle with a stirring device, an acetic anhydride high-position metering tank with a first rotor flow meter, a solid feeding hole and a first conveying pump; the acidification device comprises an acidification reaction kettle with a stirring device, a hydrochloric acid high-position metering tank with a second rotor flow meter, an online pH meter and a second delivery pump; and the solid-liquid filtering device comprises solid-liquid separation equipment, a filtrate receiving tank and a product collecting tank. All the devices of the device are connected through pipelines and stop valves. According to the utility model, the dosage of hydrochloric acid is reduced by adjusting the dosage of acetic anhydride and controlling the acidification pH value, so that the production cost is reduced, and the quality and yield of the product 3-acetamino phthalic acid are improved.

The invention belongs to the technical field of fine chemical engineering, and relates to a method for recovering 5-acetoacetamidobenzimidazolone, which comprises the following steps: adding a stabilizer into AABI acylation wastewater, concentrating under reduced pressure, cooling to 25-30 DEG C, carrying out suction filtration, and taking a filter cake for later use; adding methanol into a filter cake, dispersing and stirring for 0.5 hour, adding corresponding sodium alkoxide, stirring for 0.5 hour, adding activated carbon, stirring for 0.5 hour, decolorizing, carrying out suction filtration, and concentrating filtrate until no fraction appears; and adding water into the concentrated filtrate for refining, dropwise adding acetic acid to adjust the pH value, stirring for 0.5 h, carrying out suction filtration, and washing and drying a filter cake to obtain an AABI product. The gallic acid is selected as a stabilizer, in the high-temperature concentration process, the AABI structure cannot be damaged, water-soluble salts are filtered out after concentration, impurities are removed through alcohol dispersion and alkali adjustment through sodium alcoholate, then a qualified product is obtained through aqueous phase inversion, the purity is larger than or equal to 99.60%, operation is simpler, conversion is easier, and application and popularization are facilitated.

The application provides a production method of 2-amino-4-acetylamino anisole, relates to the technical field of organic chemical synthesis, and comprises the following steps: continuously acetylating p-aminoanisole in a tubular reactor, neutralizing, crystallizing and drying to obtain an intermediate. The intermediate, concentrated sulfuric acid and a specific auxiliary A are mixed to form a substrate liquid, and the substrate liquid is subjected to a nitration reaction with a nitration mixed acid in a three-stage continuous reaction kettle. The auxiliary A is composed of perfluoropolyether oil, boron nitride nanosheet, polyethylene glycol perfluorooctyl ether block copolymer and lipophilic fumed silica. The nitration liquid is quenched, extracted and crystallized to obtain a nitration product. The nitration product is dissolved in ethanol, and catalytic hydrogenation is carried out in a fixed bed reactor. The hydrogenation product is subjected to post-treatment to obtain 2-amino-4-acetylamino anisole. The application remarkably improves the reaction selectivity, yield and product purity through the cooperation of the continuous process and the specific auxiliary, and the by-products are few, so that the method is suitable for industrial production.

The utility model discloses an acetaminophen refined mother liquor recovery processing device which comprises a rack, a barrel shell is installed in the rack, filter screens are arranged in the barrel shell at intervals, the filter screens are clamped in a screen ring, a protruding tongue of the screen ring is rotationally connected to the barrel shell through a hinged support, an arc groove is formed in the side wall of one side of the barrel shell in a penetrating mode, and an arc plate is arranged on the outer side of the arc groove. The arc plate is connected to the outer curved surface of the net ring through an arc pad, the arc pad is clamped in the arc groove, a pressing rod mechanism is arranged on the outer side of the arc plate, and a seat plate of the pressing rod mechanism is connected to the outer wall of the barrel shell; the device is simple in structure, reasonable in design and novel and unique in thought, the adsorption layer is placed on the filter screen, the baffle ring limits the adsorption layer (particulate matter, a pad and the like), the adsorption layer adsorbs and filters mother liquor, the arc plate shields the arc groove in the barrel shell, and the arc pad on the inner side of the arc plate seals the arc groove, so that the mother liquor entering the barrel shell is prevented from leaking, and the service life of the mother liquor is prolonged. In addition, the arc plate is pressed and contacted through the pressing rod mechanism, so that the arc plate is prevented from accidentally driving the net ring and the filter net to rotate out.

The present invention provides a salt of a triazine compound which has an inhibitory action against aldosterone synthase and is useful as a drug, and especially as a drug for preventing or treating primary aldosteronism and the like, a crystal thereof, and a method for producing the same. Specifically, the present invention provides a pharmaceutically acceptable salt of 3-[4-[[trans-4-(acetamino)cyclohexyl]carbamoylmethyl]piperazin-1-yl]-5-(p-tolyl)-1,2,4-triazine, wherein the salt is hydrobromide, sulfate, succinate, or tosylate, and the like.

The invention belongs to the field of organic synthesis, and discloses a novel pymetrozine intermediate and a preparation method thereof. The structure of the novel pymetrozine intermediate is as shown in a formula I. The preparation method comprises the following steps: (1) reacting propionyl hydrazine, butyrylhydrazine or isobutyrylhydrazine with phosgene or solid phosgene in a solvent to obtain corresponding ethyl oxadiazolone, n-propyl oxadiazolone or isopropyl oxadiazolone, and then removing hydrogen chloride gas to obtain a uniform reaction solution; (2) adding an inorganic base, a phase transfer catalyst and chloroacetone into the reaction liquid obtained in the step (1) to react, and then sequentially desalting, distilling and concentrating to obtain a corresponding acetonyl intermediate; and (3) adding alcohol and hydrazine hydrate into the acetone-based intermediate obtained in the step (2), and sequentially cooling, crystallizing and separating after reaction. Compared with traditional acetamido triazinone, the acetamido triazinone is easier to synthesize, lower in cost, good in thermal stability and capable of remarkably reducing the cost of pymetrozine, and in the formula I, R is ethyl, propyl or isopropyl. Formula I.

The present disclosure relates to PI3Kα inhibitors, their crystalline forms, solvates, compositions, and methods of use. For example, the present disclosure describes solid forms of compounds including the crystalline solid form of the following compounds: N-((1S,2R,4S)-4-(((S)-(3-chloro-2,6-difluorophenyl)(4-fluorobicyclo[2.2.1]heptane-1-yl)methyl)carbamoyl)-2-hydroxycyclopentyl)pyrimidine-5-carboxamide; and (1S,3S,4R)-3-acetamido-N-((S)-(3-chloro-2,6-difluorophenyl)(4-fluorobicyclo[2.2.1]heptane-1-yl)methyl)-4-hydroxycyclopentane-1-carboxamide.

The utility model relates to the technical field of centrifugal equipment, in particular to a centrifugal machine for separating acetaminophen mother liquor, which comprises a centrifugal machine body, the centrifugal machine body comprises an outer barrel and a centrifugal filter barrel, a cleaning mechanism is arranged at the upper end of the inner side of the outer barrel and comprises a second motor, and the lower end of the second motor is connected with a supporting shaft. Two first mounting holes which are vertically distributed are formed in the supporting shaft, a first supporting rod and a second supporting rod are arranged in the two first mounting holes in a penetrating mode correspondingly, and a first connecting block and a second connecting block are arranged at one end of the first supporting rod and one end of the second supporting rod correspondingly; the cleaning mechanism in the centrifugal machine can be suitable for cleaning various centrifugal filter barrels with different diameters and depths and outer barrels on the outer sides of the centrifugal filter barrels, the application range of the cleaning mechanism is widened, the utilization rate of the cleaning mechanism is increased, and the cleaning efficiency of the centrifugal machine is improved. The limitation of the cleaning mechanism is reduced.

The invention belongs to the technical field of acetaminophen medicine synthesis, and particularly relates to a preparation method of acetaminophen, which is characterized in that acetaminophen and glacial acetic acid are subjected to one-step amidation reaction in a negative-pressure low-temperature reaction system to synthesize acetaminophen. The method solves the problems of high acetaminophen preparation temperature, easy raw material oxidation, low crude product quality, high cost and environmental protection potential safety hazard.

Presented herein are methods for making, isolating, and purifying N-acetylcysteine amide, (2R,2R′)-3,3′-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: alternatively contacting cystine with methanol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine, and an alcohol.

This invention discloses a method for degrading acetaminophen in water using PCN-224-activated persulfate. The method utilizes the PCN-224 photocatalyst to activate persulfate and degrade acetaminophen-containing water. The PCN-224 photocatalyst is prepared from tetrakis(4-carboxyphenyl)porphyrin and zirconium oxychloride through a hydrothermal reaction at 65℃–80℃. The PCN-224 photocatalyst of this invention possesses abundant microporous and mesoporous structures and numerous functional groups, which not only facilitates the rapid adsorption of acetaminophen and the rapid activation of persulfate but also enhances the activation effect of persulfate, ultimately achieving efficient and complete degradation of acetaminophen. The method of this invention has advantages such as simple process, convenient operation, good removal effect, wide applicability, and no risk of secondary pollution, making it of practical significance for the treatment of acetaminophen wastewater in the environment.

The present invention provides a process for preparing a composition having a low dissolved oxygen content comprising acetaminophen and optionally one or more NSAIDs wherein the composition has a dissolved oxygen of at most 1.0 ppm in a closed container, said process comprising flushing the mixing container at least once with water at a temperature of at least 80 DEG C, and the composition obtained therefrom, thereby heating the container and creating a hypoxic environment in the container; and dissolving the acetaminophen in water for injection in the flushed container, the water for injection having a temperature of at least 80 DEG C wherein one or more NSAIDs are optionally added before or after dissolving the acetaminophen. The method of the present invention can produce a stable, intravenously administered aqueous composition without the need to deoxidize the composition.

The present application relates to a kind of preparation methods of 4-acetamido-5-chloro-2-methoxybenzoic acid methyl ester, steps include: S1, m-amino phenol is reacted with acetic anhydride to generate m-acetylamino phenol;S2, the m-acetylamino phenol is reacted with carbon dioxide to generate 4-acetylamino salicylic acid;S3, the 4-acetylamino salicylic acid is reacted with dimethyl sulfate to generate 2-methoxy-4-acetylamino benzoic acid methyl ester;S4, the 2-methoxy-4-acetylamino benzoic acid methyl ester is reacted with hydrochloric acid to generate 4-acetamido-5-chloro-2-methoxybenzoic acid methyl ester.The preparation method of the present application not only improves product quality and production efficiency, but also reduces cost, simplifies operation, and is friendly to environment, with significant industrial application prospect and market competitiveness.

The present invention provides a salt of a triazine compound which has an inhibitory action against aldosterone synthase and is useful as a drug, and especially as a drug for preventing or treating primary aldosteronism and the like, a crystal thereof, and a method for producing the same. Specifically, the present invention provides a pharmaceutically acceptable salt of 3-[4-[[trans-4-(acetamino)cyclohexyl]carbamoylmethyl]piperazin-1-yl]-5-(p-tolyl)-1,2,4-triazine, wherein the salt is hydrobromide, sulfate, succinate, or tosylate, and the like.

The invention provides a preparation method of 3-acetamido-5-acetylfuran. The preparation method comprises the following steps: preparing 3-acetamido-5-acetylfuran; the chitin and / or crustacean waste are / is subjected to ball milling treatment under the assistance of sulfuric acid, so that the crystal structure of the chitin is broken, the molecular weight is reduced, the accessibility of a substrate is remarkably improved, and the conversion bottleneck caused by a compact three-dimensional structure of a high-molecular polymer is solved; then, in a DMAc / LiCl solvent, hydrolysis and dehydration reactions of chitin are connected in series, and the yield of 3A5AF of 68.3 mol% is obtained from chitin, or the yield of 3A5AF of 52.45 mol% is directly obtained from shrimp shells; according to the method, an extensible efficient path is opened up, the 3-acetamido-5-acetylfuran can be directly prepared from the crustacean waste biomass, tedious separation and purification steps are avoided, and a new path is opened up for economical and efficient biomass refining.

The present invention provides a salt of a triazine compound which has an inhibitory action against aldosterone synthase and is useful as a drug, and especially as a drug for preventing or treating primary aldosteronism and the like, a crystal thereof, and a method for producing the same. Specifically, the present invention provides a pharmaceutically acceptable salt of 3-[4-[[trans-4-(acetamino)cyclohexyl]carbamoylmethyl]piperazin-1-yl]-5-(p-tolyl)-1,2,4-triazine, wherein the salt is hydrobromide, sulfate, succinate, or tosilate, and the like.

The utility model provides a crushing device for acetaminophen raw material production, and relates to the technical field of acetaminophen raw material production, the crushing device comprises a support and a shell, the upper surface of the shell is provided with a feed hopper, the lower surface of the shell is provided with a discharge port, and the interior of the shell is rotatably connected with a crushing roller A and a crushing roller B. The screening plate is arranged in the shell, raw materials obtained after preliminary smashing can be screened out, the raw materials which do not meet the smashing requirement are screened out, the motor B is started to drive the threaded rod to rotate, the threaded rod is in threaded connection with the moving block, and the moving block is in sliding connection with the sliding rod; the movable block can drive the crushing roller to horizontally move, then raw materials which do not meet the crushing requirement can be crushed again, workers do not need to manually take out the raw materials which are not completely crushed to manually add the raw materials for secondary crushing, manpower is saved, and meanwhile the crushing quality and the flexibility and crushing effect of the device are improved.

The invention discloses an industrial preparation method of 4-acetaminobutyrate, which comprises the following steps: adding water and an organic phase into a ton kettle, sequentially adding 4-aminobutyric acid and inorganic alkali, dropwise adding an acylating agent, heating to react, evaporating to remove an organic solvent after the reaction is finished, adding ethanol, cooling to crystallize, carrying out suction filtration, leaching and drying to obtain the 4-acetaminobutyrate. The three steps of acylation, salification and crystallization are completed through a one-pot method, solvent loss caused by intermediate purification due to conventional step-by-step synthesis is avoided, the reaction time is shortened, the cost is reduced, the raw materials are cheap and easy to obtain, the molar yield of the product is 90% or above, and the method has wide market application prospects.

1. Name of the designed product: medicine packing box (compound paracetamol tablet (II)). 2. Use of the designed product: medicine packing box. 3. Design points of the designed product: the pattern. 4. Picture or photo best indicating the design points: front view.

N-(4-fluoro-5-(((2S,4R)-4-((6-methoxypyrimidin-4-yl)oxy)-2-methylpyrrolidin-1-yl)methyl)thiazol-2-yl)acetamide, Compound (I): Described herein are solid forms of JPEG2023536911000013.jpg53125, and processes for making such solid forms of Compound (I). The invention further relates to pharmaceutical compositions comprising crystalline Forms A and B of Compound (I), and methods of using such forms and pharmaceutical compositions in the treatment and prevention of Alzheimer's disease and related neurological disorders.

The present disclosure provides lyophilates comprising (S)-isopropyl 2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo-5-oxohexanoate: and pharmaceutical compositions, pharmaceutical formulations, and uses thereof.

The invention belongs to the technical field of harmful substance detection, and particularly relates to a preparation method of an enhanced fluorescent probe for detecting formaldehyde, which comprises the following steps: dissolving 4-methylpyridine and 1, 3-propane sultone in dry acetonitrile to obtain a product 1; dissolving the product 1 in dry acetonitrile, and adding p-acetamidobenzaldehyde to obtain a product 2; dissolving the product 2 in ethanol, and adding hydrochloric acid to obtain a fluorescent probe MA-QC; the method comprises the following steps: dissolving a fluorescent probe MA-QC in DMSO (Dimethylsulfoxide) to prepare mother liquor; the fluorescent probe provided by the invention has the advantages of enhanced recognition of formaldehyde, simple synthesis route, simple and convenient detection equipment and method, and can be used for qualitative and quantitative detection of formaldehyde in environment and biological systems.

This invention relates to a method for the selective nitration of 4-acetamidoanisole using a continuous flow microchannel reactor, belonging to the field of compound synthesis. The method includes: mixing 4-acetamidoanisole with a solvent to obtain feed solution A; using nitric acid as feed solution B; washing the microchannel reaction system with a solvent; pumping feed solution A and feed solution B separately into the microchannel reactor using metering pumps; after the reaction is complete, the product flows out from the outlet of the microchannel reactor, and the reaction solution is collected; diluting the reaction solution with ice water, precipitating the product, filtering, washing, and drying to obtain 4-acetamido-2-nitroanisole, or separating the reaction solution by washing with water, distilling under reduced pressure, and drying to obtain 4-methoxy-2-nitroacetanilide. This method only requires changing the solvent system of one feed solution to obtain two isomers with excellent selectivity. It features high reaction safety, short reaction time, simple post-processing, avoids the dangers of batch nitration reactions, and significantly reduces economic costs.

The invention discloses a method for preparing 3-acetamido-5-acetylfuran from chitin, which comprises the following steps: dissolving chitin in a deep eutectic solvent, and contacting with an L molecular sieve and / or a doped L molecular sieve for reaction to obtain 3-acetamido-5-acetylfuran, the molar ratio of the L molecular sieve is (0.9-5.0): M2 / nO: Al2O3: (2-50): SiO2; the L-doped molecular sieve is a molecular sieve doped with heteroatoms. According to the method, chitin is directly used as a raw material, so that the L molecular sieve efficiently catalyzes oriented conversion of chitin to prepare 3A5AF, the process of hydrolyzing chitin into oligomer or NAG is saved, and a green technology for preparing 3A5AF is established. The method provided by the invention has the advantages of high product yield, easy separation of the catalyst, reutilization, no corrosion to equipment and simple process, and has a very good application prospect.

The invention provides an acetaminophen ointment and a preparation method thereof. According to the ointment composition disclosed by the invention, the medicine can better play a role in local positioning treatment of arthralgia and neuralgia diseases, and meanwhile, the side effect of liver injury caused by oral medicine can be avoided. The ointment composition is good in spreadability, basically free of granular sensation, resistant to heat and stable, the preparation method is simple, the production cost is low, and the ointment composition is especially suitable for large-scale industrial production.

Provided is a compound hydrocortisone and neomycin sulfate granule, including the following components in parts by mass: 140 parts of acetaminophen, 1 part of chlorpheniramine maleate, 1.2 parts of methylephedrine hydrochloride, 2 to 2.5 parts of an inclusion stabilizer, 3.0 parts of artificial calculus bovis, and 0.5 to 1 parts of a caramel. In a method for preparing the compound hydrocortisone and neomycin sulfate granule, natural Chinese medicinal herbs are subjected to extraction to obtain natural stabilizers for stabilizing low-concentration acetaminophen and chlorpheniramine maleate, and the natural stabilizers are encapsulated with hydroxypropyl-β-cyclodextrin with a specific degree of substitution (DS).

A use of gut microbiota or a metabolite thereof and / or an antibody or a derivative thereof in preparation of immunotherapeutic drugs for colorectal cancer. The gut microbiota comprises at least one of Alistipes shahii, Butyricimonas virosa, Desulfovibrio piger, Actinomyces humiferus, Odoribacter splanchnicus, Faecalibacterium prausnitzii, Phocaeicola plebeius, Eubacterium rectale, Oscillospiraceae bacterium, and Alistipes onderdonkii. The metabolite of the gut microbiota comprises at least one of O-phosphorylethanolamine, 5,6-dihydroxyindole-2-carboxylic acid, phosphatidylcholine (O-16:0_20:4), and 4-acetamidobutyric acid. The antibody comprises an IL-17A signaling pathway monoclonal antibody and / or a colorectal cancer-targeted monoclonal antibody.

The invention relates to a preparation method of 3-(piperidine-4-yl) quinoline-2 (1H)-ketone. The method comprises the following steps: carrying out acylation reaction on methyl 2-aminobenzoate and acetic anhydride to prepare methyl 2-acetaminobenzoate; carrying out an intramolecular nucleophilic addition substitution reaction to prepare quinoline-2, 4 (1H, 3H)-diketone; carrying out nucleophilic substitution reaction on the quinoline-2, 4-diketone and 1-Boc-4-bromopiperidine to prepare 3-(1-Boc-piperidine-4-yl) quinoline-2, 4 (1H, 3H)-diketone; reducing to prepare 3-(1-Boc-piperidine-4-yl)-4-hydroxyquinoline-2 (1H)-ketone; and carrying out an elimination reaction and removing a Boc protecting group to prepare the 3-(piperidine-4-yl) quinoline-2 (1H)-ketone. The method has the advantages that the methyl 2-aminobenzoate is used as a starting raw material and is subjected to acylation reaction with acetic anhydride, intramolecular condensation, reduction into hydroxyl, elimination and deprotection to prepare the product, the cost is low, the synthesis route is novel, and industrialization is easy to realize.

1. Name of the designed product: medicine packing box (compound paracetamol tablet (II)). 2. Use of the designed product: medicine packing box. 3. Design points of the designed product: the pattern. 4. Picture or photo best indicating the design points: front view.

The present invention relates to the field of organic synthesis and discloses a continuous synthesis process of 2-acetamido-5-nitroanisole; said process uses a microchannel continuous flow reactor as the main reaction equipment and o-anisidine as the starting materials to synthesize 2-acetamido-5-nitroanisole continuously via pre-acylation, amidation, and nitration reactions; through the use of a composite amidation reagent, the process can reduce the raw material costs and achieve the unity between the amidation reagent and the reactive solvent; by introducing the continuous production processes and equipment, it can realize continuous production, improve the degree of automation, and greatly reduce the production safety risks; in addition, it reduces the reaction time, as well as the production of by-products and the difficulty of their subsequent treatment, and improves the nitration selectivity, finally realizing a win-win situation in both economic and environmental benefits, which conforms to the development concept of “green chemistry”.