9 results about "Tissue replacement" patented technology

Particulated and reconstituted tissues comprising small, densely packed tissue microparticles encapsulated in a tissue specific promoting gel packed at a percolation threshold that can be transplanted into damaged tissue thereby facilitating regeneration following trauma to the tissue. The engineered microparticle construct for tissue replacement and repair, as taught herein, provides numerous benefits including (1) encouraging a regenerative response in damaged tissue regions, (2) mimicking the structural support of native tissue, (3) establishing an environment that promotes attachment, migration, and differentiation of infiltrating stem cells, and (4) providing a source of growth factors and other anti-catabolic growth factors and cytokines. Tissue specific microparticles packed together at, or past, their percolation threshold will provide the necessary mechanical environment and to best recapitulate and integrate with native tissue. The packing of microparticles, derived from the ECM of native tissue to a concentration past the percolation point will yield both the necessary biochemical and biomechanical properties necessary for reconstituting a specific tissue.

The utility model relates to the technical field of tissue holders, in particular to a novel movable tissue holder convenient for replacing tissues, which comprises a mounting plate and a linkage mechanism, one side of the mounting plate is provided with a rectangular groove, one side of the mounting plate is fixedly connected with a connecting pipe, one end of the connecting pipe is fixedly connected with a tissue holder plate, and the other end of the connecting pipe is fixedly connected with the linkage mechanism. The linkage mechanism comprises a stop lever assembly and a locking assembly, a reset spring is hung in the rectangular groove, and the tissue holder plate is used for being connected with roll paper in an inserted mode. The stop lever assembly comprises a bearing block and a bearing pipe. When the roll paper is placed, the roll paper can be directly connected to the periphery of the tissue holder plate in a sleeved mode, so that replacement or placement is more convenient, after the roll paper is placed, the reset spring enables the locking assembly to be attached to the periphery of the roll paper, if the roll paper is rapidly pulled, the locking assembly and the stop lever assembly can be locked, and the roll paper can be conveniently replaced or placed. Rotation of the roll paper can be prevented under the action of friction force, and then the roll paper is prevented from scattering.

The present invention relates to a novel bioreactor system for preparing an engineered three-dimensional biological tissue construct. The bioreactor system comprises a cultivation chamber that is designed to allow the formation, cultivation and the subsequent testing and / or stimulation of tissue constructs on one or more support elements with a minimum risk of microbial contamination or mechanical damage. The invention furthermore relates to a method for preparing an engineered tissue construct using the novel bioreactor system. The invention also relates to the use of the bioreactor system for preparing engineered biological tissue constructs, preferably tissue constructs which are suitable for being used in clinical tissue replacement and reconstructive therapy, drug development, drug screening, toxicity testing, cosmetic studies, safety testing, developmental studies, disease modeling, or food purposes.

A plug-shaped implant for tissue replacement and regeneration, comprising a base section (2) configured to be fixed to bone tissue, a middle section (3) configured to replace cartilage tissue, and an upper section (4) configured to grow cartilage tissue upward and inward, wherein the middle section and the upper section comprise the same thermoplastic elastomer material which is porous in the upper section and non-porous in the middle section, and the base section comprises a substantially non-porous polyaryletherketone polymer having a porosity of less than 20% based on the total volume of the polyaryletherketone polymer.

Provided are systems, compositions, methods and devices for manufacturing artificial skin substitutes and related products mimicking the morphology and appearance of human skin. Applications of the invention pertain to the fields of regenerative medicine and pharma with products that can support tissue replacement and tissue engineering. The most immediate applications pertain to the field of cosmetics with the development of pigmented compositions that can be incorporated in various skin care and cosmetic foundation products.

The embodiment of the invention discloses a tissue management method and device, equipment, a storage medium and a computer program product. The method comprises the steps that the target distance between the surface of a tissue in a tissue containing box and a sensing unit is obtained; under the condition that the target distance is larger than a first preset threshold value, new tissue replacement is prompted, and the first preset threshold value is a preset distance between the surface of the tissue and the sensing unit when the tissue in the tissue containing box needs to be replaced. By implementing the method, the use condition of the tissues in the tissue accommodating box can be monitored, and the management efficiency can be improved.

Provided herein are scaffold biomaterials comprising a decellularised fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularised fungal tissue comprising a cellulose- or chitin-based 3-dimensional porous structure. Methods for preparing such scaffold biomaterials, as well as uses thereof as an implantable scaffold for supporting animal cell growth, for promoting tissue regeneration, for promoting angiogenesis, for a tissue replacement procedure, and / or as a structural implant for cosmetic surgery are also provided. Therapeutic treatment and / or cosmetic methods employing such scaffolds are additionally described.

Provided herein are scaffold biomaterials comprising a tissue-removed cellular material and a decellularized plant or fungal tissue of nucleic acid, the decellularized plant or fungal tissue comprising a cellulose or chitin-based three-dimensional porous structure. The invention also provides methods of making such scaffold biomaterials, and uses thereof as implantable scaffolds for supporting animal cell growth, promoting tissue regeneration, promoting angiogenesis, tissue replacement procedures, and / or as structural implants for cosmetic procedures. Also described are therapeutic treatment and / or cosmetic methods using such stents.

Tissue replacement implants are disclosed that include polarized retinal pigment epithelial cells on a poly(lactic-co-glycolic acid) (PLGA) scaffold, wherein the PLGA scaffold is 20-30 microns in thickness, has a DL-lactide / glycotide ratio of about 1:1, an average pore size of less than about 1 micron, and a fiber diameter of about 150 to about 650 nm. Also disclosed are methods of treating a subject with a retinal degenerative disease, retinal or retinal pigment epithelium dysfunction, retinal degradation, retinal damage, or loss of retinal pigment epithelium. These methods include locally administering to the eye of the subject the tissue replacement implant. In further embodiments, methods are disclosed for producing the tissue replacement implant.