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An extract

A technology of extracts and objects, applied in the direction of food science, drug combination, digestive system, etc., can solve the problems of extracts that do not involve NAE compounds, and do not recognize the effectiveness

Inactive Publication Date: 2010-02-03
SEPEREX NUTRITIONALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0044] None of the aforementioned patents address the production of extracts enriched in NAE compounds, nor do they recognize the effectiveness of these compounds in a variety of treatments

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] PEA content in blue mussels (Mytilus edulis) and green-lipped mussels (Perna canaliculus) commercially harvested from New Zealand waters was determined by a laboratory-scale experiment (Test 1). The second test was to determine the content of PEA and AEA in Perna canaliculus on a simulated industrial scale (test 2).

[0108] method

[0109] The contents of PEA and AEA were determined by LC / MS in crude lipids extracted from the dried meat of freshly harvested blue and green mussels and expressed in μg / g wet meat (see table below 1; Giuffrida et al., 2000).

[0110] through as figure 1 The LC / MS shown confirms the presence of PEA in the lipid extract of Perna canaliculus, and the arrows in the figure indicate the PEA peak.

[0111] result

[0112] Table 1 NAE content in three different mussel species

[0113]

[0114] Note 1: NAE content was determined by back-calculation from lipid extract data.

[0115] Note 2: NAE content is estimated using conversion factors...

Embodiment 2

[0120] A method for enriching endogenous NAE content in fresh Perna canaliculus prior to extraction is described. In this example, commercially collected homogenized / intact mussel meat was incubated in the laboratory under different conditions as described below. Incubate for 0 to 144 hours at 4 or 10° C. under aerobic or anaerobic conditions at atmospheric pressure. Tissue pH monitoring was performed at intervals throughout the test period. At the end of the incubation period, the tissue was frozen and subsequently lyophilized. The experimental conditions were strictly controlled to minimize potential confounding factors, such as differences in batches of mussels, freezing or freeze-drying conditions, etc. Determination of NAE and omega-3 content in freeze-dried mussels.

[0121] Experimental results showed that dried meat prepared from homogenized mussels incubated at 10°C under aerobic conditions for up to 144 hours had lower PEA levels than dried meat obtained from the ...

Embodiment 3

[0125] As mentioned above, we all know that the oil extract of the present invention is rich in NAE compounds, including but not limited to PEA. For example, the extracts of the invention contain PEA, AEA and / or polyunsaturated fatty acids. Content data in lipid extracts are expected to be: 3.0-57.0 micrograms / gram or greater for PEA; 0.1-5.2 micrograms / gram or greater for cannabinoids; and / or at least 3 grams / 100 grams of DHA, and At least 5 g / 100 g of EPA.

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PUM

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Abstract

The invention relates to compositions that include an oil extract rich in fatty acid amide compounds including N-acylethanolamine (NAE) compounds such as N-palmitoylethanolamide (PEA) and N-arachidonoylethanolamide (AEA). The composition may be derived from marine materials including mussel meat.

Description

[0001] Statement of relevant application [0002] This application is based on the provisional specification of New Zealand Patent Application No. 552238 as filed, the entire contents of which are incorporated herein by reference. technical field [0003] The present invention relates to an extract. More specifically, the present invention relates to certain oil extracts derived from marine sources rich in fatty amide compounds, including N-acyl ethanolamide (NAE) compounds such as N-hexadecanoyl ethanolamide (PEA ) and N-anandamide (cannabinoid, AEA). Background technique [0004] N-Petyl ethanolamide (PEA) is an endogenous fatty acid amide that belongs to the well-known N-acyl ethanolamine (NAE) family, which includes "cannabinoid" compounds such as: N-Arachidamide Elethanolamine (cannabinoid, AEA). PEA and AEA have the potential to treat several human / animal diseases involving abnormal inflammatory and / or immune responses and associated pain (see Lambert et al., 2002,...

Claims

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Application Information

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IPC IPC(8): A61K31/164A61K31/202A61P25/28A61P19/02A61P29/00A61P9/14A61P11/06A61P25/02A23L33/00
CPCA61K31/202A61K31/164A61P1/00A61P11/00A61P11/06A61P13/12A61P17/00A61P19/02A61P25/02A61P25/28A61P29/00A61P9/10A61P9/14A61K35/56
Inventor 查尔斯·爱德华·威廉姆斯安德鲁·约翰·桑赛姆
Owner SEPEREX NUTRITIONALS
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