474results about How to "Increased mortality" patented technology

A user borne portable personal digital assistant, a brain activity sensing system, a surround sensing system, and correlation system are provided for video logging and memory enhancement. Signatures simultaneously input from the brain system and surround system representing the environment around the user at a given time and place are correlated into a historical relational database. Real-time query means for identifying correlations between the historical database and current internal and external signatures as the user moves through space and time are provided. Body integrated sensor, processing, and display devices are provided to accomplish statistically valid neural representations within the brain correlated to externally originated geo-spatial information and sensory representations surrounding the user. Methods and systems are disclosed for using the resultant data from the data logging system as input into a simulation, stimulation, search engine, social network, telecommunication, or emulation system within a biological, mechanical, and bio-mechanical system.

Medical diagnostic apparatus and methods are disclosed. Ultrasound radiation pressure selectively modulates a target area within a body. One or more pulses of radiation containing temporally correlated groups of photons are generated. The photons are characterized by two or more different wavelengths that are selected to have specific interaction with a target chromophore. The two or more different wavelengths are also selected to have substantially similar scattering cross-sections and anisotropy parameters in the target and its surroundings. The pulses of radiation are injected into the body proximate the target area being modulated by the radiation pressure field. Photon groups at each of the different wavelengths that are backscattered from the target area are detected in temporal coincidence. Time-gated background-free amplification of the return signal is used to exclude photons which could not by virtue of their arrival time have interacted with the radiation-pressure-modulated target. Photon groups are selected with a modulation component at the modulation frequency of the radiation pressure modulation field, or at a harmonic of the modulation frequency. From the arrival rate of the detected temporally correlated photon pairs or multiplets, chemical information about the target area, such as an oxygenation or pH level can be inferred. Cardiac output may be computed from measurements of venous and / or arterial oxygenation using this technique.

The present invention relates to improved methods for treating anemia. Methods and compounds useful for treating anemia, wherein the anemia treatment is associated with a lower risk of thrombosis or hypertension compared to that observed with rhEPO therapy, are provided.

This invention provides methods of obtaining vaccines by use of non-stochastic methods of directed evolution (DirectEvolution(TM)). These methods include non-stochastic polynucleotide site-satuaration mutagenesis (Gene Site Saturation Mutagenesis(TM)) and non-stochastic polynucleotide reassembly (GeneReassembly(TM)). Through use of the claimed methods, vectors can be obtained which exhibit increased efficacy for use as genetic vaccines. Vectors obtained by using the methods can have, for example, enhanced antigen expression, increased uptake into a cell, increased stability in a cell, ability to tailor an immune response, and the like.

The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and / or iatrogenic condition of the colon.

There is disclosed a method for treating an individual having a disease caused by cytokine-mediated toxicity comprising administering to the individual an effective amount of (a) an antibody that binds to an MIF polypeptide, wherein the MIF polypeptide has a molecular weight of about 12.5 kDa in combination with (b) anti-TNF alpha , anti-IL1, anti-IFN- gamma , IL-1RA, a steroid, a glucocorticoid, or IL-10.

Compositions and methods for controlling plant pests are disclosed. In particular, novel nucleic acid sequences encoding modified Cry3A toxins having increased toxicity to corn rootworm are provided. By inserting a protease recognition site, such as cathepsin G, that is recognized by a gut protease of a target insect in at least one position of a Cry3A toxin a modified Cry3A toxin having significantly greater toxicity, particularly to western and northern corn rootworm is designed. Further, a method of making the modified Cry3A toxins and methods of using the modified cry3A nucleic acid sequences, for example in microorganisms to control insects or in transgenic plants to confer protection from insect damage, and a method of using the modified Cry3A toxins, and compositions and formulations comprising the modified Cry3A toxins, for example applying the modified Cry3A toxins or compositions or formulations to insect-infested areas, or to prophylactically treat insect-susceptible areas or plants to confer protection against the insect pests are disclosed.

This invention provides methods of obtaining novel polynucleotides and encoded polypeptides by use of non-stochastic methods of directed evolution (DirectEvolution(TM)). These methods include non-stochastic polynucleotide site-saturation mutagenesis (Gene Site Saturation Mutagenesis(TM)) and non-stochastic polynucleotide reassembly (GeneReassembly(TM)). Through use of the claimed methods, genetic vaccines, enzymes, and other desirable molecules can be evolved towards desirable properties. For example, vaccine vectors can be obtained that exhibit increased efficacy for use as genetic vaccines. Vectors obtained by using the methods can have, for example, enhanced antigen expression, increased uptake into a cell, increased stability in a cell, ability to tailor an immune response, and the like. This invention provides methods of obtaining novel enzymes that have optimized physical & / or biological properties. Furthermore, this invention provides methods of obtaining a variety of novel biologically active molecules, in the fields of antibiotics, pharmacotherapeutics, and transgenic traits.

A method for treating or preventing spontaneous preterm birth in pregnant women and improving neonatal morbidity and mortality. The method includes administering to a pregnant woman in need thereof an effective amount of progesterone sufficient to prolong gestation by minimizing the shortening or effacing of her cervix. Treatment and prophylaxis with progesterone in pregnant women having symptoms of short cervix has been clinically shown to increase neonatal health.

The present invention relates to compositions and methods for inhibiting the release and / or biological activity of migration inhibitory factor (MIF). In particular, the invention relates to the uses of such compositions and methods for the treatment of various conditions involving cytokine-mediated toxicity, which include, but are not limited to shock, inflammation, graft versus host disease, and / or autoimmune diseases.

The present invention is a method for treating anxiety or mood disorders in elderly subjects comprising administering to the subject exhibiting an anxiety or mood disorder an effective amount of an agent that modulates Aβ in the subject.

The present invention relates to a new formulation characterised by the presence of two components, one of which (A) possesses insecticidal, acaricidal, fungicidal, snailcidal or vermicidal activity and the other (B) exhibits synergistic activity with the first by enhancing its effectiveness, and in which the average release time of component (A) is 1 to 12 hours later than the average release time of component (B). The formulation is obtained by: a) separate microencapsulation of both components (A) and (B) within a multilayer system of specific polymers in which component (A) is in a more interior portion of the capsule than component (B), being separated from component (B) by a polymer layer of suitable thickness (FIG. 1); b) microencapsulation of both components within a single layer system (FIG. 2), combined with an immediate-release emulsion / microemulsion containing an additional amount of component (B).

A composition comprising (S)-5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole and (R)-5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole, enantiomerically enriched in the (S)-enantiomer.

A fleet of autonomous sailing vessels that are equipped with monitoring and communication equipment for reporting environmental and other conditions. For optimal stability, the autonomous sailing vessels are multi-hulled vessels (catamarans) with self-righting capabilities. Each sailing vessel sends and receives information via one or more satellite links, using solar power to power the communications equipment as well as the monitoring equipment. Each sailing vessel includes an auto-sailtrim system to maintain a desired attack angle with the wind, and electric propulsion for use as required to maintain a desired heading. A modular design is used to support mission-specific payloads.

An integrated tele-health system / device for monitoring and reporting medical information for the evidence-based management of patients with chronic respiratory disease. The device includes a central unit which measures and collects information related to the state of health of the patient, and is provided with elements for wireless or cable transmission of the collected data using a microprocessor based system with a touch screen display, USB communication port and Bluetooth. The device further includes: a removable sensor for the measurement of respiratory air flow and volume, a removable pulse oximetry sensor and a motion sensor. Stored data can be then delivered through landline, broadband, wireless and cell-phone technology to be received by a web server and can then be accessed by medical staff. Being completely portable, the device is provided with a battery of known type, which can be substituted by the user or can be rechargeable.

The invention relates to a system for breath test of a person. It includes a sensor unit configured to sense the presence / concentration of a volatile substance, e.g. alcohol, present in air flowing through a predefined inlet area and generating a signal corresponding to the concentration of said substance. An analyzer determines the concentration of said substance in the breath of said person. It comprises means for the temporary interruption of said air flow at a point in time coinciding with the detection of a breath. It also relates to a method comprising interrupting the flow through said predefined area for a predetermined period of time, and detecting the concentration of said substance during said interruption.

The invention provides a compound crucian feed and a preparation method thereof. The compound crucian feed can solve a series of problems that the traditionally bred crucian grows fast in the early and middle periods, but the subsequent growth is slow, the death rate rises, the anti-stress ability is reduced and the like because hepatobiliary syndrome frequently occurs in the middle and later periods. The compound feed comprises the following formula in percentage by weight: 5-20% of imported fish meal, 10-30% of soybean meal, 10-20% of rapeseed meal, 10-15% of cottonseed meal, 10-20% of wheat, 2-3% of fish oil, 5-15% of maize germ cake, 5-15% of DDGS(distillers dried grains with soluble), 5-10% of full-fat rice bran, 1.0-2.0% of calcium biphosphate, 0.1-0.3% of salt, 0.1-0.3% of choline chloride, 0.05-0.15% of microecologics for fish, 0.01-0.02% of plant extracts, 0.02-0.04% of bile acid, 0.05-0.1% of hepatobiliary protecting agent, 0.1-0.3% of multivitamin for fish, 0.1-0.3% of multi-mineral for fish, 0.015-0.030% of vitamin E and 0.04-0.08% of 35% vitamin C phosphate. All the raw materials are finely ground, 95% of the ground raw materials pass through a 40-mesh standard sieve,the sieved raw materials are granulated at 95 DEG C, and the degree of gelatinization reaches 95%. The compound crucian feed can meet the requirements of crucian bred in the middle and later periods for nutrition, and can effectively prevent the occurrence of hepatobiliary syndrome and achieve the health protection purpose.

The present invention is directed to compositions and methods using microorganisms to benefit an environment or recipient subject. The present invention relates to the use of microorganism based compositions and methods to enhance the health of recipient subjects, improve soil conditions, and accelerate biodegradation. The present invention also relates to controlling insect and pest populations. Further, the present invention relates to the replacement of chemical compositions with microorganism based compositions.

The invention provides, in some aspects, a system for implementing a rule derived basis to display image sets. In various embodiments of the invention, the selection of the images to be displayed, the layout of the images, as well as the rendering parameters and styles can be determined using a rule derived basis. In an embodiment of the present invention, the user is presented with images displayed based on their preferences without having to first manually adjust parameters.

The present invention relates to methods of stimulating stem cell proliferation and engraftment, and methods of preventing and / or treating disorders associated with radiation exposure, chemotherapy, exposed to chemical / biological warfare agents, and / or any other insults affecting rapidly proliferating tissues in a body, or one or more symptoms thereof. In particular, the present invention provides methods of stimulating stem cell proliferation and / or engraftment and methods of preventing and / or treating disorders associated with one or more insults affecting rapidly proliferating tissues in a body (e.g., radiation exposure, chemical and / or biological insults) or one or more symptoms thereof by administering to a subject a composition comprising a Fibroblast Growth Factor-20 (FGF-20) protein, or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.

The invention provides, in some aspects, a system for implementing a rule derived basis to display image sets. In various embodiments of the invention, the selection of the images to be displayed, the layout of the images, as well as the rendering parameters and styles can be determined using a rule derived basis. The rules are based on meta data of the examination as well as image content that is being analyzed by neuronal networks. In an embodiment of the present invention, the user is presented with images displayed based on their preferences without having to first manually adjust parameters.

The invention discloses application of two dsRNAs (double-stranded ribonucleic acids) and combination thereof in controlling aphid damage. The dsRNA provided by the invention is disclosed as 1), 2) or 3): 1) dsRNA composed of nucleotide disclosed as Sequence 4 in the sequence table and nucleotide disclosed as reverse complementary sequence thereof; 2) dsRNA composed of nucleotide disclosed as Sequence 5 in the sequence table and nucleotide disclosed as reverse complementary sequence thereof; and 3) composed of the following two dsRNAs: dsRNA disclosed as 1) and dsRNA disclosed as 2). The experiment proves that dsRNAs of grain aphid growth and development related gene 23028 and salivary secretion protein gene coo2 are obtained, and the grain aphid in-vivo growth and development related gene 23028 and salivary secretion protein gene coo2 are silenced by an in-vitro dsRNA feeding method by using an RNAi (ribonucleic acid interference) technique, thereby resulting in hindrance of grain aphid growth and development and generating lethal effect.

Extracts of vetiver oil were found to significantly repel termites. In one extract, nootkatone was isolated and found to be a significant repellent and toxicant of termites. Nootkatone significantly decreased food consumption, decreased tunneling behavior, and increased mortality in termites. Nootkatone is an effective repellent and toxicant of termites either by itself or as an addition to other materials or substrates, including mulches made from vetiver grass roots or other wood products. Nootkatone can also be used to protect construction wood from attack by Formosan subterranean termites. Nootkatone as a repellent is non-toxic to humans and other mammals and is environmentally safe. In addition, α-cedrene was found to be a weak termite repellent; and both zizanol and bicyclovetivenol were found to be repellents and toxicants of termites.

The invention discloses a medical sampling-detection integrated device. The device comprises a sampling rod and a shell; the shell comprises a test paper containing chamber and a diluent chamber; a liquid outlet is arranged at the bottom of the diluent chamber, and a hole plugging matter is arranged on the liquid outlet; the sampling rod is connected with a plunger, and the plunger is arranged inthe diluent chamber; two ends of the sampling rod are an A end and a B end; the B end of the sampling rod is pushed so that the sampling rod can be propelled to the A end of the sampling rod in the diluent chamber along the plunger to open the hole plugging matter at the liquid outlet; the device disclosed by the invention is simple in structure; the structure can realize the sampling, diluting and detection of the excrement, the collection, the diluting, the uniform mixing, the sampling injection and the detection of the excrement sample can be integrated; the ordinary being can screen the intestinal cancer and gastric cancer high-risk people at home, and the social meaning is of great significance; the device is ingenious in structure and convenient to use; and the structure further guarantees the leakproofness of the diluent pre-filled in a liquid bottle.

An alarm capable of determining the flow time remaining of irrigation fluid is disclosed. It is also contemplated that the device can detect a partial or complete blockage in the system or empty fluid bag and alert medical personnel locally or remotely as required. The device is capable of calculating the time remaining before the CBI irrigation fluid in the irrigation fluid bag reaches a pre-set level that necessitates changing the bag or the actual time of day or night when the irrigation will be approaching the critical level. Additionally, the user can be alerted to the CBI irrigation fluid in the irrigation fluid bag reaching a pre-set level that necessitates changing the bag before the fluid level becomes critical.

The invention discloses a composite photocatalytic antibacterial material and a preparation method thereof; particularly, a ytterbium-erbium co-doped sodium yttrium fluoride (NaYF4:Yb,Er) and manganese-doped zinc oxide are combined to prepare the photocatalytic antibacterial material driven by visible / near-infrared light. The preparation method comprises the steps: together dissolving sodium chloride, yttrium acetate, ytterbium acetate, erbium acetate and ammonium fluoride in an ethylene glycol / water mixed solvent, and carrying out a microwave assisted solvothermal reaction to obtain NaYF4:Yb,Er spherical nanoparticles; dispersing the NaYF4:Yb,Er in an isopropanol / water / ammonia water mixed solvent, adding tetraethyl orthosilicate, and carrying out hydrolysis for 5 h, to obtain an NaYF4:Yb,Er@SiO2 core-shell structure; and carrying out ultrasonic dispersion of the NaYF4:Yb,Er@SiO2 in diethylene glycol, adding a zinc salt and a manganese salt, carrying out a heating reflux reaction at the temperature of 180 DEG C for 1-6 h, then washing, drying, and calcining for 2 h at the temperature of 500 DEG C to obtain the product. The material can convert the visible / near-infrared light into UV / visible light, manganese-doped zinc oxide absorbs the UV / visible light to produce electrons-holes, and the electrons-holes act on the environment to produce free radicals to participate in a sterilization process, and the material can be used in the field of photodynamic therapy.

The use of lipopeptides as inducers of NF-κB for the protection of mammals from the effects of apoptosis is described.