15 results about "Vaginal secretion" patented technology

The invention provides lactobacillus rhamnosus and application thereof. The lactobacillus rhamnosus is an original strain separated and purified from vaginal secretion of healthy women. The lactobacillus rhamnosus is identified by the China General Microbiological Culture Collection Center (CGMCC) and is classified and named as lactobacillus rhamnosus, and the preservation number is CGMCC No.33918. According to the lactobacillus rhamnosus disclosed by the invention, through optimization of growth conditions, a large amount of efficient antibacterial substances such as L-lactic acid and H2O2 can be generated in a fermentation culture solution of the lactobacillus rhamnosus, and the growth of gardneria vaginalis can be effectively inhibited. The lactobacillus rhamnosus disclosed by the invention is a microorganism capable of efficiently inhibiting gardneria vaginalis and relieving bacterial vaginosis of mice, and has a relatively high application value.

The application discloses a composite amplification detection system for body fluid tracing based on mRNA markers and application thereof, high-specificity mRNA markers can realize accurate tracing of five main body fluid types including peripheral blood, saliva, semen, menstrual blood and vaginal secretion, and can make up for the problem that in the previous body fluid tracing system, less markers lead to false positive or false negative problems caused by cross-reaction, and effectively improve the accuracy of single source and mixed body fluid, and old body fluid identification, and improve the applicability and feasibility of the system in forensic practice and biological research. Based on the fluorescence labeling technology, the application realizes stable, specific and efficient composite amplification reaction of multiple high-specificity mRNA markers at the same time, and the number of composite mRNA markers in the system is relatively large, and the identification efficiency of single source and mixed body fluid, and old body fluid is high.

The gynecological uterine cavity sampler comprises a sampling tube and a sampling hole formed in the end part of the sampling tube, and further comprises a piston, and the piston is arranged in the sampling tube; one end of the push-pull rod is positioned in the sampling tube and is fixed with the piston; the plugging assembly is arranged on the sampling tube, the plugging assembly is used for plugging the sampling hole, the sampling tube is moved into the uterine cavity, the plugging assembly is used for removing plugging, and the sampling hole is temporarily plugged through the sliding sleeve, so that when a medical worker uses the sampling tube to penetrate through the vagina of a patient, the plugging assembly is used for plugging the sampling hole and moving the sampling tube into the uterine cavity; the condition that secreta in the vagina enters the sampling tube from the sampling hole in the uterine cavity penetrating process is avoided, then the sampling purity is improved, the detection accuracy is improved, when the sampling hole is located in the uterine cavity of a patient, the handle is pulled to drive the arc-shaped piece to move, and therefore the sliding sleeve is driven to move to open the sampling hole, and the sampling tube is closed. And meanwhile, sampling operation is performed.

Provided is a product that enables easy monitoring of early rupture of membranes and relates to a wearing article provided with a test strip using immunochromatography, wherein the test strip is designed to detect amniotic fluid-derived insulin-like growth factor binding protein 1 in vaginal secretion, and wherein, when the test strip detects 0.3-25 mg / L of insulin-like growth factor binding protein 1, the result is considered positive.

The invention relates to the technical field of medical instruments, in particular to a vaginal lubricant and a preparation method thereof.The vaginal lubricant is prepared from, by mass, 0.05-0.5 part of tremella polysaccharide and 0.1-1.5 parts of soluble proteoglycan, all the ingredients are odorless, mild in property, free of vagina irritation and free of adverse reaction on the human body, and the vaginal lubricant is free of side effects on the human body. The tremella polysaccharide with the molecular weight of 1000000-150000 Da and the soluble proteoglycan with the molecular weight of 400000-600000 Da are adopted for compatibility, so that vaginal secretion can be fully absorbed, and the imaging effect of colposcopy is improved; the vaginal dilator has the advantages that the vaginal dilator is convenient to use, vagina injury caused by cervical forceps and other instruments can be quickly repaired, the elasticity of the dilated vagina can be quickly recovered, good lubricity is achieved, friction force between the instruments and a cavity can be reduced to a great extent, and mechanical injury is effectively avoided.

The utility model discloses a vaginal secretion collector relates to medical equipment technical field. Prior art adopts traditional glass tube or plastic tube as sampling tube, and it is easy to cause sample leakage. The utility model's sampling tube inside preset physiological saline, and sampling tube is set up elastic diaphragm self -sealed structure relative to physiological saline top, and sampling tube top detachable connecting pipe cover, and the quick sample storage cover is rotatably arranged on the pipe cover, and the elastic diaphragm self -sealed structure is directly passed through by the quick sample storage cover, and the elastic diaphragm self -sealed structure is symmetrically set up the intercommunication trapezoidal round hole on the two sides of center respectively, and the sampling cotton swab is convenient, and the trapezoidal round hole is quickly passed through through the sample storage hole of pipe cover when using, and then closes quick sample storage cover can seal. The utility model not only can guarantee sampling result accuracy, improve sampling efficiency, but also improve its sealing performance through multilayer sealing design, has very high practicality.

The invention relates to a capsule for treating gynecological diseases and a preparation method thereof. The capsule is prepared from polygonum cuspidatum, sargentgloryvine stem, coptis chinensis, rhizoma bletillae, radix gentianae, dragon's blood, cuttlebone, rheum officinale, aloe, catechu, astragalus membranaceus, chloramphenicol and purified water. The capsule is prepared through a powder preparation process, a conventional vaginal medicine filling method is adopted for administration, the capsule is dissolved by virtue of vaginal secretion to release medicine, and the medicine acts on the vagina, the cervix uteri and the endometrium and directly reaches a focus, so that the effects of diminishing inflammation, sterilizing, resisting viruses, diminishing swelling, removing stasis and repairing mucosa are achieved; the traditional Chinese medicine composition can be used for treating colpitis mycotica, infectious microbe vaginitis, cervical erosion, cervicitis, HPV infection and endometritis. The capsule is a proved recipe inherited by several generations, has a good curative effect, takes traditional Chinese medicines as main raw materials, is added with a small amount of western medicines, has the advantages of benefiting and eliminating disadvantages, has no side effect, no preservative and no irritation, has an effective rate of 99% and a cure rate of 98%, and is worthy of popularization.

The invention discloses a vagina micro-ecology automatic detection system and method based on immunofluorescence microscopic scanning and AI analysis. The system comprises a fluorescence imaging module, a motion control module, an image processing module and an AI intelligent analysis module. The motion control module is used for bearing a vaginal secretion slide sample and controlling the vaginal secretion slide sample to move in a three-dimensional space, and is matched with the fluorescence imaging module to carry out full-automatic scanning; the image processing module is used for enhancing and de-noising the collected original fluorescence image so as to improve the image quality; the AI analysis module performs multi-target recognition and quantitative analysis on the processed image based on a deep learning algorithm, and counts the number and proportion of various bacteria and cells; and finally, automatically generating a micro-ecology assessment report according to clinical rules. The full-flow automatic and intelligent detection of the vaginal secretion sample is realized, the problems of strong subjectivity and low efficiency of manual microscopic examination are effectively solved, and higher sensitivity, specificity and repeatability in vaginitis diagnosis are realized.

The application discloses a kind of based on attention mechanism and multi-scale fusion's vaginitis pathogen cell detection method and system.The method will be obtained in advance vaginal secretion immunofluorescence microscopic image input training completed optimal pathogen detection model, output the detection result of recognition trichomonad, leukocyte, epithelial cell, clue cell and spore.The application is based on deep learning algorithm to realize the automatic high-efficiency accurate detection of vaginitis pathogen cell, improve the confirmed diagnosis rate of vaginitis, greatly reduce the probability of missed detection, misdiagnosis phenomenon in diagnosis process.According to pathogen cell detection result, simulate clinical diagnosis output, realize pathogen cell classification judgment, provide reliable basis for the automation auxiliary diagnosis of vaginitis.

This invention belongs to the field of biomedicine and discloses the application of HMOX1 inhibitors in the preparation of drugs for treating senile vaginitis. This invention is the first to discover that the content of the metabolite MESV1 (Guggulsterone) is significantly elevated in the vaginal secretions of patients with senile vaginitis. MESV1 induces ferroptosis in vaginal epithelial cells by upregulating HMOX1 protein expression, thereby driving the disease. Based on this, this invention proposes a novel therapeutic strategy targeting HMOX1. The inhibitors include shRNAs targeting HMOX1 (such as SEQ ID NO: 1-3), which can be prepared into vaginal gels, creams, and other dosage forms. Simultaneously, MESV1 can also be used to prepare auxiliary diagnostic kits. This invention provides a novel target and precise treatment approach for non-hormonal treatment of senile vaginitis.

The application discloses a composition for preventing and / or treating candidal vaginitis, and belongs to the field of medicine. It is found for the first time that a composition containing volatile oil of pachystachys jutna and total alkaloids of Sophora flavescens can significantly inhibit the adhesion and invasion ability of Candida albicans to VK2 / E6E7 cells. Meanwhile, in a mouse candidal vaginitis model, the composition can effectively reduce the vaginal fungal load of the mouse candidal vaginitis model, improve the pH value of vaginal secretion, and improve the inflammatory cell infiltration of the vaginal tissue, and has clinical popularization and application value.

The invention provides a quality control product for detecting vaginal secretion and a preparation method of the quality control product. The quality control product comprises a negative quality control product and a positive quality control product; the positive quality control product comprises 20-200 mM of a second basic buffer solution, 1-5% of a second enzyme protective agent, 0-0.04% of lactic acid, 0-0.005% of hydrogen peroxide, 0.01-0.1 U / mL of a second leukocyte esterase item, 0.02-0.1 U / mL of sialidase, 0.05-0.5 U / mL of a second N-acetylglucosaminidase item, 50-200 U / mL of a second oxidase item, 2-40 U / mL of a second coagulase item, 50-200 U / mL of beta-glucuronidase, 5-20 U / mL of proline aminopeptidase, 1-5 U / mL of a second alkaline phosphatase item and 0.2-0.2. And 1% of bovine serum albumin.

The application discloses Lactobacillus gasseri and a composition thereof for simultaneously improving female private health and skin aging, and belongs to the technical field of microorganisms.The application screens a Lactobacillus gasseri CCFM1313 from vaginal secretions of healthy women, the Lactobacillus gasseri CCFM1313 and the composition containing the Lactobacillus gasseri CCFM1313 and Paracaseiclovor CCFM1316 or a fermentation liquor thereof have the effects of repairing oxidative damage related symptoms caused by vaginitis and relieving skin aging.Therefore, the Lactobacillus gasseri CCFM1313 and the composition containing the Lactobacillus gasseri CCFM1313 and Paracaseiclovor CCFM1316 or the fermentation liquor thereof have great application prospects in products for improving and repairing oxidative damage caused by vaginitis and skin health problems caused by vaginitis.

The invention relates to the technical field of gynecological medical instruments, in particular to a vaginal secretion sampling device which comprises an intubation tube, a sampling assembly, a plurality of expansion assemblies, a plurality of push plates, a limiting frame and an adjusting assembly. One end of the intubation tube is open, and the sampling assembly sleeves the outer surface of the intubation tube. The plurality of expansion assemblies are arranged in the insertion pipe, and the plurality of push plates are arranged between the insertion pipe and the sampling assembly. The limiting frame is fixedly arranged at the open end of the insertion pipe and comprises a guide cylinder. The adjusting assembly comprises a position adjusting rod, the position adjusting rod is arranged in the guide cylinder and can slide along the inner wall of the guide cylinder, an ejector rod is fixedly arranged at the end, close to the insertion pipe, of the position adjusting rod, and the central axis of the guide cylinder, the central axis of the position adjusting rod and the central axis of the ejector rod are collinear with the central axis of the insertion pipe. When the device is used, the guide cylinder can limit the position adjusting rod to move along the central axis of the cannula all the time, the ejector rod cannot incline, and the sampling assembly can be uniformly stretched, so that the normal sampling process can be ensured, and the comfort of a female patient is improved.

The invention relates to a dry chemical detection device and a vaginal secretion analyzer, the dry chemical detection device comprises a multi-channel card pushing module, a curve transfer module, a lifting transfer module, a detection card pushing module and an incubation module, the multi-channel card pushing module, the curve transfer module, the lifting transfer module and the incubation module are installed in sequence; the detection card pushing module is used for switching detection cards among different stations of the curve transfer module, the lifting transfer module and the incubation module; the multi-channel card pushing module separates the stacked detection cards one by one through a plurality of independent pushing mechanisms, and conveys the single detection card to a corresponding station of the curve transfer module along a preset path; the curve transfer module comprises a driving assembly and a transfer assembly, and the driving assembly is a single driving source and is used for providing power for the transfer assembly; the transfer assembly is used for carrying out horizontal and lifting motion on the detection card. The detection flux and the operation efficiency are synergistically improved, the overall size and the space occupancy rate of equipment are remarkably reduced, and the cost is greatly reduced.