14 results about "Ethanolamide" patented technology

The invention discloses a positive ion saliva marker related to brain glioma and meningioma and application of the positive ion saliva marker, and relates to the field of biological medicine. The positive ion saliva marker is prepared from one or more of L-arabitol, 20-hydroxyarachidonic acid, sulfonate and palm oil acylethanolamide. The invention provides a kit which is used for detecting positive ion saliva markers related to brain glioma and meningioma and comprises a specific detection reagent. Besides, the invention further provides a computer program product which can judge whether the patient to be detected is a glioma patient or a meningioma patient, so that a solid foundation is laid for subsequent treatment. The method has good feasibility and accuracy, is safe and noninvasive, can effectively distinguish brain glioma and meningioma, and provides a brand new powerful tool for clinical diagnosis.

The invention discloses application of a metabonomics marker combination in preparation of a product for identifying benign and malignant lung ground glass nodules. The metabonomics marker combination comprises the following 11 metabonomics markers: 5 '-S-methyl-5'-thioadenosine, 5 '-S-methyl-4'-thioadenosine, 5 '-S-methyl-4'-thioadenosine, 5 '-S-methyl-4'-thioadenosine, 5 '-S-methyl-4'- And gamma-glutamylglutamic acid; the component A is N-stearoyl-D-red sphingosine; sphingosine; palmitoyl ethanolamide; 2-(4-(diethylamino) butyl-2-alkyne-1-yl) isoindene-1, 3-diketone is used as a raw material; vesenadine; zolpidem; the preparation method comprises the following steps: adding 4-hydroxyl-3-(2 '-hydroxyl-1, 1'-biphenyl-4-yl)-6-oxo-6, 7-dihydrothieno [2, 3-b] pyridine-5-formonitrile into a reaction kettle, and stirring for 20-30 minutes; and D-erythro-sphingosine; the invention relates to 3-methylpyrrole-2, 4-dicarboxylic acid. According to the invention, 11 specific metabolic markers closely related to benign and malignant lung ground glass nodules are found, the AUC value of a diagnosis model constructed on the basis of the 11 metabolic markers is up to 0.888, and the diagnosis model has extremely high identification accuracy and specificity.

The present invention provides a dispersant, a suspension containing the same, a water-based drilling fluid and a water-based fracturing fluid. The dispersant comprises diethanolamide of linoleic acid, sodium dodecyl sulfate, isomeric tridecanol polyoxyethylene ether, triethylene glycol butyl ether, a tackifier and a solvent.

The invention provides application of a metabolic marker in pulmonary fibrosis diagnosis or prognosis evaluation, and belongs to the technical field of biological medicine. Systematic analysis of metabonomics discovers that lipid metabolism of a patient suffering from pulmonary fibrosis is remarkably changed, downstream products Palmitoyl ethanolamide and 2-amino-1, 3, 4-octadecantool of lipid metabolism can be used as potential biomarkers for diagnosing pulmonary fibrosis, and objective quantitative indexes are provided for diagnosis and prognosis evaluation of pulmonary fibrosis. The invention proves that the Palmitoyl ethanolamide and the 2-amino-1, 3, 4-octadecantool are obviously related to the lung function injury degree and the concentration of the acute-stage blood inflammation marker of the pulmonary fibrosis patient, and the related characteristics prove that the Palmitoyl ethanolamide and the 2-amino-1, 3, 4-octadecantool can be used as the biomarker for evaluating the prognosis of the patient.

The invention discloses an Anandamide composition, which comprises, by weight, 30-75 parts of Anandamide, 5-15 parts of Linolcoylethanolamide, 2-18 parts of Oleoylethanolamide. The Anandamide composition of the invention can achieve a good antidepressant effect.

The invention discloses a crude oil pour point depressant which comprises a main agent, an auxiliary agent and a high-flash-point organic solvent, and the mass ratio of the main agent to the auxiliary agent to the high-flash-point organic solvent is (25-35): (1-3): (62-74); wherein the main agent is formed by polymerizing ethylene-vinyl acetate, polyacrylic acid octadecanamide and alkyl maleimide according to a molar ratio of (2.8 to 3.2): (1.8 to 2.2): (1.8 to 2.2); the auxiliary agent is one or any combination of oleic acid diethanolamide, N-oleoyl sarcosine and hydroxy fatty acid; the high-flash-point organic solvent is one or any combination of trimethylbenzene, tetramethylbenzene, propylene glycol butyl ether and diethylene glycol monobutyl ether. The invention also discloses a preparation method and application thereof. The crude oil pour point depressant provided by the invention can effectively reduce the condensation point of high-condensation-point crude oil of which the condensation point is greater than 40 DEG C and improve the fluidity of the high-condensation-point crude oil of which the condensation point is greater than 40 DEG C, so that normal transportation of the crude oil is ensured, and powerful support is provided for reducing the operation cost of the high-condensation-point crude oil and ensuring normal transportation of the crude oil.

The application relates to a shrinkage-reducing alkali-free liquid accelerator, which comprises the following raw materials in parts by weight: 10-15 parts of a shrinkage-reducing agent, 1-4 parts of a stabilizer, 30-50 parts of an aluminum salt, 3-15 parts of an alcohol amine and 20-30 parts of water; the shrinkage-reducing agent comprises the following raw materials: an organic amine, a polyhydric alcohol acrylate, an initiator, a chain transfer agent and water; the organic amine comprises at least one of linoleyl ethanolamine, linoleamide, ethylene bisoleic acid amide, linoleic acid diethanol amide, triisopropylamine oleate, arachidonylethanolamine and triisopropylamine linoleate; the prepared accelerator can reduce the late shrinkage of sprayed concrete, and meanwhile, the early accelerating effect of the accelerator is not affected.

The application discloses a super-hydrophobic self-cleaning coating material and a preparation method thereof. The super-hydrophobic self-cleaning coating material comprises 1-3 parts of a silicon-based mesoporous material, 4-5 parts of coconut oil diethanolamide, 1-3 parts of nano-titanium dioxide, 3-5 parts of methacrylic acid dodecanol ester, 1-3 parts of a polyethylene glycol type antistatic agent, 1-3 parts of expanded graphite, 1-3 parts of nano-graphene, 30-50 parts of anhydrous ethanol and 20-30 parts of acetone. In the application, the synergistic effect of the components is used, so that the coating has good hydrophobicity, durability, stain resistance, transmittance and antistatic property, the self-cleaning effect of the coating is good, the service time of the coating is greatly improved, and the cost of frequently replacing the coating is reduced.

The application discloses a dispersant for MTO washing water and a use method thereof, and the dispersant is composed of 10-25% of sodium cocoyl monoethanolamide ether carboxylate, 2-12% of lauryl amidopropyl hydroxyl sulfobetaine, 2-13% of polyvinyl alcohol and solvent water according to mass percentage, can effectively prevent the catalyst in the washing tower from being scaled with polymethylbenzene substances, eliminate the generated scale layer, prevent the tray from being blocked, thereby prolonging the operation cycle of the washing tower and improving the economic benefit of the device. Meanwhile, the dispersant has good anti-crystallization performance and cannot cause the crystallization to block the pipeline; the dispersing effect does not change with the change of the catalyst of the MTO device.

The present application belongs to the field of prodrugs, and specifically relates to N-acylethanolamide derivatives, preparation methods, and applications thereof. More specifically, the present invention discloses a novel PEA amino acid derivative prodrug, which can be rapidly converted into PEA after oral administration to beagle dogs. Only PEA is detected in the plasma, and almost no PEA amino acid derivatives, especially PEA-(L)-P and PEA-(L)-P-(L)-V, are detected. The prodrug has unexpected bioavailability and faster conversion rate, and its pharmacokinetic properties are significantly better than those of other PEA amino acid derivatives.

The invention relates to soothing anti-inflammatory microemulsion and a preparation method and application thereof.The soothing anti-inflammatory microemulsion comprises a mixture A and a solution A. The mixture A comprises oryzanol, palmitoyl ethanolamide (PEA) and an oil-carrying substance, and the mass ratio of palmitoyl ethanolamide to the oil-carrying substance in the mixture A is 1: (4-14); the solvent of the solution A is polyhydric alcohol, and the solute of the solution A comprises palmitoyl ethanolamide. The particle size range of the soothing anti-inflammatory micro-emulsion is 50 to 100 nm. The soothing anti-inflammatory microemulsion can be directly compounded in a cosmetic matrix, can improve the skin permeation efficiency and bioavailability of palmitoyl ethanolamide and oryzanol, and has good anti-inflammatory, skin barrier repairing and itching relieving effects.

The application relates to the technical field of surfactant synthesis, and discloses a synthesis process of cocoyl ethanolamine, which adopts a specific catalyst and comprises the following steps: S1, adding coconut oil fatty acid and methyl monoethanolamine into a reactor according to a certain feeding ratio, and then adding sodium hydroxide and a catalyst into the reactor; S2, reacting under specific reaction conditions under the protection of nitrogen to obtain a reaction mixture; S3, adding diethyl ether and deionized water into the reaction mixture, taking the oil phase after static stratification, distilling and recovering the diethyl ether, and preparing a cocoyl ethanolamine crude product; and S4, purifying and treating the cocoyl ethanolamine crude product prepared in the step S3 to prepare a cocoyl ethanolamine pure product. The specific composite catalyst is adopted, the reaction conversion rate is high, the prepared product is high in purity, the catalyst can be recycled and reused, and the synthesis cost is low.

The invention discloses a phosphate-and-ethanol-amide-based hydrophobic-polar synergistic phosphate fertilizer wrapping agent, and relates to the technical field of phosphate fertilizer wrapping agents. The preparation method comprises the following steps: weighing alkyl phosphate monoester and stearic acid monoethanolamide, heating and premixing to obtain a premix; and adding mineral asphalt and mineral oil into the premix, and continuously heating and mixing to obtain the phosphate fertilizer wrapping agent. The phosphate fertilizer wrapping agent is used for wrapping monoammonium phosphate or diammonium phosphate. -POOH of alkyl phosphate monoester and-CONH-in stearic acid monoethanolamide are preheated to generate-PO-N (CO)-bonds, and a double oxygen bond P = O in the alkyl phosphate monoester and-OH in an ethanol group on the stearic acid monoethanolamide form hydrogen bonds at the same time; a three-dimensional hydrophobic-polar network system based on cooperation of alkyl phosphate monoester and stearic acid monoethanolamide is constructed through the connection effect of acting force of two bonds, the three-dimensional hydrophobic-polar network system cooperates with components of mineral asphalt and mineral oil, compactness between the three-dimensional hydrophobic-polar network system and a wrapped object ammonium phosphate is high, and stability and hydrophobicity are improved compared with those of an existing wrapping agent.

To provide a toothpaste composition that can suppress discoloration over time. [Solution] A toothpaste composition comprising (A) component: pyridoxine or a salt thereof, and (B) component: one or more nonionic surfactants selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, alkyl glycoside, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, sugar alcohol fatty acid ester, alkylolamide, fatty acid ethanolamide, sorbitan fatty acid ester, polyoxyethylene polyoxypropylene block copolymer, and polyoxyethylene polyoxypropylene fatty acid ester, wherein the content of component (A) is 0.01% by mass or more and less than 0.2% by mass.