Traditional Chinese medicine composition capable of simultaneously treating globus hysteriocus and chronic pharyngitis and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and provides a traditional Chinese medicine composition capable of simultaneously treating globus hysteriocus and chronic pharyngitis and a preparation method thereof. The traditional Chinese medicine composition comprises pinellia ternate, magnolia obavata, poria cocos, caulis perllae, fritillaria thunbergii, radix curcumae, salvia miltiorrhiza and raw malt, and under specific compatibility, pinellia ternate and cortex magnoliae officinalis decoction is used for breaking qi and phlegm stagnation; the radix salviae miltiorrhizae and the radix curcumae penetrate into blood to remove blood stasis caused by long illness; the raw malt is used for nourishing liver and tonifying spleen and caring the source; acorus tatarinowii is used for inducing resuscitation and directly smashing a disease site; and the thunberg fritillary bulb is used for strengthening the local stagnation eliminating function. The medicines are combined to achieve the effects of promoting qi circulation, reducing phlegm, promoting blood circulation, removing blood stasis, soothing the liver, strengthening the spleen, relieving depression and soothing the nerves.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, and in particular to a traditional Chinese medicine composition that can simultaneously treat globus hystericus and chronic pharyngitis, and its preparation method. Background Technology

[0002] Globus hystericus, a traditional Chinese medicine (TCM) syndrome, refers to a condition caused by emotional distress, stagnation of liver qi, and the accumulation of phlegm and qi in the throat. Its main symptoms are a sensation of a plum pit obstructing the throat, which cannot be coughed up or swallowed, and occurs intermittently. Clinically, it is characterized by an abnormal sensation in the throat that does not affect eating. This syndrome can be seen in TCM treatments of liver diseases, throat diseases, and mental illnesses. In modern medicine, it is called globus pharyngeus, and is often diagnosed as pharyngeal neurosis, or globus pharyngeus. This condition is more common in young and middle-aged adults, especially women.

[0003] Chronic pharyngitis is a chronic inflammation of the pharyngeal mucosa, submucosa, and lymphoid tissue, and has no common alternative name. This disease primarily occurs in otolaryngology departments, and its causes are complex and varied, including bacteria, environment, laryngopharyngeal reflux, allergic diseases, and other factors. Chronic pharyngitis is relatively common in adults, and is characterized by a long course, high recurrence rate, persistent symptoms, and difficulty in cure.

[0004] To date, existing traditional Chinese medicine techniques cannot simultaneously treat globus hystericus and chronic pharyngitis. Summary of the Invention

[0005] The purpose of this invention is to provide a traditional Chinese medicine composition that can simultaneously treat globus hystericus and chronic pharyngitis, and its preparation method, so as to make up for the shortcomings of the prior art.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a traditional Chinese medicine composition that can simultaneously treat globus hystericus and chronic pharyngitis, comprising the following raw materials in parts by weight: Pinellia ternata 13-17 parts 27-32 portions of Chuanpu Poria cocos 28-33 parts 17-24 portions of Su Geng 18-23 servings of large scallops 25-34 parts of turmeric Sweet flag 26-33 parts 27-32 parts of Salvia miltiorrhiza 45-55 parts raw malt.

[0007] Preferably, the raw materials comprise the following parts by weight: 15-16 portions of Pinellia ternata 30-31 servings of Sichuan Pu 29-30 parts of Poria cocos 20-22 portions of Su Geng 20-21 servings of scallops 29-30 parts of turmeric 30-31 parts of sweet flag 30-31 doses of Salvia miltiorrhiza 47-50 parts raw malt.

[0008] Preferably, the large clam is Fritillaria thunbergii.

[0009] The present invention also provides a method for preparing the aforementioned traditional Chinese medicine composition, comprising the following steps: Mix all the ingredients together, add water, and boil for the first time. Filter to obtain the first decoction and the first dregs. Add water to the first batch of dregs again, boil for a second time, and filter to obtain the second batch of liquid. The first and second medicinal solutions are combined to obtain the final product.

[0010] Preferably, the first simmering involves bringing the water to a boil and then reducing the heat to a simmer for 90-120 minutes.

[0011] Preferably, the second simmering involves bringing the water to a boil and then reducing the heat to a simmer for 30-60 minutes.

[0012] The present invention also provides tablets, capsules, and granules prepared from the aforementioned traditional Chinese medicine composition.

[0013] The beneficial effects of this invention are as follows: The existing medicines for treating globus hystericus and chronic pharyngitis are mainly Banxia Houpu Decoction. This application makes many significant innovations compared to this traditional formula, achieving a leap from "regulating qi and resolving phlegm" to "treating qi and blood simultaneously, eliminating phlegm and blood stasis, regulating the liver and spleen, and addressing both physical and mental well-being." It is more in line with the complex pathogenesis of modern people caused by long-term mental stress and chronic disease, with a higher level of understanding, a more comprehensive formula, and a more potent effect.

[0014] 1. The core pathogenesis of Banxia Houpu Decoction is "qi stagnation and phlegm accumulation," and the treatment focuses on regulating qi (Perilla leaf, Magnolia bark) and resolving phlegm (Pinellia, Poria, ginger). Based on the understanding of "qi stagnation and phlegm accumulation," the inventors of this application have deeply grasped the pathogenesis of "prolonged illness entering the collaterals" and "prolonged illness inevitably leading to blood stasis." They added Danshen and Yujin, two key herbs for invigorating blood, cooling blood, regulating qi, and relieving stagnation, thus achieving a dual regulation of qi and blood. This not only resolves the current qi stagnation but also clears the blood stasis that may have formed due to prolonged qi stagnation. For patients with chronic diseases that have not healed for many days, this approach is more targeted and has a deeper therapeutic effect.

[0015] 2. While Perilla leaf in Banxia Houpu Decoction has a liver-soothing effect, its effect is mild and tends to disperse. This application uses a large dose of raw malt up to 50 parts. Raw malt is neutral in nature and enters the spleen and liver meridians. Its advantage lies in soothing the liver and relieving depression without depleting stomach qi, and it can also strengthen the spleen and improve appetite. For patients suffering from emotional depression and excessive thinking, where liver qi is stagnant and liver blood is being depleted, the "gentle" way of soothing the liver with raw malt is more appropriate than strong herbs such as Bupleurum. This aligns with the principle that "the liver is a rigid organ, and cannot be overcome without gentleness," making it especially suitable for long-term conditioning.

[0016] 3. In Banxia Houpu Decoction, phlegm-resolving mainly relies on Pinellia ternata and Poria cocos. This application adds Fritillaria thunbergii (Zhejiang Fritillaria). Zhejiang Fritillaria is bitter and cold, and excels at clearing heat, resolving phlegm, relieving stagnation, and dispersing nodules. For symptoms such as follicular hyperplasia (necrosporotic pharyngitis) and phlegm nodule accumulation that may occur in chronic pharyngitis, its nodule-dispersing power is far stronger than the original formula. When combined with Pinellia ternata, one is warm and the other is cool, working together to enhance the phlegm-resolving and nodule-dispersing effects.

[0017] 4. This application includes Acorus tatarinowii. Acorus tatarinowii is aromatic and penetrating, excelling at resolving dampness and phlegm, opening the orifices and calming the mind. It can "open the heart orifices and clear the nine orifices," directly treating symptoms such as depression, emotional distress, and forgetfulness caused by phlegm obstructing the clear orifices. This makes the formula not only treat the "form" of the throat but also the "root" of the mind, closely addressing the primary symptom of "replenishing essence (mind) to alleviate depression."

[0018] 5. This application uses Banxia Houpu Decoction to break up phlegm and qi stagnation; Danshen and Yujin to penetrate deep into the blood and resolve blood stasis caused by prolonged illness; Shengmaiya to soothe the liver and strengthen the spleen, protecting the root cause; Shichangpu to open the orifices and awaken the mind, directly targeting the affected area; and Zhebeimu to enhance the local dissipation of stagnation. The combined effects of these herbs are to promote qi circulation and resolve phlegm, invigorate blood and remove blood stasis, soothe the liver and strengthen the spleen, relieve depression and calm the mind. Detailed Implementation

[0019] In this invention, the clam is preferably Fritillaria thunbergii.

[0020] In this invention, the herbal composition is preferably soaked in cold water for 30 to 60 minutes before decoction, more preferably for 40 to 50 minutes; the water level should be 3 to 5 cm above the surface of the herbs during the first decoction and 2 to 3 cm above the surface of the herbs during the second decoction.

[0021] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention. Example

[0022] Weigh out 15g of Pinellia ternata, 30g of Magnolia officinalis, 30g of Poria cocos, 20g of Perilla frutescens stem, 20g of Fritillaria thunbergii, 30g of Curcuma longa, 30g of Acorus tatarinowii, 30g of Salvia miltiorrhiza, and 50g of raw malt. Soak in cold water for 45 minutes. After filtering, decoct in the soaking liquid, adding water to cover the herbs by 4cm. After boiling, reduce to a simmer and decoct for 90 minutes. Add water to the first batch of dregs again, covering the herbs by 2cm. After boiling, reduce to a simmer and decoct for 40 minutes for a second decoction. Filter to obtain the second decoction. Combine the first and second decoctions to obtain the final product.

[0023] Thirty healthy adult mice were selected and divided into a control group and a treatment group. Except for the treatment group, which was given the drug once a day (prepared according to the method in Example 1), all other feeding conditions were the same.

[0024] After two months of observation, it was found that all physiological indicators of mice in both the control group and the treatment group were normal, and no abnormalities were observed in the treatment group, indicating that the traditional Chinese medicine composition has no toxic side effects and has good safety.

[0025] (1) Mouse experiment Five mice with chronic pharyngitis were obtained by stimulating the pharynx of healthy adult mice with ammonia spray.

[0026] All mice were fed normally and administered the drug once in the morning, noon and evening for a total of 4 weeks. The behavior of the mice was observed and the therapeutic effect of the drug on chronic pharyngitis in the mice was evaluated.

[0027] Results: One mouse recovered to near normal after 12 days of medication, three mice recovered to near normal after the third week of medication, and one mouse recovered to normal after the fourth week of medication. All mice fully recovered after four weeks of medication, with normal eating and movement, and no longer exhibited the behavior of scratching their mouths.

[0028] The inconsistent recovery time in mice may be due to the different tolerance levels of each mouse to ammonia spray, resulting in varying degrees of chronic pharyngitis infection. Additionally, individual differences among mice may have led to different recovery speeds after medication.

[0029] (2) Clinical medication Ten patients were selected, all exhibiting typical symptoms of chronic pharyngitis. The herbal decoction was prepared according to the method described in Example 1, and administered orally three times daily for 14 days as one course of treatment. After 4-6 courses of treatment, the symptoms disappeared in all cases, and no recurrence was observed.

[0030] Typical Case 1: Ms. Wang, age 56, has had chronic pharyngitis for many years. Her throat is dry and itchy for a long time, with a foreign body sensation, burning sensation, and a lot of phlegm. She wants to cough but cannot cough it up.

[0031] After the first course of treatment: no significant improvement was observed; After the second course of treatment: the dryness and itching improved, and other symptoms were alleviated; After the third course of treatment: all symptoms were significantly relieved, but typical symptoms still occasionally reappeared.

[0032] After the fourth course of treatment: symptoms were significantly reduced and there was no recurrence.

[0033] After the fifth course of treatment: symptoms disappeared.

[0034] Follow-up visit three months later: no recurrence was found.

[0035] The selected patients, totaling 13 cases, all met the typical symptoms of globus hystericus. The herbal decoction was prepared according to Example 1, and the patients took it orally three times daily for 14 days as one course of treatment. After 3-6 courses of treatment, the symptoms disappeared in all cases, and no recurrence was observed.

[0036] Typical Case 2: Ms. Han, age 22, presented with symptoms including throat discomfort, fatigue, and poor appetite.

[0037] After the first course of treatment: appetite returned and physical weakness lessened, but the condition was still not good; After the second course of treatment: the throat symptoms improved significantly; After the third course of treatment: all symptoms improved significantly, with only occasional fatigue and throat discomfort.

[0038] After the fourth course of treatment: symptoms disappeared.

[0039] Follow-up visit three months later: no recurrence was found. Example

[0040] Weigh out 16g of Pinellia ternata, 29g of Magnolia officinalis, 31g of Poria cocos, 21g of Perilla frutescens stem, 20g of Fritillaria thunbergii, 30g of Curcuma longa, 31g of Acorus tatarinowii, 30g of Salvia miltiorrhiza, and 48g of raw malt. Soak in cold water for 45 minutes. After filtering, decoct in the soaking liquid, adding water to cover the herbs by 4cm. After boiling, reduce to a simmer and decoct for 90 minutes. Add water to the first batch of dregs again, covering the herbs by 2cm. After boiling, reduce to a simmer and decoct for 40 minutes for a second decoction. Filter to obtain the second decoction. Combine the first and second decoctions to obtain the final product.

[0041] The formula was verified by the experiment described above, and the results showed that the formula can treat both globus hystericus and chronic pharyngitis at the same time. Example

[0042] Weigh out 14g of Pinellia ternata, 31g of Magnolia officinalis, 30g of Poria cocos, 21g of Perilla frutescens stem, 19g of Fritillaria thunbergii, 30g of Curcuma longa, 31g of Acorus tatarinowii, 29g of Salvia miltiorrhiza, and 51g of raw malt. Soak in cold water for 45 minutes. After filtering, decoct in the soaking liquid, adding water to cover the herbs by 4cm. After boiling, adjust to a simmer and decoct for 90 minutes. Add water to the first batch of dregs again, adding water to cover the herbs by 2cm. After boiling, adjust to a simmer and decoct for 40 minutes for a second decoction. Filter to obtain the second decoction. Combine the first and second decoctions to obtain the final product.

[0043] The formula was verified by the experiment described above, and the results showed that the formula can treat both globus hystericus and chronic pharyngitis at the same time. As can be seen from the above embodiments, the traditional Chinese medicine composition of the present invention comprises several components including Pinellia ternata, Magnolia officinalis, Poria cocos, Perilla frutescens, Fritillaria cirrhosa, Curcuma longa, Salvia miltiorrhiza, and raw malt. Under specific compatibility, this application uses Pinellia ternata and Magnolia officinalis decoction to break up phlegm and qi stagnation; Salvia miltiorrhiza and Curcuma longa penetrate deep into the blood to resolve blood stasis caused by prolonged illness; raw malt softens the liver and strengthens the spleen, protecting the root cause; Acorus tatarinowii opens the orifices and awakens the mind, directly targeting the disease site; and Fritillaria thunbergii further enhances the effect of local dispersing stagnation. The combined effects of these herbs are to regulate qi and resolve phlegm, invigorate blood and remove blood stasis, soothe the liver and strengthen the spleen, relieve depression and calm the mind. The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition capable of treating both laryngopharyngeal nodosa and chronic pharyngitis simultaneously, characterized in that, The raw materials comprise the following mass fractions: Pinellia 13-17 parts Magnolia officinalis 27-32 parts Poria 28-33 parts Perilla 17-24 parts Fritillaria 18-23 parts Radix notoginseng 25-34 parts Acorus 26-33 parts Salvia 27-32 parts Green malt 45-55 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The raw materials comprise the following mass fractions: Pinellia 15-16 parts Magnolia officinalis 30-31 parts Poria 29-30 parts Perilla 20-22 parts Fritillaria 20-21 parts Radix notoginseng 29-30 parts Acorus 30-31 parts Salvia 30-31 parts Green malt 47-50 parts.

3. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The Fritillaria is preferably Fritillaria thunbergii.

4. The preparation method of the traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The method comprises the following steps: After mixing all the raw materials, water is added, and first decoction is performed, and the first decoction liquid and the first decoction residue are obtained by filtration; The first decoction residue is added with water again, and second decoction is performed, and the second decoction liquid is obtained by filtration; The first decoction liquid and the second decoction liquid are combined, and the Chinese medicine composition is obtained.

5. The preparation method of the traditional Chinese medicine composition according to claim 4, characterized in that, The first decoction is adjusted to warm fire after boiling, and the first decoction time is 90-120 minutes.

6. The preparation method of the traditional Chinese medicine composition according to claim 4 or 5, characterized in that, The second decoction is adjusted to warm fire after boiling, and the second decoction time is 30-60 minutes.

7. Tablets, capsules, and Chinese medicine granules prepared from the Chinese medicine composition of any one of claims 1-3.