The invention relates to a system and method for controlling excrement and urine of poultries and placentae of disease-caused dead poultries in a large-scale farm. The system comprises a source separated poultry house, a solid-liquid separation system, a liquid high-temperature aerobic fermentation system, a solid fermentation system, a stink-flue gas treatment system, a circulating water system and a detection control system, wherein the source separated poultry house is a poultry house in which rainwater and sewage are separated, drinking water and sewage are separated, and fence flushing water and the excrement and urine of the poultries are separated; the solid-liquid separation system comprises a excrement collecting pool, a sludge pump and a solid-liquid separation device; the liquid high-temperature aerobic fermentation system comprises a liquid thermal-insulation fermentation reactor; the stink-flue gas treatment system comprises a stink heat exchange condenser, a flue gas heat exchange condenser, a biological deodorization filter tower, an aeration fan, an air blower and an induced draft fan; and the detection control system comprises a material temperature sensor, a material level sensor, a pressure sensor, a water temperature sensor and a controller. According to the system, the harmless treatment, the reduction and the recycling are realized, the environment is protected, and the energy is saved.