74 results about "Cimicifuga foetida" patented technology

The invention provides a traditional Chinese medicine composition for treating acute altitude sickness. The traditional Chinese medicine composition is prepared from ginseng, astragalus membranaceus, acanthopanax, rhodiola rosea, turnip, salvia miltiorrhiza, dogwood, poria cocos, rhizoma cimicifugae, radix bupleuri, platycodon grandiflorum, aster, elecampane, rhizoma anemarrhenae and liquorice. The traditional Chinese medicine composition disclosed by the invention can be used for treating the acute altitude sickness, remarkably prolonging the load-bearing swimming time of rats, remarkably increasing the arterial oxygen partial pressure and the arterial oxygen saturation of acute altitude sickness model rats and relieving physical fatigue, has obvious effects of resisting anoxia, improving acid-base balance and resisting inflammation, and has obvious curative effects on myocardial injury, liver injury, liver injury and the like. And the kidney injury can be protected.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for improving systemic lupus erythematosus and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15-30 parts of dry rehmannia, 12-26 parts of calcined turtle shell, 13-25 parts of chicken tendon ginseng, 11-18 parts of red peony root, 10-20 parts of white flower snake tongue grass, 6-18 parts of small rosmarinus officinalis, 4-15 parts of artemisia annua, 5-10 parts of centella asiatica, 4-12 parts of cimicifuga foetida, 3-10 parts of coix seed, 2-9 parts of bergamot slice, and 3-7 parts of raw licorice. Test results show that the traditional Chinese medicine composition for improving systemic lupus erythematosus prepared by the application can inhibit the expression of IL-10 and IL-17 in serum, reduce anti-dsDNA antibodies in serum, significantly improve the clinical symptoms of systemic lupus erythematosus, and has a wide application prospect.

The invention belongs to the technical field of traditional Chinese medicine compositions, and discloses a traditional Chinese medicine composition suitable for myasthenia patients and a preparation method and application thereof. The traditional Chinese medicine is prepared from the following traditional Chinese medicine raw materials in parts by weight: 15-60 parts of astragalus membranaceus, 15-60 parts of humulus scandens, 10-30 parts of philippine flemingia root, 10-30 parts of beautiful millettia root, 10-20 parts of codonopsis pilosula, 5-15 parts of poria cocos, 5-15 parts of bighead atractylodes rhizome, 3-10 parts of liquorice, 5-15 parts of rhizoma cimicifugae, 5-15 parts of radix bupleuri, 5-15 parts of radix angelicae sinensis and 3-10 parts of pericarpium citri reticulatae. The invention solves the technical problems that the existing muscle-strengthening medicine has a limited improvement effect on symptoms such as blepharoptosis, dysphagia, weakness of limbs, soreness and weakness of waist and knees, unstable standing, difficulty in walking and the like caused by deficiency of spleen and stomach and deficiency of lower jiao kidney essence, and is not suitable for patients with fire excess from yin deficiency, liver-yang hyperactivity constitution and dampness stagnation.

The invention discloses a traditional Chinese medicine composition for chronic obstructive pulmonary disease and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by mass: main medicines: 15-30 parts of radix rehmanniae preparata and 3-9 parts of semen allii tuberosi; auxiliary medicines: 10-30 parts of ginseng, 15-30 parts of astragalus membranaceus, 6-12 parts of ganoderma sinense, 6-12 parts of bighead atractylodes rhizome and 3-6 parts of schisandra chinensis; adjuvant drugs: 6-12 parts of radix ophiopogonis, 6-10 parts of rhizoma anemarrhenae, 6-10 parts of radix cyathulae and 6-10 parts of platycodon grandiflorum; and conductant drugs: 3-6 parts of radix bupleuri and 3-6 parts of rhizoma cimicifugae. The composition directly refers to the core pathogenesis of lung-kidney deficiency, the adjuvants reinforce lung and kidney tonifying, spleen strengthening and superficies consolidating, the adjuvants have the effects of nourishing yin, moistening dryness, reducing phlegm and activating blood, and the medicines prevent tonifying and stagnation, are orderly in lifting and descending and promote synergistic efficacy.

The invention discloses a medicated diet composition for improving haemorrhoids and a preparation method thereof, and belongs to the field of traditional Chinese medicine, the medicated diet composition is specially used for qi deficiency and blood deficiency type haemorrhoids, and the medicated diet composition is prepared from the following raw materials in parts by mass: 15-30 parts of hairyvein agrimony, 50-80 parts of streaky pork, 15-30 parts of astragalus membranaceus, 10-20 parts of angelica sinensis, 6-10 parts of rhizoma cimicifugae, 100-150 parts of Chinese yam, 6-10 parts of pericarpium citri reticulatae and 10-15 parts of hawthorn. The traditional Chinese medicine composition realizes precise conditioning of homology of medicine and food, not only exerts the treatment effects of tonifying qi and lifting, nourishing blood and stopping bleeding through the medicinal materials, but also supplements nutrition and assists in improving the qi and blood deficiency state by means of food materials, solves the problem that patients of the type need long-term independent conditioning after conventional medicine treatment, and gives consideration to the synergistic effect of treatment and deficiency tonifying.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine oral ulcer patch and a preparation method thereof. The application provides a traditional Chinese medicine oral ulcer patch, wherein the patch comprises a drug-containing layer and an isolation layer which are sequentially arranged in layers; according to mass fractions, the drug-containing layer comprises 4-8 parts of bletilla striata polysaccharide, 7-14 parts of bletilla striata powder or 14-28 parts of bletilla striata decoction, 16-32 parts of indigo extract, 8-16 parts of cimicifuga foetida extract, 8-16 parts of mentha extract, 0.5-2 parts of tea polyphenol, 10-15 parts of glycerol and 1-2 parts of sodium carboxymethyl cellulose; and the isolation layer comprises 10-15 parts of glycerol and 20-30 parts of polyvinyl alcohol. The oral ulcer double-layer patch prepared from pure traditional Chinese medicine is mild, safe and reliable, has good healing effect, long-acting effect, simple preparation and low cost, and has a wide application prospect.

The present invention relates to a composition for enhancing immunity, containing Cheongwi-san as an active ingredient. The Cheongwi-san of the present invention is a mixed herbal medicine extract consisting of Cimicifuga heracleifolia, Moutan Radicis Cortex, Angelica gigas, Coptis Rhizome, and fresh root of Rehmannia glutinosa. The Cheongwi-san of the present invention has excellent effects of increasing the activity of NK cells, increasing the production amounts of IFN-γ and TNF-α, and reducing the survival rate of cancer cells, and has the effect of inhibiting influenza virus infection, and thus can be effectively used as a health functional food for enhancing immunity, a feed additive for animals for enhancing immunity, or a pharmaceutical product for preventing and treating diseases caused by decreased immunity.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition and a preparation method and application thereof. The traditional Chinese medicine composition comprises astragalus membranaceus, bighead atractylodes rhizome, rehmannia, angelica sinensis, bran-fried immature bitter orange, platycodon grandiflorum, radix ophiopogonis, radix scrophulariae, semen raphani, trichosanthes kirilowii maxim, elecampane, fructus cannabis, fried spina date seed, bunge cherry seed, platycladi seed, bupleurum chinense, cimicifugae foetidae and honey-fried licorice root. And prophase research proves that the traditional Chinese medicine composition for treating STC constipation is satisfactory in clinical curative effect, small in side effect and worthy of popularization when being used for treating STC constipation.

The invention discloses a traditional Chinese medicine composition for preventing and treating insomnia due to yang deficiency. The traditional Chinese medicine composition is mainly prepared from prepared rehmannia root, semen cuscutae, fructus psoraleae, radix aconiti carmichaeli, wine-processed radix bupleuri, rhizoma cimicifugae, cassia twig, herba taxilli, herba cistanche, pericarpium citri reticulatae, radix acanthopanacis senticosi and the like according to a certain weight ratio. The traditional Chinese medicine can be prepared into any common oral dosage form. The whole formula has the effects of warming kidney to strengthen yang, boosting essence and filling marrow, raising yang and transforming qi, warming channel and strengthening spleen, regulating qi and Chong, nourishing heart and tranquilizing mind, and has an exact curative effect of preventing and treating insomnia due to yang deficiency.

The invention belongs to the technical field of traditional Chinese medicine pharmacy, and particularly relates to a rhizoma cimicifugae extract grading treatment device. The invention discloses a rhizoma cimicifugae extract grading treatment device, and aims to solve the problems that in the prior art, a rhizoma cimicifugae extract is easy to agglomerate, thermosensitive components are easy to degrade, the grading precision is greatly influenced by flow field fluctuation, and the continuous production stability is poor. The device comprises a multi-dimensional pre-dispersion unit, a low-temperature controlled grading cavity, a dynamic balance centripetal moment adjusting mechanism, a self-adaptive anti-adhesion lining system and a closed-loop circulation flow control system. Through the synergistic effects of high-frequency sound field pre-dispersion, low-temperature jacket temperature control, centrifugation-air resistance dynamic balance separation, micro-vibration adhesion prevention and the like, efficient protection and accurate classification of triterpenoid saponin and phenolic acid components are achieved. The grading precision, the drug effect retention rate and the continuous operation stability can be remarkably improved, and the method is suitable for precise grading of the heat-sensitive traditional Chinese medicine extract.

The invention discloses a long-term stable homogeneous middle-Jiao and Qi tonifying oral liquid and a preparation process thereof, and belongs to the technical field of Chinese patent medicine production. The oral liquid is prepared from genuine traditional Chinese medicinal materials such as astragalus membranaceus, codonopsis pilosula, liquorice, angelica sinensis, rhizoma atractylodis macrocephalae, rhizoma cimicifugae, radix bupleuri, pericarpium citri reticulatae, ginger and Chinese dates through compatibility, the oral liquid inherits a classic famous formula, and a sweetening agent, a preservative and a pH regulator are added; the preparation method of the product comprises the following steps: treating medicinal materials, decocting and extracting twice, concentrating in stages, performing alcohol precipitation treatment, concentrating twice, preparing and adjusting pH, filtering and filling in multiple stages, sterilizing and the like. According to the invention, by optimizing the formula and the production process, the generation of precipitates is effectively reduced, the uniformity and stability of the preparation are improved, the high retention rate of main active components is ensured, irreversible precipitates are not easy to appear during the storage period of the product, and the preparation has a good application prospect.

This invention discloses a traditional Chinese medicine composition for assisting in the improvement of hand-foot-mouth disease in infants and young children, belonging to the field of traditional Chinese medicine technology. The composition consists of eight medicinal herbs: lotus leaf, coix seed, angelica dahurica, kudzu root, platycodon root, agastache rugosa, cimicifuga rhizome, and dandelion, with a defined optimal medicinal ratio. Based on the seasonal differences in the pathogenesis of hand-foot-mouth disease, this invention targets the core pathologies of winter (cold congestion of microvessels, water and sodium retention, and internal heat generation) and spring and summer (hypothalamic sympathetic activation, increased heart rate, and visceral heat overload). It also addresses the technical deficiencies of clinical Western medicine, cold-natured traditional Chinese medicine, calamine lotion, and diuretics, such as vasoconstriction, kidney damage, central nervous system disorders, increased skin exudation, and rebound water retention. This invention employs a combination of warming and cooling herbs, regulating the ascending and descending functions, and promoting diuresis and protecting the body's vital energy. The synergistic effects of these herbs can dilate spasmodic microvessels, improve renal perfusion, stabilize abnormal heart rates, stabilize the hypothalamic center, and assist in antagonizing enteroviruses. By targeting and reducing abnormal permeability of skin capillaries with Angelica dahurica and Platycodon grandiflorus, it reduces blood extravasation and inhibits the formation and exudation of herpes from the root cause. This invention has mild medicinal properties, is suitable for all seasons, and has high safety. It can effectively improve symptoms of hand-foot-mouth disease such as fever, herpes, irritability, and cold extremities, reduce the risk of severe illness, antagonize the toxic side effects of commonly used clinical drugs, and is suitable for the delicate constitution of infants and young children, possessing good prospects for clinical application and promotion.

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating toothache and a preparation method thereof. The traditional Chinese medicine composition for treating toothache is prepared from the following raw materials in parts by weight: 3 to 4 parts of radix angelicae sinensis, 3 to 4 parts of radix rehmanniae recen, 5 to 7 parts of rhizoma cimicifugae, 2 to 4 parts of cortex moutan, 2 to 4 parts of gypsum and 4 to 5 parts of rhizoma coptidis from Sichuan of China. The traditional Chinese medicine composition for treating toothache is scientific and reasonable in compatibility, can perform targeted pain relieving treatment on different parts of teeth, can stabilize the teeth and promote secondary growth of the teeth, and solves the problems of non-fine treatment and single effect in the prior art. The preparation method of the traditional Chinese medicine composition for treating toothache is simple and easy to control, and large-scale production is facilitated.

The invention relates to a traditional Chinese medicine composition for treating qi-stagnation and body fluid deficiency and blood-deficiency dampness loss type intestinal pseudoobstruction, which can effectively solve the medication problem of the qi-stagnation and body fluid deficiency and blood-deficiency dampness loss type intestinal pseudoobstruction. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine raw materials by weight: radix asteris, semen raphani, fructus aurantii, radix rehmanniae, herba cistanche, angelica sinensis, peach kernels, fructus cannabis, rhizoma cimicifugae and liquorice, and is prepared by soaking the raw materials in water, boiling with strong fire, decocting with slow fire, filtering and concentrating. The traditional Chinese medicine composition disclosed by the invention is matched and mutually supported according to a main and secondary relationship of monarch, minister, assistant and guide, is scientifically prepared, has the effects of promoting qi circulation, nourishing yin, nourishing blood and moistening intestines, is convenient to take and good in effect, is a new breakthrough in medicines for treating qi stagnation, fluid deficiency and blood deficiency type intestinal pseudoobstruction, and has practical popularization and application values.

The application discloses a method for detecting the content of a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises angelica, radix cyathulae, cistanche, alisma, radix clematidis and fructus aurantii; the method comprises: taking a traditional Chinese medicine composition test sample solution to perform HPLC detection, and the chromatographic conditions comprise: adopting a C18 chromatographic column, taking acetonitrile as mobile phase A, and taking a 0.1% concentration phosphoric acid aqueous solution as mobile phase B; the elution in the chromatographic conditions of the HPLC detection is gradient elution, and the gradient elution program is as follows: 0-35 min, the mobile phase is 12% A, 35-40 min, the mobile phase is 12%-16% A, 40-60 min, the mobile phase is 16%-16.5% A, 60-70 min, the mobile phase is 16.5%-20% A, 70-75 min, the mobile phase is 20% A, 75-76 min, the mobile phase is 20%-90% A, 76-90 min, the mobile phase is 90% A. The content of the chemical components contained in the traditional Chinese medicine composition is detected by the method, a content determination method of the granules is established, and the quality of the granules can be comprehensively reflected, so that the whole preparation quality can be described and evaluated.

The invention provides a traditional Chinese medicine composition for treating rash, a medicinal preparation and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition comprises the following components: radix rehmanniae, radix ophiopogonis, radix scutellariae, fried tribulus terrestris, fructus kochiae, cortex lycii radicis, radix scrophulariae, radix puerariae, rhizoma cimicifugae, radix paeoniae alba, radix saposhnikoviae and liquorice. The traditional Chinese medicine composition and the medicinal preparation provided by the invention have the effects of removing heat to cool blood and nourishing yin to dispel wind, and can be used for treating rash, especially yin deficiency and internal heat type chronic rash with symptoms of dry and erythema of skin, severe itching at night and red tongue with little tongue fur.

This invention relates to the field of traditional Chinese medicine technology, and in particular to a combined formula for strengthening the spleen and calming the mind. The formula includes a daytime spleen-strengthening formula and a nighttime calming formula. The daytime spleen-strengthening formula includes: Astragalus membranaceus 10-30g, Codonopsis pilosula 10-20g, Atractylodes macrocephala 10-20g, Angelica sinensis 6-12g, Citrus reticulata 6-10g, Cimicifuga foetida 3-6g, Bupleurum chinense 6-15g, Pinellia ternata 6-12g, Scutellaria baicalensis 6-15g, Agrimonia pilosa 15-35g, Ziziphus jujuba var. spinosa 10-20g, and Glycyrrhiza uralensis 3-10g. The nighttime calming formula includes: Bupleurum chinense 6-15g, Paeonia lactiflora 10-20g, Os draconis 15-35g, Ostrea gigas 15-35g, Ziziphus jujuba var. spinosa 10-30g, Polygonum multiflorum vine 15-30g, Pinellia ternata 6-12g, Scutellaria baicalensis 6-15g, Codonopsis pilosula 10-20g, Poria cocos 10-20g, Atractylodes macrocephala 10-20g, Albizia julibrissin 5-10g, Ziziphus jujuba var. spinosa 10-20g, and Glycyrrhiza uralensis 3-10g. This combined formula for strengthening the spleen and calming the mind is applied at different times, day and night: The daytime formula for strengthening the spleen targets the pathogenesis of "qi deficiency and failure of clear yang to rise" during the day, using the method of tonifying the middle and replenishing qi to boost function and improve daytime energy and physical strength; The nighttime formula for calming the mind targets the pathogenesis of "liver stagnation, floating yang, and disturbed mind" at night, using the method of heavy calming to guide yang into yin and promote sleep.

A wild-imitating cultivation method for under-forest cimicifuga foetida comprises the following steps: 1) forest land selection: selecting a forest land with the coverage of 40-80%; 2) soil preparation and fertilization; 3) transplanting plantlets: transplanting cimicifuga foetida with the seedling age of 3-5 years, dipping roots with a bactericide before transplanting, covering with soil after transplanting, treading tightly, and watering sufficiently; 4) field management; 5) harvesting and seedling stage management: starting to harvest fresh and tender stems of the cimicifuga foetida in the second year after transplanting, covering the seedlings with organic detritus sandy soil after the cimicifuga foetida is unearthed, performing shading treatment to prevent lignification of the fresh and tender stems, and when leaves of part of branches of the cimicifuga foetida grow out of the covered organic detritus sandy soil heap and the leaves are about to unfold, covering the seedlings with the organic detritus sandy soil heap with the covering height of 20-25cm to prevent lignification of the fresh and tender stems. Removing the organic detritus sand soil heap, cutting off the fresh and tender stems close to the earth surface, then recovering the organic detritus sand soil heap, keeping 3-5 branches for each cluster of cimicifuga foetida, and ensuring the later growth of the cimicifuga foetida; according to the method, the growth condition of the cimicifuga foetida is good, the harvesting period is long, and the yield is high.

The invention belongs to the technical field of traditional Chinese medicine compositions and cosmetics, and discloses a repairing type Chinese herbal medicine compound lip mask and a preparation method and application thereof. The lip mask is prepared by compounding fifteen Chinese herbal medicines including wintersweet flowers, honeysuckle flowers, cortex lycii radicis, poria peel, white mulberry root-bark, wild chrysanthemum flowers, almonds, angelica sinensis, radix arnebiae seu lithospermi, radix semiaquilegiae, dandelions, herba violae, gypsum, fructus forsythiae and rhizoma cimicifugae with an aloe extracting solution and performing precipitation and refining through chitosan. The lip care solution is suitable for dry, sensitive and damaged lip skin care.

This invention provides an extract of *Cimicifuga foetida*, made from *Cimicifuga foetida* produced in Guizhou Province, using an intermittent warm percolation method for water extraction. The extract contains 10%-25% cimicifugoside, 3%-15% iso-cimicifugoside, and 20%-50% plantago asiatica glycoside. The preparation method and applications are also disclosed. The *Cimicifuga foetida* extract provided by this invention has a high content of active ingredients and significant anti-inflammatory and litholytic pharmacological activities. It can be used as a raw material for the treatment and adjuvant treatment of cholecystitis, gallstones, hydronephrosis, kidney stones, nephritis, bladder stones, and uric acid stones. It can also be used as an intermediate raw material for the separation and purification of plantago asiatica glycoside, cimicifugoside, and iso-cimicifugoside chemical standards or reference standards. The preparation method provided by this invention effectively solves the problem of extraction and enrichment of active ingredients in *Cimicifuga foetida*, and has advantages such as low production cost, ease of large-scale production, and stable and controllable quality.

The invention discloses an external traditional Chinese medicine composition for treating joint soft tissue pain and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: 1) arisaema cum bile and radix aconiti carmichaeli; the mass ratio of the two components is (1-1.2): 1; 2) pericarpium zanthoxyli, radix aucklandiae, fructus psoraleae, rhizoma cimicifugae, cortex cinnamomi, radix angelicae, rhizoma zingiberis, ligusticum wallichii, cortex erythrinae, radix clematidis, rhizoma corydalis, szechwan chinaberry fruit and clove; the mass ratio of the thirteen traditional Chinese medicines is 1: (0.8-1): (1-1.2): 1: (1-1.2): 1: (1-1.2): (1-2): 1: (1-2): 1: (1-2): 1: 1. The mass ratio of the folium artemisiae argyi to the pawpaw is 1: (1-1.5), and the ratio of the sum of the mass of the traditional Chinese medicines in the first group, the second group and the third group is 1: 13: 3. The traditional Chinese medicine composition provided by the invention has the efficacy of improving the heat pain area of mice, and can be widely popularized and applied to arthralgia diseases clinically so as to achieve the effects of relaxing the muscles, stimulating the blood circulation and relieving pain.

This invention relates to the field of traditional Chinese medicine preparations, and discloses a Tongli capsule and its preparation process, comprising the following raw materials: Eupolyphaga sinensis, processed Arisaema heterophyllum, vinegar-processed frankincense, vinegar-processed myrrh, dragon bone, Angelica dahurica, Lysimachia christinae, safflower, Notopterygium incisum, Angelica sinensis, Saposhnikovia divaricata, Cimicifuga foetida, Ligusticum chuanxiong, and Acorus tatarinowii; wherein, the raw materials are dried, pulverized, mixed, and then filled into capsule shells to form capsules. This Tongli capsule, using a total of fourteen traditional Chinese medicines as raw materials, follows the treatment principles of traditional Chinese medicine of dispelling wind and dampness, relaxing muscles and tendons, and promoting blood circulation and removing blood stasis. It has significant efficacy for late-stage fractures and joint dislocations, joint pain, synovitis, and other diseases caused by wind-cold-dampness obstructing the meridians. Furthermore, the capsule dosage form, with its uniform fine powder contents, makes it convenient to take, provides accurate dosage, has high bioavailability, and improves patient compliance. Compared to decoctions, capsules do not require decocting, making them easier to carry and store; compared to pills and powders, capsules can mask unpleasant odors of the medicine, and disintegrate rapidly, resulting in faster onset of action.

The application discloses a eucommia ulmoides oliver particle for treating osteopenia, which is prepared from the following raw materials in a weight ratio: eucommia ulmoides oliver 25-35 parts, rehmannia 20-30 parts, yam 18-22 parts, rhizoma discontinuorum 20-30 parts, myrrh 18-22 parts, chuanxiong 20-30 parts, panax notoginseng 15-25 parts, safflower 18-22 parts, white atractylodes 20-30 parts, poria cocos 20-30 parts, astragalus 25-35 parts, ginseng 20-30 parts, polygonatum 18-22 parts, dendrobium 15-25 parts, notopterygium 18-22 parts, angelica pubescens 20-30 parts, rhizoma cimicifugae 20-30 parts, siler 18-22 parts, which is capable of tonifying liver and kidney, promoting blood circulation, invigorating spleen and stomach, and dispelling wind and dampness, so as to achieve the purpose of treating osteopenia caused by kidney deficiency and blood stasis, and a preparation method thereof.

This invention belongs to the field of biomedical technology, specifically disclosing the application of cimicifuga in the preparation of drugs for treating periodontitis. Specifically, it relates to the application of cimicifuga in the preparation of drugs for treating periodontitis; and the application of cimicifuga in the preparation of drugs for treating alveolar bone defects (periodontal bone defects) caused by periodontitis. It also relates to the application of cimicifuga in the preparation of products for inhibiting macrophage polarization towards M1 and / or promoting macrophage polarization towards M2 in a single macrophage system. In this disclosure, cimicifuga has no significant toxicity to macrophages and has high safety; it targets and regulates macrophage polarization, inhibiting periodontal inflammation at its source; it significantly reduces inflammatory infiltration and osteoclast formation in periodontal tissues, effectively alleviating alveolar bone defects; and it provides a novel targeted immunotherapy drug for periodontitis, expanding the clinical application of single traditional Chinese medicine monomers.

This invention discloses a fermented traditional Chinese medicine product, its preparation method, and its application, belonging to the field of traditional Chinese medicine fermentation technology. The product uses peppermint, astragalus, wolfberry, mulberry bark, anemarrhena, arborvitae leaf, scrophularia, cimicifuga, elsholtzia, angelica, lily, ginkgo, licorice, schisandra, eleutherococcus senticosus, ophiopogon japonicus, and dried ginger as raw materials, sorghum as a co-fermentation raw material, and brewing liquid as a fermentation enhancer. The process involves pretreatment of the traditional Chinese medicine, co-cooking with sorghum, saccharification with small-grain starter, segmented fermentation, extraction and purification, and post-treatment. This invention utilizes a "compound traditional Chinese medicine ~ sorghum" co-fermentation system, combined with the microbial community and active substances rich in brewing liquid, to increase the dissolution rate of active ingredients such as astragaloside A, lily polysaccharide, and wolfberry polysaccharide in the traditional Chinese medicine by more than 50%, while simultaneously converting them into easily absorbed small molecule derivatives. The finished product has an alcohol content controlled at 6-8 degrees, which not only promotes the absorption of active ingredients but also possesses synergistic effects of clearing the lungs and regulating qi, tonifying qi and benefiting the lungs, moistening the lungs and relieving cough, and clearing heat and resolving phlegm. The process enables the resource utilization of yellow water from brewing, reducing costs by 35%, and the product exhibits excellent stability, making it suitable for industrial production. It also has significant value in the field of lung function regulation and health care.

The invention discloses Yao-strengthening ointment for improving immune disorder of an HIV infected person. The Yao-strengthening ointment is mainly prepared from the following raw materials: astragalus membranaceus, poria cocos, rhizoma cimicifugae, radix achyranthis bidentatae, roasted ephedra, prepared radix aconiti carmichaeli, asarum, roasted liquorice, philippine flemingia root, giantleaf ardisia rhizome, caulis sinomenii, tripterygium wilfordii and gynostemma pentaphylla. The preparation method of the Zhuang Yao ointment comprises the steps of medicinal material treatment, medicinal material extraction and ointment preparation. The whole formula is mainly used for strengthening the body resistance (tonifying qi and warming yang) and eliminating evil (dehumidifying, activating blood and detoxifying), through the compatibility of monarch, minister, assistant and guide, the traditional Chinese medicine aims at core qi deficiency and yang deficiency of immune disorder of HIV infected people and also eliminates pathological products such as dampness, stasis and heat toxin, meanwhile, honey-fried licorice root is used for regulating the medicine property, CD4 cells of the HIV infected people can be improved, immune disorder can be improved to a certain extent, and immune reconstitution is promoted.

The application discloses a traditional Chinese medicine composition for tonifying kidney, promoting blood circulation and nourishing fetus, which comprises an external ointment and an internal medicine, wherein the external ointment is prepared from specific proportion of taxilli herba, rhizoma discontinu, semen euryales, radix codonopsis, rhizoma atractylodis, fried lentil, rhizoma dioscoreae, amomum villosum, radix puerariae, dendrobium, angelica sinensis, salvia miltiorrhiza, cortex moutan, chuanxiong rhizome, radix astragali, frankincense, myrrh, radix angelicae, and zanthoxylum bungeanum; and the internal medicine is prepared from specific proportion of semen euryales, cornus officinalis, ligustrum lucidum, eucommia ulmoides, taxilli herba, fried radix atractylodis, rhizoma discontinu, amomum villosum, radix codonopsis, rhizoma cimicifugae, herba agastache, radix puerariae, dendrobium, angelica sinensis, salvia miltiorrhiza, cortex moutan, radix notoginseng and radix ophiopogonis. The application can treat the root and branch by oral administration and external application on blood sea, yinlingquan and san yin jiao, has the effects of benefiting qi and blood, nourishing yin and promoting blood circulation, and can improve the blood supply of uterus during pregnancy, and is used for treating the symptoms of vaginal bleeding during pregnancy, slow embryo development, less moss and fine and smooth pulse caused by deficiency of qi and blood, deficiency of kidney yin and stagnation of qi and blood.

The invention discloses application of a compound Cimiracemoside C in preparation of a medicine for treating and / or preventing systemic lupus erythematosus, the molecular formula of the Cimiracemoside C is C35H56O9, the Cimiracemoside C is used for inhibiting phosphorylation of Erk signals and promoting T cell apoptosis, so that production of autoantibodies is reduced, progress of systemic lupus erythematosus is relieved, and an effective treatment means with small side effects is provided. The traditional Chinese medicine monomer Cimiracemoside C can effectively promote T cell apoptosis, and compared with a compound traditional Chinese medicine, the traditional Chinese medicine monomer Cimiracemoside C has more advantages in efficacy control and curative effect evaluation due to use of a single component. In addition, Cimiracemoside C is derived from rhizoma cimicifugae, is low in cost and free of toxic and side effects, and is very suitable for treating systemic lupus erythematosus for a long time.

This invention belongs to the field of traditional Chinese medicine technology, and particularly relates to a traditional Chinese medicine composition and its application for the prevention and / or treatment of atrial arrhythmias. The composition comprises the following medicinal materials: raw Astragalus membranaceus, Ophiopogon japonicus, Platycodon grandiflorus, Cimicifuga foetida, Bupleurum chinense, Platycladus orientalis seed, Sophora flavescens, Imperata cylindrica root, raw ginseng, raw dragon bone, and raw oyster shell. The composition effectively improves palpitations, chest tightness, and shortness of breath caused by atrial arrhythmias. Its raw materials are mild, the proportions are reasonable, and the materials are inexpensive and readily available, making it suitable for large-scale production.