29 results about "Forensic Pharmacy" patented technology

The invention discloses a 26 Multi-InDel genetic marker system for highly degraded sample typing, a detection primer and application of the 26 Multi-InDel genetic marker system, and belongs to the technical field of forensic medicine identification. According to the invention, through bioinformatics screening and experimental verification, a multi-InDel genetic marker system of which the lengths of 26 amplicons do not exceed 125 bp is constructed. The problem that degradation detection material detection and high system efficiency are difficult to consider at the same time is solved. The random matching probability of the system in Han population in Hunan reaches 2.25 * 10 <-17 >, the cumulative paternity exclusion rate is 0.999925, complete typing of highly degraded DNA can be achieved, triad paternity test can be completed, and a new technical scheme which is efficient and compatible with a capillary electrophoresis platform is provided for forensic practice.

The invention relates to the technical field of forensic genomics, in particular to a primer group and a kit for detecting genetic markers of 365 Y chromosomes and application of the primer group and the kit. According to the invention, an amplification primer group for specific 57 Y-STRs and 308 Y-SNPs of Chinese population is optimally designed, and a joint detection method with high sensitivity and high resolution is constructed. Y-STR haplotype analysis and Y-SNP haplogroup accurate typing can be synchronously realized, and the problems of high family checking false positive rate, insufficient geographic ancestor inference resolution and the like caused by single site type detection in the traditional technology are solved. The method is suitable for diversified biological samples such as blood, seminal stains and saliva, and provides a novel technical scheme of high-throughput, low-cost and multi-dimensional paternal genetic information analysis for forensic practice. Comprising construction of a Y-STR and Y-SNP composite amplification system based on next-generation sequencing and application of the Y-STR and Y-SNP composite amplification system in forensic medicine individual recognition, family investigation and biogeography ancestor inference.

A method and apparatus for collecting DNA samples from uncooperative suspects are provided. A modified bathroom fixture, including a toilet with an empty reservoir tank and a missing handle on the water fill valve, retains excreted material in the toilet bowl, allowing for easy collection of DNA samples. In an alternate embodiment, the toilet's reservoir tank is full, and the water fill valve is in the on position, but the waste flush is diverted to a holding tank. This enables DNA technicians to collect samples from the excreted material for forensic analysis. The invention eliminates the need for costly and time-consuming stakeouts, provides a quick and reliable method for DNA sample collection, reduces the risk of contamination, and allows for immediate sample collection, advancing forensic DNA analysis.

This invention relates to the field of gene detection technology and discloses a high-throughput gene sequencing data multivariate quality control system, including a sample information management module, a sequencing data acquisition module, a multivariate quality control analysis module, a result output and traceability module, an equipment collaborative control module, and a data storage module. Each module communicates bidirectionally via a data bus to achieve real-time data transmission and interaction. This invention addresses the dual needs of clinical medical testing and forensic evidence identification, adapting to multiple application scenarios and solving the problem of single-scenario application in existing systems. It can simultaneously meet the quality control requirements for non-invasive prenatal testing, reproductive genetic testing, tumor gene testing, and forensic kinship identification, eliminating the need for multiple quality control systems, reducing equipment costs and operational complexity, and improving laboratory efficiency.

This invention discloses a method for predicting sudden cardiac death based on forensic autopsy data using machine learning and its forensic applications, belonging to the fields of machine learning, statistics, and forensic identification. This invention provides a method for screening independent predictors of forensic diagnosis of sudden cardiac death using LASSO regression and logistic regression. Using 10-fold cross-validation, the method selects the minimum lambda(λ) to identify 14 risk factors. Logistic regression ultimately identifies 9 independent predictors, including age, heart weight, left ventricular wall thickness, right ventricular wall thickness, interventricular septum thickness, aortic valve circumference, mitral valve circumference, liver weight, and left kidney weight. A nomogram and a web-based calculator are constructed for predicting sudden cardiac death in forensic practice, thereby determining sudden cardiac death using objective indicators. This method has not been reported worldwide.

The invention discloses an interpretation method and system for mixed DNA diallelic SNP data based on WGA-WGS, and relates to the technical field of forensic genetics, and the specific steps are as follows: obtaining intersection SNP sites based on WGA-WGS typing data of a mixed sample and a target individual sample, and generating an SNP site set; determining the number N of mixed contributors and a single allele typing error rate; calling a preset integrated typing error observation probability model based on the application scene, and calculating a total likelihood ratio based on the number N of mixed contributors and a single allele typing error rate on the basis of the SNP site set; the mixed sample is explained based on the total likelihood ratio, the whole process is operated based on a preset mathematical model and objective parameters, and potential bias caused by manual intervention and subjective judgment is reduced to the maximum extent; the scientific preciseness of evidence explanation is ensured, and the repeatability and verifiability of an analysis result are also ensured.

The present invention provides a rapid method for forensic drug testing in a post-mortem individual using muscle tissue and fluid associated with the muscle tissue obtained from remains of the post-mortem individual. The method comprises obtaining muscle tissue and associated fluid from a post-mortem individual, collecting the fluid associated with the muscle tissue, analyzing the fluid associated with the muscle tissue to detect and quantify one or more non-naturally occurring drugs in the post-mortem individual, and identifying the one or more non-naturally occurring drugs in the post-mortem individual. The detection and quantification of non-naturally occurring drugs in muscle tissue and associated fluid is surprisingly faster than detection and quantification of the non-naturally occurring drugs in muscle tissue obtained from the same post-mortem individual and prepared as muscle tissue homogenates using the LC-MS / MS method, with results obtained in as soon as three hours.

The utility model discloses a forensic dissection work platform relates to the technical field of dissection table, it includes elevating seat, dissection table is set up in elevating seat, the top of dissection table is opened with recessed cavity, the inner wall of recessed cavity is opened with a plurality of through -opening, the inside of dissection table is opened with chamber relative to the position below recessed cavity, negative pressure component sets up in the bottom of dissection table for forming negative pressure in the chamber, thereby can reduce the diffusion of corpse smell, reduce the inhale of forensic doctor, cause the discomfort, simultaneously, the liquid produced in the dissection process of corpse also can enter into the chamber through through -opening.

Automated Saliva- Based Biomarker Detection and Forensic Assessment Device

Compositions, assays, methods, diagnostic methods, kits, and diagnostic kits are disclosed for the specific and differential detection of SARS-COV-2 and / or other viruses from samples, including veterinary samples, clinical samples, food samples, forensic sample, environmental samples (e.g., obtained from soil, garbage, sewage, air, water, food processing and manufacturing surfaces, or likewise), or biological sample obtained from a human or non-human animal.

The invention relates to the technical field of molecular detection, in particular to forensic body fluid identification based on GC-MS metabolites. By means of the identified metabolite, body fluid type identification under the low sample size in a forensic identification scene can be achieved, the method has the advantages of being high in sensitivity, good in reproducibility, nondestructive in detection and the like, and a brand new thought is provided for forensic physical evidence identification.

The application discloses a mixed DNA biallelic SNP data interpretation method and system based on WGA-WGS, and relates to the technical field of forensic genetics, and the specific steps are as follows: obtaining intersection SNP sites based on WGA-WGS typing data of a mixed sample and a target individual sample, and generating a SNP site set; determining the number N of mixed contributors and a single allele typing error rate; calling a preset observation probability model of integrated typing errors based on an application scenario, calculating a total likelihood ratio based on the number N of mixed contributors and the single allele typing error rate on the basis of the SNP site set; and interpreting the mixed sample based on the total likelihood ratio, wherein the whole process in the application is operated based on a preset mathematical model and objective parameters, so that potential bias caused by artificial intervention and subjective judgment is minimized, the scientific rigor of evidence interpretation is ensured, and the repeatability and verifiability of analysis results are also ensured.

The invention discloses an autopsy bed special for a forensic. Comprising a first supporting assembly used for supporting the upper body and a second supporting assembly used for supporting the legs. The first supporting assembly comprises a plurality of first telescopic plates which are adjacent in sequence, the second supporting assembly comprises a plurality of second telescopic plates, all the second telescopic plates are arranged side by side to form two groups, all the second telescopic plates of each group of second telescopic plates are adjacent in sequence, and the two groups of second telescopic plates are arranged side by side beside the same first telescopic plate; the two short edges of all the first telescopic plates and the two short edges of all the second telescopic plates are supported on the ground through the lifting supports, and the heights and the horizontal inclination angles of the first supporting assemblies and the second supporting assemblies are adjusted by changing the heights of the lifting supports. All the lifting supports are the same in structure, and each lifting support comprises a telescopic motor, a ball joint bearing and a longitudinal beam. Adjusting functions of lifting, inclining and the like of the bed body are added, and the working difficulty of a forensic is reduced.

The present application relates to the field of forensic pathology, forensic genetics and molecular identification technology, in particular to a primer composition for evaluating genetic susceptibility of unexplained sudden death, products and applications thereof. The primer composition provided by the present application comprises nucleotide sequences such as amplification primers shown in SEQ ID NO. 1-512, that is, 256 pairs of primers related to 238 quantitative trait loci. The present application further provides products and methods for evaluating genetic susceptibility of unexplained sudden death of individuals. Experimental results show that the primer composition or kit provided by the present application can detect consistent and highly repeatable genotyping results, and on this basis, the genetic susceptibility of unexplained sudden death can be further evaluated by calculating the polygenic risk score, which has important significance for the genetic background research of unexplained sudden death and the accurate cause of death identification in sudden death related cases in forensic identification work.

When the image acquisition module is used, the left-right position of the camera can be adjusted through the transverse movement mechanism, the vertical position of the camera can be adjusted through the vertical movement mechanism, and the front-back position of the camera can be adjusted through the longitudinal movement mechanism; the camera rotating mechanism drives the camera to rotate in the front-back direction, and the bottom light source and the side light source are matched, so that the consumable on the consumable frame, the liquid image in the consumable and the liquid image in the suction head of the automatic pipettor can be collected. The image acquisition device can acquire images of consumables and liquid in the consumables and images of liquid in a suction head of an automatic pipettor, is suitable for a forensic biochemical test full-automatic extraction and detection platform, can complete monitoring and recording of various automatic pipetting processes in cooperation with an image identification module, and improves test accuracy and reliability.

This invention relates to the interdisciplinary field of artificial intelligence and forensic medicine, and discloses a system for analyzing and reasoning about the injury mechanism of craniocerebral injury by integrating a multimodal large-scale model. The system includes a multimodal data preprocessing and alignment module, a multimodal large-scale model inference engine, an intelligent report generation module, and an interactive natural language query interface. This system, by constructing a multimodal data preprocessing and alignment module, for the first time spatially registers biomechanical simulation stress cloud maps as an independent visual modality with cranial CT images in a standard anatomical coordinate system. Combined with forensic autopsy text and case descriptions, a multimodal encoder is used to achieve deep fusion of heterogeneous data from three sources—image, mechanical, and text—in a shared semantic space. This effectively breaks down the barriers of isolated information and semantic fragmentation among different modalities in traditional forensic analysis, providing a structured and aligned input foundation for subsequent high-precision injury mechanism inference.

The application belongs to the technical field of forensic medicine, and discloses an East Asian group fine division AIM-SNP typing system and application. The application is based on a machine learning algorithm, systematically screens and optimizes a set of biogeographical ancestral tracing markers in the whole genome range, optimizes 58 high ancestral information amount SNP sites from 2135 candidate di-allele SNPs, provides a core feature set for accurate tracing, and further screens 2 Y chromosome deletion / insertion sites and 1 tooth enamel gene for gender identification. The feature set can accurately trace to five major continental populations, namely, Africa, Europe, East Asia, South Asia and America (excluding mixed American descent). In particular, the problem of insufficient tracing resolution in the East Asian population is solved, and the ancestral resolution capability of the East Asian population is significantly improved, making it more applicable and feasible in Chinese forensic practice.

A portable repositioning evidence support stand for supporting forensic evidence primarily for 3D scanning applications. The evidence support stand features a base plate containing a number of mounting apertures, a number of support members, and a number of fasteners. A method for adjusting support of a piece of forensic evidence for 3D scanning, featuring: positioning a plurality of support members of an evidence support stand into a predetermined position, adjusting the height of each support member, securing each support member to the base plate with a fastener, and providing the piece of forensic evidence to bumper pads on the support members.

There is provided a computer implemented method of detecting a deepfake video, comprising: feeding a video into at least one forensic model, obtaining at least one indication of at least one property of a person or object depicted in the video as an outcome of the at least one forensic model, comparing the at least one indication to at least one ground truth obtained by applying the at least one forensic model to at least one authentic video depicting the person or object and / or by searching a ground truth dataset, in response to a mismatch between the at least one indication and the at least one ground truth, increasing likelihood that the video is deepfake, and in response to a match between the at least one indication and the at least one ground truth, increasing likelihood that the video is authentic.

The application relates to the technical field of biological information collection, and discloses a biological information collection system for forensic material evidence, which comprises a multidimensional collection module and an intelligent management module. The system obtains the management data, the environmental parameters and the development data of all the material evidence through the multidimensional collection module, and classifies and forms data sets; the intelligent management module analyzes the characteristics of each material evidence, predicts the development effect, judges the retention state of the fingerprint residues, generates a penetration score, avoids invalid collection, analyzes the compactness and the obsolescence of each material evidence again, generates an adaptation index, guides a forensic person to select a suitable solution, judges whether the environmental parameters meet the reaction conditions, evaluates the development effect of the material evidence, generates a reaction score, has strong multidimensional analysis and perception ability, judges whether the material evidence meets the detection conditions of the silver nitrate development method, outputs the material evidence grade, judges the solution type again, outputs corresponding biological information collection suggestions, and the intelligent collection success rate is high.

The invention provides a body fluid spot identification and deposition time inference model based on microbial markers and a construction method and application thereof, and belongs to the technical field of forensic physical evidence identification. According to the established detection and analysis system, accurate identification of three common body fluids, namely blood, semen and saliva, can be realized from a single or mixed spot trace sample, and reliable inference on the deposition time of the body fluids can be synchronously completed. The method breaks through the dependence of the traditional technology on speckle traces or high-purity nucleic acid samples, and obviously widens the range and information depth of detectable samples in forensic practice. The method has the advantages that more comprehensive and more objective time sequence physical evidence support is provided for case detection, a crime occurrence time window can be delimited more accurately, the field activity process can be reconstructed more accurately, and therefore the actual combat ability and the application value of criminal science and technology in the aspect of complex spot inspection are improved.

The invention discloses an animal species identification method based on a nanopore sequencing technology, and relates to the field of forensic genetics, the method comprises the following steps: (1) constructing a 12S rRNA gene reference database; (2) collecting a sample to be detected and extracting DNA; (3) carrying out PCR (Polymerase Chain Reaction) amplification by using a universal primer; (4) carrying out QNome nanopore sequencing; and (5) ClassIdent data analysis is carried out to confirm species. According to the animal species identification method based on the nanopore sequencing technology, a universal primer is adopted to simplify an experimental process, the long-reading-length portable nanopore sequencing technology is used to provide real-time sequencing data, and an automatic species identification process ClassIdent is constructed to perform data analysis, so that species identification can be performed on a sample with a single source, and the accuracy of species identification is improved. And the method has the characteristics of simplicity in operation, low cost, high accuracy and the like, and has a wide application prospect.

A primer set and a kit for individual identification of a hair shaft, and use thereof, which belongs to the technical field of forensic science. The primer set enables the detection of coding single nucleotide polymorphism (cSNP) sites and / or microhaplotype (MH) sites on highly-expressed mRNA markers in hair shafts, addressing the challenge of individual identification using hair shaft samples with high accuracy. Additionally, instruments and reagents required are conventionally available in forensic laboratories, making the detection straightforward to conduct and easy to promote.

This invention provides a composition for detecting Y-SNP locus combination genotypes and its application. The Y-SNP locus combination provided by this invention includes 2854 Y-SNP loci, and the composition for detecting the genotypes of these 2854 Y-SNP loci comprises a single-stranded DNA molecule with the nucleotide sequence SEQ ID NO: 1-5446. The composition provided by this invention enables single-tube, one-time detection of the Y-SNP locus combination genotypes, efficiently analyzing the paternal genetic background of male individuals. For the highly challenging mixed-sex stains and degraded samples encountered in forensic practice, the composition provided by this invention also exhibits high stability, maintaining a high level of marker detection rate and genotyping concordance rate. Therefore, this invention provides a powerful technical means to solve the challenges of paternal tracing and individual identification in complex environments.

The application belongs to the technical field of forensic medicine, and particularly relates to a primer group for hair shaft individual identification, a kit and application thereof. The primer group can realize detection of cSNP and / or MH sites on a high-expression mRNA marker of a hair shaft, solve the problem that a hair shaft sample cannot be subjected to individual identification, and has high precision. Meanwhile, the instrument and reagent used in the application are commonly equipped in a forensic laboratory, and the operation is simple and easy to popularize.

Multimodal Biometric Computer Device, Incorporating Vedic Math for Forensic Analysis

The invention discloses an SNP (Single Nucleotide Polymorphism) genetic marker system for genetic relationship identification of a highly degraded sample, a detection primer and application of the SNP genetic marker system and the detection primer, and belongs to the technical field of forensic medicine identification. According to the invention, through bioinformatics screening and experimental verification, a triallelic SNP genetic marker system of which the lengths of 25 amplicons all do not exceed 110 bp is constructed. The problem that it is difficult to give consideration to genetic marker typing and high system efficiency of highly degraded samples is solved. The random matching probability of the system in Han population in Hunan reaches 1.59 * 10 <-18 >, the cumulative paternity exclusion rate is 0.99979, complete typing of highly degraded DNA can be realized, triad paternity test can be completed, and a new technical scheme which is efficient and compatible with a capillary electrophoresis platform is provided for forensic practice.

The utility model discloses a special examination couch for forensic clinics relates to medical examination couch field, including support structure, couch body structure and receiving groove, couch body structure is fixedly connected to support structure top end, couch body structure includes soft rubber mat, bed board, first measuring structure and second measuring structure, bed board is fixedly connected to soft rubber mat bottom end, and the first measuring structure and second measuring structure are connected to soft rubber mat bottom end. The first measuring structures are connected to the two sides of the bed board in a sliding mode, the measuring structures of the examination bed can measure the length of the upper body and the length of the lower body of the body placed on the surface of the bed body structure, and due to the fact that the sizes of all bodies are different, the length of the upper body and the length of the lower body of the body can be measured. During use, the measuring structure can slide on the surface of the bed board until the measuring structure is located at the waist of the body, then the first clamping block and the second clamping block in the measuring structure are pulled outwards, length data of the upper body and the lower body of the body can be obtained according to data measured by each group of measuring tapes, and the joint motion range can be measured by stretching and bending limbs through the second measuring structure.

The invention provides a forensic model for medium-non-flowing population source identification based on oral microorganisms and a construction method of the forensic model, and belongs to the technical field of medical model construction. The identification model provided by the invention can accurately distinguish groups living in China for a long time, groups living in African for a long time and floating crowds migrating from African to China. The model can be directly applied to analysis of biological samples such as saliva spots in a crime scene, key clues about sources and flow behaviors of suspects are provided for investigation organizations, the investigation direction can be quickly locked in cross-regional cases related to overseas personnel, the case solving efficiency is improved, and the method has important forensic practice value and social safety significance.