Traditional Chinese medicine composition for treating chronic pharyngitis and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic pharyngitis and application of the traditional Chinese medicine composition, and belongs to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition comprises the following components in parts by weight: 10-20 parts of radix glehniae, 10-20 parts of radix ophiopogonis, 10-20 parts of radix scrophulariae, 10-20 parts of radix salviae miltiorrhizae, 15-25 parts of radix rehmanniae, 15-25 parts of radix paeoniae rubra, 20-30 parts of rhizoma cimicifugae, 1-8 parts of liquorice and 10-20 parts of semen sesami nigrum. The traditional Chinese medicine composition blocks the case development of chronic pharyngitis from the two aspects of tonifying deficiency and removing stasis, plays a good role in treating chronic pharyngitis, and effectively solves the problems existing in the prior art.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating chronic pharyngitis and application thereof. Background Art

[0002] Pharyngitis refers to an inflammatory disease of the pharyngeal mucosa, submucosal tissue and lymphoid tissue. It is a common upper respiratory tract disease and can be divided into acute pharyngitis and chronic pharyngitis. Chronic pharyngitis is manifested by a foreign body sensation, itching, burning, dryness or slight pain in the pharynx; frequent irritating coughs may occur in the morning, accompanied by a small amount of white sticky sputum, and in severe cases, nausea, but no obvious sputum or hemoptysis; examination of the pharynx can reveal chronic congestion of the mucosa, granular proliferation of lymphoid follicles on the posterior pharyngeal wall, or thickening of the lateral pharyngeal cords. In some patients, sticky secretions can be seen adhering to the posterior pharyngeal wall. The clinical characteristics are mainly characterized by pharyngeal discomfort as the core symptom, mild systemic symptoms, and easy recurrence. The onset of chronic pharyngitis is mostly related to long-term local irritation (smoking, dust, etc.) or autoimmune factors.

[0003] Chronic pharyngitis can be treated by gargling with liquid, taking lozenges, using sprays, etc., but these can only temporarily relieve pharyngeal symptoms and cannot achieve a cure. It can also be treated by using traditional Chinese medicine prescriptions or Chinese patent medicines that clear heat and detoxify, nourish yin and relieve pharyngeal pain, but there are also problems with insignificant efficacy and a long treatment cycle. Summary of the Invention

[0004] In view of the above-mentioned deficiencies in the prior art, the present invention provides a traditional Chinese medicine composition for treating chronic pharyngitis and its application. The traditional Chinese medicine composition blocks the progression of chronic pharyngitis from the aspects of tonifying deficiency and removing blood stasis, exerts a good therapeutic effect on chronic pharyngitis, and effectively solves the problems existing in the prior art.

[0005] To achieve the above-mentioned purpose, the technical solution adopted by the present invention to solve the technical problem is:

[0006] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 10-20 parts of Glehnia littoralis, 10-20 parts of Radix Ophiopogonis, 10-20 parts of Scrophulariae ningpoensis, 10-20 parts of Salvia miltiorrhiza, 15-25 parts of Rehmannia glutinosa, 15-25 parts of Paeonia lactiflora, 20-30 parts of Cimicifuga heracleifolia, 1-8 parts of Licorice root and 10-20 parts of Black sesame.

[0007] Further, the invention comprises the following components in parts by weight: 13-17 parts of Adenophora adenophora, 13-17 parts of Ophiopogon japonicus, 13-17 parts of Scrophularia ningpoensis, 13-17 parts of Salvia miltiorrhiza, 18-22 parts of Rehmannia glutinosa, 18-22 parts of Paeonia lactiflora, 23-27 parts of Cimicifuga heracleifolia, 3-7 parts of Licorice root and 13-17 parts of Black sesame.

[0008] Furthermore, the invention comprises the following components in parts by weight: 13 parts of Adenophora adenophora, 15 parts of Ophiopogon japonicus, 17 parts of Scrophularia ningpoensis, 13 parts of Salvia miltiorrhiza, 18 parts of Rehmannia glutinosa, 22 parts of Paeonia lactiflora, 23 parts of Cimicifuga heracleifolia, 3 parts of Licorice and 17 parts of Black Sesame.

[0009] Furthermore, the invention comprises the following components in parts by weight: 17 parts of Adenophora adenophora, 13 parts of Ophiopogon japonicus, 15 parts of Scrophularia ningpoensis, 17 parts of Salvia miltiorrhiza, 22 parts of Rehmannia glutinosa, 18 parts of Paeonia lactiflora, 27 parts of Cimicifuga heracleifolia, 7 parts of Licorice root and 13 parts of Black sesame.

[0010] Furthermore, the invention comprises the following components in parts by weight: 15 parts of Adenophora adenophora, 17 parts of Ophiopogon japonicus, 13 parts of Scrophularia ningpoensis, 14 parts of Salvia miltiorrhiza, 20 parts of Rehmannia glutinosa, 21 parts of Paeonia lactiflora, 26 parts of Cimicifuga heracleifolia, 6 parts of Licorice root and 16 parts of Black sesame.

[0011] Furthermore, the invention comprises the following components in parts by weight: 15 parts of Adenophora adenophora, 15 parts of Radix Ophiopogonis, 15 parts of Scrophulariae ningpoensis, 15 parts of Salvia miltiorrhiza, 20 parts of Rehmannia glutinosa, 20 parts of Paeonia lactiflora, 25 parts of Cimicifuga heracleifolia, 5 parts of Licorice and 15 parts of Black Sesame.

[0012] Application of the above-mentioned traditional Chinese medicine composition for treating chronic pharyngitis in preparing medicine for treating chronic pharyngitis.

[0013] The beneficial effects produced by the present invention are:

[0014] The present invention discloses adenophora root, which is sweet and cool, nourishes yin, moistens the lungs and benefits the stomach, and treats dry throat and itchy throat caused by yin deficiency and metal deficiency in chronic pharyngitis. Ophiopogon japonicus nourishes yin and produces body fluid, moistens the lungs and clears the heart, enhances the ability to nourish yin and moisten dryness, and relieves the burning sensation in the throat. Scrophularia ningpoensis clears heat and cools the blood, nourishes yin and reduces fire, can soften and disperse nodules, and improve pharyngeal lymph follicle hyperplasia. The above three herbs are all yin-nourishing and heat-clearing, and play a synergistic role in the core pathogenesis of chronic pharyngitis caused by yin deficiency and excessive fire, and are collectively the main drugs.

[0015] Rehmannia nourishes kidney yin, replenishes essence and benefits marrow, and synergizes with the monarch drug to enhance the effect of nourishing yin and treating the root cause; black sesame nourishes the liver and kidneys, benefits essence and blood, moistens dryness and lubricates the intestines, and can alleviate the nourishing and greasy nature of yin-nourishing drugs; salvia miltiorrhiza and red peony root invigorate blood circulation and dissipate blood stasis, unblocking pharyngeal qi and blood stasis, relieving the foreign body sensation in the pharynx and reducing pharyngeal congestion; rehmannia and black sesame treat from the perspective of kidney yin, while salvia miltiorrhiza and red peony root treat from the perspective of blood stasis, both assisting the monarch drug in nourishing yin and targeting the characteristics of long-term illness entering the collaterals, forming a combination of attracting and activating blood circulation. These are collectively referred to as minister drugs.

[0016] Cimicifuga ephedra can raise Yang, lift the sunken, clear away heat and detoxify, and can guide the medicine upward to the pharynx, treating symptoms such as itchy throat and cough. It also clears away heat and toxins in the pharynx caused by the upward inflammation of deficiency fire, relieving pain. It is used in the largest amount in the formula, and can assist in controlling the nourishing and greasy properties of the monarch and minister drugs, preventing excessive nourishment of Yin from causing Qi stagnation. Its characteristics are to promote and disperse the nourishing and greasy properties, and to clear heat and treat the symptoms. It is an adjuvant.

[0017] Licorice plays the role of clearing away heat and detoxifying, moistening the lungs and relieving sore throat, assisting the main drug in improving throat discomfort, and at the same time acting as a guiding drug to guide the meridians into the throat, so it is an assistant drug.

[0018] In this application, Yin-nourishing drugs such as Adenophora Root, Ophiopogon japonicus, and Scrophularia ningpoensis are used to improve the essence of Yin deficiency, while Salvia miltiorrhiza and Paeonia lactiflora promote blood circulation and remove blood stasis, and are used to improve congestion of the pharyngeal mucosa and hyperplasia of lymph follicles. The combination of the two blocks the pathological development of chronic pharyngitis from the aspects of deficiency and blood stasis; the ascending and dispersing nature of Cimicifuga heracleifolia can offset the nourishing and greasy stagnation of Adenophora Root, Ophiopogon japonicus, and Rehmannia glutinosa, and at the same time can lead the drugs upward, concentrate the medicinal power in the pharynx, and enhance the local efficacy; Rehmannia glutinosa and black sesame have the effect of nourishing the kidney and replenishing essence, and fundamentally improve the Yin deficiency constitution. The above drugs are centered on nourishing Yin, activating blood circulation, and ascending the clear and detoxifying, and through the precise combination of monarch, minister, assistant and envoy, they achieve the purpose of treating both the symptoms and the root cause of chronic pharyngitis. DETAILED DESCRIPTION

[0019] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention. That is, the embodiments described are only part of the embodiments of the present invention, rather than all embodiments.

[0020] Therefore, the detailed description of the embodiments of the present invention provided below is not intended to limit the scope of the invention as claimed, but is merely intended to represent selected embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative work are within the scope of protection of the present invention.

[0021] It should be noted that relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus. In the absence of further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of other identical elements in the process, method, article, or apparatus comprising the element.

[0022] The features and performance of the present invention are further described in detail below with reference to the embodiments.

[0023] Example 1

[0024] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 10 parts of Glehnia littoralis, 20 parts of Radix Ophiopogonis, 10 parts of Scrophulariae ningpoensis, 10 parts of Salvia miltiorrhiza, 15 parts of Rehmannia glutinosa, 25 parts of Paeonia lactiflora, 30 parts of Cimicifuga heracleifolia, 1 part of Licorice root and 20 parts of Black sesame.

[0025] Example 2

[0026] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 20 parts of Glehnia littoralis, 10 parts of Radix Ophiopogonis, 20 parts of Scrophulariae ningpoensis, 20 parts of Salvia miltiorrhiza, 25 parts of Rehmannia glutinosa, 15 parts of Paeonia lactiflora, 20 parts of Cimicifuga heracleifolia, 8 parts of Licorice root and 10 parts of Black sesame.

[0027] Example 3

[0028] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 13 parts of Glehnia littoralis, 15 parts of Radix Ophiopogonis, 17 parts of Scrophulariae ningpoensis, 13 parts of Salvia miltiorrhiza, 18 parts of Rehmannia glutinosa, 22 parts of Paeonia lactiflora, 23 parts of Cimicifuga heracleifolia, 3 parts of Licorice root and 17 parts of Black sesame.

[0029] Example 4

[0030] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 17 parts of Glehnia littoralis, 13 parts of Radix Ophiopogonis, 15 parts of Scrophulariae ningpoensis, 17 parts of Salvia miltiorrhiza, 22 parts of Rehmannia glutinosa, 18 parts of Paeonia lactiflora, 27 parts of Cimicifuga heracleifolia, 7 parts of Licorice root and 13 parts of Black sesame.

[0031] Example 5

[0032] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 15 parts of Glehnia littoralis, 17 parts of Radix Ophiopogonis, 13 parts of Scrophulariae ningpoensis, 14 parts of Salvia miltiorrhiza, 20 parts of Rehmannia glutinosa, 21 parts of Paeonia lactiflora, 26 parts of Cimicifuga heracleifolia, 6 parts of Licorice root and 16 parts of Black sesame.

[0033] Example 6

[0034] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 15 parts of Glehnia littoralis, 15 parts of Radix Ophiopogonis, 15 parts of Scrophulariae ningpoensis, 15 parts of Salvia miltiorrhiza, 20 parts of Rehmannia glutinosa, 20 parts of Paeonia lactiflora, 25 parts of Cimicifuga heracleifolia, 5 parts of Licorice root and 15 parts of Black sesame.

[0035] Comparative Example 1

[0036] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 15 parts of Glehnia littoralis, 15 parts of Polygonatum odoratum, 15 parts of Scrophularia ningpoensis, 15 parts of Salvia miltiorrhiza, 20 parts of Rehmannia root, 20 parts of Paeonia lactiflora, 25 parts of Bupleurum root, 5 parts of Licorice root and 15 parts of Cannabis sativa seed.

[0037] Comparative Example 2

[0038] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 15 parts of dendrobium, 15 parts of ophiopogon, 15 parts of scrophulariae, 15 parts of ligusticum, 20 parts of rehmannia, 20 parts of peach kernel, 25 parts of cimicifuga, 5 parts of liquorice and 15 parts of black sesame.

[0039] Test example

[0040] 1. General Information

[0041] A total of 60 patients who visited the hospital and were diagnosed with chronic pharyngitis were selected, including 44 males and 16 females, with an age range of 25-55 years and an average age of 35.4 years.

[0042] 2. Diagnostic Criteria

[0043] Symptom duration: Pharyngeal discomfort symptoms (such as dry throat, itchy throat, sore throat, foreign body sensation, burning sensation, cough, etc.) lasting ≥ 3 months, or recurring for more than 6 months;

[0044] Symptom characteristics: At least two or more typical symptoms must be present, and the symptoms must be aggravated in the morning, when talking too much, when exposed to irritating odors, or when the seasons change;

[0045] Dry throat: Feeling of dryness in the pharyngeal mucosa, which can be temporarily relieved by drinking water;

[0046] Foreign body sensation: a feeling of phlegm sticking to the throat, blockage, or a "plum pit"-like sensation, which is obvious when swallowing, but there is no dysphagia;

[0047] Itchy throat or irritating cough: mostly dry cough, no phlegm or a small amount of sticky phlegm;

[0048] Sore throat: It is usually a mild dull pain rather than severe pain.

[0049] 3. Treatment Methods

[0050] The patients were randomly divided into 3 groups, with 20 people in each group. The drugs in Example 6 and Comparative Examples 1-2 were then taken by the patients in each group three times a day, 10 g each time (each gram is equivalent to 1.76 g of the original medicinal material), for 2 consecutive weeks, and the patients' conditions were observed.

[0051] IV. Efficacy Evaluation Indicators

[0052] Symptom Quantification Scoring:

[0053] Symptoms such as dry throat, foreign body sensation, sore throat, itchy throat, and cough were scored according to their severity (0-3 points, 0 = no symptoms, 3 = severe), and the changes in total scores were compared before and after treatment;

[0054] Cured: Complete disappearance of symptoms (total symptom score reduced by ≥95%), laryngoscopy showed that pharyngeal mucosal congestion subsided and lymphoid follicles basically disappeared, and no recurrence was observed during the 3-month follow-up;

[0055] Markedly effective: symptoms are significantly improved (total symptom score is reduced by 70-94%), mucosal congestion is reduced under laryngoscopy, lymph follicles are reduced by ≥50%, and there is no obvious secretion adhesion;

[0056] Effective: Symptoms improved (total symptom score decreased by 30-69), and laryngoscopic mucosal and lymphoid follicle lesions were alleviated compared with those before treatment;

[0057] Ineffective: The total symptom score decreases by less than 30%, or the physical signs do not change significantly or even worsen;

[0058] Total effective rate (%) = (number of cured patients + number of markedly effective patients + number of effective patients) / total number of patients * 100%

[0059] 5. Treatment Outcomes

[0060]

[0061] It can be seen from the results in the above table that the drug in the present application has a good therapeutic effect on chronic pharyngitis, with a total effective rate of 100%, while the total effective rates of the drugs in Comparative Examples 1 and 2 are 60% and 70%, respectively, and the therapeutic effect is far less than that of Example 6. According to the statistical results, the number of cured patients and the number of significantly effective patients in Example 6 are significantly higher than those in Comparative Examples 1 and 2, which proves that the drug in the present application has a good therapeutic effect on chronic pharyngitis, and after taking the drug for the same period of time, the number of cured patients in Example 6 is much higher than that in Comparative Examples 1 and 2.

Claims

1. A Chinese medicine composition for treating chronic pharyngitis, characterized in that: The invention comprises the following components in parts by weight: 10-20 parts of Adenophora adenophora, 10-20 parts of Radix Ophiopogonis, 10-20 parts of Scrophulariae ningpoensis, 10-20 parts of Salvia miltiorrhiza, 15-25 parts of Rehmannia glutinosa, 15-25 parts of Paeonia lactiflora, 20-30 parts of Cimicifuga heracleifolia, 1-8 parts of Licorice and 10-20 parts of Black Sesame.

2. The Chinese medicine composition for treating chronic pharyngitis according to claim 1, wherein The invention comprises the following components in parts by weight: 13-17 parts of Adenophora adenophora, 13-17 parts of Radix Ophiopogonis, 13-17 parts of Scrophulariae ningpoensis, 13-17 parts of Salvia miltiorrhiza, 18-22 parts of Rehmannia glutinosa, 18-22 parts of Paeonia lactiflora, 23-27 parts of Cimicifuga heracleifolia, 3-7 parts of Licorice and 13-17 parts of Black Sesame.

3. The Chinese medicine composition for treating chronic pharyngitis according to claim 1, wherein The invention comprises the following components in parts by weight: 13 parts of Adenophora adenophora, 15 parts of Radix Ophiopogonis, 17 parts of Scrophulariae ningpoensis, 13 parts of Salvia miltiorrhiza, 18 parts of Rehmannia glutinosa, 22 parts of Paeonia lactiflora, 23 parts of Cimicifuga heracleifolia, 3 parts of Licorice and 17 parts of Black Sesame.

4. The Chinese medicine composition for treating chronic pharyngitis according to claim 1, wherein The invention comprises the following components in parts by weight: 17 parts of Adenophora adenophora, 13 parts of Radix Ophiopogonis, 15 parts of Scrophulariae ningpoensis, 17 parts of Salvia miltiorrhiza, 22 parts of Rehmannia root, 18 parts of Paeonia lactiflora, 27 parts of Cimicifuga heracleifolia, 7 parts of Licorice root and 13 parts of Black Sesame.

5. The Chinese medicine composition for treating chronic pharyngitis according to claim 1, wherein The invention comprises the following components in parts by weight: 15 parts of Adenophora adenophora, 17 parts of Radix Ophiopogonis, 13 parts of Scrophulariae ningpoensis, 14 parts of Salvia miltiorrhiza, 20 parts of Rehmannia glutinosa, 21 parts of Paeonia lactiflora, 26 parts of Cimicifuga heracleifolia, 6 parts of Licorice and 16 parts of Black Sesame.

6. The Chinese medicine composition for treating chronic pharyngitis according to claim 1, wherein The invention comprises the following components in parts by weight: 15 parts of Adenophora adenophora, 15 parts of Radix Ophiopogonis, 15 parts of Scrophulariae ningpoensis, 15 parts of Salvia miltiorrhiza, 20 parts of Rehmannia glutinosa, 20 parts of Paeonia lactiflora, 25 parts of Cimicifuga heracleifolia, 5 parts of Licorice and 15 parts of Black Sesame.

7. Use of the traditional Chinese medicine composition for treating chronic pharyngitis according to any one of claims 1 to 6 in the preparation of a medicament for treating chronic pharyngitis.

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