5 results about "Tissue replacement" patented technology

Particulated and reconstituted tissues comprising small, densely packed tissue microparticles encapsulated in a tissue specific promoting gel packed at a percolation threshold that can be transplanted into damaged tissue thereby facilitating regeneration following trauma to the tissue. The engineered microparticle construct for tissue replacement and repair, as taught herein, provides numerous benefits including (1) encouraging a regenerative response in damaged tissue regions, (2) mimicking the structural support of native tissue, (3) establishing an environment that promotes attachment, migration, and differentiation of infiltrating stem cells, and (4) providing a source of growth factors and other anti-catabolic growth factors and cytokines. Tissue specific microparticles packed together at, or past, their percolation threshold will provide the necessary mechanical environment and to best recapitulate and integrate with native tissue. The packing of microparticles, derived from the ECM of native tissue to a concentration past the percolation point will yield both the necessary biochemical and biomechanical properties necessary for reconstituting a specific tissue.

The present invention relates to a novel bioreactor system for preparing an engineered three-dimensional biological tissue construct. The bioreactor system comprises a cultivation chamber that is designed to allow the formation, cultivation and the subsequent testing and / or stimulation of tissue constructs on one or more support elements with a minimum risk of microbial contamination or mechanical damage. The invention furthermore relates to a method for preparing an engineered tissue construct using the novel bioreactor system. The invention also relates to the use of the bioreactor system for preparing engineered biological tissue constructs, preferably tissue constructs which are suitable for being used in clinical tissue replacement and reconstructive therapy, drug development, drug screening, toxicity testing, cosmetic studies, safety testing, developmental studies, disease modeling, or food purposes.

A plug-shaped implant for tissue replacement and regeneration, comprising a base section (2) configured to be fixed to bone tissue, a middle section (3) configured to replace cartilage tissue, and an upper section (4) configured to grow cartilage tissue upward and inward, wherein the middle section and the upper section comprise the same thermoplastic elastomer material which is porous in the upper section and non-porous in the middle section, and the base section comprises a substantially non-porous polyaryletherketone polymer having a porosity of less than 20% based on the total volume of the polyaryletherketone polymer.

Provided are systems, compositions, methods and devices for manufacturing artificial skin substitutes and related products mimicking the morphology and appearance of human skin. Applications of the invention pertain to the fields of regenerative medicine and pharma with products that can support tissue replacement and tissue engineering. The most immediate applications pertain to the field of cosmetics with the development of pigmented compositions that can be incorporated in various skin care and cosmetic foundation products.

The embodiment of the invention discloses a tissue management method and device, equipment, a storage medium and a computer program product. The method comprises the steps that the target distance between the surface of a tissue in a tissue containing box and a sensing unit is obtained; under the condition that the target distance is larger than a first preset threshold value, new tissue replacement is prompted, and the first preset threshold value is a preset distance between the surface of the tissue and the sensing unit when the tissue in the tissue containing box needs to be replaced. By implementing the method, the use condition of the tissues in the tissue accommodating box can be monitored, and the management efficiency can be improved.