121 results about "Acetamido-CNU" patented technology

The invention relates to the technical field of dye synthesis, and particularly discloses a 5-substituted amino-5 '-acetamido-3, 3'-dipyridyl derivative as well as a preparation method and application of the 5-substituted amino-5 '-acetamido-3, 3'-dipyridyl derivative. The structure of the 5-substituted amino-5 '-acetamido-3, 3'-dipyridyl derivative is as shown in a formula (I) in the specification, according to the application, N-acetyl blue is used as a parent for modification, and different derivative structures are introduced to amino groups, so that the novel bipyridine dye, namely the 5-substituted amino-5 '-acetamido-3, 3'-bipyridine derivative, is obtained. The 5-substituted amino-5 '-acetamido-3, 3'-dipyridyl derivative has higher color development intensity, and has the advantages of comprehensive color fastness, water washing resistance, acid resistance, sublimation resistance, wet friction resistance, excellent performance and the like when being applied to fabric dyeing.

The invention relates to the technical field of acetaminophen feeding, and particularly provides a spiral feeder for preparing acetaminophen, which comprises a premixing barrel, a spiral feeding mechanism, an integrated locking mechanism, a spiral quantitative feeding mechanism and a synchronous driving mechanism. The multiple spiral quantitative feeding mechanisms are matched with the rotating shaft in the premixing barrel and the premixing conveying piece to conduct premixing spiral feeding on raw materials, when the raw materials are put into the reaction kettle, the spiral feeding machine does not need to be continuously replaced to be connected with a feeding port of the reaction kettle, the problems that operation is tedious, and time and labor are wasted are solved, and the production efficiency is improved. The raw materials can be premixed before entering the reaction kettle, the acetaminophen preparation efficiency is greatly improved, the rotating shaft drives the multiple material stirring sets to stir the raw materials in the corresponding feeding hoppers through the synchronous driving mechanism, and therefore the function of integrated driving of the rotating shaft and the multiple material stirring sets is achieved.

A novel 7-marker metabolite panel (7MetP) comprising or consisting of diacetylspermine, diacetylspermidine, N-(3-acetamidopropyl)pyrrolidin-2-one, N-acetylneuraminate, N-acetyl-mannosamine, N-acetyl-lactosamine, and hydroxyisobutyric acid is described.

The invention discloses a tannic acid modified tungsten disulfide nanosheet and application thereof in treatment of acetaminophen acute liver injury, the nanosheet takes a tungsten disulfide nanosheet as a core, and the surface of the tungsten disulfide nanosheet is modified with electronegative tannic acid. The nanosheet disclosed by the invention has good stability and biocompatibility, can be used for preparing a nano-drug for treating acetaminophen acute liver injury, and specifically targets and removes active oxygen at a liver injury part through an electrostatic adsorption effect, so that inflammatory response is inhibited, and symptoms caused by the acute liver injury are effectively relieved.

The invention relates to a preparation and synthesis method of an amino-substituted nitrogen-containing heterocyclic ring, which is carried out by using an ice bath auxiliary device, and is characterized by comprising the following steps: adding p-aminobenzaldehyde into a toluene solution of aminoacetaldehyde dimethyl acetal, heating to reflux to obtain (Z)-N-(4-acetamido-benzylidene)-2, 2-dimethoxyethylamine, and reacting for 2-4 hours to obtain the N-(4-acetamido-benzylidene)-2, 2-dimethoxyethylamine. And carrying out three steps to obtain the 6-aminoisoquinoline. Wherein the reaction liquid is poured into the crushed ice, an ice bath auxiliary device is used for implementing, and the ice bath auxiliary device comprises an ice crusher (1), a carrying table (2), a heating plate array (3) and a tray (4).

The reaction kettle for the reaction preparation of the diethyl acetamidomalonate comprises a kettle body, a raw material dropwise adding assembly, a linkage structure, a stirring structure and an auxiliary cooling assembly. In order to solve the problems that when an ordinary reaction kettle is used for oximation reaction in diethyl acetamidomalonate reaction preparation, the reaction is violent and the reaction is not uniform and insufficient due to the fact that raw materials are mixed at a time, a raw material dropwise adding assembly is designed, the raw materials can be conveniently and gradually dropwise added into a kettle body through the raw material dropwise adding assembly, and the reaction efficiency is greatly improved. The reaction can be carried out step by step, the problem that the reaction is too intense is avoided, further, a stirring structure is designed, and automatic stirring and mixing can be carried out through the stirring structure during the reaction, so that the reaction is sufficient.

The invention relates to the technical field of acetaminophen crystallization, in particular to a multi-stage continuous cooling crystallization device and method for acetaminophen. The invention provides a multi-stage continuous cooling crystallization method for acetaminophen, which comprises the following steps: S1, at least five stages of continuous cooling crystallization are adopted, and circulating water with a set temperature is injected into a jacket of a crystallization kettle during each stage of cooling crystallization; wherein during the first several stages of crystallization, the difference between the initial temperature of the material entering the crystallization kettle and the initial temperature of the circulating water is 13-25 DEG C; and during the last crystallization, the initial temperature of the material entering the crystallization kettle is 30-35 DEG C. According to the multi-stage continuous cooling crystallization method, different water temperatures are adopted to carry out gradient cooling on the materials, so that the problems of non-uniform grain size and low purity caused by crystal explosion due to large temperature difference between the materials and a refrigerant and high cooling rate in the early stage of cooling are avoided.

The invention discloses a method for degrading acetaminophen in a water body by activating persulfate with iron-doped carbon quantum dots. According to the method, the acetaminophen-containing water body is degraded by activating the persulfate with the iron-doped carbon quantum dots. Wherein the iron-doped carbon quantum dots are prepared by taking ferrous gluconate as a raw material, carrying out hydrothermal reaction at 180-220 DEG C and dialyzing. According to the method disclosed by the invention, the persulfate can be effectively activated by using light energy in an activation process dominated by a photo-generated hole to generate more free radicals and non-free radical species, namely an efficient mixed oxidation system of a free radical pathway dominated by hydroxyl free radicals and a non-free radical pathway dominated by singlet oxygen is formed; the method has the advantages of being simple in process, convenient to operate, low in cost, extremely low in catalyst addition amount, low in oxidant addition amount, high in utilization rate, high in degradation efficiency, good in removal effect, environmentally friendly and the like.

The invention discloses a synthesis process of trans-p-aminocyclohexanol, and belongs to the technical field of chemical synthesis. The synthesis process of the trans-p-acetamido cyclohexanol comprises the following steps: performing catalytic hydrogenation on p-acetamido phenol, a catalyst A, an additive and a solvent A at a certain pressure and temperature to obtain p-acetamido cyclohexanol, and performing esterification, recrystallization and separation on acetic anhydride and p-acetamido cyclohexanol to obtain trans-p-acetamido cyclohexanol acetate; then, the trans-p-acetamido cyclohexanol acetate is hydrolyzed, and trans-p-aminocyclohexanol is obtained; the trans-p-aminocyclohexanol prepared by the method disclosed by the invention is high in yield and high in purity.

The utility model discloses a production device of 3-acetamino phthalic acid, and belongs to the technical field of chemical production devices. The device comprises an acylation reaction device, an acidification device and a solid-liquid filtering device. The acylation reaction device comprises an acylation reaction kettle with a stirring device, an acetic anhydride high-position metering tank with a first rotor flow meter, a solid feeding hole and a first conveying pump; the acidification device comprises an acidification reaction kettle with a stirring device, a hydrochloric acid high-position metering tank with a second rotor flow meter, an online pH meter and a second delivery pump; and the solid-liquid filtering device comprises solid-liquid separation equipment, a filtrate receiving tank and a product collecting tank. All the devices of the device are connected through pipelines and stop valves. According to the utility model, the dosage of hydrochloric acid is reduced by adjusting the dosage of acetic anhydride and controlling the acidification pH value, so that the production cost is reduced, and the quality and yield of the product 3-acetamino phthalic acid are improved.

The invention provides a synthesis method of 1-methyl-L-histidine, which comprises the following steps: firstly, carrying out methylation reaction on a compound 1 and N, N-dimethylformamide dimethyl acetal to obtain a compound 3; the compound 3 and NCS are subjected to a chlorination reaction, and a compound 4 is obtained; then reacting the compound 4 with diethyl acetamidomalonate to obtain a compound 5; then carrying out hydrolysis decarboxylation on the compound 5 to obtain a compound 6; and finally, splitting the compound 6 by using acetyl hydrolase to obtain a chiral compound 7 (namely 1-methyl-L-histidine). The synthesis route is short, the raw materials are cheap, the production cost can be reduced, the product yield and purity are high, and large-scale industrial production is facilitated.

It is described and claimed a pharmaceutical composition comprising celecoxib and acetaminophen as active ingredients, wherein the pharmaceutical composition is an immediate release coated tablet. The pharmaceutical composition of the invention is particularly stable and allows the oral administration in a single dosage unit of two active ingredients. It is further provided a process for manufacturing the pharmaceutical composition, as well as the use of said pharmaceutical composition for the treatment of pain, it provides analgesia and a reduction of adverse effects.

The invention belongs to the technical field of fine chemical engineering, and relates to a method for recovering 5-acetoacetamidobenzimidazolone, which comprises the following steps: adding a stabilizer into AABI acylation wastewater, concentrating under reduced pressure, cooling to 25-30 DEG C, carrying out suction filtration, and taking a filter cake for later use; adding methanol into a filter cake, dispersing and stirring for 0.5 hour, adding corresponding sodium alkoxide, stirring for 0.5 hour, adding activated carbon, stirring for 0.5 hour, decolorizing, carrying out suction filtration, and concentrating filtrate until no fraction appears; and adding water into the concentrated filtrate for refining, dropwise adding acetic acid to adjust the pH value, stirring for 0.5 h, carrying out suction filtration, and washing and drying a filter cake to obtain an AABI product. The gallic acid is selected as a stabilizer, in the high-temperature concentration process, the AABI structure cannot be damaged, water-soluble salts are filtered out after concentration, impurities are removed through alcohol dispersion and alkali adjustment through sodium alcoholate, then a qualified product is obtained through aqueous phase inversion, the purity is larger than or equal to 99.60%, operation is simpler, conversion is easier, and application and popularization are facilitated.

The invention provides a marker for predicting caries occurrence based on saliva metabolites, which is characterized by comprising 4-acetaminobutyric acid, adipic acid, pantetheine and palmitoyl ethanolamide, and the marker is used for preparing a kit for detecting the caries occurrence risk of a subject. The invention provides four markers in saliva metabolites, and early warning of future caries can be realized in a non-invasive and low-cost manner; according to the basis of detection numerical values of the markers, the morbidity state of the constant dentition caries can be reflected, so that accurate prevention and control of the caries can be realized, and finally the purposes of reducing the morbidity of the caries, helping disease pathological typing and researching drug action targets, accurate medication and pathogenesis can be achieved.

The invention relates to the technical field of acetaminophen production equipment, and discloses a tank loading device for acetaminophen production, which comprises a plurality of acetaminophen storage tanks gathered together, and further comprises connecting snap rings fixedly sleeved on the tops of the acetaminophen storage tanks, an adjusting sliding groove and a sliding clamping groove which communicate with each other are formed in the outer wall of the connecting clamping ring; the first sliding rod is arranged in the adjusting sliding groove in a sliding mode, and the first sliding rod is provided with an anti-reversion clamping sleeve mechanism which is manually opened; the second sliding rod is connected into the adjusting sliding groove in a sliding mode and corresponds to the first sliding rod. According to the acetaminophen storage tank, through the structural design of the connecting clamping ring, the first sliding rod, the second sliding rod, the anti-reversal clamping sleeve mechanism, the insertion strip mechanism and the like, a plurality of acetaminophen storage tanks can be connected into a whole without using disposable ribbons, plastic waste can be reduced, meanwhile, the long-term use cost can be reduced through the repeated use connecting mode, and the service life of the acetaminophen storage tank is prolonged. And frequent buying of ribbons is avoided.

The invention relates to the field of organic synthesis, and discloses a preparation method of a flufenoxuron intermediate. According to the preparation method disclosed by the invention, 3-fluoro-4-acetaminophenol and 3-chloro-4-fluorobenzotrifluoride are taken as reaction raw materials, and an isomer impurity 4-(5-trifluoromethyl-2-chlorophenoxy)-2-fluoroaniline which is difficult to separate is not generated. When the Williamson reaction is carried out, the No.4 site of the 3-chloro-4-fluorobenzotrifluoride is a fluorine element, so that the 3-fluoro-4-acetaminophenol can be better positioned and then substituted, the reaction efficiency is higher, the reaction is more complete, and the yield is higher. The purity of the product 2-fluoro-4-(2-chloro-4-trifluoromethylphenoxy) acetanilide (an intermediate of the target product 4-(4-trifluoromethyl-2-chlorophenoxy)-2-fluoroaniline) in the step is higher, and the purity of the target product 4-(4-trifluoromethyl-2-chlorophenoxy)-2-fluoroaniline is finally improved.

The application provides a production method of 2-amino-4-acetylamino anisole, relates to the technical field of organic chemical synthesis, and comprises the following steps: continuously acetylating p-aminoanisole in a tubular reactor, neutralizing, crystallizing and drying to obtain an intermediate. The intermediate, concentrated sulfuric acid and a specific auxiliary A are mixed to form a substrate liquid, and the substrate liquid is subjected to a nitration reaction with a nitration mixed acid in a three-stage continuous reaction kettle. The auxiliary A is composed of perfluoropolyether oil, boron nitride nanosheet, polyethylene glycol perfluorooctyl ether block copolymer and lipophilic fumed silica. The nitration liquid is quenched, extracted and crystallized to obtain a nitration product. The nitration product is dissolved in ethanol, and catalytic hydrogenation is carried out in a fixed bed reactor. The hydrogenation product is subjected to post-treatment to obtain 2-amino-4-acetylamino anisole. The application remarkably improves the reaction selectivity, yield and product purity through the cooperation of the continuous process and the specific auxiliary, and the by-products are few, so that the method is suitable for industrial production.

The utility model discloses an acetaminophen refined mother liquor recovery processing device which comprises a rack, a barrel shell is installed in the rack, filter screens are arranged in the barrel shell at intervals, the filter screens are clamped in a screen ring, a protruding tongue of the screen ring is rotationally connected to the barrel shell through a hinged support, an arc groove is formed in the side wall of one side of the barrel shell in a penetrating mode, and an arc plate is arranged on the outer side of the arc groove. The arc plate is connected to the outer curved surface of the net ring through an arc pad, the arc pad is clamped in the arc groove, a pressing rod mechanism is arranged on the outer side of the arc plate, and a seat plate of the pressing rod mechanism is connected to the outer wall of the barrel shell; the device is simple in structure, reasonable in design and novel and unique in thought, the adsorption layer is placed on the filter screen, the baffle ring limits the adsorption layer (particulate matter, a pad and the like), the adsorption layer adsorbs and filters mother liquor, the arc plate shields the arc groove in the barrel shell, and the arc pad on the inner side of the arc plate seals the arc groove, so that the mother liquor entering the barrel shell is prevented from leaking, and the service life of the mother liquor is prolonged. In addition, the arc plate is pressed and contacted through the pressing rod mechanism, so that the arc plate is prevented from accidentally driving the net ring and the filter net to rotate out.

The present invention provides a salt of a triazine compound which has an inhibitory action against aldosterone synthase and is useful as a drug, and especially as a drug for preventing or treating primary aldosteronism and the like, a crystal thereof, and a method for producing the same. Specifically, the present invention provides a pharmaceutically acceptable salt of 3-[4-[[trans-4-(acetamino)cyclohexyl]carbamoylmethyl]piperazin-1-yl]-5-(p-tolyl)-1,2,4-triazine, wherein the salt is hydrobromide, sulfate, succinate, or tosylate, and the like.

The invention belongs to the field of organic synthesis, and discloses a novel pymetrozine intermediate and a preparation method thereof. The structure of the novel pymetrozine intermediate is as shown in a formula I. The preparation method comprises the following steps: (1) reacting propionyl hydrazine, butyrylhydrazine or isobutyrylhydrazine with phosgene or solid phosgene in a solvent to obtain corresponding ethyl oxadiazolone, n-propyl oxadiazolone or isopropyl oxadiazolone, and then removing hydrogen chloride gas to obtain a uniform reaction solution; (2) adding an inorganic base, a phase transfer catalyst and chloroacetone into the reaction liquid obtained in the step (1) to react, and then sequentially desalting, distilling and concentrating to obtain a corresponding acetonyl intermediate; and (3) adding alcohol and hydrazine hydrate into the acetone-based intermediate obtained in the step (2), and sequentially cooling, crystallizing and separating after reaction. Compared with traditional acetamido triazinone, the acetamido triazinone is easier to synthesize, lower in cost, good in thermal stability and capable of remarkably reducing the cost of pymetrozine, and in the formula I, R is ethyl, propyl or isopropyl. Formula I.

The present disclosure relates to PI3Kα inhibitors, their crystalline forms, solvates, compositions, and methods of use. For example, the present disclosure describes solid forms of compounds including the crystalline solid form of the following compounds: N-((1S,2R,4S)-4-(((S)-(3-chloro-2,6-difluorophenyl)(4-fluorobicyclo[2.2.1]heptane-1-yl)methyl)carbamoyl)-2-hydroxycyclopentyl)pyrimidine-5-carboxamide; and (1S,3S,4R)-3-acetamido-N-((S)-(3-chloro-2,6-difluorophenyl)(4-fluorobicyclo[2.2.1]heptane-1-yl)methyl)-4-hydroxycyclopentane-1-carboxamide.

The present invention relates to the field of medical technology, and in particular to a method for preparing L-carnosine, the method comprising the following steps: using L-aspartic acid as a starting material, reacting with cyanoacetyl chloride to obtain (S)-2-(2-cyanoacetylamino)succinic acid, (S)-2-(2-cyanoacetylamino)succinic acid under the action of a dehydrating agent to obtain (S)-2-(2-cyanoacetylamino)succinic anhydride, (S)-2-(2-cyanoacetylamino)succinic anhydride reacting with trimethylsulfoxide iodide and hydrochloric acid, then cyclizing with formamidine acetate to obtain cyanoacetyl-L-histidine, and finally reducing with hydrogen to obtain the target product L-carnosine. The L-carnosine prepared by the preparation method of the present invention has the characteristics of high purity, high yield, low raw material cost and low energy consumption, and is suitable for industrial production.

The invention belongs to the field of pharmaceutical reagents, and provides a preparation method of an intermediate containing an acetylfuran structure. According to the invention, N-acetyl-D-glucosamine is used as a raw material, a La2O3 catalyst with a nanoscale sheet-shaped wrinkle structure is used for catalytic dehydration reaction, and the design of segmented temperature control and a multi-step cascade recrystallization process is combined; according to the method, the total purity of the target products N-3-furyl-acetamide and N-(5-acetyl-3-furyl)-acetamide reaches 97.5-99.5%, the product is in a needle-like crystal form, the high quality performance is achieved, the problems that an existing intermediate containing an acetylfuran structure is low in catalytic activity and product purity are solved, the catalyst can be repeatedly used for 4-6 times, the activity retention rate is larger than or equal to 90%, and the method is suitable for industrial production. The intermediate can be used for preparing key intermediates of bioactive molecules such as antitumor drugs and antibiotics, and has wide application value.

The utility model relates to the technical field of centrifugal equipment, in particular to a centrifugal machine for separating acetaminophen mother liquor, which comprises a centrifugal machine body, the centrifugal machine body comprises an outer barrel and a centrifugal filter barrel, a cleaning mechanism is arranged at the upper end of the inner side of the outer barrel and comprises a second motor, and the lower end of the second motor is connected with a supporting shaft. Two first mounting holes which are vertically distributed are formed in the supporting shaft, a first supporting rod and a second supporting rod are arranged in the two first mounting holes in a penetrating mode correspondingly, and a first connecting block and a second connecting block are arranged at one end of the first supporting rod and one end of the second supporting rod correspondingly; the cleaning mechanism in the centrifugal machine can be suitable for cleaning various centrifugal filter barrels with different diameters and depths and outer barrels on the outer sides of the centrifugal filter barrels, the application range of the cleaning mechanism is widened, the utilization rate of the cleaning mechanism is increased, and the cleaning efficiency of the centrifugal machine is improved. The limitation of the cleaning mechanism is reduced.

The present invention includes a method for the treatment of age-related macular degeneration, glaucoma, or diabetic retinopathy in a human that comprises administering to the human a therapeutically effective amount of N-acetylcysteine amide (NACA) or (2R,2R′)-3,3′-disulfanediyl bis(2-acetamidopropanamide) (diNACA) sufficient to treat or reduce the symptoms of the age-related macular degeneration, glaucoma, or diabetic retinopathy.

The invention discloses an acetamido abamectin injection and a preparation method thereof, and belongs to the technical field of veterinary drug preparations. The injection comprises the following components in percentage by weight: 1%-10% of acetamido abamectin, 5%-20% of a sustained-release material, 0.1%-1% of an antioxidant, 5%-15% of a cosolvent and the balance of oil for injection. Wherein the sustained-release material is a polylactic acid-glycolic acid copolymer or polycaprolactone with a specific proportion and molecular weight, the antioxidant is selected from an efficient antioxidant such as tert-butylhydroquinone, the cosolvent is common cosolvent such as propylene glycol, and the oil for injection is soybean oil, sesame oil or corn oil and the like which meet the standard of veterinary drug poeia. The preparation method comprises the steps of oil phase preparation, medicine dissolution, mixing, antioxidant addition, filtration, filling and the like. The injection provided by the invention has the characteristics of long-acting slow release and high stability, can effectively prolong the plasma concentration duration time and reduce the administration frequency, and is simple in preparation process and suitable for large-scale industrial production.

The invention belongs to the technical field of acetaminophen medicine synthesis, and particularly relates to a preparation method of acetaminophen, which is characterized in that acetaminophen and glacial acetic acid are subjected to one-step amidation reaction in a negative-pressure low-temperature reaction system to synthesize acetaminophen. The method solves the problems of high acetaminophen preparation temperature, easy raw material oxidation, low crude product quality, high cost and environmental protection potential safety hazard.

Presented herein are methods for making, isolating, and purifying N-acetylcysteine amide, (2R,2R′)-3,3′-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: alternatively contacting cystine with methanol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine, and an alcohol.

Provided herein are methods and compositions for treating a subject suffering from an enzyme deficiency in the central nervous system (CNS). The bifunctional fusion antibody provided herein comprise an antibody to an endogenous blood brain barrier (BBB) receptor and an enzyme deficient in mucopolysaccharidosis IIIB (MPS-IIIB). The fusion antibodies provided herein comprise alpha-N-acetylgulcosaminidase (NAGLU). The methods of treating an enzyme deficiency in the CNS comprise systemic administration of a fusion antibody provided herein.