47results about How to "Suitable for implantation" patented technology

The present invention is directed generally to a layered polymeric monofilament fiber drug delivery device, where each layer of the device can contain a different polymer, drug, additive, or any combination or mixture thereof. The layered nature of the current monofilament polymeric monofilament device provides the capability to modulate the release of one or more drugs and / or the mechanical properties of the fiber so that drug release and device failure can be separately tuned to provide for the tailored introduction of therapeutically effective drugs or agents to a target tissue. Moreover, the fiber may comprise more than one distinct segments along its length, each segment itself having different combinations and / or numbers of layers thereby providing even greater freedom in the design of the therapeutic delivery device. The invention is also directed to a method of manufacturing such a layered polymeric monofilament fiber drug delivery device, and methods of treatment using such devices.

The present invention is related to an interstitial marker for localizing an organ, tumor or tumor bed within a mammalian body wherein said marker has a proximal end, a distal end, and a continuous intervening length, at least a portion of the intervening length of said marker being visible under at least one imaging modality and having a flexibility such that said marker follows movements and changes of shape of said organ, tumor or tumor bed.

Bifunctional and assembled implants are provided for osteochondral implantation.

The present invention is directed to the field of implants that include soft tissue. More particularly, the present invention is directed to processes for treating implants that include soft tissues such as tendons and ligaments, and to implants produced by such processes. The present invention is also directed to processes and apparatus for improved processing of implants that include soft tissue, by applying kinematic restraint, preferably tension, to the implant or specific portions of the implants during the treatment, and to implants produced by such processes and apparatus. The present techniques yield soft tissue implants having superior structural, mechanical, and / or biochemical integrity.

Disclosed are engineered, living, three-dimensional connective tissue constructs comprising connective tissue cells. In some embodiments, the connective tissue cells are derived from multi-potent cells such as mesenchymal stem / stromal cells. In some embodiments, the cells are cohered to one another. In some embodiments, the multi-potent cells have been exposed to one or more differentiation signals to provide a living, three-dimensional connective tissue construct. In some embodiments, the constructs are substantially free of pre-formed scaffold at the time of use. Also disclosed are implants for engraftment, arrays of connective tissue constructs for in vitro experimentation, as well as methods of making the same.

The invention provides microfabricated devices and methods for directing the growth of a cell process to form an artificial synapse. The devices are called artificial synapse chips. The artificial synapse comprises a nanofabricated aperture (about 50–100 nm in size) that connects the cell process to a chemical or electrical means of neuronal excitation. Such an aperture width mimics the length scales of a natural synapse and thus emphasizes the localized spatial relationship between a neuron and a stimulation source. The invention further provides devices and methods for regenerating a nerve fiber into an electrode. The invention thus provides a regeneration electrode that uses a novel neural interface for stimulation and that uses novel surface methods for directing neuronal growth making possible in vivo connection of the devices to neural circuitry in a retina and other anatomical locations.

The present invention is related to an interstitial marker for localizing an organ, tumor or tumor bed within a mammalian body wherein said marker has a proximal end, a distal end, and a continuous intervening length, at least a portion of the intervening length of said marker being visible under at least one imaging modality and having a flexibility such that said marker follows movements and changes of shape of said organ, tumor or tumor bed.

Stretchable multi-chip modules (SMCMs) are capable of withstanding large mechanical deformations and conforming to curved surfaces. These SMCMs may find their utilities in elastic consumer electronics such as elastic displays, skin-like electronic sensors, etc. In particular, stretchable neural implants provide improved performances as to cause less mechanical stress and thus fewer traumas to surrounding soft tissues. Such SMCMs usually comprise of various electronic components attached to or embedded in a polydimethylsiloxane (PDMS) substrate and wired through stretchable interconnects. However, reliably and compactly connecting the electronic components to PDMS-based stretchable interconnects is very challenging. This invention describes an integrated method for high-density interconnection of electronic components through stretchable interconnects in an SMCM. This invention has applications in high-density SMCMs, as well as high-density stretchable / conformable neural interfaces.

Cyclic peptides comprising a cadherin cell adhesion recognition sequence HAV, and compositions comprising such cyclic peptides, are provided. Methods for using such peptides for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.

There is provided a process for preparing a HA cryogel, the process comprising the steps of combining HA, a cross-linking agent and a solvent to form a solution, freezing the solution before the formation of less than 10% of the cross-linking bonds of the cross-linked HA cryogel formed and thawing the solution. An HA cryogel is also provided, in particular an HA cryogel obtained from this process.

Bifunctional and assembled implants are provided for osteochondral implantation.

Aspects according to the present invention provide a method and implant suitable for implantation inside a human body that includes a power consuming means responsive to a physiological requirement of the human body, a power source and a power storage device. The power source comprises a sheathed piezoelectric assembly that is configured to generate an electrical current when flexed by the tissue of the body and communicate the generated current to the power storage device, which is electrically coupled to the power source and to the power consuming means.

A soft breast prosthesis is provided, the prosthesis having a surface configuration advantageous for dual plane placement of the prosthesis in a breast.

Stretchable multi-chip modules (SMCMs) are capable of withstanding large mechanical deformations and conforming to curved surfaces. These SMCMs may find their utilities in elastic consumer electronics such as elastic displays, skin-like electronic sensors, etc. In particular, stretchable neural implants provide improved performances as to cause less mechanical stress and thus fewer traumas to surrounding soft tissues. Such SMCMs usually comprise of various electronic components attached to or embedded in a polydimethylsiloxane (PDMS) substrate and wired through stretchable interconnects. However, reliably and compactly connecting the electronic components to PDMS-based stretchable interconnects is very challenging. This invention describes an integrated method for high-density interconnection of electronic components through stretchable interconnects in an SMCM. This invention has applications in high-density SMCMs, as well as high-density stretchable / conformable neural interfaces.

A plasma based ion implantation apparatus. The apparatus includes a first chamber in which plasma is generated, a coil antenna to generate the plasma in the first chamber, a second chamber in which ions of the plasma are implanted into a target, the second chamber having an incoming port through which the plasma is diffused from the first chamber to the second chamber, a power source to supply high voltage power to the target in the second chamber, and a grounded conductor positioned to face the target seated on the seating table. The first chamber is formed with a ring shape opening of a predetermined width at an upper periphery of the second chamber to communicate with the second chamber.

The invention provides articles of 3D printed biomaterials with retained physical properties and biological activity and methods of using the articles. Furthermore, the invention provides manufacturing conditions to generate 3D printed biomaterials with highly preserved biological activity.

The invention discloses an anterior cervical interbody fusion cage which comprises a main body and a development needle arranged on the main body, wherein the main body is a hollow tetrahedron; the cross section of the hollow periphery of the tetrahedron is ladder-shaped; the cross section of the hollow inner circumference of the tetrahedron is square or rectangular; the main body comprises a front wall, a rear wall, a left side wall and a right side wall; and the front wall is connected with the rear wall through the left side wall and the right side wall. The shape of the main body confirms to the anatomic form of the cervical intervertebral disc of a normal human body; while the safe implantation is ensured, the main body can be in tight contact with end plates of an upper cervical vertebral body and a lower cervical vertebral body under the compression state to create a good condition for bone fusion; and the cross section of the hollow inner circumference of the main body is square or rectangular, so that the contact surface of the main body and the end plates of the cervical vertebral bodies is increased to the greatest extent, the bone implementation amount is increased, and the fusion is speeded up.

The present invention relates to an implantable sensor configured to be implanted within the body of the subject and being configured to measure impedance within a body tissue of the subject resulting from an electrical current flowing through the body tissue, wherein the body tissue is sub-dermal or subcutaneous tissue of the subject. One pair of injection electrodes is configured for injection of electrical current into the body tissue and one pair of sensing electrodes is configured to detect the resulting voltage. A detector is operatively connected to the sensing electrodes and is configured to receive the voltage detected by the sensing electrodes, wherein the detector is configured to measure the impedance of the body tissue based on the voltage detected by the pair of sensing electrodes. A microcontroller is operatively connected to the detector and is configured to receive impedance signals from the detector and to provide control signals to the current signal output circuit and a powering and communication circuit including a coil configured to be powered by an electromagnetic field produced by an external coil.

A soft prosthetic implant, such as a silicone breast implant, is provided. The implant has a variety of different surfaces, for example, different textures, located on different areas of the outer surface of the implant.

The present invention relates to a health monitoring system comprising an implantable sensor configured to measure impedance within a body tissue of the subject resulting from an electrical current flowing through said body tissue, wherein the body tissue is sub-dermal or subcutaneous tissue of said subject, the sensor including a powering and communication circuit having a coil configured to be powered by an electromagnetic field and to communicate with external devices. Further, the system comprises a reader module including a coil configured to produce the electromagnetic field for powering the powering and communication circuit and for communicating with the powering and communication circuit, a computing device comprising a display device, a processing device and at least one storage device, the computing device being configured to communicate with other devices via at least one wireless network and a monitoring engine for determining or monitoring at least one physiological parameter based on measured impedance, wherein the reader module and the computing device and the monitoring engine are configured to communicate with each other.

A modular catheter system. The modular catheter system may include a first tubular member, a first catheter tubing, a second tubular member, a second catheter tubing and a plurality of concentric seals. The first catheter tubing may be disposed within an interior portion of the first tubular member while the second catheter tubing may be disposed within an interior portion of the second tubular member. The first tubular member and the second tubular member are removably attachable to each other. The plurality of concentric seals may encircling the first catheter tubing and the second catheter tubing, and the first catheter tubing and the second catheter tubing form a continuous path when the first tubular member and the second tubular member are removably attached to each other. The catheter system may also be formed as a dual lumen catheter.

Stent designs for use in vessels, such as the carotid and coronary arteries, are disclosed. The stents consist of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by one or more interconnecting members placed so that the stent is flexible in a longitudinal direction. The cylindrical elements form a generally serpentine wave pattern transverse to the longitudinal axis between alternating valley portions and peak portions. The interconnecting members are attached to the double-curved portions to connect a cylindrical element to an adjacent cylindrical element and interconnecting members are attached to the inverted double-curved portions to connect the cylindrical element to the other adjacent cylindrical element. The stent designs include both a six crown and an eight crown stent which exhibit flexibility and sufficient radial strength to support the vessel.

A vascular occluder includes first and second baffle members which are formed of an expansion device such as a stent across which extends an impermeable membrane. The baffle members are held at a given separation by spacer elements. The separation creates a chamber between the baffle members in which the blood is able to stagnate, thereby creating a second occlusion barrier. One of the baffle members may have an aperture within its membrane for receiving a delivery catheter for delivery of thrombogenic agent into the chamber. The occluder has a given length, thereby making it suitable for implantation in difficult vessel sections and is also able to avoid problems of recanalization of the vessel which can occur with prior art occluders.

Cyclic peptides comprising a cadherin cell adhesion recognition sequence HAV, and compositions comprising such cyclic peptides, are provided. Methods for using such peptides for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.

A device for treating regurgitation of a tricuspid valve (4). The device comprises a tricuspid valve plug (21) capable of compressing and expanding and a tricuspid valve plug fixing device used for anchoring the tricuspid valve plug (21) to an orifice of the tricuspid valve (4). The tricuspid valve plug (21) is provided with an inflow end (42, 52) and an opposite outflow end (47, 57), and a prosthetic valve (50, 70) capable of being opened and closed is disposed in the tricuspid valve plug (21). When the tricuspid valve (4) is closed, the prosthetic valve (50, 70) is automatically closed, and when the tricuspid valve (4) is opened, the prosthetic valve (50, 70) is automatically opened. The device for treating regurgitation of a tricuspid valve (4) and the implantation method therefor help to treat regurgitation of a tricuspid valve and do not block the flow of blood in a heart, and the device can be recycled, has the characteristics of high operationality and high safety in minimally-invasive repair, and has high clinical value.

The invention provides an interventional therapy device realizing steering and positioning fenestration through a laser catheter. The interventional therapy device is characterized by comprising the laser catheter and a balloon catheter which are parallelly arranged from the head end to the tail end, the balloon catheter is provided with a balloon, the head end of the laser catheter exceeds that of the balloon catheter, one end of the balloon catheter is fixed to the catheter wall of one end of the laser catheter, the fixing position is positioned in front of the balloon of the balloon catheter, and at least four laser optical fibers are embedded in the catheter wall of the head end of the laser catheter and straightly extend to the tail end of the laser catheter. The invention further provides an interventional therapy device realizing steering and positioning fenestration through the laser catheter. Steering and positioning functions are realized through the laser catheter, and a fenestration function is realized; the laser catheter and the balloon catheter are combined for accurate positioning fenestration of artificial blood vessels of covered stents.

The application relates to a bone screw assembly for fixation into a bone, comprising a first screw element with a body including a threaded first end with a first external screw thread having a first handedness and a first lead length. The first screw element comprises an internal thread feature with a second handedness and a second lead length located within a bore within said body. The screw assembly includes a second screw element comprising a second external screw thread with the second handedness and the second lead length. Said second screw element is arranged within said bore and said second external screw thread is engaged with said internal thread feature. The second screw element is movable from a first implantation configuration where the second screw element is arranged completely within said bore and a second implantation configuration where the second screw element protrudes from said bore.

The invention provides a reversible laser balloon catheter which comprises a laser catheter and a balloon catheter. The balloon catheter is divided into two portions; a first portion of the balloon catheter is provided with a balloon, and the tail end of the laser catheter and the tail end of the first portion of the balloon catheter are connected with the head end of the second portion of the balloon catheter; the head end of the laser catheter goes beyond the head end of the first portion of the balloon catheter, and the first portion of the balloon catheter is fixed to the wall of the laser catheter; at least four laser fibers are embedded in the wall of the head end of the laser catheter and extend all along to the tail end of the second portion of the balloon catheter. The invention further provides a method for applying the reversible laser balloon catheter. The reversible laser balloon catheter and the method have the advantages that the laser catheter has reversing and positioning functions, and the reversible laser balloon catheter further has a fenestration function; the laser catheter and the balloon catheter are used jointly for carrying out accurate positioning and fenestration on artificial blood vessels of covered stents.