106 results about "Vaginal secretion" patented technology

The present invention discloses one plant lactobacillus strain and its application. The plant lactobacillus, Lactobacillus plantarum L323 CGMCC No. 1329, is separated from Chinese pregnant woman's vaginal secretion, and has relatively high bacteriotasis on common vaginal pathogens, such as staphylococcus aureus, candida albicans, colibacillus and vaginal Gardnar bacillus, and acid producing and H2O2 producing capacity higher than other lactobacillus. The plant lactobacillus, Lactobacillus plantarum L323 CGMCC No. 1329, may be used in preparing vaginal microbial preparation for preventing and / or treating vaginal infectious diseases.

The present invention provides a non-toxic diagnostic composition for intravaginal monitoring of vaginal infections. The present invention further provides a diagnostic article for intravaginal monitoring of vaginal infections with the article including an absorbent material for absorbing vaginal secretions and a composition suitable for identification of the pH or the buffer capacities associated with vaginal secretions. The diagnostic composition provides a visible indication of vaginal infections, such as bacterial vaginosis.

A container assembly comprises a vessel for containing a biological medium, gametes and / or one or more embryo(s). The vessel has a CO2 permeable seal and a closure valve device for selective access. A buffer chamber for a CO2 enriched atmosphere cooperates with the vessel and is in communication with the CO2 permeable wall. Such a container assembly is particularly adapted for intravaginal use in which case the permeable seal prevents ingress of vaginal secretions. The buffer chamber mediates the aqueous pH in the vessel after the container assembly is removed from a CO2 enriched environment.

A method is taught for the accurate determination of the premature rupture of membranes (PROM), defined as spontaneous rupture of membranes before the onset of uterine contractions. More specifically, a lateral flow assay strip tests for at least two antigens to greatly limit or eliminate the possibility of false negatives. A built in timer in the cassette holding the lateral flow assay further increases the accuracy of the test. A collection buffer vial with self-contained shipping and dropper caps and built in stand is also taught.

The invention discloses a vaginitis test kit which comprises a reaction device, a sampling test tube, a straw, joint test diluent, joint test chromogenic reagent, joint test stop solution, a user manual and a joint test colourimetric card, wherein a hydrogen peroxide reaction hole, a leukocyte esterase reaction hole, a sialic acid glucoside enzyme reaction hole, a beta- glucuronic acid enzyme reaction hole, a P glucosidase reation hole and a pH value hole; relevant reaction bases are arranged in the reaction holes; reach reaction base comprises a corresponding reaction substrate curing layer,a chromogenic promotional layer and a chemical inert carrier layer. The invention also provides a preparation method of the test kit and the preparation method of a novel chemical carrier. The test kit can be used for distinguishing bacterial vaginosis and vaginitis, and can further identify aerobic / anaerobic bacteria, facultative anaerobic bacteria and other flora in vaginal secretion. The method is simple and quick to operate, has high accuracy, and is applicable to clinical practice, particularly hospital outpatient practice.

The invention discloses a vaginal secretion wet sheet candida detection method based on a Hough round detection and deep CNN (convolutional neural network). The method comprises the following steps of (1) by aiming at the round features (oval or 8 shape) of the candida, dividing a candidate region of the vaginal secretion wet sheet candida on the basis of a Hough round detection and morphological operation method; (2) performing feature extraction based on the deep CNN; (3) building a CNN-SVM (support vector machine)-based classification model, and realizing the candida identification. The image processing and recognition method based on the Hough round detection and deep CNN is used; the vaginal secretion wet sheet candida detection can be conveniently, economically and efficiently realized; the requirements of intelligence, high speed and high precision of the medical application can be met.

The presence of 3-chlorotyrosine in vaginal secretions in a predictor of the likelihood preterm premature rupture of the fetal membranes, i.e., the chorioamnion and / or the occurrence of the risk of preterm labor. 3-chlorotyrosine is a marker for the excessive production of hypochlorous acid which causes focal areas of increased collagen destruction in the chorioamnion, preterm premature rupture of membranes, or increased production of postaglandin and preterm labor. The inventive method comprises determining the likelihood of the occurrence of preterm premature rupture of membranes or increased production of postaglandin and preterm labor in a pregnant female by obtaining a sample of the females vaginal secretions, and analyzing the secretions for the presence and amount of 3-chlorotyrosine in the sample. Various antibody-based tests can be used to measure 3-chlorotyrosine, and a number of neoantigens, useful in raising antibodies to 3-chlorotyrosine, are disclosed.

This invention relates to a body fluids identification method and kit. A parallel, multiplex reverse transcription-polymerase chain reaction (RT-PCR) assay for the definitive identification of body fluids commonly encountered in forensic casework analysis, namely blood, saliva, semen, and vaginal secretions. The methodology is based on gene expression profiling analysis in which the body fluid-specific genes are identified by detecting the presence of appropriate messenger RNA species. Gene-specific primers are labeled with fluorescent dyes, separated and subjected to laser induced fluorescence for identification of body fluid-specific genes present in a sample stain.

The present invention relates to a diagnostic method for the detection of small quantities of amniotic fluid in the vagina. More specifically, the invention relates to the detection of PAMG-1 in the vagina using anti-PAMG-1 antibodies.

The quick releasing vagina tablet includes various active medicinal components, such as antibiotic, antifungal, antiviral, hormone, prostanoid, etc.; and medicinal supplementary material stuffing, adhesive and disintegrating agent. The stuffing includes water soluble stuffing and water insoluble stuffing. The quick releasing vagina tablet, after contacting with vagina secretion, can disintegrate to disperse or dissolve so that it is absorbed via vagina mucous membrane to produce local treatment effect and made to enter body circulation to produce bodily treatment effect. It is convenient and accommodative.

The invention relates to an improved periodic acid Schiff (PAS) rapid staining kit. The kit comprises: a staining liquid, shedding-proof films, and cover slips. The staining liquid is a mixture of active fuchsine liquid and active fast green liquid, which is diluted with 95% of ethanol and 0.5% of sodium binitrite solution. The kit is advantaged in that: fuchsine and fast green are firstly prepared into a rapid biological rapid staining liquid; the staining process is fast, wherein the staining process takes 10 seconds; the detection process is simple, wherein a result can be observed directly, and washing is not required; the application scope is wide, wherein the kit can be used for staining various clinic specimens such as scurf, mucous and vaginal secretion. Periodic acid is attached on object slides, such that packing materials of the product is saved, and the operation process is simplified. The kit is especially suitable for a large clinic specimen amount. Because periodic acid, which is a flammable and combustible product, is attached to the object slides, periodic acid turns from liquid into a dried status. Therefore, danger of periodic acid is greatly reduced, and a standardized operation is easy to achieve. Poor repeatability due to personal operation errors can be avoided.

The invention provides a method and a system for identifying a histologic origin of body fluids of Chinese population from gene level. The method comprises the following step: detecting the expression status of seven genes: GYPA, SPTB, MMP-7, STATH, MUC4, PRM2 and TGM4 in body fluids, wherein the body fluids comprise one or more of peripheral blood, menstrual blood, saliva, vaginal secretion and seminal fluid. The invention further provides the system for identifying the histologic origin of body fluids of Chinese population from gene level. According to the scheme provided by the invention, the histologic origin of body fluids of Chinese population can be effectively determined from the gene level, so that steps of identifying the histologic origin of body fluids in criminal investigation fields or spots thereof are greatly simplified, and an accurate scientific basis is provided for defining case property, determining criminal suspects, convicting and sentencing and the like.

The present invention provides a non-toxic diagnostic composition for intravaginal monitoring of vaginal infections. The present invention further provides a diagnostic article for intravaginal monitoring of vaginal infections with the article including an absorbent material for absorbing vaginal secretions and a composition suitable for identification of the pH or the buffer capacities associated with vaginal secretions. The diagnostic composition provides a visible indication of vaginal infections, such as bacterial vaginosis.

Embodiments of the invention disclose a vaginal secretion detection device and method. The detection device comprises a base and a control circuit board; a bar code scanning head, an upper card assembly and an incubation assembly are sequentially arranged on one side of the base; the other side of the base is sequentially provided with a test tube rack assembly, a consumable replacement assembly,a slide upward and downward moving assembly and a microscope electric platform; the upper card assembly is provided with a card storage box; a reagent card clip is arranged in the card storage box; afirst optical detection assembly and a second optical detection assembly are arranged above the incubation assembly; a reagent card recovery box is arranged on the outer side of the incubation assembly; a Y-direction driving assembly is further arranged on the base; a liquid shifting assembly is arranged on the Y-direction driving assembly; a microscope is arranged above the microscope electric platform; a slide recovery box is arranged on the outer side of the microscope electric platform; and a slide clip is arranged on the slide upward and downward moving assembly. According to the vaginalsecretion detection device and method, the detection speed and the recognition accuracy are improved; and manual feature extraction and image preprocessing are not needed, so that the misdiagnosis isreduced.

The invention belongs to the field of medical health care technology, and particularly provides a screening method for difference protein of vaginal secretion in pregnant woman with premature ruptureof membranes based on iTRAQ technology. By combining the iTRAQ technology and the 2DLC-MS-MS technology, a rapid and high correlation degree comprehensively screening of the vaginal secretion difference protein of the premature woman with premature rupture of membranes is achieved, after further identification analysis, the screened differential proteins IGFBP-1, AFP, PRL and LZM can be used as biomarkers for diagnosis of premature rupture of membranes with higher sensitivity and specificity.

The invention relates to a medicament for treating vaginitis. The vaginitis is the most common infectious disease of women and the common symptoms thereof are vaginal secretions increase, pruritus vulvae and burning pain possibly accompanied by frequent urination, painful urination and dyspareunia. After a long-term research and clinical verifications, a traditional Chinese medicine for external use for treating vaginitis with better curative effect is finally found by the inventor. The dosage of the medicament compositions provided by the invention is also gained through a great deal of development of the inventor and the optimum proportion is as follow: 6 parts of radix sophorae flavescentis, 20 parts of rhizoma smilacis glabrae, 20 parts of stemona, 15 parts of radices sileris, 20 parts of belvedere fruit, 20 parts of fructus cnidii, 20 parts of cortex dictamni, 20 parts of golden cypress and 10 parts of schizonepeta. Each medicament functions to generate the synergistic effect by combining all, which has the effects of clearing heat and removing toxicity, killing parasites and relieving itching, and thus effectively treating vaginitis.

The invention provides a cervical carcinoma and uterus cancer detection method and a system thereof, which relate to the fields of biological and microbiological analysis detection. The method comprises the following steps: obtaining a microscopic image of vaginal secretion; performing edge detection, filling up an internal gas of the edge to form a complete exfoliative cell shape; obtaining a microscopic image of exfoliative cell, performing edge detection to obtain cell nucleus; calculating an area difference and curvature of the exfoliative cell to determine the result as cervical carcinomaand uterus cancer; calculating the ovality of the exfoliative cell, and when the ovality of the exfoliative cell is lower than a first set value, determining the result as precancerous lesions of cervical carcinoma and uterus cancer; calculating a ratio of an area of the exfoliative cell nucleus to the area of the exfoliative cell, and when the ratio of the area of the exfoliative cell nucleus tothe area of the exfoliative cell is higher than a second set value, determining the result as an early stage of precancerous lesions of cervical carcinoma and uterus cancer. Compared with the prior art, the method has the advantages that the measurement time is short, the complex processes such as dyeing culture cannot be required, and the process is simple and reliable.

The invention discloses a vaginal secretion sampling device for gynecological clinic. The vaginal secretion sampling device comprises a sampling pipe, a handle is fixed at the bottom end of the sampling pipe, a power supply and a control switching group are mounted on the side surface of the sampling pipe, the sampling pipe is connected with a flexible pad through a first clamping connection mechanism in a clamping manner, a rotating mechanism is mounted at the inner bottom of the sampling pipe, a telescopic mechanism is mounted at the top of the rotating mechanism, and a silica gel sampling head is connected at the end of the telescopic mechanism through a second clamping connection mechanism in a clamping manner. The vaginal secretion sampling device is electrically controlled and conveniently operated by a patient with one hand, doctor-patient disputes are avoided, privacy of the patient is protected, the silica gel sampling head serves as a sampling carrier, is free from toxicity and good in flexibility and cannot stimulate skins, discomfort of the patient is avoided, normal sampling can be ensured, the silica gel sampling head rotatably samples through the rotating mechanism,and sampling integrity is ensured.

The invention discloses a quality control material for detecting visible components of vaginal secretion. The quality control material comprises buffer solution, surfactant, erythrocyte simulated particles, leukocyte simulated particles, epithelial cell simulated particles, fungus simulated particles, trichomonad simulated particles and bacillus simulated particles. Compared with the present quality control solution, the quality control material provided by the invention has the advantages of quality control on different visible components, higher real-time stability, low toxicity, high sensitivity, accurate detection result and wide application in external quality assessment.

The invention discloses a variable-diameter gynecological endoscopic examination device, which comprises an inspection rod, wherein a through hole is formed in the examination rod; two arc-shaped plates are arranged on the outer side of the examination rod; two pushing grooves which are horizontally and symmetrically arranged are formed in the outer side of the examination rod; two pushing blocksare slidably arranged on the inner walls of one sides of the two pushing grooves, close to each other, one end of a pushing rod is rotatably arranged on each pushing block, a connecting block is rotatably arranged on the other end of each pushing rod, one side of each connecting block is welded with the arc-shaped plates, screw rods are rotatably arranged on the inner wall of the top part and theinner wall of the bottom parts of the pushing grooves, and one sides of the two screw rods, which are close to each other, are welded. According to the invention, a vagina is conveniently opened, theexamination is convenient, the size of the opening is controllable, the two arc-shaped plates drive two arc-shaped shells to open, vaginal secretions are prevented from sticking to the arc-shaped shells, which blocks the examination sight line of the objective lens, meanwhile, the length of the handle is conveniently adjusted, and practical use is facilitated.

The present invention relates to the use of benzoic acid and / or its sodium salt in combination with saccharide(s) as active components in the manufacture of a vaginal composition for modulating vaginal flora and vaginal acidity, thereby maintaining the pH value of vaginal secretion within a range from 3.5 to 4.5; and the present invention further relates to a vaginal composition and a method for modulating and maintaining normal vaginal flora and vaginal acidity.

The invention discloses a vaginal secretion sampling device for obstetric clinic comprising a housing; an installing hole is installed inside the housing; an internal screw thread is installed at a right end inside the installing hole; a sampling tube is installed inside the installing hole; a sampling head is installed at a lower end of the sampling tube; an elastic probe is installed at a left end of the sampling tube; a clamp groove is installed at the left end of the sampling tube; a buckle is installed at a right end of the elastic probe; the elastic probe and the sampling tube are clamped and connected; a connecting body is installed at a right end of the sampling tube; a handle is installed at the right end of the connecting body; the handle and the connecting body are provided withworking chambers therein. The invention has the advantages of simple structure and convenient use; the device can reduce the angularity of the sampling device and the direct contact of the affected part of the patient, avoids the damage of the sampling device to the patient, and reduces the suffering of the patient; sampling at multiple locations at one time can be achieved, avoiding multiple sampling by doctors, improving work efficiency, and ensuring the accuracy of sampling data.

The invention discloses a vaginal fluid detection kit, which comprises a reaction device and a color developing agent, wherein the reaction device comprises a reaction hole for detecting beta-glucuronidase, a reaction hole for detecting acetylglucosaminidase, a reaction hole for detecting coagulase and a reaction hole for detecting proline aminopeptidase; when the kit is used for detecting vaginal secretion, the used diluent is normal saline. The vaginal secretion detection kit has the advantage that pathogenic bacteria or pathogens of bacterial vaginal diseases and trichomonas vaginitis can be used for assisting in the fast judgment of the vaginal disease condition. The invention also discloses a preparation method of the vaginal secretion detection kit.

The invention relates to a vaginal secretion fetching / medicating cannula device for female children and adolescents. The secretion fetching / medicating cannula device comprises a suction tube and a negative-pressure device. Suction holes are formed in the far end and sidewalls of the suction tube; a metal guide wire clings to the inner wall of the suction tube; the negative-pressure device comprises a drum body, a piston and a drawing rod; a connecting port is formed in the far end of the drum body; and the connecting port is connected to the suction tube. The vaginal secretion fetching / medicating cannula device disclosed by the invention has the following advantages: 1) the cannula device, when used for fetching vaginal secretions, is controllable in length, and the vaginal secretions are prevented from being contaminated by external environment, so that working difficulty of medical personnel is reduced and injuries are avoided; and the cannula device, which is good in controllability, can be used for as a special medical apparatus for fetching the vaginal secretions from the female children and adolescents; and 2) the cannula device, when conducting vaginal and vulvar administration, can precisely control administration positions, and meanwhile, by virtue of a threaded structure on the drum body, the cannula device is capable of completing drug loading and administration precisely; therefore, the cannula device has a broad application prospect in the clinical field.

The invention provides a strutting device with high safety performance for gynecological examination, and relates to the technical field of a medical care appliance. The right sides of a first strutting plate and a second strutting plate are rotationally connected through a rotating shaft; a plurality of torsion springs are fixedly sleeved onto the rotating shaft arranged in the middle part of thefirst strutting plate; a positioning convex block is vertically and fixedly arranged on the inner top surface of the first strutting plate; a detouring seat is vertically and fixedly arranged on theinner bottom surface of the second strutting plate; the upper part of the detouring seat is fixedly connected with a positioning groove; the positioning convex block is matched, clamped and connectedwith the positioning groove; a pulling lug is fixedly arranged onto the bottom of the positioning groove; a pull rope is fixedly connected onto the pulling lug; a liquid suction mechanism is arrangedat the right side of the first strutting plate and the second strutting plate; an anti-clamping gasket is fixedly arranged on the opening edges of the first strutting plate and the second strutting plate; the strutting device can help medical personnel to strut the vagina position of a patient; the continuous consumption of the physical power of the medical personnel is not needed; meanwhile, thewhole safety performance of the device is greatly improved; the use is very convenient; the vaginal secretion of the patient can be simply collected.