The application discloses a marine-source
collagen fiber hemostatic
sponge and a preparation method thereof, and belongs to the field of biomedical materials. The preparation method is as follows: a true sea
moss is
cut open, a bag is removed, internal tissues are taken out, and digests, excrements and the like are removed after washing; the internal tissues are
cut into pieces and then added into a NaCl solution, and are placed at 0-4 DEG C for 6-18 hours;
urea solution is added after
filtration and cleaning; a high-speed
homogenizer is used for primary stirring to obtain a collagen-
urea blend solution, and the solution is frozen and then thawed at 4 DEG C for 5-15 minutes; a high-speed
homogenizer is used for secondary stirring; and finally, a vacuum
filter press is used for
solid-liquid separation of the solution to obtain collagen fibers; the collagen fibers are dispersed in water, and freeze-
drying is carried out to obtain the
collagen fiber hemostatic
sponge. The application provides a porous hemostatic
sponge with a capillary rapid liquid
absorption capacity, which has the advantages of rapid preparation, low economic cost, ecological friendliness in a whole life cycle, strong liquid absorption, good hemostatic effect and low
hemolysis rate.