The invention relates to buccal tablets for preventing altitude stress and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The buccal tablets for preventing altitude stress comprises the following raw materials in parts by weight: 10-20 parts of rhodiola rosea, 8-15 parts of snow lotus herb, 3-8 parts of Chinese wolfberries, 6-10 parts of stigma croci, 3-7 parts of santalum album, 2-6 parts of lignum dalbergiae odoriferae, 2-6 parts of clove, 3-7 parts of fructus phyllanthi, 2-9 parts of strawberries, 5-11 parts of alpine radix codonopsis, 2-7 parts of radix glycyrrhizae, 3-5 parts of calculus bovis, 4-8 parts of moschus and 2-6 parts of indigo naturalis. According to the buccal tablets for preventing altitude stress provided by the invention, the various components supplement each other and are reasonable in compatibility, so that the buccal tablets can quickly eliminate symptoms of altitude stress, have the characteristics of having obvious curative effect, taking effect quickly and being not easy to relapse and is remarkable in curative effect in remitting symptoms of headache, palpitation, anhelation, appetite loss, lassitude, lack of power, dizziness, nausea, emesis and the like.