38 results about "Fibrocartilage" patented technology

Disclosed is an endoprosthetic implant for a human spinal disc. The structure of the implant allows it to be inserted posteriorly. This insertion is accomplished by performing a partial discectomy in the affected region. An intervertebral space is then created by removing the fibrocartilage between the facing surfaces of adjacent vertebrae. The implant is then inserted into the intervertebral space. The implant is thus adapted to replace damaged or worn intervertebral discs. Furthermore, the structure of the implant, and its posterior insertion, alleviate most spinal pathologies.

Disclosed is an endoprosthetic implant for a human spinal disc. The structure of the implant allows it to be inserted posteriorly. This insertion is accomplished by performing a partial discectomy in the affected region. An intervertebral space is then created by removing the fibrocartilage between the facing surfaces of adjacent vertebrae. The implant is then inserted into the intervertebral space. The implant is thus adapted to replace damaged or worn intervertebral discs. Furthermore, the structure of the implant, and its posterior insertion, alleviate most spinal pathologies.

The present invention is a system for a partially biological disc replacement that stimulates natural fibrous, cartilaginous or other tissue growth in the DDD cavity, resulting in a partial biological disc replacement. Multiplicities of fibronous pieces of fibro-cartilaginous tissue promoting material are inserted into the DDD cavity inducing tissue growth. The fibro-cartilaginous tissue

A method for treating a non-weight bearing arthritic joint involves resecting at least one of the opposed joint surfaces to expose a cancellous bone surface. A bioresorbable implant is mounted to one of the joint surfaces so that the resected joint surface rubs against the surface of the implant. This causes the fibroblast to change into fibrocartilage at the resected bone surface as the implant is resorbed thereby effectively replacing the implant with fibrocartilage during such resorption.

This application describes apparatuses and methods for musculoskeletal tissue engineering. Specifically, graft collar and scaffold apparatuses are provided for promoting fixation of musculoskeletal soft tissue to bone.This application provides for graft collars comprising biopolymer mesh and / or polymer-fiber mesh for fixing tendon to bone. In one aspect, the graft collar comprises more than one region, wherein the regions can comprise different materials configured to promote integration of and the regeneration of the interfacial region between tendon and bone.This application also provides for scaffold apparatuses and methods for fixing musculoskeletal soft tissue to bone. The scaffold apparatus is multiphasic, preferably triphasic, and each phase is configured promote growth and proliferation of a different cell and its associated tissue. In one aspect, the scaffold apparatus is triphasic, with phases comprising materials to promote growth and proliferation of fibroblasts, chondroblasts, and osteoblasts. In addition, an apparatus comprising two portions, each of said portion being the scaffold apparatus described above is provided, wherein each of said portion encases one end of a soft tissue graft. Further, a triphasic interference screw is provided.This application further provides apparatuses and methods for inducing formation of fibrocartilage comprising wrapping a graft collar with polymer-fiber mesh configured to apply compression to the graft collar. In another aspect, the polymer-fiber is applied directly to the graft to apply compression to the graft.

The present application discloses methods for repairing hyaline cartilage defects. The methods comprise a combination of introducing autologous bone mesenchymal stem cells to a joint, and applying to the joint a membrane comprising a polyester entangled with a polysaccharide. In some aspects, the bone mesenchymal stem cells are mesenchymal stem cells originating in bone underlying the joint. In these aspects, contact between the joint and the mesenchymal stem cells can be effected by introducing apertures through the bone using standard surgical techniques such as microfracture, abrasion, or drilling. Cartilage which forms in response to application of these methods is hyaline cartilage rather than fibrocartilage.

Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.

A microfracture awl includes an articulating portion that enables the microfracture awl to strike a subchondral bone plate at a precise desired angle to prevent scuffing or undue scraping of the targeted subchondral bone plate. The articulating portion of the microfracture awl is received through a guide sleeve. A proximal end of the articulating portion is rigid and connects to a base. The articulating portion is placed through a guide sleeve and the base resides in a handle attached to the sleeve. The guide sleeve has a curved distal end. The practitioner strikes the rigid base of the microfracture awl and thereby transmits a force to the articulating portion of the awl however, the force is not transmitted to the guide sleeve or handle. Accordingly, the articulating portion of the awl may smoothly travel through the guide sleeve at the angle defined by the curved distal end of the guide sleeve, thereby angularly positioning the tip of the awl with the targeted bone plate. The articulating portion includes a plurality of articulating members configured in a series of ball and socket configurations. A method includes selection of a guide sleeve with the desired curvature and impacting the awl a number of times at the targeted area to produce a desired effect with respect to the release of bone marrow cells to induce growth of fibrocartilage tissue.

Herein described is a biocompatible material comprising a polymer matrix based on hyaluronic acid derivatives and poly-εCaprolactone, the process for preparing this material, a prosthetic device constituted by this biocompatible material and a reinforcing material, the process for preparing the prosthetic device, and its use for the partial or total replacement of meniscus, and regeneration of the meniscal fibrocartilage.

Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci, intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.

The present invention includes tailored fiber-reinforced hydrogel composites for implantation into a subject. The present invention also includes systems and methods for controlling the relative percent volume of the hydrogel and fibers, cross-linking, fiber orientation, weave and density, such that the material properties of the composite can be controlled and / or customized to match particular tissue types. The composites of the present invention are suitable for repairing or replacing musculoskeletal tissues and / or fibrocartilage, such as the meniscus, ligaments and tendons.

The present application discloses methods for repairing hyaline cartilage defects. The methods comprise a combination of introducing autologous bone mesenchymal stem cells to a joint, and applying to the joint a membrane comprising a polyester entangled with a polysaccharide. In some aspects, the bone mesenchymal stem cells are mesenchymal stem cells originating in bone underlying the joint. In these aspects, contact between the joint and the mesenchymal stem cells can be effected by introducing apertures through the bone using standard surgical techniques such as microfracture, abrasion, or drilling. Cartilage which forms in response to application of these methods is hyaline cartilage rather than fibrocartilage.

The present invention provides a method of using locally administered collagenase as a non-invasive means of enhancing cell release from the cartilage or fibrocartilage tissues adjacent to a disease or injury site. The subsequent migration of cells from these tissues into the lesion or wound, followed by deposition of the appropriate extracellular matrix, results in closure of the lesion or fusion of a tissue gap.

Shaped constructs for repair of a defect in a body part or tissue of a subject are discussed herein. More specifically, implants suitable for delivery to a subject, such as a subject having a defect in a body part or body tissue, are discussed. Even more specifically, implants for intervertebral disc repair comprising corticocancellous bone, which can extend into the nucleus pulposus of an intervertebral disc and can be integrally attached to the annulus fibrosus of the disc to keep the implant in position, are described. Also, implants for meniscal repair comprising corticocancellous bone, which can extend from the outer edge of the meniscus to the inner region of the meniscus and can be integrally attached to the meniscal rim to keep the implant in position, are described. Implants for the repair of defects in bone, cartilage, and fibrocartilage are further described. Further described are methods for making such implants and for delivering the implants to a defect in a body part or body tissue of a subject.

Herein described is a biocompatible material comprising a polymer matrix based on hyaluronic acid derivatives and poly-εCaprolactone, the process for preparing this material, a prosthetic device constituted by this biocompatible material and a reinforcing material, the process for preparing the prosthetic device, and its use for the partial or total replacement of meniscus, and regeneration of the meniscal fibrocartilage.

The invention relates to a composite tendon repair material. The composite tendon repair material is characterized by comprising a base layer and one or more active units, wherein the base layer and the active units are fixedly arranged with each other; the base layer comprises an extracellular matrix material; each active unit in the active units comprises a first active layer, a second active layer and a covering layer; the first active layer comprises an extracellular matrix material and a first active component; the second active layer comprises an extracellular matrix material and a second active component; and each active unit is prepared by a mechanical compression method. The repair material promotes bone tissue wound surface growth repair and tendon tissue wound surface growth repair at the tendon and bone tearing positions respectively, finally, promotes healing of dead points at the junction of tendons and the bone, and effectively forms a dead-point-like structure from thebone, calcified cartilage and fibrous cartilage to the tendons. By means of the structure, repair of huge rotator cuff tendon tearing can be achieved.

The present invention provides a method of using locally administered collagenase as a non-invasive means of enhancing cell release from the cartilage or fibrocartilage tissues adjacent to a disease or injury site. The subsequent migration of cells from these tissues into the lesion or wound, followed by deposition of the appropriate extracellular matrix, results in closure of the lesion or fusion of a tissue gap.

A tissue engineered meniscus repair sheet and a preparation method thereof. The tissue engineered meniscus repair sheet prepared by the present invention includes a decellularized meniscus sheet, seed cells and growth factor slow-release carriers, wherein the two surfaces of the decellularized meniscus sheet are uniform Micro blind holes are distributed, and seed cells and slow-release growth factor carriers are compounded on both surfaces of the decellularized meniscus sheet. The micro-blind pores distributed on the decellularized meniscus sheet increase the area of ​​the scaffold material, which can be used as a storage pool for seed cells and slow-release carriers of growth factors, making them firmly attached and not easy to fall off; The carrier can release nutrients for a long time, improve the efficiency of cell expansion, maintain cell phenotype, inhibit cell aging, and promote the fusion of tissue engineering meniscus repair sheet and its own tissue. The prepared tissue engineered meniscus repair sheet has structural characteristics similar to natural meniscus, and can be used for repairing meniscus injury and inducing meniscus fibrocartilage tissue regeneration.

The present invention provides a method of using locally administered collagenase as a non-invasive means of enhancing cell release from the cartilage or fibrocartilage tissues adjacent to a disease or injury site. The subsequent migration of cells from these tissues into the lesion or wound, followed by deposition of the appropriate extracellular matrix, results in closure of the lesion or fusion of a tissue gap.

Systems (500, 1000) and methods (1700) for fabricating a soft tissue implant (100, 400). The methods generally involve: receiving implant data representative of the target implant; determining a planned weaving path for forming the soft tissue implant; and communicating the planned weaving path to an output device.

In certain embodiments, the present invention provides a method for preventing or treating post-traumatic osteoarthritis (PTOA) in the temporomandibular joint (TMJ) in a subject in need thereof, comprising administrating a pharmaceutical composition comprising an effective amount of mesenchymal stem cell-derived exosomes or mesenchymal stem cell-derived exosomal microRNA to the subject. In certain embodiments, the present invention provides a method for preventing progressive fibrocartilage degeneration in a subject in need thereof, comprising administrating a pharmaceutical composition comprising an effective amount of mesenchymal stem cell-derived exosomes or mesenchymal stem cell-derived exosomal microRNA to the subject.

The present invention relates to a composition and a kit for regeneration and treatment of cartilage, preferably, fibrous cartilage or elastic cartilage and a regeneration method using the same. A composition and a kit for cartilage regeneration according to the present invention can be administered simply in a minimally invasive manner to a site in which fibrous cartilage or elastic cartilage isneeded to be regenerated or restored from injury, exhibit resistance to degradation enzymes without toxicity within the body, and are attached to or detained at and thus retained at the injured, administered site, whereby behavioral improvement can be brought about in surrounding cells, which leads to effectively inducing defected tissues of the meniscus to be regenerated. Therefore, the composition of the present invention is useful as a mediator for aiding the regeneration of biological tissue defected regions in the biomaterials field.

The invention provides fibrocartilage glycosaminoglycan and an extraction method thereof. The extraction method comprises the following steps that fresh animal fibrocartilage is taken, surrounding adipose muscle tissue is removed, cleaning is conducted, 4-6 freezing and thawing cycles are conducted in the temperature interval of-20 DEG C to 37 DEG C, and then the fibrocartilage is cut into tissueblocks with the size being 3-5 mm; the tissue blocks are soaked in ultrapure water, stirring is performed for 36-60 hours at the temperature of 3-5 DEG C, centrifuging is performed, the supernatant iscollected, and then freeze-drying is performed to obtain the cellochondral glycosaminoglycan. The invention also discloses the fibrocartilage glycosaminoglycan prepared by the extraction method. According to the method, the glycosaminoglycan is extracted from the fibrous cartilage through a simple and feasible method, the cost is low, no chemical reagent is adopted, and the problems that in the prior art, chemical reagents need to be added, and the manufacturing cost is high are effectively solved.

Provided herein are compositions and methods for healing cartilage tissue defects or injury by forming fibrochondrocyte cells or fibrochondrocyte-like cells from recruited progenitor cells, such as mesenchymal stem cells.

A fibrocartilage suturing device is provided to solve the problem where the conventional procedure of the surgery is inconvenient. The fibrocartilage suturing device includes a tube assembly, a tubular member, and an anchor. The tube assembly extends through the tube assembly and includes an insertion section. The movement member is coupled with the tube assembly and includes a thrust rod extending through the tubular member. The anchor is located at one end of the thrust rod and includes a body and at least two wings connected to the body is able to be folded and unfolded relative to the body. The body of the anchor is connected to an end of a thread. Another end of the thread is connected to the tubular member.

The present invention concerns a modular arthrodesis device, used to enable fusing of two contiguous vertebrae by development of bony tissues with replacement of fibrocartilaginous discs ensuring the bonding between the vertebrae of the vertebral column or the end of the latter, and including interchangeable types of fixation means. Intervertebral arthrodesis device designed to be inserted in an intervertebral space (E) separating the opposite plates (V0) of two adjacent vertebrae (V), characterised in that it comprises at least one structure called intervertebral cage (1) presenting the shape of a ring that mayor may not be open, in which at least one part, along the axis of the spine, has a lower height that the rest of this same cage and forms a small bar (12) crossed by at least one drilling (121, 122) of the axis approximately perpendicular to the plate (V0) of at least one of the adjacent vertebrae (V).

The invention provides methods for treating tendinopathy. The disorders treated or prevented include, for example tendinitis, tendonitis, tendinosis, paratendinitis, tenocynovitis, tendon overuse injury and trauma, peritendinitis, paratenonitis, or other tendon degenerative disorders. The disclosed therapeutic methods include administering to a patient an inhibitor of molecules involved in cartilage or fibrocartilage formation in tendinopathic tendon in an amount effective to treat or prevent a tendon degenerative disorder, slow tendon deterioration, restore tendon healthy structure, stimulate tendon regeneration, and / or maintain tendon mass and / or quality.

The present invention relates to a composition and a kit for regeneration and treatment of cartilage, preferably, fibrous cartilage or elastic cartilage and a regeneration method using the same. A composition and a kit for cartilage regeneration according to the present invention may be administered simply in a minimally invasive manner to a site in which fibrous cartilage or elastic cartilage is needed to be regenerated or restored from injury, exhibit resistance to degradation enzymes without toxicity within the body, and are attached to or detained at and thus retained at the injured, administered site, whereby behavioral improvement may be brought about in surrounding cells, which leads to effectively inducing defected tissues of the meniscus to be regenerated. Therefore, the composition of the present invention is useful as a mediator for aiding the regeneration of biological tissue defected regions in the biomaterials field.

The invention discloses a medical micro-fracture tool kit, the medical micro-fracture tool kit comprises a guide, a flexible soft drill and a medicine pushing and injecting rod which are connected with the guider in a matched mode. The guider comprises a toothed head end, an outer sleeve and a handle part, the interiors of the outer sleeve and the handle part are of cavity structures, one end of the outer sleeve is connected with the toothed head end into a whole, the other end of the outer sleeve is sleeved with the handle to be connected, and an included angle of 0-180 degrees is formed between the toothed head end and the outer sleeve. The flexible soft drill comprises a drill bit, a spring, a soft drill rod part and a soft drill handle part which are connected in sequence, a tough inner core is arranged in the soft drill rod part, and the drill bit can be bent to be matched with the guiders at different angles by combining with the spring. Clinically, a 30-degree guider, a 60-degree guider and a 90-degree guider are commonly used. The flexible soft drill can be matched with the guiders at different angles, multi-angle and accurate drilling can be achieved, fibrocartilage osteogenesis is improved, and the curative effect is greatly improved.