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126 results about "Subcutaneous implant" patented technology

Hydrogel nanoparticles used as injectable subcutaneous implant agent

The invention relates to hydrogel nanoparticles used as an injectable subcutaneous implant agent, which can effectively solves the problem of fulfilling an aim of realizing tumor treatment by locally injecting the hydrogel nanoparticles beside a subcutaneous tumor, changing the hydrogel nanoparticles into a gel and slowly releasing nanoparticles in vivo. The hydrogel nanoparticles are prepared from hydrogel solution and 2-methoxyl estradiol liposome nanoparticle powder or solid liposome nanoparticle powder by a method which comprises the following steps of: adding the 2-methoxyl estradiol liposome nanoparticle powder or the solid liposome nanoparticle powder into the hydrogel solution; and uniformly mixing to form the hydrogel nanoparticles which can be used as an injectable subcutaneous implant agent, wherein 100mg of the 2-methoxyl estradiol liposome nanoparticle powder is added into every 1ml of the hydrogel solution. The injectable hydrogel implant agent of the invention can be used for treating subcutaneous tumors such as breast cancer and the like, keep an effective medicament concentration in a local target site, can realize sustained release and controlled release, can avoid medicament resistance caused by long-term medication, simultaneously improve a curative effect and reduce dosage, reduce toxic and side effects on a whole body, and also can prevent lymphatic metastasis of the tumors such as the breast cancer and the like.
Owner:ZHENGZHOU UNIV

Subcutaneous medicine controllable release biological needle and preparation method thereof

InactiveCN108464967AEfficient and fast targeted releaseTargeted Release ControllableOrganic active ingredientsPharmaceutical non-active ingredientsMicrosphereDrug carrier
The invention relates to a subcutaneous medicine controllable release biological needle and a preparation method thereof. By adopting the biological needle, a medicine can be controlled to being released subcutaneously with slight pain, and in addition, the medicine can be administrated by a patient self. The biological needle comprises a needle shell part and a needle core part, wherein the needle shell part is made of a soluble polymer material; the needle core part is composed of accumulated medicine carrier microspheres. The biological needle is sufficient in mechanical property to puncture into skin and is rapidly dissolved to release medicine carrier microspheres carried by the biological needle, and the medicine carrier microspheres carried by the biological needle can be degraded subcutaneously to release the medicine. By adopting the subcutaneous medicine controllable release biological needle provided by the invention, a liver first-pass effect caused by an orally taken slowrelease tablet can be avoided, in addition, the defect that a subcutaneous implanting agent needs to be operated by a medical operator manually can be avoided, and both medicinal effects and economy can be greatly improved.
Owner:BEIJING UNIV OF CHEM TECH
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