A traditional Chinese medicine composition, preparation and preparation method for treating chronic pharyngitis

Abstract

The application discloses a traditional Chinese medicine composition for treating chronic pharyngitis, a preparation and a preparation method thereof. The composition comprises the following components in parts by weight: pinellia 10-30 parts, dried tangerine or orange peel 10-28 parts, poria 5-15 parts, prepared liquorice 3-8 parts, cortex moutan 5-15 parts, bitter almond 5-15 parts, cassia twig 3-8 parts, white peony root 5-15 parts, prepared fo-ti-tieng 10-30 parts, periostracum cicada 3-8 parts, inula flower 10-20 parts, perilla stem 5-15 parts, scrophularia 5-15 parts and bupleurum 5-15 parts. The traditional Chinese medicine composition has a good treatment effect on pharyngitis, and can effectively solve the problem of unsatisfactory treatment effect of existing traditional Chinese medicines.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine preparation technology, specifically relating to a traditional Chinese medicine composition, preparation and preparation method for treating chronic pharyngitis. Background Technology

[0002] Chronic pharyngitis is a diffuse chronic inflammation of the pharyngeal mucosa, submucosa, and lymphoid tissue. It is often triggered by various irritating gases, sudden weather changes, poor lifestyle habits, and prolonged emotional disturbances, leading to recurrent attacks. Symptoms include itching, dryness, burning sensation, mild pain, a foreign body sensation in the throat, and an irritating cough. Nausea may occur when brushing teeth in the morning. With economic development, accelerated urbanization, increased work pressure, and changes in the natural and social environment, the clinical incidence of chronic pharyngitis is showing a year-on-year upward trend. Statistics show that chronic pharyngitis accounts for 10%–12% of throat diseases and 1%–4% of ear, nose, and throat diseases. If chronic pharyngitis is not effectively treated, it can also lead to bronchitis, pneumonia, tonsillitis, and other conditions, greatly disrupting people's daily lives. Western medicine treats this condition with anti-inflammatory, anti-allergic, acid-suppressing, stomach-protecting, sleep-aiding, anti-anxiety, vitamin supplementation, local nebulization, laser irradiation, and other physical therapies. Initial symptoms may improve, but over time the throat symptoms return to their previous state, and drug resistance develops, making the condition chronic and difficult to cure. Western medicine lacks specific treatments. Traditional Chinese medicine, based on the principles of syndrome differentiation and treatment, often achieves better results in relieving symptoms and reducing recurrence rates in chronic pharyngitis. This disease falls under the categories of "throat obstruction," "plum pit qi," and "chronic throat obstruction" in traditional Chinese medicine. Traditional Chinese medicine has unique advantages and rich clinical experience in treating this type of disease. The term "throat obstruction" originates from the *Yin Yang Shi Yi Mai Jiu Jing*, and the earliest related description appears in the *Huangdi Neijing*: "When one yin and one yang are bound together, it is called throat obstruction." Before the Qing Dynasty, records of this disease were relatively general, including diseases such as tonsillitis and pharyngeal wind. After the Qing Dynasty, it gradually became a distinct category. The pharynx is a crucial point for the circulation of meridians; any lesion in any meridian can affect the normal physiological function of the pharynx and lead to this disease. Traditional Chinese medicine (TCM) textbooks commonly classify pharyngitis into syndromes such as spleen qi deficiency, spleen and kidney yang deficiency, phlegm stagnation and blood stasis, and lung and kidney yin deficiency. However, this classification falls far short of capturing the complex and varied pathogenesis in clinical practice. Existing prescriptions for chronic pharyngitis often employ a single treatment method, such as using Banxia Houpu Decoction to relieve stagnation, promote qi circulation, disperse phlegm, or use Kujiu Decoction to dispel pathogens, disperse stagnation, and reduce swelling; or using Jiegeng Decoction to clear heat, detoxify, and soothe the throat; or using Liuwei Dihuang Pills to nourish yin, tonify the kidneys, and soothe the throat. Overall, the current treatment outcomes for pharyngitis are not ideal. Summary of the Invention

[0003] In view of the above-mentioned shortcomings in the prior art, the present invention provides a traditional Chinese medicine composition, preparation and preparation method for treating chronic pharyngitis. The traditional Chinese medicine composition has a good therapeutic effect on pharyngitis and can effectively solve the problem of unsatisfactory therapeutic effects of existing traditional Chinese medicines.

[0004] To achieve the above objectives, the technical solution adopted by the present invention to solve its technical problem is as follows:

[0005] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 10-30 parts of Pinellia ternata, 10-28 parts of Citrus reticulata peel, 5-15 parts of Poria cocos, 3-8 parts of prepared Glycyrrhiza uralensis, 5-15 parts of Paeonia suffruticosa bark, 5-15 parts of bitter apricot kernel, 3-8 parts of Cinnamomum cassia twig, 5-15 parts of Paeonia lactiflora, 10-30 parts of prepared Polygonum multiflorum, 3-8 parts of Cicadae periostracum, 10-20 parts of Inula japonica, 5-15 parts of Perilla frutescens stem, 5-15 parts of Scrophularia ningpoensis, and 5-15 parts of Bupleurum chinense.

[0006] Further, it includes the following components in parts by weight: 17-23 parts of Pinellia ternata, 15-20 parts of Citrus reticulata peel, 8-12 parts of Poria cocos, 5-7 parts of prepared Glycyrrhiza uralensis, 8-12 parts of Paeonia suffruticosa bark, 8-12 parts of bitter apricot kernel, 5-7 parts of Cinnamomum cassia twig, 8-12 parts of Paeonia lactiflora, 17-23 parts of prepared Polygonum multiflorum, 5-7 parts of Cicadae periostracum, 12-18 parts of Inula japonica, 8-12 parts of Perilla frutescens stem, 8-12 parts of Scrophularia ningpoensis, and 8-12 parts of Bupleurum chinense.

[0007] Further, it includes the following components in parts by weight: 20 parts Pinellia ternata, 18 parts Citrus reticulata peel, 10 parts Poria cocos, 6 parts prepared Glycyrrhiza uralensis, 10 parts Paeonia suffruticosa root bark, 10 parts bitter apricot kernel, 6 parts Cinnamomum cassia twig, 10 parts Paeonia lactiflora, 20 parts prepared Polygonum multiflorum, 6 parts Cicadae periostracum, 15 parts Inula japonica, 10 parts Perilla frutescens stem, 10 parts Scrophularia ningpoensis, and 10 parts Bupleurum chinense.

[0008] An preparation for treating chronic pharyngitis, comprising the above-mentioned traditional Chinese medicine composition.

[0009] Furthermore, the dosage form of the preparation is a decoction, syrup, mixture, granules, tablets or capsules.

[0010] Furthermore, the above-mentioned medicinal materials are decocted with water 2-3 times, each time for 0.3-0.8 hours. The filtrates from each decoction are combined and concentrated to make a clear paste. Then, excipients are added to make the corresponding dosage form.

[0011] The beneficial effects of this invention are as follows:

[0012] The Chinese herb Pinellia ternata used in this invention enters the Lung Meridian of Hand Taiyin and the Stomach Meridian of Foot Yangming. It has the functions of purging rebellious Qi and reducing turbid Yin. It can dry dampness and resolve phlegm, regulate Qi and stomach to stop vomiting, and eliminate lumps and nodules. It is most effective in reducing rebellious Qi in the lungs and stomach. Modern research shows that Pinellia ternata extract contains a variety of organic acids, polysaccharides, alkaloids, etc., which can inhibit the production of airway mucus, improve airway inflammatory response, inhibit gastric acid secretion, and reduce the pH value of gastric juice, thereby protecting the esophagus.

[0013] The spleen is associated with the damp earth element of Taiyin. When its function is impaired, it is prone to generating dampness. In this formula, Poria cocos is sweet and bland in nature. Sweetness can nourish the spleen, and blandness can drain dampness. It enters the spleen and stomach meridians, which can promote urination and dry the earth element, thus restoring the function of the middle earth element. It is an excellent medicine for strengthening the spleen and replenishing the middle earth element. When combined with prepared licorice root, it warms the middle earth element and dries the earth element, thus treating the root cause.

[0014] Dried tangerine peel regulates qi, harmonizes the middle jiao, dries dampness, resolves phlegm, and can also clear the lungs, stop coughing, and warm and transform cold phlegm, making it an essential medicine for treating phlegm. This medicine can also improve pharyngitis caused by acid reflux by inhibiting acetylcholine, reducing gastrointestinal spasmodic contractions, and promoting gastric emptying. Apricot kernels clear and descend lung qi, break up stagnation, and relieve coughing and asthma. Dried tangerine peel and bitter apricot kernels together enter the qi level, clearing the lungs, regulating qi, and resolving phlegm.

[0015] Inula japonica has a bitter taste and a descending effect, effectively lowering qi. It can reduce phlegm, relieve nausea and vomiting, and promote urination. Modern research shows that this herb also has anti-inflammatory, antibacterial, and immune-regulating properties. Bupleurum chinense tends to ascend. Small doses can raise yang qi, medium doses can soothe the liver and relieve depression, and large doses can disperse and reduce fever. Adding Bupleurum chinense enhances its ascending effect while soothing the liver and relieving depression. When combined with other herbs such as apricot kernel, the ascending and descending effects restore the qi mechanism of the middle jiao.

[0016] Cinnamon twig is pungent, sweet, and warm. It can warm the yang and transform qi, promote the body's yang qi, and warm the middle jiao. It is used for phlegm, cold, and dampness. Pinellia, apricot kernel, and inula flower descend the lung and stomach on the right, while bupleurum and cinnamon twig ascend the liver and spleen on the left to ascend the clear and descend the turbid. Together, they can strengthen the spleen and harmonize the middle jiao, soothe the liver and descend the stomach, and regulate the upper and lower parts of the body.

[0017] White peony root, being sour and cold in nature, enters the liver and spleen meridians, effectively eliminating diseases caused by stagnation of liver qi and wind. It can also astringe the gallbladder and reduce fire, thus relieving stagnation of liver and spleen qi and harmonizing the flow of qi. When combined with licorice root, it transforms into yin through its sour and sweet properties, relieving spasms and pain. Cicada molting, belonging to the insect category, treats both internal and external wind-related ailments. It is sweet and cold in nature, entering the lung and liver meridians. It can disperse wind-heat in the lung meridian to promote lung function and soothe the throat, improve voice and treat hoarseness, and also promote rash eruption and relieve itching. Modern research indicates that it has sedative and anti-allergic effects.

[0018] Perilla stem is pungent and warm in nature, and enters the lung and spleen meridians. It can regulate qi, relieve chest tightness, and dissipate stagnation, making it an essential medicine for treating plum-pit qi. Scrophularia is sweet, bitter, cold, and moist. It can clear heat and cool blood, nourish yin and generate fluids, reduce fire, detoxify, and dissipate stagnation. It is pungent and slightly salty, and directly enters the blood to resolve blood stasis. When combined with peony bark and processed Polygonum multiflorum, which also enter the blood, it can soothe the liver, lift sunken qi, and regulate the qi and blood in the liver, achieving the effect of both eliminating and tonifying.

[0019] The formula fully exerts its effects of raising spleen yang, lowering stomach qi, resolving phlegm and turbidity, soothing liver stagnation, tonifying liver and kidney, and regulating qi and blood. It treats both the symptoms and the root cause, and its precise combination makes it highly effective. It can also be taken for a long time. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to embodiments. It should be understood that the specific embodiments described herein are only for explaining the invention and are not intended to limit the invention; that is, the described embodiments are merely some embodiments of the invention, and not all embodiments.

[0021] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0022] It should be noted that relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes the element.

[0023] The features and performance of the present invention will be further described in detail below with reference to embodiments.

[0024] Example 1

[0025] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 30 parts Pinellia ternata, 10 parts Citrus reticulata peel, 15 parts Poria cocos, 8 parts prepared Glycyrrhiza uralensis, 5 parts Paeonia suffruticosa root bark, 15 parts bitter apricot kernel, 8 parts Cinnamomum cassia twig, 5 parts Paeonia lactiflora, 30 parts prepared Polygonum multiflorum, 8 parts Cicadae periostracum, 10 parts Inula japonica, 15 parts Perilla frutescens stem, 15 parts Scrophularia ningpoensis, and 15 parts Bupleurum chinense.

[0026] A preparation for treating chronic pharyngitis is prepared by decocting the above-mentioned medicinal materials with water three times, each time for 0.3 hours, combining the filtrates from each decoction, and concentrating them into a decoction.

[0027] Example 2

[0028] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 10 parts Pinellia ternata, 28 parts Citrus reticulata peel, 5 parts Poria cocos, 3 parts prepared Glycyrrhiza uralensis, 15 parts Paeonia suffruticosa root bark, 5 parts bitter apricot kernel, 3 parts Cinnamomum cassia twig, 15 parts Paeonia lactiflora, 10 parts prepared Polygonum multiflorum, 3 parts Cicadae periostracum, 20 parts Inula japonica, 5 parts Perilla frutescens stem, 10 parts Scrophularia ningpoensis, and 5 parts Bupleurum chinense.

[0029] A preparation for treating chronic pharyngitis is prepared by decocting the above-mentioned medicinal materials twice with water, each time for 0.8 hours, combining the filtrates from each decoction, and concentrating them into a decoction.

[0030] Example 3

[0031] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 17 parts Pinellia ternata, 15 parts Citrus reticulata peel, 8 parts Poria cocos, 5 parts prepared Glycyrrhiza uralensis, 8 parts Paeonia suffruticosa root bark, 8 parts bitter apricot kernel, 5 parts Cinnamomum cassia twig, 8 parts Paeonia lactiflora, 17 parts prepared Polygonum multiflorum, 5 parts Cicadae periostracum, 12 parts Inula japonica, 8 parts Perilla frutescens stem, 8 parts Scrophularia ningpoensis, and 8 parts Bupleurum chinense.

[0032] A preparation for treating chronic pharyngitis is prepared by decocting the above-mentioned medicinal materials with water three times, each time for 0.4 hours, combining the filtrates from each decoction, and concentrating them into a decoction.

[0033] Example 4

[0034] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 23 parts Pinellia ternata, 20 parts Citrus reticulata peel, 12 parts Poria cocos, 7 parts prepared Glycyrrhiza uralensis, 12 parts Paeonia suffruticosa root bark, 12 parts bitter apricot kernel, 7 parts Cinnamomum cassia twig, 12 parts Paeonia lactiflora, 23 parts prepared Polygonum multiflorum, 7 parts Cicadae periostracum, 18 parts Inula japonica, 12 parts Perilla frutescens stem, 12 parts Scrophularia ningpoensis, and 12 parts Bupleurum chinense.

[0035] A preparation for treating chronic pharyngitis is prepared by decocting the above-mentioned medicinal materials with water three times, each time for 0.6 hours, combining the filtrates from each decoction, and concentrating them into a decoction.

[0036] Example 5

[0037] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 20 parts Pinellia ternata, 18 parts Citrus reticulata peel, 10 parts Poria cocos, 6 parts prepared Glycyrrhiza uralensis, 10 parts Paeonia suffruticosa root bark, 10 parts bitter apricot kernel, 6 parts Cinnamomum cassia twig, 10 parts Paeonia lactiflora, 20 parts prepared Polygonum multiflorum, 6 parts Cicadae periostracum, 15 parts Inula japonica, 10 parts Perilla frutescens stem, 10 parts Scrophularia ningpoensis, and 10 parts Bupleurum chinense.

[0038] A preparation for treating chronic pharyngitis is prepared by decocting the above-mentioned medicinal materials with water three times, each time for 0.5 hours, combining the filtrates from each decoction, and concentrating them into a decoction.

[0039] Comparative Example 1

[0040] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 20 parts Pinellia ternata, 18 parts Citrus reticulata peel, 10 parts stir-fried Coix lacryma-jobi, 6 parts prepared Glycyrrhiza uralensis, 10 parts Paeonia suffruticosa root bark, 10 parts bitter apricot kernel, 6 parts Schizonepeta tenuifolia, 10 parts Paeonia lactiflora, 20 parts prepared Polygonum multiflorum, 6 parts Cicadae periostracum, 15 parts Inula japonica, 10 parts Perilla frutescens stem, 10 parts Scrophularia ningpoensis, and 10 parts Bupleurum chinense.

[0041] A preparation for treating chronic pharyngitis is prepared by decocting the above-mentioned medicinal materials with water three times, each time for 0.5 hours, combining the filtrates from each decoction, and concentrating them into a decoction.

[0042] Comparative Example 2

[0043] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 20 parts Pinellia ternata, 18 parts Citrus reticulata peel, 10 parts Poria cocos, 6 parts prepared Glycyrrhiza uralensis, 10 parts Paeonia suffruticosa root bark, 10 parts bitter apricot kernel, 6 parts Cinnamomum cassia twig, 10 parts Paeonia lactiflora, 20 parts prepared Polygonum multiflorum, 6 parts Cicadae periostracum, 15 parts Evodia rutaecarpa, 10 parts Perilla frutescens stem, 10 parts Scrophularia ningpoensis, and 10 parts Cyperus rotundus.

[0044] A preparation for treating chronic pharyngitis is prepared by decocting the above-mentioned medicinal materials with water three times, each time for 0.5 hours, combining the filtrates from each decoction, and concentrating them into a decoction.

[0045] Comparative Example 3

[0046] A traditional Chinese medicine composition for treating chronic pharyngitis comprises the following components in parts by weight: 20 parts bamboo shavings, 18 parts dried tangerine peel, 10 parts poria cocos, 6 parts prepared licorice root, 10 parts peony bark, 10 parts bitter almond, 6 parts cinnamon twig, 10 parts white peony root, 20 parts prepared rehmannia root, 6 parts cicada slough, 15 parts inula flower, 10 parts perilla stem, 10 parts scrophularia root, and 10 parts bupleurum root.

[0047] A preparation for treating chronic pharyngitis is prepared by decocting the above-mentioned medicinal materials with water three times, each time for 0.5 hours, combining the filtrates from each decoction, and concentrating them into a decoction.

[0048] Experimental Example

[0049] Patients visiting the Affiliated Hospital of North Sichuan Medical College were screened, and those diagnosed with pharyngitis were randomly divided into 10 groups of 20 patients each. The main symptoms of the patients were throat discomfort, including sore throat, redness, swelling, congestion, or cough. Each group of patients was given Example 1-5 (each dose for two days, three times a day), Comparative Example 1-3 (each dose for two days, three times a day), warm water (50ml each time, as the blank group), and Yinhuang granule suspension (10g each time, three times a day, as the model group) for 4 consecutive days. The changes in the throat of each group of patients were observed and statistically analyzed. The specific results are shown in Table 1.

[0050] Recovery: Symptoms such as sore throat, congestion, swelling, or cough disappear;

[0051] Effective: Relief of symptoms such as sore throat, congestion, swelling, or cough;

[0052] Ineffective: No change or worsening of symptoms such as sore throat, congestion, swelling, or cough;

[0053] Effectiveness rate % = (Number of cured patients + Number of effective patients) / Total number of patients * 100%

[0054] Recovery rate % = (Number of recovered patients / Total number of patients) * 100%

[0055] Table 1:

[0056]

[0057] As can be seen from the data in the table above, the therapeutic effects of the examples 1-5 of this application on pharyngitis are better than those of the comparative example, the blank group, and the model group, proving that the traditional Chinese medicine composition of this application has a better therapeutic effect on pharyngitis.

[0058] Compared with Example 5, Comparative Example 1 replaced Poria cocos with stir-fried Coix lacryma-jobi and Cinnamomum cassia with Schizonepeta tenuifolia. The therapeutic effect of the composition shows that although the replaced composition has a certain therapeutic effect on pharyngitis, the number of people cured is small and the cure rate is relatively low.

[0059] Compared with Example 5, Comparative Example 2 replaced Inula japonica with Evodia rutaecarpa and Bupleurum chinense with Cyperus rotundus. The therapeutic effect of the composition shows that although the replaced composition has a certain therapeutic effect on pharyngitis, the number of people cured is small and the cure rate is relatively low.

[0060] Comparing Comparative Example 3 with Example 5, Pinellia ternata was replaced with bamboo shavings and processed Polygonum multiflorum was replaced with Rehmannia glutinosa. The therapeutic effect of the composition showed that although the replaced composition had a certain therapeutic effect on pharyngitis, the number of people cured was small and the cure rate was relatively low.

[0061] The data from Examples 1-3 show that when the medicinal materials in the composition were changed to other medicinal materials with similar effects, the therapeutic effect of the composition on pharyngitis became worse and the cure rate decreased. This proves that there is an interaction between the different medicinal materials in the composition, and they work together to exert a better therapeutic effect.

[0062] The following is a description of a typical case:

[0063] Typical Case 1

[0064] Ms. Li, 61 years old, sought medical attention for "throat discomfort," complaining of phlegm obstruction in the throat, cough with expectoration, and a red tongue. After taking a total of 10 doses, her throat discomfort improved, and her cough subsided.

[0065] Typical Case 2

[0066] Mr. Yang, male, 54 years old, came to the clinic complaining of throat discomfort for one month. His symptoms included throat discomfort, difficulty swallowing saliva, belching, a pale, dark tongue with a thin white coating, and a weak pulse. He took a total of 4 doses of traditional Chinese medicine. During follow-up, he reported improvement in his throat discomfort.

[0067] Typical Case 3

[0068] Ms. Yu, 51 years old, presented with a two-week history of throat discomfort, complaining of dryness and pain in the throat, dry cough without phlegm, pale tongue, and weak pulse. After taking this prescription for a total of 8 doses, her throat discomfort improved.

[0069] Typical Case 4

[0070] Ms. Xie, 42 years old, presented with a 3-year history of throat discomfort, including dryness and itching in the throat, phlegm, and a foreign body sensation in the throat. Her tongue was pale and tender, and her pulse was weak. After taking 12 doses of traditional Chinese medicine, her condition improved.

[0071] Typical Case 5

[0072] Ms. Dai, 60 years old, came to the clinic complaining of "phlegm obstruction in the throat for 3 months." She reported discomfort from phlegm obstruction in the throat, chest tightness, poor sleep, fever upon exertion, fatigue, pale tongue, and weak pulse. After taking this prescription for 4 doses, the phlegm obstruction in the throat and chest tightness improved. After taking another 9 doses, the phlegm obstruction in the throat was basically resolved, and the chest tightness and poor sleep were also relieved.

[0073] Typical Case 6

[0074] Mr. Cheng, 66 years old, came to the clinic complaining of "phlegm obstruction in the throat and fever in the back for half a year." He reported phlegm obstruction in the throat, dry mouth with a desire to drink, low-grade fever in the back at night affecting his sleep, cold feet, pale tongue, and weak pulse. After taking 15 doses of the prescription, the phlegm obstruction in the throat and the fever in the back improved.

[0075] Typical Case 7

[0076] Mr. Li, male, 8 years old, presented with a chief complaint of "recurrent phlegm obstruction in the throat for one month." He complained of phlegm obstruction in the throat, frequent throat clearing, purulent nasal discharge, pale tongue with a thin white coating, and weak pulse. He had a history of rhinitis for over one year. Physical examination revealed mild enlargement of the pharyngeal tonsils. After four doses of this prescription, his throat discomfort and purulent nasal discharge improved.

[0077] Typical Case 8

[0078] Ms. Jiang, 29 years old, presented with a chief complaint of "phlegm obstruction in the throat for 5 years." Her symptoms included throat discomfort, a foreign body sensation, nasal congestion, a large, dark tongue with a yellow coating, a weight of 67 kg, and a height of 155 cm. She was prescribed this formula for 15 doses. Her throat discomfort improved, and she felt refreshed after taking the medication.

[0079] Typical Case 9

[0080] Ms. Teng, 56 years old, came to the clinic complaining of "phlegm obstruction in the throat for 3 years." Her symptoms included phlegm obstruction, a foreign body sensation in the throat, poor sleep (only 4-5 hours), body aches, a pale and dark tongue, and a weak pulse. After taking this prescription for 15 doses, her throat sensation improved, her body aches improved, and she was able to sleep for about 6 hours.

[0081] Typical Case 10

[0082] Ms. Zhang, 52 years old, presented with a chief complaint of "throat discomfort for over a year," including a foreign body sensation in the throat, dull pain in the epigastric region, a pale, swollen tongue with a white, greasy coating, and a weak pulse. She was prescribed this formula for 4 doses. Follow-up revealed a slight improvement in the foreign body sensation in her throat. (Typical Case 11)

[0083] Mr. Tian, ​​male, 23 years old, came to the clinic complaining of "phlegm obstruction and discomfort for 6 months." He reported throat discomfort, occasional cough with a small amount of sticky phlegm, pale and dark tongue with a thin yellow coating, and weak pulse. He was prescribed this prescription for 5 doses. Follow-up showed that his cough and throat discomfort symptoms had improved compared to before.

[0084] Typical Case 12

[0085] Mr. Li, male, 42 years old, came to the clinic complaining of "phlegm obstruction and discomfort for one month." He reported phlegm obstruction and discomfort, poor sleep, pale and tender tongue with a thin white coating, and weak pulse. He was prescribed this formula for 10 doses, after which the patient's phlegm obstruction and discomfort lessened, and his sleep improved.

[0086] Typical Case 13

[0087] Ms. Xiang, 39 years old, presented with a chief complaint of "throat discomfort and a foreign body sensation for over 6 years." She complained of throat discomfort, a foreign body sensation, a small amount of phlegm in her throat, acid reflux, and belching. Her tongue was pale and dark, and her pulse was weak. The pharyngeal mucosa was congested, and a mass was palpable at the base of her right neck. She was given this prescription for 5 doses, which slightly improved the phlegm obstruction sensation. She was then given the same prescription for 15 doses, after which the throat discomfort, acid reflux, and belching all improved significantly. She was given the same prescription for another 5 doses, after which the phlegm obstruction, acid reflux, and belching were essentially resolved. The patient also reported that the mass at the base of her right neck had decreased in size.

[0088] Typical Case 14

[0089] Ms. Liu, 64 years old, came to the clinic complaining of "throat discomfort for more than 3 months." She complained of throat discomfort, itching, hoarseness, pale tongue, and weak pulse. After 5 doses of the same prescription, she reported that the itching and hoarseness had improved. However, she experienced severe dry mouth at night, headache, and neck pain. Her pale tongue and weak pulse were also noted. The same prescription was then given for 5 more doses with modifications. She reported that her hoarseness and throat discomfort had further improved, and her dry mouth at night had also been relieved. The prescription was not changed, and she was given another 10 doses of the same prescription. Upon her return visit, she reported that her hoarseness, itching, dry mouth, and headache and neck pain had all significantly improved.

[0090] Typical Case 15

[0091] Ms. Chen, 53 years old, came to the clinic complaining of "sore throat for one year." She reported sore throat, a feeling of phlegm obstruction, accompanied by abdominal distension, belching, poor appetite, aversion to oily food, fatigue, lethargy, and low mood. Her tongue was red with a thin coating, and her pulse was weak. She was given the same prescription for 5 doses. At the follow-up visit, she reported slight improvement in the phlegm obstruction in her throat. The prescription was not changed, and she was given the same prescription with modifications for 8 doses. At the follow-up visit, she reported slight improvement in the sore throat, but hoarseness, bitter taste in her mouth, and halitosis. She was given the same prescription with modifications for 12 doses. At the follow-up visit, she reported significant improvement in the sore throat, phlegm obstruction, and abdominal distension. She was then given the same prescription in pill form for consolidation treatment.

[0092] Typical Case 16

[0093] Mr. Tang, male, 72 years old, came to the clinic complaining of "phlegm obstruction in the throat for 1 month". He said that his throat was obstructed and uncomfortable, his tongue was pale and tender and his pulse was weak. He was given the same prescription with modifications for 5 doses. When he returned for a follow-up visit, he said that his throat obstruction had improved.

[0094] Typical Case 17

[0095] Mr. Guo, male, 61 years old, came to the clinic complaining of "phlegm obstruction in the throat for 1 month". He reported phlegm obstruction in the throat, dry cough, pale and tender tongue with thin white coating, and floating and slippery pulse. After 4 doses of the modified prescription, his dry cough and phlegm obstruction in the throat improved.

[0096] Typical Case 18

[0097] Mr. He, male, 65 years old, came to the clinic complaining of a cough for two weeks, with symptoms of cough and discomfort due to phlegm obstruction in the throat. He was given a modified version of the previous prescription for four doses. At the follow-up visit, he reported that his cough and phlegm obstruction had slightly improved. The prescription was not changed, and he was given a modified version of the previous prescription for five doses. At the follow-up visit, he reported that his cough and phlegm obstruction had further improved, and the amount of phlegm had decreased. He was given a modified version of the previous prescription for another five doses. (Typical Case 19)

[0098] Ms. Yang, 36 years old, came to the clinic complaining of "phlegm obstruction in the throat for 3 weeks". She complained of discomfort in the throat, occasional cough and phlegm, dark red tongue, and weak pulse. She was given the previous prescription for 5 doses. At the follow-up visit, she said that the prescription was effective and that the feeling of phlegm obstruction in the throat had improved significantly after taking the medicine.

[0099] Typical Case 20

[0100] Ms. Su, female, 30 years old, came to the clinic complaining of "throat discomfort for 1 month". She complained of throat discomfort, cough with phlegm, red tongue and weak pulse. She was given the same prescription with modifications for 5 doses. At the follow-up visit, she said that the feeling of phlegm obstruction in her throat had been slightly relieved, but she had poor sleep. Physical examination revealed "thyroid and breast nodules". Her tongue was red and her pulse was weak. The prescription was not changed due to the effect, and she was given the same prescription with modifications for 5 doses.

[0101] Typical Case 21

[0102] Ms. Qian, 49 years old, came to the clinic complaining of "dry throat and foreign body sensation for more than 1 year." Physical examination revealed congestion of the pharyngeal mucosa, red tongue, and weak pulse. She was given 5 doses of the same prescription. At the follow-up visit, she reported that her throat symptoms were slightly relieved. She was given another 5 doses of the same prescription. At the follow-up visit, she reported that the foreign body sensation in her throat had further improved. She was usually weak and fatigued. Her tongue was red, tender, and swollen, and her pulse was weak. She was given another 5 doses of the same prescription. At the follow-up visit, she reported that her dry throat and foreign body sensation had greatly improved, and her weakness and fatigue had slightly improved. The prescription was not changed and she was given another 5 doses of the same prescription.

[0103] Typical Case 22

[0104] Ms. Xiao, 53 years old, came to the clinic complaining of "throat discomfort for one week". She complained of throat discomfort, phlegm obstruction, belching, pale and tender tongue, and weak pulse. She was given the same prescription for 5 doses. At the follow-up visit, she said that the phlegm obstruction in her throat had improved slightly and the belching had been relieved. Her tongue was pale and tender and her pulse was weak. She was given the same prescription with modifications for 5 doses. During the follow-up visit, she said that the phlegm obstruction in her throat had basically improved.

[0105] Typical Case 23

[0106] Mr. Feng, male, 85 years old, came to the clinic complaining of "pharyngeal and oral pain for one year." He reported a stinging pain and a feeling of obstruction in his throat. His tongue was red with a dry yellow coating, and his right pulse was wiry and slippery, while his left pulse was wiry. He was given the same prescription for 5 doses. At the follow-up visit, he reported that the feeling of obstruction in his throat had improved. He was then given the same prescription with modifications for another 5 doses. At the follow-up visit, he reported that the feeling of obstruction in his throat had further improved, and the oral pain had slightly improved. He still had poor sleep. His tongue was red with a thin yellow coating, and his pulse was floating and wiry when lightly palpated, but weak when deeply palpated. He was then given the same prescription for another 5 doses. At the follow-up visit, he reported that the oral pain had disappeared, and the feeling of phlegm obstruction in his throat had improved. He still had poor sleep. His tongue was red with a thin yellow coating, and his pulse was wiry and weak when deeply palpated. The prescription was not changed due to its effectiveness, and he was given the same prescription for 10 doses.

[0107] Typical Case 24

[0108] Ms. Li, 55 years old, came to the clinic complaining of "throat discomfort for 3 weeks". She reported throat discomfort, a feeling of phlegm obstruction, excessive sweating, pale and dark swollen tongue, and weak pulse. She was given 5 doses of this prescription. During follow-up, she reported that the feeling of phlegm obstruction in her throat had improved.

[0109] Typical Case 25

[0110] Ms. Xie, female, 42 years old, came to the clinic complaining of "throat discomfort for 3 years," reporting dryness and itching in the throat, a foreign body sensation, pale and tender tongue, and a weak pulse. She was given 5 doses of the same prescription. At the follow-up visit, she reported that the dryness and itching in her throat had improved, but the foreign body sensation remained. Her tongue was pale and tender, and her pulse was weak. The prescription was not changed, and she was given another 5 doses of the same prescription. At the follow-up visit, she reported that both the dryness and itching in her throat and the foreign body sensation had improved. She was then given another 5 doses of the same prescription with modifications.

[0111] Typical Case 26

[0112] Ms. Long, female, 16 years old, came to the clinic complaining of "phlegm obstruction in the throat for half a year." She reported phlegm obstruction in the throat, with no other particular discomfort. Her tongue was pale and tender, and her pulse was weak. She was given 5 doses of the same prescription. At the follow-up visit, she reported that the phlegm obstruction in her throat had improved. The prescription was not changed, and she was given another 5 doses of the same prescription. During the follow-up visit, she reported that the phlegm obstruction in her throat had basically improved.

[0113] Typical Case 27

[0114] Ms. Liu, 31 years old, came to the clinic complaining of "phlegm obstruction discomfort for 1 month". She complained of phlegm obstruction discomfort, dizziness, fatigue, poor sleep, red tongue and weak pulse. She was given the same prescription with modifications for 5 doses. During the follow-up, she reported that her dizziness and phlegm obstruction discomfort had improved.

[0115] Typical Case 28

[0116] Ms. Chen, 49 years old, came to the clinic complaining of "dry mouth for 4 months and throat discomfort". She complained of dry mouth and greasy taste, loss of taste, and throat discomfort with phlegm. Her tongue was pale red with a thin yellow coating and her pulse was slow and slippery. Physical examination revealed "pulmonary nodules". She was given 5 doses of this prescription. During follow-up, she reported that her throat discomfort with phlegm had improved slightly.

[0117] Typical Case 29

[0118] Ms. Zhou, 59 years old, came to the clinic complaining of "phlegm obstruction and discomfort for 2 weeks". She complained of phlegm obstruction and discomfort, nausea when brushing her teeth, pale and dark tongue, and weak pulse. She was given 5 doses of this prescription. During the follow-up, she reported that the nausea when brushing her teeth had improved and the phlegm obstruction in her throat had lessened.

[0119] Typical Case 30

[0120] Ms. Du, female, 32 years old, came to the clinic complaining of "throat discomfort for 3 months." She complained of phlegm obstruction in her throat and poor sleep. Physical examination revealed congestion of the pharyngeal mucosa, red tongue with a thin yellow coating, and weak pulse. She was given the same prescription with modifications for 5 doses. At the follow-up visit, she reported that her throat discomfort had improved and her sleep quality had improved. Her tongue was red with a thin yellow coating, and her pulse was weak. She was given the same prescription with modifications for 10 doses. At the follow-up visit, she reported that her throat symptoms had further improved and her sleep had improved. She now has constipation and difficulty passing stool. Her tongue is red with a thin yellow coating, and her pulse is weak. She was given the same prescription with modifications for 5 doses.

Claims

1. A traditional Chinese medicine composition for treating chronic pharyngitis, characterized in that, The composition is made from the following components in parts by weight: Banxia 10-30 parts, Chenpi 10-28 parts, Fuling 5-15 parts, Zhigancao 3-8 parts, Mudanpi 5-15 parts, Kuaxingren 5-15 parts, Guizhi 3-8 parts, Baishao 5-15 parts, Zhishouwu 10-30 parts, Chantui 3-8 parts, Xuanfuye 10-20 parts, Zisugeng 5-15 parts, Xuanshen 5-15 parts, and Chaihu 5-15 parts.

2. The Chinese medicine composition for treating chronic pharyngitis according to claim 1, wherein, The composition is made from the following components in parts by weight: Banxia 17-23 parts, Chenpi 15-20 parts, Fuling 8-12 parts, Zhigancao 5-7 parts, Mudanpi 8-12 parts, Kuaxingren 8-12 parts, Guizhi 5-7 parts, Baishao 8-12 parts, Zhishouwu 17-23 parts, Chantui 5-7 parts, Xuanfuye 12-18 parts, Zisugeng 8-12 parts, Xuanshen 8-12 parts, and Chaihu 8-12 parts.

3. The traditional Chinese medicine composition for treating chronic pharyngitis as described in claim 1, characterized in that, The composition is made from the following components in parts by weight: Banxia 20 parts, Chenpi 18 parts, Fuling 10 parts, Zhigancao 6 parts, Mudanpi 10 parts, Kuaxingren 10 parts, Guizhi 6 parts, Baishao 10 parts, Zhishouwu 20 parts, Chantui 6 parts, Xuanfuye 15 parts, Zisugeng 10 parts, Xuanshen 10 parts, and Chaihu 10 parts.

4. A preparation for treating chronic pharyngitis, characterized by, The traditional Chinese medicine composition of any one of claims 1-3.

5. The preparation for treating chronic pharyngitis according to claim 4, wherein the preparation is administered in an amount of 0.1 to 1.0 g per day. The dosage form of the preparation is water decoction, syrup, mixture, granules, tablets, or capsules.

6. The method of preparing the preparation for treating chronic pharyngitis according to claim 4 or 5, characterized in that, The method comprises the following steps: The medicinal materials are decocted with water for 2-3 times, each time for 0.3-0.8 h, and the filtrates of each time are combined and concentrated to form a clear paste, and then the adjuvants are added to form the corresponding dosage form.

Images