Traditional Chinese medicine composition for promoting sleep and growth as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a sleep-aiding and growth-promoting traditional Chinese medicine composition which is mainly prepared from the following traditional Chinese medicine raw materials by weight: 10-30 g of astragalus membranaceus, 5-15 g of roasted rhizoma atractylodis macrocephalae, 2-8 g of pericarpium citri reticulatae, 10-20 g of codonopsis pilosula, 5-15 g of rhizoma cimicifugae, 2-8 g of radix bupleuri, 2-8 g of angelica sinensis, 10-30 g of radix rehmanniae, 5-15 g of honey-fried licorice root, 10-20 g of Chinese yam, 5-15 g of cortex moutan, 5-15 g of rhizoma alismatis, 5-15 g of dogwood, 1-5 g of cinnamon, 5-15 g of poria cocos and 2-8 g of myristica fragrans. The traditional Chinese medicine is prepared from 5-15 g of radix aucklandiae, 1-5 g of rhizoma coptidis, 2-8 g of fructus amomi, 5-15 g of fructus crataegi, 5- Correspondingly, the invention further discloses a preparation method and application of the traditional Chinese medicine composition for helping sleep and growth. The traditional Chinese medicine composition has outstanding curative effects on poor sleep quality, slow growth, short body, easy cold constitution and adenoid hypertrophy at the same time, and has the effect of treating multiple diseases by one medicine.

Description

Technical Field

[0001] The present invention relates to the medical field, and in particular to a Chinese medicine composition for promoting sleep and growth, and a preparation method and application thereof. Background Art

[0002] With the enrichment of material and cultural life and the improvement of medical standards, parents pay more and more attention to their children's height. More and more parents go to pediatric departments for consultation because of their children's short stature. However, people pay far less attention to children with growth retardation, short stature, and those who do not meet the diagnostic criteria for dwarfism than to children with dwarfism.

[0003] Growth retardation refers to a height below the 3rd percentile of the height standard for Chinese children of the same age and gender. Short stature is defined as a child's height being between one standard deviation (or the 25th percentile) and two standard deviations (or the 3rd percentile) below the average height of normal children of the same age, race, and gender. Children with short stature are similar to those with idiopathic short stature, except that their height does not meet the diagnostic criteria for children with dwarfism. They are also inevitably prone to negative emotions such as inferiority complex and negative attitudes. Such negative emotions can gradually evolve into psychological disorders as they age, thus seriously affecting the physical and mental health of the children. "If not corrected in time, short stature can further develop into dwarfism, ultimately resulting in damage to the child's adult height.

[0004] Children's growth retardation and short stature are the result of the combined influence of multiple factors such as genetic factors, nutritional status, and diseases. The factors that affect children's height growth can be roughly divided into two categories: congenital and acquired. Congenital factors mainly include genetic gene expression, hormonal environment, etc., while acquired factors mainly include economic development, medical level, child health care, environmental factors, etc. Among them, environmental factors including exercise, diet, and sleep have a huge impact on children's growth potential.

[0005] At present, Western medicine mostly uses injections of growth hormone to promote growth and development of children and adolescents and increase height, but the efficacy is limited and has no positive effect on appetite, sleep, and mood. It is also expensive and has potential uncertain health risks. Traditional Chinese medicine mainly supplements through food, such as milk, eggs, meat with high protein content, etc., and some Chinese medicine that promotes growth can also be taken.

[0006] For example, prior art 1 is "Professor Ju Wei's Experience in Using Anti-allergic Growth-promoting Paste to Treat Growth Delay in Children with Food Allergies", Duan Fengyang, Chinese Medicine Research, Vol. 36, No. 8, August 2023. It discloses an anti-allergic growth-promoting paste that can treat growth retardation in children caused by food allergies. The anti-allergic growth-promoting paste is composed of Codonopsis pilosula, Astragalus, Stir-fried Atractylodes macrocephala, White Peony Root, Poria, Chinese Yam, White Lablab, Rehmannia glutinosa, Wine Cornus Officinalis, Polygonatum, Asparagus, Viscum album, Cibotium barometz, Dipsacus asper, Achyranthes bidentata, Drynaria fortunei, Plum, Schisandra chinensis, Angelica sinensis, Chuanxiong, Longan Meat, Streptococcus australis, Mulberry Branch, Millettia reticulata, Eclipta prostrata, Lycium barbarum, Hawthorn, Malt, Amomum villosum, Tangerine Peel, Stir-fried Citrus aurantium, Phragmites australis, Rhizoma Anemarrhenae, Roasted Licorice, Donkey-hide Gelatin, Tortoise Shell Glue, and Honey.

[0007] In the above-mentioned anti-allergic growth-promoting cream, Codonopsis, Astragalus, and Rehmannia nourish the lungs, strengthen the spleen, and nourish the kidneys, and are the main drugs. Stir-fried Atractylodes and Poria strengthen the spleen, eliminate dampness, and calm the mind; Chinese yam and white hyacinth bean nourish the lungs and spleen at the same time; Plum and Schisandrae Chinensis restrain the lungs and produce body fluid; Crataegus and malt move the spleen and digest food; Wine Cornus officinalis, Longan meat, and Polygonatum sibiricum nourish the kidney essence; Viscum parasiticus, Drynaria fortunei, and Cibotium barometz nourish the kidneys and strengthen the tendons and bones. All of the above are ministerial drugs. Herba Ecliptae, Fructus Lycii, Dipsacus asper, and Achyranthes bidentata nourish the kidneys and strengthen the bones; Angelica sinensis, Ligusticum chuanxiong, Millettia reticulata promote blood circulation and dredge the collaterals; Herba Lycopodii and Morus alba relax the tendons and activate the collaterals; Fructus Amomi and Tangerine peel strengthen the spleen, eliminate dampness, wake up the spleen and harmonize the stomach; Stir-fried Fructus Citrus aurantium promotes qi and relieves the middle. Rhizoma Anemarrhenae, Paeonia lactiflora, Rhizoma Phragmites, and Asparagus cochinchinensis nourish the yin of the lungs, spleen, and kidneys to prevent the drugs from being too dry and damaging the yin. All of the above are adjuvant drugs. Roasted Licorice root strengthens the spleen and harmonizes the middle, and is the guiding drug. Donkey hide gelatin nourishes the lungs and blood, while tortoise shell glue and honey nourish the yin and moisten the lungs. These medicines are combined to nourish the lungs, strengthen the spleen and kidneys, and strengthen the bones and promote growth. For patients with recurrent respiratory tract infections and coughs, add Cordyceps sinensis, Lilium bulbs, and Stemona tuberosa to regulate lung qi, benefit the lungs and relieve coughs; for patients with stagnation and constipation, add stir-fried Pharbitis seeds, Rhizoma Alismatis, and Areca nut to regulate qi and relieve swelling, and promote qi circulation and remove stagnation; for patients with recurrent rashes, add Herba Agrimoniae, Rubia cordifolia, and Fructus Kochiae to clear heat and cool blood, remove dampness and relieve itching.

[0008] However, the above-mentioned anti-allergic growth-promoting cream is for the growth retardation caused by food allergies. Its growth-promoting effect is limited, its scope of application is narrow, and it cannot effectively improve the problem of short stature.

[0009] On the other hand, students in today's society are under great academic pressure, have poor sleep quality, poor physical fitness, and are prone to repeated colds, which are also problems that cannot be ignored. Repeated colds can easily induce adenoids hypertrophy. The main cause of adenoids hypertrophy is repeated attacks of acute and chronic nasopharyngitis, or inflammation of the nasal cavity, sinuses, tonsils, etc., which affects the nasopharynx and stimulates the proliferation of adenoids tissue. Children may experience otorhinolaryngitis and other symptoms due to blockage of the posterior nasal cavity and the pharyngeal opening of the Eustachian tube due to adenoids hypertrophy. It manifests as open-mouth breathing during sleep, snoring with the root of the tongue falling back, restless sleep at night, excessive nasal secretions, occlusive nasal sounds when speaking, and slurred voice. In addition, secretions may flow down to irritate the respiratory mucosa, making it easy to suffer from tracheitis; obstruction of the Eustachian tube can easily cause non-suppurative otitis media, resulting in hearing loss, tympanic membrane retraction and other symptoms. Long-term adenoid hypertrophy may also affect the development of maxillofacial bones, resulting in adenoid facies, that is, facial bone development disorder, elongated maxilla, high arched hard palate, irregular dentition, exposed upper incisors, thick lips, and lack of facial expression.

[0010] The treatment of adenoids hypertrophy mainly includes drug therapy and surgical treatment: 1. Drug therapy: For mild adenoids hypertrophy, doctors may use anti-infective drugs and nasal spray hormones to reduce inflammation and relieve symptoms. 2. Surgical treatment: When adenoids hypertrophy causes severe respiratory disorders, hearing loss, or recurrent secretory otitis media, doctors may recommend adenoidectomy. At present, resection surgery under general anesthesia and direct nasal endoscopy and plasma radiofrequency ablation are the main surgical methods. Summary of the invention

[0011] The technical problem to be solved by the present invention is to provide a Chinese medicine composition for promoting sleep and growth, which can have outstanding therapeutic effects on poor sleep quality, growth retardation and short stature, susceptibility to colds and adenoids hypertrophy, and play the role of treating multiple diseases with one medicine.

[0012] The technical problem to be solved by the present invention is also to provide a method for preparing the above-mentioned traditional Chinese medicine composition.

[0013] The technical problem to be solved by the present invention is also to provide an application containing the above-mentioned traditional Chinese medicine composition.

[0014] In order to achieve the above technical effects, the present invention provides a Chinese medicine composition for promoting sleep and growth, wherein the Chinese medicine composition is mainly made of the following Chinese medicine raw materials in the following weight ratios:

[0015] Astragalus 10-30g, stir-fried Atractylodes 5-15g, dried tangerine peel 2-8g, Codonopsis pilosula 10-20g, Cimicifuga 5-15g, Bupleurum 2-8g, Angelica 2-8g, Rehmannia glutinosa 10-30g, roasted Licorice root 5-15g, Huaishan 10-20g, Moutan bark 5-15g, Alisma orientalis 5-15g, Cornus officinalis 5-15g, cinnamon bark 1-5g, Poria 5-15g, nutmeg 2-8g, costusroot 5-15g, Coptis chinensis 1-5g, Amomum villosum 2-8g, Hawthorn 5-15g, Shenqu 5-15g, stir-fried malt 5-15g.

[0016] As an improvement of the above scheme, the Chinese medicine composition for helping sleep and promoting growth is mainly made of the following Chinese medicine raw materials in the following weight ratio: 15-25g of Astragalus, 8-12g of stir-fried Atractylodes, 3-6g of dried tangerine peel, 12-18g of Codonopsis, 8-12g of Cimicifuga, 3-6g of Bupleurum, 3-6g of Angelica, 15-25g of Rehmannia, 8-12g of roasted Licorice, 12-18g of Huaishan, 8-12g of Moutan, 8-12g of Alisma, 8-12g of Cornus, 2-4g of Cinnamon, 8-12g of Poria, 3-6g of Nutmeg, 8-12g of Costusroot, 2-4g of Coptis, 3-6g of Amomum, 8-12g of Hawthorn, 8-12g of Shenqu, and 8-12g of stir-fried malt.

[0017] As an improvement of the above scheme, the Chinese medicine composition for promoting sleep and growth is mainly made of the following Chinese medicine raw materials in the following weight ratio:

[0018] Astragalus 20g, stir-fried Atractylodes 10g, dried tangerine peel 5g, Codonopsis pilosula 15g, Cimicifuga 10g, Bupleurum 5g, Angelica 5g, Rehmannia glutinosa 20g, roasted Licorice root 10g, Huaishan 15g, Moutan bark 10g, Alisma orientalis 10g, Cornus officinalis 10g, cinnamon 3g, Poria 10g, nutmeg 5g, costusroot 10g, Coptis chinensis 3g, Amomum villosum 5g, Crataegus pinnatifida 10g, Shenqu 10g, stir-fried malt 10g.

[0019] Accordingly, the present invention also provides a method for preparing a Chinese medicine composition for promoting sleep and growth, comprising:

[0020] A. Weigh each Chinese medicine raw material according to the formula and soak it;

[0021] B. Extract and concentrate each Chinese medicine raw material to obtain the finished product.

[0022] Accordingly, the present invention also provides a use of a sleep-promoting and growth-promoting Chinese medicinal composition in the preparation of a medicine for preventing and / or treating insomnia.

[0023] Correspondingly, the present invention also provides a use of a Chinese medicinal composition for promoting sleep and growth in the preparation of a medicine for treating growth retardation, short stature and / or dwarfism.

[0024] Correspondingly, the present invention also provides a use of a Chinese medicinal composition for promoting sleep and growth in the preparation of a medicament for preventing and / or treating adenoids hypertrophy in children.

[0025] As an improvement of the above scheme, the medicine is an oral preparation, and the oral preparation is an ointment, decoction, powder, capsule, tablet, granule or pill.

[0026] As an improvement of the above scheme, the drug includes pharmaceutically acceptable excipients, which are one or more of disintegrants, emulsifiers, fillers, flavoring agents, wetting agents and solubilizers.

[0027] The implementation of the present invention has the following beneficial effects:

[0028] The present invention strengthens the original essence, invigorates the spleen and nourishes the kidney, and calms the mind to promote growth. Astragalus, stir-fried Atractylodes macrocephala, dried orange peel, roasted liquorice, Chinese yam are used to invigorate the spleen and nourish the lung, and Codonopsis pilosula and Chinese angelica are used to regulate qi and blood. Then, with Poria, Aucklandia lappa, Coptis chinensis, Fructus Amomi, Crataegus pinnatifida, Shenqu, Fructus Hordei Germinatus, and Myristica Fragrance, the spleen and stomach are played together, the merit of digestion, distension, and diarrhea is relieved, and then with Radix Rehmanniae, Fructus Corni, Cortex Moutan, Rhizoma Alismatis is matched to protect the innate foundation, nourish the kidney, produce marrow and strengthen bones, and then by warming kidney water with cinnamon to guide fire downward, Coptis chinensis is used to clear the heart and reduce fire, so that the heart fire is lowered, the heart and kidney intersect, strengthen sleep, improve sleep quality, and promote the secretion of growth hormone. In summary, the present invention can reach the balance of yin and yang, nourish less fire, make less fire slowly germinate, less fire is born, then yin and yang are flat, qi and blood are abundant, airway is unblocked, muscle is slippery, and bone marrow is born, so as to play a good effect of helping sleep and promoting growth, effectively treat the problems such as poor sleep quality, insomnia, growth retardation and short stature.

[0029] In addition to having good sleep-inducing and growth-promoting effects, the invention can also improve the constitution prone to colds and has an outstanding therapeutic effect on adenoids hypertrophy.

[0030] In summary, the present invention can simultaneously have outstanding therapeutic effects on poor sleep quality, growth retardation and short stature, susceptibility to colds and adenoids hypertrophy, playing the role of treating multiple diseases with one medicine. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 The present invention is a flow chart of an embodiment of a method for preparing a Chinese medicine composition. DETAILED DESCRIPTION

[0032] In order to make the objectives, technical solutions and advantages of the present invention more clear, the present invention will be further described in detail below with reference to the accompanying drawings.

[0033] The present invention provides a Chinese medicine composition for promoting sleep and growth, wherein the Chinese medicine composition is mainly made of the following Chinese medicine raw materials in the following weight ratios:

[0034] Astragalus 10-30g, stir-fried Atractylodes 5-15g, dried tangerine peel 2-8g, Codonopsis pilosula 10-20g, Cimicifuga 5-15g, Bupleurum 2-8g, Angelica 2-8g, Rehmannia glutinosa 10-30g, roasted Licorice root 5-15g, Huaishan 10-20g, Moutan bark 5-15g, Alisma orientalis 5-15g, Cornus officinalis 5-15g, cinnamon bark 1-5g, Poria 5-15g, nutmeg 2-8g, costusroot 5-15g, Coptis chinensis 1-5g, Amomum villosum 2-8g, Hawthorn 5-15g, Shenqu 5-15g, stir-fried malt 5-15g.

[0035] Preferably, the sleep-promoting and growth-promoting Chinese medicine composition is mainly made of the following Chinese medicine raw materials in the following weight ratio: 15-25g of Astragalus, 8-12g of stir-fried Atractylodes, 3-6g of dried tangerine peel, 12-18g of Codonopsis, 8-12g of Cimicifuga, 3-6g of Bupleurum, 3-6g of Angelica, 15-25g of Rehmannia, 8-12g of Radix Glycyrrhizae, 12-18g of Huaishan, 8-12g of Moutan, 8-12g of Alisma, 8-12g of Cornus, 2-4g of Cinnamon, 8-12g of Poria, 3-6g of Nutmeg, 8-12g of Costusroot, 2-4g of Coptis, 3-6g of Amomum, 8-12g of Crataegus, 8-12g of Shenqu, and 8-12g of stir-fried malt.

[0036] More preferably, the sleep-promoting and growth-promoting Chinese medicinal composition is mainly made of the following Chinese medicinal raw materials in the following weight ratios:

[0037] Astragalus 20g, stir-fried Atractylodes 10g, dried tangerine peel 5g, Codonopsis pilosula 15g, Cimicifuga 10g, Bupleurum 5g, Angelica 5g, Rehmannia glutinosa 20g, roasted Licorice root 10g, Huaishan 15g, Moutan bark 10g, Alisma orientalis 10g, Cornus officinalis 10g, cinnamon 3g, Poria 10g, nutmeg 5g, costusroot 10g, Coptis chinensis 3g, Amomum villosum 5g, Crataegus pinnatifida 10g, Shenqu 10g, stir-fried malt 10g.

[0038] In the Chinese medicine composition that helps sleep and promotes growth, Astragalus is sweet and warm in nature. It enters the lung and spleen meridians, and has the effects of replenishing qi and strengthening the exterior, promoting diuresis and expelling toxins, draining pus, and healing sores and promoting tissue regeneration. Modern research has found that it contains a variety of effective ingredients such as glycosides, flavonoids, polysaccharides, amino acids and trace elements, which has important guiding significance for clinical treatment. Modern research has found that Astragalus has a variety of pharmacological effects, can inhibit inflammation, scavenge free radicals, inhibit the permeability of vascular endothelial monolayer, and has antiviral, cardiovascular and cerebrovascular protection, immunity enhancement, and anti-tumor effects.

[0039] Stir-fried Atractylodes macrocephala tastes bitter and sweet, and is warm in nature. It enters the spleen and stomach meridians, and has the effects of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, stopping sweating, and calming the fetus. Atractylodes macrocephala contains a variety of chemical components, including sesquiterpenes and lactones, flavonoids, phenylpropanoids, alkynes and their glycosides, polysaccharides, etc. Modern pharmacological studies have shown that Atractylodes macrocephala has pharmacological effects such as anti-inflammatory, anti-tumor, improving gastrointestinal function, regulating the urinary system, improving nerve function, improving immunity, exciting uterine smooth muscle, and lowering blood lipids and blood sugar.

[0040] Tangerine peel tastes bitter and spicy, is warm in nature, and belongs to the lung and spleen meridians. It has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm. Modern pharmacological research shows that tangerine peel contains volatile oils, hesperidin, vitamins B and C, etc., which can regulate gastrointestinal motility, promote gastric juice secretion, anti-oxidation, and relieve expectorant and asthma.

[0041] Codonopsis pilosula is sweet and flat in nature. It belongs to the spleen and lung meridians. It has the effects of strengthening the spleen and lungs, nourishing blood and promoting the production of body fluids. Modern pharmacological studies have shown that Codonopsis pilosula contains triterpenoids, sugars, volatile oils, saponins, trace alkaloids, polysaccharides, 17 kinds of amino acids such as aspartic acid, 4 kinds of macroelements (K, Na, Ca, Mg) and 7 kinds of trace elements necessary for the human body. It can regulate the gastrointestinal tract, protect gastric mucosa, promote the healing of gastric ulcers, increase the body's immune function, improve the body's anti-stress ability, increase the number of red blood cells, white blood cells and hemoglobin content, inhibit platelet aggregation, strengthen the heart, regulate blood pressure, resist myocardial ischemia, improve learning and memory, and have antibacterial effects.

[0042] Cimicifuga heracleifolia is pungent, slightly sweet, and slightly cold in nature. It enters the lung, spleen, stomach, and large intestine meridians. It has the effects of relieving rash, clearing away heat and detoxifying, and raising Yang Qi. Modern pharmacological studies have shown that Cimicifuga heracleifolia contains a variety of steroidal terpenoid components: β-sitosterol, cimicifuga alcohol, cimicifuga alcohol xyloside, and northern cimicifuga alcohol. In addition, it also contains isoferulic acid, trace amounts of ferulic acid, caffeic acid, and furanocoumarin components dentamicin and dentamifuga alcohol. It has a variety of physiological activities such as inhibiting nucleotide movement, anti-virus, anti-tumor, regulating neuroendocrine function, anti-osteoporosis, and anti-inflammatory.

[0043] Bupleurum has a pungent and bitter taste and is slightly cold in nature. It enters the liver, gallbladder, and lung meridians and has the effects of dispersing fever, relieving liver depression, and raising Yang Qi. Modern pharmacological studies have shown that Bupleurum contains mainly saponins, sterols, volatile oils, fatty oils, and polysaccharides. In addition, it also contains alkaloids, flavonoids, kaempferol, glucose, amino acids, and the like. Pharmacological experiments have shown that Bupleurum has anti-inflammatory, antipyretic, sedative, analgesic, antitussive, and anticonvulsant effects; it can reduce liver damage and promote bile secretion; it has the effects of lowering blood pressure, lowering serum cholesterol, and hemolysis; it has the effects of anti-ulcer, antibacterial, antiviral, anti-tumor, increasing blood sugar, reducing blood fat content, and resisting radiation damage.

[0044] Angelica sinensis is sweet and pungent in taste and warm in nature. It enters the liver, heart and spleen meridians and has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. Modern pharmacological studies have shown that the main chemical components of Angelica sinensis are volatile oils, organic acids, polysaccharides and coumarins, among which volatile oils and polysaccharide chemical components are the main active substances of Angelica sinensis. Angelica sinensis has a wide range of pharmacological effects such as promoting hematopoiesis, anticoagulation, lowering blood pressure, anti-inflammatory analgesia, anti-oxidation, anti-tumor, liver and kidney protection.

[0045] Raw Rehmannia root is cold in nature, sweet and bitter in taste, and enters the heart, liver, and kidney meridians. It has the effects of clearing heat and cooling blood, nourishing yin and promoting body fluid. Raw Rehmannia root mainly contains iridoids, ionones, and phenylethanol compounds, as well as other compounds such as triterpenes, flavonoids, lignans, and phenolic acids. Pharmacological studies have found that Rehmannia root has a significant regulatory effect on the blood system, cardiovascular and cerebrovascular system, central nervous system, and immune system. In addition, it also has the effects of regulating blood sugar and blood lipids, anti-aging, anti-tumor, antibacterial, anti-gastric ulcer, and protecting gastric mucosa.

[0046] Licorice root is sweet and neutral in nature. It enters the heart, lung, spleen and stomach meridians and has the effects of tonifying the spleen and stomach, replenishing qi and restoring pulse. Licorice has diverse chemical components. So far, more than 400 compounds such as flavonoids, triterpenes, coumarins, and diphenylethylene have been discovered. Modern pharmacological studies have shown that licorice root has a wide range of pharmacological effects such as anti-tumor, anti-inflammatory, antibacterial, antiviral, neuroprotective, and liver protective.

[0047] Chinese yam is sweet in taste and neutral in nature. It enters the spleen, lung and kidney meridians. It has the effects of nourishing the spleen and stomach, promoting fluid production and benefiting the lungs, nourishing the kidneys and astringing the essence. Modern pharmacological research shows that Chinese yam is rich in saponins, mucus, choline, starch, sugar, protein, amino acids, vitamin C and other nutrients as well as a variety of trace elements. It is a good food supplement for recovery after illness. It contains amylase, polyphenol oxidase and other substances, which are beneficial to the digestion and absorption function of the spleen and stomach; it contains a large amount of mucus protein, vitamins and trace elements, which can lower blood sugar, effectively prevent the precipitation of blood lipids in the blood vessel wall, and prevent cardiovascular diseases; it can promote the proliferation of T lymphocytes in the body, enhance immune function, and delay cell aging. Regular consumption of Chinese yam can prolong life.

[0048] Peony bark is bitter, pungent, slightly cold, and enters the heart, liver, and kidney meridians. It has the effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis. Modern pharmacological studies have shown that the chemical composition of peony bark is relatively complex, mainly containing phenols and glycosides, monoterpenes and their glycosides, triterpenes, organic acids, flavonoids, coumarins, etc. In addition, it also has a large amount of polysaccharides and volatile oils. It has strong antibacterial and anti-inflammatory, anti-tumor, anti-arrhythmic, hypoglycemic, activating the body's immune system, and protecting the cardiovascular system.

[0049] Alisma orientalis is sweet and light in taste, cold in nature, and enters the kidney and bladder meridians. Its main functions are to promote diuresis and eliminate dampness, relieve heat, and reduce turbidity and lipids. Alisma orientalis mainly contains alismatol A, B and acetate, as well as volatile oils, alkaloids, asparagine, choline, lecithin, fatty acids and other ingredients. Modern pharmacological studies have confirmed that Alisma orientalis has a significant diuretic effect, and has the effects of lowering blood lipids, lowering blood pressure, dilating coronary arteries, relieving cough, removing phlegm, resisting fatty liver, resisting blood coagulation and anti-cancer.

[0050] Cornus officinalis is sour and slightly warm in nature. It enters the liver and kidney meridians. It has the effects of nourishing the liver and kidneys and consolidating and astringing. Modern pharmacological studies have shown that the main chemical components of Cornus officinalis are polysaccharides, cyclopentane ethers, mushrooms, etc., which have pharmacological activities such as hypoglycemic, anti-inflammatory, antioxidant, anti-aging, anti-tumor, neuroprotection, and liver and kidney protection.

[0051] Cinnamon bark is pungent and sweet in taste, very hot in nature, and enters the kidney, spleen, heart, and liver meridians. Its main functions include warming the qi and blood, replenishing fire and yang, and dispelling cold and relieving pain. Cinnamon bark contains volatile components such as cinnamaldehyde and non-volatile components such as polysaccharides, diterpenes, polyphenols, and flavonoids. Modern pharmacological studies have shown that cinnamon bark has biological activities such as antibacterial, antioxidant, anti-inflammatory, anti-cancer, and hypoglycemic.

[0052] Poria cocos is sweet and neutral in nature. It has the effects of promoting diuresis and eliminating dampness, strengthening the spleen and calming the mind. Modern research shows that the main chemical components of Poria cocos are terpenes, polysaccharides, sterols, fatty acids, etc., which can play pharmacological effects such as anti-tumor, anti-inflammatory, antioxidant, liver protection, and immunomodulation.

[0053] Nutmeg is spicy and warm in nature. It enters the spleen, stomach and large intestine meridians. It has the effects of warming the middle and promoting the flow of qi, astringing the intestines and stopping diarrhea. Modern pharmacological studies have shown that nutmeg mainly contains volatile oils, fatty oils, lignans and other ingredients, which not only play a role in protecting the liver and intestines, resisting gastric ulcers and stopping diarrhea in the treatment of digestive system diseases, but also has pharmacological effects such as regulating the nervous system and cardiovascular and cerebrovascular, lowering blood sugar, anti-cancer, anti-inflammatory and analgesic.

[0054] Muxiang, with a pungent and bitter taste and warm nature, enters the spleen, stomach, large intestine, triple burner, and gallbladder meridians, and has the effects of promoting qi and relieving pain, strengthening the spleen and digesting food. Muxiang mainly contains volatile oils. Modern pharmacological studies have shown that Muxiang has the effects of improving gastrointestinal function, promoting gallbladder contraction, anti-inflammatory, anti-ulcer, anti-tumor, and improving myocardial infarction and angina pectoris.

[0055] Coptis chinensis is bitter and cold in nature. It enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians and has the effects of clearing away heat and dampness, purging fire and detoxifying. Its chemical components mainly include alkaloids, lignans, flavonoids, acidic components, etc. Modern pharmacological studies have shown that Coptis chinensis has pharmacological effects such as protecting cardiovascular and cerebrovascular vessels, lowering blood sugar, anti-inflammatory, and anti-tumor.

[0056] Amomum villosum is warm in nature, pungent in taste, and enters the spleen, stomach, and kidney meridians. It has multiple functions such as removing dampness and stimulating appetite, warming the spleen and stopping diarrhea, regulating qi and calming the fetus. Amomum villosum mainly contains volatile oil components such as borneol and camphor. Modern pharmacological studies have shown that this product has anti-ulcer, inhibits gastric acid secretion, promotes gastrointestinal motility, inhibits platelet aggregation, analgesic, anti-inflammatory, choleretic, antioxidant, and immune function regulation effects.

[0057] Hawthorn is warm in nature, sour and sweet in taste, and enters the spleen, stomach, and liver meridians. It has the effects of strengthening the stomach, digesting food, removing stagnation, promoting qi and blood circulation, and removing blood stasis. Modern pharmacological research has found that hawthorn mainly contains flavonoids, including hyperoside, quercetin, and flavonoid polymers; organic acids, including citric acid, hawthorn acid, etc., and also contains lactones, sugars, and glycosides. Modern pharmacological research has found that hawthorn has the effects of promoting fat digestion, protecting the heart, lowering blood pressure, lowering blood lipids, anti-oxidation, improving immunity, antibacterial, and anti-tumor.

[0058] Shenqu tastes sweet and spicy, and is warm in nature. It enters the spleen and stomach meridians. It has the effects of strengthening the spleen and stomach, and digesting food and eliminating accumulation. Studies have shown that Shenqu mainly contains yeast, enzymes, vitamin B complex, ergosterol, volatile oils, glycosides and other chemical components. Modern pharmacological studies have shown that Shenqu has the effects of promoting gastrointestinal motility, improving appetite, regulating intestinal flora, enhancing the body's immune function, antibacterial, protecting the intestines and stopping diarrhea.

[0059] Fried malt is sweet in taste, neutral in nature, and enters the spleen and stomach meridians. It has the effects of promoting qi and digestion, strengthening the spleen and appetite, and promoting lactation and relieving bloating.

[0060] The chemical components of malt mainly include polysaccharides, enzymes, alkaloids, vitamins, amino acids, proteins, flavonoids, folic acid, phenols and other chemical components. Modern pharmacological research shows that malt has antioxidant, anti-tumor, lactation, lactation, digestion, intestinal flora regulation, liver protection, blood sugar reduction, anti-inflammatory and other functional activities.

[0061] According to traditional Chinese medicine, the growth and development of the human body is closely related to the functions of the spleen and kidney. The spleen is responsible for transportation and transformation, and its main function is to digest and absorb food and provide the body with sufficient nutrients. The kidney is responsible for bone marrow production, promoting bone growth and development. If the spleen and kidney function is out of balance, it will affect the growth and development of children. Therefore, strengthening the spleen and kidney is of great significance to promoting the growth of children.

[0062] The sleep-aiding and growth-promoting paste provided by the embodiment of the present invention can strengthen the body's foundation, invigorate the spleen and tonify the kidney, clear the heart and calm the nerves to promote growth, use astragalus, stir-fried atractylodes, tangerine peel, roasted liquorice, and yam to invigorate the spleen and tonify the lungs, use codonopsis and angelica to regulate qi and blood, and then use tuckahoe, costusroot, coptis root, amomum, hawthorn, Shenqu, malt, and nutmeg to strengthen the spleen and stomach, digest food, eliminate bloating and stop diarrhea, then use raw rehmannia with cornus officinalis, peony bark, and oriental water plantain to protect the innate foundation, nourish the kidney, produce marrow and strengthen bones, then use cinnamon to warm the kidney water to guide the fire downward, use coptis root to clear the heart and reduce fire, so that the heart fire can be reduced, the heart and kidney interact, strengthen sleep, improve sleep quality, and promote the secretion of growth hormone. In summary, the present invention can balance yin and yang, nourish the Shaohuo, and make the Shaohuo grow slowly. When the Shaohuo grows, the yin and yang are balanced, the qi and blood are abundant, the airways are unblocked, the muscles are smooth, and the bone marrow grows, thereby playing a good role in helping sleep and promoting growth, and effectively treating problems such as poor sleep quality, insomnia, growth retardation and short stature.

[0063] In addition, the present invention has anti-inflammatory, antiviral, and anti-tissue fibrosis effects, and can inhibit the formation of fibrosis on the surface of swollen adenoids to a certain extent. At the same time, clinical trials have shown that the Chinese medicine composition of the present invention can effectively improve clinical symptoms such as nasal congestion, mouth breathing, and snoring during sleep in children, reduce the volume of adenoid hypertrophy, and effectively prevent children from suffering from repeated troubles of the disease. It also has outstanding therapeutic effects on children with a constitution that is prone to colds.

[0064] Preferably, the dosage ratio of nutmeg and costus root is 1:(2-3). Nutmeg and costus root can play a good role in strengthening and invigorating the spleen. At the same time, the dosage ratio of cimicifuga, bupleurum and cinnamon is 10:(4-6):(2-3), which can achieve kidney and spleen coordination. The dosage ratio of cinnamon and coptis root is 1:(1-2), which can guide fire downward and clear the heart and reduce fire, thereby playing a good role in helping sleep and promoting growth. More preferably, the dosage ratio of nutmeg and costus root is 1:2; the dosage ratio of cimicifuga, bupleurum and cinnamon is 10:5:3. The dosage ratio of cinnamon and coptis root is 1:1.

[0065] In summary, the present invention has the effects of nourishing the kidney and promoting growth, strengthening the spleen and harmonizing qi, calming the nerves and promoting sleep, and has obvious therapeutic effects on the following children:

[0066] 1. Suitable for 3-14 years old;

[0067] 2. Children with slow growth and development and slow reaction. Slow growth and development include growth retardation, short stature and / or dwarfism;

[0068] 3. Children with thin stature, anorexia, indigestion, and food accumulation;

[0069] 4. Children with poor resistance, prone to colds and coughs;

[0070] 5. Children who have unstable sleep, are easily awakened, and have poor sleep quality.

[0071] Accordingly, the present invention also provides a method for preparing a Chinese medicine composition for promoting sleep and growth.

[0072] A. Weigh each Chinese medicine raw material according to the formula and soak it;

[0073] B. Extract and concentrate each Chinese medicine raw material to obtain the finished product.

[0074] In some preferred embodiments, the preparation method of the sleep-promoting and growth-promoting Chinese medicine composition comprises:

[0075] S101, weighing each Chinese medicinal material according to the formula and soaking it;

[0076] S102, extracting and concentrating each Chinese medicine raw material to obtain a paste;

[0077] S103, packaging the paste and making a cooling cream to obtain a finished product.

[0078] Preferably, step S101 includes:

[0079] Weigh the various Chinese medicinal raw materials according to the formula, put in and soak astragalus, stir-fried atractylodes, tangerine peel, codonopsis, cimicifuga, bupleurum, angelica, raw rehmannia, roasted licorice, yam, moutan bark, oriental water plantain, cornus officinalis, cinnamon, poria, coptis, hawthorn, Shenqu, and stir-fried malt first, and then add nutmeg, costus root, and amomum and soak them.

[0080] Preferably, the present invention extracts and concentrates each Chinese medicine raw material by mixed drug concentration, removes part of the solvent in the drug solution, and obtains a concentrated solution with a higher concentration. The specific concentration method can be achieved by homogenization, spraying, atomization, evaporation, reduced pressure distillation, etc., but is not limited thereto.

[0081] This embodiment obtains a Chinese medicine composition paste for helping sleep and growth, which can be added with maltose and honey, etc., and then packaged with transparent packaging materials, 20g / bag, 2 bags for one dose. Store at room temperature, take one dose each time. The paste of the present invention is not easy to deteriorate and moldy when stored at room temperature for 30 days, and the quality of the remaining unused paste is not affected after the outer packaging is opened.

[0082] In some preferred embodiments, the preparation method of the sleep-promoting and growth-promoting Chinese medicine composition comprises:

[0083] S101, weighing each Chinese medicinal material according to the formula and soaking it;

[0084] S102, first decoct astragalus, stir-fried atractylodes, dried orange peel, codonopsis, cimicifuga, bupleurum, angelica, raw rehmannia, roasted licorice, Chinese yam, moutan bark, oriental water plantain, cornus officinalis, cinnamon bark, tuckahoe, coptis root, hawthorn, Shenqu, and stir-fried malt for 5-30 minutes;

[0085] S103, then add nutmeg, costusroot and amomum villosum and boil for 5-10 minutes to obtain a finished product.

[0086] It should be noted that the Chinese medicine composition of the present invention can also be made into other dosage forms, such as decoctions, powders, capsules, tablets, granules or pills, etc., and its implementation is not limited to the embodiments of the present invention. Accordingly, its preparation method can be adjusted accordingly according to different dosage forms.

[0087] Accordingly, the present invention also provides a use of a sleep-promoting and growth-promoting Chinese medicinal composition in the preparation of a medicine for preventing and / or treating insomnia.

[0088] Correspondingly, the present invention also provides a use of a Chinese medicinal composition for promoting sleep and growth in the preparation of a medicine for treating growth retardation, short stature and / or dwarfism.

[0089] Accordingly, the present invention also provides a use of a Chinese medicine composition for promoting sleep and growth in the preparation of a drug for preventing and / or treating adenoids hypertrophy in children. Preferably, the drug is an oral preparation, and the oral preparation is an ointment, decoction, powder, capsule, tablet, granule or pill.

[0090] The drug comprises pharmaceutically acceptable excipients, which are one or more of disintegrants, emulsifiers, fillers, flavoring agents, wetting agents and solubilizers.

[0091] The present invention is further described below with specific embodiments

[0092] Example 1

[0093] Astragalus 10g, stir-fried Atractylodes 5g, Tangerine Peel 2g, Codonopsis pilosula 10g, Cimicifuga 5g, Bupleurum 2g, Angelica 2g, Rehmannia glutinosa 10g, roasted Licorice root 5g, Huaishan 10g, Moutan bark 5g, Alisma orientalis 5g, Cornus officinalis 5g, Cinnamon bark 1g, Poria 5g, Nutmeg 2g, Costus root 5g, Coptis chinensis 1g, Amomum villosum 2g, Crataegus pinnatifida 5g, Shenqu 5g, stir-fried malt 5g.

[0094] Preparation method: According to the above formula, add astragalus, fried atractylodes, tangerine peel, codonopsis, cimicifuga, bupleurum, angelica, raw rehmannia, roasted licorice, yam, moutan bark, oriental water plantain, cornus officinalis, cinnamon, poria, coptis, hawthorn, and fried malt to ethanol solution, mix and soak for 2-4h, then add nutmeg, costusroot, and amomum and soak for 5-20min; then reflux extraction twice, 2h / time, combine the extracts and concentrate, finally collect the paste and add auxiliary materials 3.0g maltose and 1.0g honey, package and make a cooling paste to obtain a sleep-aiding and growth-promoting paste.

[0095] Example 2

[0096] Astragalus 20g, stir-fried Atractylodes 10g, dried tangerine peel 5g, Codonopsis pilosula 15g, Cimicifuga 10g, Bupleurum 5g, Angelica 5g, Rehmannia glutinosa 20g, roasted Licorice root 10g, Huaishan 15g, Moutan bark 10g, Alisma orientalis 10g, Cornus officinalis 10g, cinnamon 3g, Poria 10g, nutmeg 5g, costusroot 10g, Coptis chinensis 3g, Amomum villosum 5g, Crataegus pinnatifida 10g, Shenqu 10g, stir-fried malt 10g.

[0097] Preparation method: According to the above formula, add astragalus, fried atractylodes, tangerine peel, codonopsis, cimicifuga, bupleurum, angelica, raw rehmannia, roasted licorice, yam, moutan bark, oriental water plantain, cornus officinalis, cinnamon, poria, coptis, hawthorn, and fried malt to ethanol solution, mix and soak for 2-4h, then add nutmeg, costusroot, and amomum and soak for 5-20min; then reflux extraction twice, 2h / time, combine the extracts and concentrate, finally collect the paste and add auxiliary materials 4.2g maltose and 1.5g honey, package and make a cooling paste to obtain a sleep-aiding and growth-promoting paste.

[0098] Example 3

[0099] Astragalus 30g, stir-fried Atractylodes 15g, dried tangerine peel 8g, Codonopsis pilosula 20g, Cimicifuga 15g, Bupleurum 8g, Angelica 8g, Rehmannia glutinosa 30g, roasted Licorice root 15g, Huaishan 20g, Moutan bark 15g, Alisma orientalis 15g, Cornus officinalis 15g, cinnamon bark 5g, Poria 15g, nutmeg 8g, costusroot 15g, Coptis chinensis 5g, Amomum villosum 8g, Crataegus pinnatifida 15g, Shenqu 15g, and stir-fried malt 15g.

[0100] Preparation method: According to the above formula, add astragalus, fried atractylodes, tangerine peel, codonopsis, cimicifuga, bupleurum, angelica, raw rehmannia, roasted licorice, yam, moutan bark, oriental water plantain, cornus officinalis, cinnamon, poria, coptis, hawthorn, and fried malt to ethanol solution, mix and soak for 2-4h, then add nutmeg, costusroot, and amomum and soak for 5-20min; then reflux extraction twice, 2h / time, combine the extracts and concentrate, finally collect the paste and add auxiliary materials 4.8g maltose and 2.0g honey, package and make a cooling paste to obtain a sleep-aiding and growth-promoting paste.

[0101] Example 4

[0102] Astragalus 15g, stir-fried Atractylodes 8g, Tangerine Peel 5g, Codonopsis pilosula 15g, Cimicifuga 8g, Bupleurum 6g, Angelica 6g, Rehmannia glutinosa 15g, Roasted Licorice 10g, Huaishan 15g, Moutan Bark 8g, Alisma Orientalis 8g, Cornus officinalis 8g, Cinnamon 2g, Poria 8g, Nutmeg 5g, Costusroot 8g, Coptis chinensis 2g, Amomum villosum 5g, Crataegus pinnatifida 8g, Shenqu 8g, and stir-fried malt 8g.

[0103] Preparation method: According to the above formula, add astragalus, fried atractylodes, tangerine peel, codonopsis, cimicifuga, bupleurum, angelica, raw rehmannia, roasted licorice, yam, moutan bark, oriental water plantain, cornus officinalis, cinnamon, poria, coptis, hawthorn, and fried malt to ethanol solution, mix and soak for 2-4h, then add nutmeg, costusroot, and amomum and soak for 5-20min; then reflux extraction twice, 2h / time, combine the extracts and concentrate, finally collect the paste and add auxiliary materials 3.0g maltose and 1.0g honey, package and make a cooling paste to obtain a sleep-aiding and growth-promoting paste.

[0104] Example 5

[0105] Astragalus 18g, stir-fried Atractylodes 12g, dried tangerine peel 6g, Codonopsis pilosula 12g, Cimicifuga 12g, Bupleurum 6g, Angelica 6g, Rehmannia glutinosa 20g, roasted Licorice root 12g, Huaishan 18g, Moutan bark 12g, Alisma orientalis 12g, Cornus officinalis 12g, cinnamon bark 3g, Poria 12g, nutmeg 6g, costusroot 12g, Coptis chinensis 4g, Amomum villosum 6g, Crataegus pinnatifida 12g, Shenqu 12g, stir-fried malt 12g.

[0106] Preparation method: According to the above formula, add astragalus, fried atractylodes, tangerine peel, codonopsis, cimicifuga, bupleurum, angelica, raw rehmannia, roasted licorice, yam, moutan bark, oriental water plantain, cornus officinalis, cinnamon, poria, coptis, hawthorn, and fried malt to ethanol solution, mix and soak for 2-4h, then add nutmeg, costusroot, and amomum and soak for 5-20min; then reflux extraction twice, 2h / time, combine the extracts and concentrate, finally collect the paste and add auxiliary materials maltose 3.2g and honey 1.5g, package and make a cooling paste to obtain a sleep-aiding and growth-promoting paste.

[0107] Example 6

[0108] Astragalus 25g, stir-fried Atractylodes 12g, Tangerine Peel 4g, Codonopsis pilosula 18g, Cimicifuga 14g, Bupleurum 7g, Angelica 7g, Rehmannia glutinosa 25g, roasted Licorice root 12g, Huaishan 18g, Moutan bark 14g, Alisma orientalis 14g, Cornus officinalis 14g, Cinnamon bark 4g, Poria 14g, Nutmeg 7g, Costus root 14g, Coptis chinensis 4g, Amomum villosum 7g, Crataegus pinnatifida 14g, Shenqu 14g, stir-fried malt 14g.

[0109] Preparation method: According to the above formula, add astragalus, fried atractylodes, tangerine peel, codonopsis, cimicifuga, bupleurum, angelica, raw rehmannia, roasted licorice, yam, moutan bark, oriental water plantain, cornus officinalis, cinnamon, poria, coptis, hawthorn, and fried malt to ethanol solution, mix and soak for 2-4h, then add nutmeg, costusroot, and amomum and soak for 5-20min; then reflux extraction twice, 2h / time, combine the extracts and concentrate, finally collect the paste and add auxiliary materials 4.0g maltose and 2.0g honey, package and make a cooling paste to obtain a sleep-aiding and growth-promoting paste.

[0110] Comparative Example 1

[0111] A commercially available stomach-strengthening and digestion-promoting oral liquid was selected, the main ingredients of which were Pseudostellaria heterophylla, tangerine peel, yam, malt (fried), and hawthorn.

[0112] 1. The sleep-promoting and growth-promoting cream obtained in Example 2 is selected to carry out growth-promoting experimental research, as follows:

[0113] 1 Research objectives:

[0114] Through observation and analysis of the research project, and comparison of the efficacy with the control group, the differences between the two were compared to explore the clinical efficacy, safety and clinical application value of the sleep-aiding and growth-promoting cream for children with short stature. The sleep-aiding and growth-promoting cream of Example 2 is 20g / pack, and 2 packs are one dose. Store at room temperature and take one dose each time.

[0115] 2 Research Methods:

[0116] 60 children with short stature who met the criteria were selected and divided into an observation group and a treatment group according to the treatment time. The observation group was treated with the sleep-aiding and growth-promoting ointment prepared in Example 2 of the present invention, one dose each after meals in the morning and evening; the control group was treated with the stomach-strengthening and digestion-promoting oral liquid, 10 ml each time, once in the morning and evening. It was taken for 12 consecutive months, and the height, weight, BMI, growth rate, cognitive and intelligence scores were compared before and after treatment, respectively, to evaluate the difference in efficacy between the two groups.

[0117] 3 Research subjects:

[0118] A total of 60 children aged 6-8 years with short stature who visited the Department of Preventive Medicine of Traditional Chinese Medicine Hospital of Gaoming District, Foshan City from February 1, 2023 to February 1, 2024 were selected. The 60 cases that met the inclusion criteria were divided into an observation group and a control group with 30 cases in each group according to the random number table method.

[0119] 4. Western medicine inclusion criteria for short stature:

[0120] According to the 2005 National Height Standard and the "Guidelines for the Diagnosis and Treatment of Short Stature Children", children whose height is between one standard deviation (or 25th percentile) and two standard deviations (or 3rd percentile) of the normal height of children of the same age, race, and gender are defined as short.

[0121] The body is well-proportioned, and the height and weight at birth are within the normal range for the same gestational age:

[0122] The difference between bone age and actual age should not exceed 1 year;

[0123] GH stimulation test: GH peak ≥10ug / L.

[0124] 5Other inclusion criteria:

[0125] (1) Children aged 6-8 years old with short stature;

[0126] (2) The subjects and their legal guardians were informed and signed an informed consent form.

[0127] 6 Exclusion criteria

[0128] If any of the following conditions are met, the person will be excluded:

[0129] (1) Patients with acute exacerbation of acute or chronic diseases due to various reasons.

[0130] (2) Patients with severe diseases of other systems such as heart, lung, brain, liver, and kidney.

[0131] 7 General Information

[0132] In the sleep-aiding and growth-enhancing ointment group, there were 15 males and 15 females, aged 6-8 years old, with an average age of (7.1±0.84) years old; in the stomach-strengthening and digestion-promoting oral liquid group, there were 16 males and 14 females, aged 6-8 years old, with an average age of (6.97±0.85) years old. The two groups were compared in terms of gender, age and other general data, and no statistically significant differences were found (P>0.05), so they were comparable. See Tables 1 and 2. The weight of the children in the growth-promoting paste group was (19.63±1.58) kg, height was (115.28±4.03) cm, BMI was (14.75±0.63), and Montreal Cognitive Assessment (MoCA) was (20.27±1.41). The weight of the children in the Jianweixiaoshi oral liquid group was (19.09±1.29) kg, height was (114.6±3.77) cm, BMI was (18.72±23.11), and Montreal Cognitive Assessment (MoCA) was (19.87±1.50). See Table 3. After comparison, it was found that there was no significant difference between the two groups (P>0.05), and they were comparable.

[0133] Table 1 Gender of the two groups before treatment

[0134]

[0135] Table 2 Age of the two groups before treatment

[0136]

[0137] Table 3 Weight, height, BMI and MoCA scale scores of the two groups before treatment

[0138]

[0139] 8 Observation indicators:

[0140] The height, weight, BMI and growth rate of the two groups were observed before and after treatment;

[0141] The cognitive and intelligence scores of the two groups of children were compared before and after treatment. The cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA), which mainly includes the evaluation of attention, naming ability, memory, abstract thinking ability, delayed memory ability, etc. The total score is 30 points. When the score is greater than 26 points, the cognitive function is considered normal.

[0142] 9 Statistical analysis

[0143] SPSS 26.0 software was used to uniformly process the data recorded in this study. Count data were expressed as cases (%), and inter-group comparisons were performed using χ 2 Inspection, measurement data The t test was used. The differences between the groups were considered comparable when P < 0.05.

[0144] 10 Results

[0145] Before and after treatment, the height, weight and BMI of the two groups increased. The indicators of the sleep-aiding and growth-enhancing ointment group were significantly higher than those of the stomach-strengthening and digestion-promoting oral liquid group, and P<0.05, indicating that the differences between the groups were comparable. See Table 4.

[0146] Table 4 Weight, height and BMI of the two groups after treatment

[0147]

[0148] Before and after treatment, MoCA of both groups increased compared with that before medication, and the improvement of the sleep-aiding and growth-enhancing paste group was greater than that of the stomach-strengthening and digestion-promoting oral liquid group, P<0.05, and the difference between the groups was comparable. After medication, the growth rate of the two groups was compared, P<0.05, and the difference between the groups was comparable (see Table 5).

[0149] Table 5 MoCA scale scores and growth rate after treatment

[0150]

[0151] Second, the sleep-aiding and growth-promoting cream obtained in Example 2 is selected to carry out experimental research on sleep-aiding, as follows:

[0152] The observation index of this study was the Sleep Disturbance Scale for Children (SDSC) compiled by Bruni et al. to investigate the sleep status of students, with a Cronbach's coefficient of 0.81. The scale consists of 26 questions, with "never, occasionally (1-2 times a month), sometimes (1-2 times a week), often (3-5 times a week), always (every day) corresponding to 1 point, 2 points, 3 points, 4 points, and 5 points". The total score of the scale ranges from 26 to 130 points. The higher the score, the worse the sleep quality. A score >39 points is considered to have sleep disorder, and a score >50 points is considered to be moderate to severe sleep disorder.

[0153] By comparing before and after treatment, both groups showed improvement. In the growth-promoting paste group, there were 17 cases of sleep disorder and 13 cases of moderate to severe sleep disorder before treatment. After treatment, there was overall improvement, including 17 cases of normal sleep, 12 cases of sleep disorder, and 1 case of moderate to severe sleep disorder; in the stomach-strengthening and digestion-promoting oral liquid group, there were 17 cases of sleep disorder and 13 cases of moderate to severe sleep disorder before treatment. After treatment, there was overall improvement, including 5 cases of normal sleep, 17 cases of sleep disorder, and 8 cases of moderate to severe sleep disorder; see Table 6. Sleep status distribution table.

[0154] Table 6 Sleep status breakdown

[0155]

[0156] By comparison, there was no difference in the Sleep Disturbance Scale for Children (SDSC) between the two groups before treatment (P>0.05). After treatment, the two groups were comparable (P<0.05), as shown in Table 7.

[0157] Table 7 Sleep Disturbance Scale for Children (SDSC)

[0158]

[0159] 3. The sleep-promoting and growth-promoting cream obtained in Example 2 is selected to carry out experimental research on the treatment of adenoids hypertrophy, as follows:

[0160] TCM syndrome is one of the important outcome indicators for evaluating the clinical efficacy of TCM. The TCM syndrome efficacy evaluation scale under the disease-syndrome combination model can provide a basis for objectively evaluating the efficacy of TCM syndrome. This time, we referred to the "Chinese Medicine Otorhinolaryngology" and the "Expert Consensus on the Diagnosis and Treatment of Sleep Disorders Caused by Adenoid Hypertrophy in Children". According to the quantitative scoring of the main symptoms and secondary symptoms, the main symptoms (nasal congestion, snoring, mouth breathing, etc.) are usually scored as 0, 2, 4, and 6 points according to the four levels of no, mild, moderate, and severe, respectively, and the secondary symptoms (cough, inattention, enuresis, etc.) are scored as 0 and 2 points according to the two levels of no and present. The efficacy evaluation is mostly based on the relevant standards of the "Guidelines for Clinical Research of New Chinese Medicines (Trial)", and the efficacy of TCM syndromes is divided into four levels: cure, marked effect, effectiveness, and ineffectiveness. Cure: clinical symptoms and signs disappear or basically disappear, and the syndrome score reduction rate is ≥95%; marked effect: clinical symptoms and signs are significantly improved, 70%≤ syndrome score reduction rate <95%; effective: clinical symptoms and signs are improved, 30%≤ syndrome score reduction rate <70%; ineffective: clinical symptoms and signs are not significantly improved, or even aggravated, and the syndrome score reduction rate is <30%. According to the nimodipine algorithm, the TCM syndrome score reduction rate = (pre-treatment score - post-treatment score) / pre-treatment score.

[0161] By comparing the two groups, in terms of the effects of TCM syndrome scores on adenoids hypertrophy, the total effective rate of the sleep-aiding and growth-promoting paste group was 96.67%, as shown in Table 8, which was significantly higher than that of the stomach-strengthening and digestion-promoting oral liquid group. This may be because the main effect of the stomach-strengthening and digestion-promoting oral liquid is to tonify the spleen and digest food, and it has no effect on improving ventilation.

[0162] Table 8 Reduction rate of TCM syndrome score and total effective rate

[0163]

[0164] Before and after treatment, the TCM syndrome scores of adenoids hypertrophy in both groups were improved compared with those before medication, and the improvement in the sleep-aiding and growth-promoting paste group was higher than that in the stomach-strengthening and digestion-promoting oral liquid group, P<0.05, and the differences between the groups were comparable, as shown in Table 9. Among the secondary symptoms in the sleep-aiding and growth-promoting paste group, there were 14 cases of inattention, 3 cases of symptoms were cured, and 11 cases were improved; there were 9 cases of enuresis, 6 cases were cured, and 3 cases were improved; the symptoms of inattention and enuresis in children were more obvious than before, but the problem still existed.

[0165] Table 9 TCM syndrome scores for adenoids hypertrophy

[0166]

[0167] 4. The sleep-promoting and growth-promoting ointment obtained in Example 2 was selected to carry out an experimental study on the treatment of upper respiratory tract infection, as follows:

[0168] Upper respiratory tract infection is the most common acute infectious disease in pediatrics. Pathogens invade the nose, pharynx, larynx and other parts of the child, causing acute inflammation. The disease can occur all year round, and the incidence rate is higher during seasonal changes. By observing the annual number of illnesses in the two groups, including acute nasopharyngitis, tonsillitis, acute upper respiratory tract infection, etc., the two groups were compared before and after treatment. Before treatment, P>0.05, and the difference between the two groups was comparable; after treatment, the growth-promoting paste group improved more than the stomach-strengthening and digestion-promoting oral liquid group, P<0.05, and the comparability is shown in Table 10.

[0169] Table 10 Upper respiratory tract infection frequency / year

[0170]

[0171] Conclusion: After taking the sleep-aiding and growth-promoting ointment, the symptoms of adenoids hypertrophy and the number of upper respiratory tract infections in the children were significantly reduced compared with before.

[0172] The above is a preferred embodiment of the present invention. It should be pointed out that a person skilled in the art can make several improvements and modifications without departing from the principle of the present invention. These improvements and modifications are also considered to be within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for promoting sleep and growth, characterized in that: The sleep-promoting and growth-promoting Chinese medicine composition is mainly made of the following Chinese medicine raw materials in the following weight ratios: Astragalus 10-30g, stir-fried Atractylodes 5-15g, dried tangerine peel 2-8g, Codonopsis pilosula 10-20g, Cimicifuga 5-15g, Bupleurum 2-8g, Angelica 2-8g, Rehmannia glutinosa 10-30g, roasted Licorice root 5-15g, Huaishan 10-20g, Moutan bark 5-15g, Alisma orientalis 5-15g, Cornus officinalis 5-15g, cinnamon bark 1-5g, Poria 5-15g, nutmeg 2-8g, costusroot 5-15g, Coptis chinensis 1-5g, Amomum villosum 2-8g, Hawthorn 5-15g, Shenqu 5-15g, stir-fried malt 5-15g.

2. The Chinese medicine composition according to claim 1, characterized in that The sleep-promoting and growth-promoting Chinese medicine composition is mainly made of the following Chinese medicine raw materials in the following weight ratios: Astragalus 15-25g, stir-fried Atractylodes 8-12g, dried tangerine peel 3-6g, Codonopsis pilosula 12-18g, Cimicifuga heracleifolia 8-12g, Bupleurum 3-6g, Angelica sinensis 3-6g, Rehmannia glutinosa 15-25g, roasted Licorice root 8-12g, Huaishan 12-18g, Moutan bark 8-12g, Alisma orientalis 8-12g, Cornus officinalis 8-12g, cinnamon bark 2-4g, Poria 8-12g, nutmeg 3-6g, costusroot 8-12g, Coptis chinensis 2-4g, Amomum villosum 3-6g, Hawthorn 8-12g, Shenqu 8-12g, stir-fried malt 8-12g.

3. The Chinese medicine composition according to claim 2, characterized in that: The sleep-promoting and growth-promoting Chinese medicine composition is mainly made of the following Chinese medicine raw materials in the following weight ratios: Astragalus 20g, stir-fried Atractylodes 10g, dried tangerine peel 5g, Codonopsis pilosula 15g, Cimicifuga 10g, Bupleurum 5g, Angelica 5g, Rehmannia glutinosa 20g, roasted Licorice root 10g, Huaishan 15g, Moutan bark 10g, Alisma orientalis 10g, Cornus officinalis 10g, cinnamon 3g, Poria 10g, nutmeg 5g, costusroot 10g, Coptis chinensis 3g, Amomum villosum 5g, Crataegus pinnatifida 10g, Shenqu 10g, stir-fried malt 10g.

4. A method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: include: A. Weigh each Chinese medicine raw material according to the formula and soak it; B. Extract and concentrate each Chinese medicine raw material to obtain the finished product.

5. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for preventing and / or treating insomnia.

6. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating growth retardation, short stature and / or dwarfism.

7. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for preventing and / or treating adenoids hypertrophy in children.

8. The use according to any one of claims 5 to 7, characterized in that: The medicine is an oral preparation, which is an ointment, decoction, powder, capsule, tablet, granule or pill.

9. The use according to any one of claims 5 to 7, characterized in that: The drug comprises pharmaceutically acceptable excipients, which are one or more of disintegrants, emulsifiers, fillers, flavoring agents, wetting agents and solubilizers.

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