8 results about "Susceptible population" patented technology

The invention discloses a genetic locus marker combination for diagnosis or prognosis evaluation of keloid susceptible population as well as a detection method and application of the genetic locus marker combination, and belongs to the field of detection, and genetic loci comprise the following loci: rs873549, rs1442440, rs2271289, rs17431184 and rs2299939. According to the invention, the genetic susceptibility of Keloid keloid in North China can be comprehensively predicted according to genotype detection results of the selected five gene loci. Therefore, targeted treatment on the patient is achieved, and the curing possibility of the patient is improved.

The present application relates to a kind of composition for preventing and treating new crown and its preparation method.It is made of Huangqi, Baizhu, Wuweizi, Fangfeng, Jinyinhua, Lianqiao, Banlangen, Yuxingcao, Lugen, Tianhuafen, Jiegeng, Gancao, any dosage form is made using pharmaceutically acceptable carrier or excipient, such as formula granule, granule, decoction, tablet, capsule, soft capsule, drop pill or pill.It has the effect of benefiting qi and consolidating the exterior, clearing heat and detoxifying, clearing lung and benefiting throat.It is suitable for low immunity, weak or with other diseases of the body resistance decline susceptible population to prevent exogenous disease and or infectious disease, and new coronavirus infection population.Clinical studies show that new coronavirus infection patients treated by the present application, body temperature, sore throat, general soreness, sleep difficulty mostly in 6-8 hours improvement, generally in 20 hours symptom can basically disappear, indicating that the present application has exact curative effect on new coronavirus infection patients.

The present invention provides biomarkers for predicting immune-related myasthenia gravis, myocarditis, and myositis. The key locus HLA-DQB1 * 03: 03 is obtained through HLA typing, and the method has a good prediction value on whether tumor patients subjected to ICI treatment suffer from irMG and / or myositis and myocarditis or not. The invention provides a screening tool which can identify a potential high-risk irAE patient before ICI treatment, and provides inspiration for preventive treatment development of irMG susceptible people.

This invention relates to an adenovirus susceptibility risk assessment model and biomarkers, belonging to the field of gene analysis technology. The method for establishing this model includes the following steps: Susceptibility locus and susceptibility effect value analysis: obtaining whole-genome SNP locus data from adenovirus-infected and non-infected individuals, and analyzing them using the GWAS method to obtain the susceptibility loci for adenovirus infection and their corresponding susceptibility effect values; Establishment of an adenovirus susceptibility polygenic risk prediction model: calculating the adenovirus susceptibility polygenic risk score PRS using the formula: PRS = β1x1 + β2x2 + ... + β k x k +…+β n x n β represents the susceptibility effect value corresponding to the susceptibility locus obtained from GWAS analysis, x represents the number of risky allele mutations, n represents the total number of SNPs included in the PRS analysis model, and k represents each SNP included in the PRS analysis model. This adenovirus susceptibility risk assessment model, validated with sample groups from different data sources, can distinguish between adenovirus-susceptible populations and control groups, demonstrating the superior discriminative power of the model of this invention.

The invention discloses an application of an HLA (human leukocyte antigen) gene SNP (single nucleotide polymorphism) site in predicting the genetic susceptibility risk of immune thrombocytopenic purpura of Chinese population, and the HLA gene SNP site is rs2187668 and has Cgt; according to the present invention, the genotype of the site is detected, and the genotypes of the site have different risks of immune thrombocytopenic purpura, such that the effective prediction can be performed by detecting the genotype of the site so as to achieve the purpose of predicting the Chinese iTTP genetic susceptible population through the molecular diagnosis method detection, and the significant clinical diagnosis application value is provided.

The application discloses a kind of fuzzy model construction methods for the characteristics of infectious disease patient, comprising: 1 by collecting the medical record of patient, examination report, medical history, lifestyle information, construct a comprehensive patient feature set;2, the representative, uniqueness and anti-noise score of each patient are calculated after selecting the patient representative with representation ability;3, around high total score representation, a fuzzy interval two type granularity model containing fuzzy feature description of multiple patients is constructed.The application can quickly construct a patient group model with better anti-noise ability, stronger interpretability and more information content under the condition of only a small amount of disease-related data, so as to quickly model susceptible population, describe the fuzzy characteristics affecting disease infection, and assist doctors in understanding the characteristics of infectious diseases and susceptible population characteristics.

The invention discloses a respiratory infectious disease early warning method and system based on new-safety medicine, and particularly relates to the technical field of infectious disease early warning. The method comprises the following steps: acquiring symptom self-reporting information of a crowd in an incubation period and environmental climate data of an environment in which the crowd is located, and constructing incubation period symptom and climate abnormality associated data; extracting time-space coupling characteristic data of symptoms in the incubation period by establishing a time-space coupling relationship between weak symptoms in the incubation period and regional climate anomalies; identifying an incubation period infection enhancement effect by combining a new-safety medical theory, generating risk judgment data of incubation period infection enhancement, and performing risk threshold judgment on the incubation period infection enhancement effect to obtain incubation period group high-risk judgment data; according to the high-risk judgment data of the incubation period population, the high-risk area of the incubation period population and the spatial distribution of the susceptible population are determined, and finally, the respiratory infectious disease early warning information is generated in combination with the infectious disease early warning grading decision model, so that the accuracy and timeliness of the early warning of the respiratory infectious disease are improved.

The application discloses application of indole-3-propionic acid in preparation of a medicine for preventing or treating blood-borne infection and belongs to the technical field of biological medicine. The application discloses, for the first time, the use of indole-3-propionic acid in resisting blood-borne infection. The use of indole-3-propionic acid can significantly enhance the ability of liver Kupffer cells to capture blood-borne pathogenic bacteria and reduce the pathogenic bacterial load in circulating blood. The application provides a new idea for the treatment of blood-borne infection, especially the anti-infection treatment of susceptible populations such as severe hepatitis or cirrhosis. Indole-3-propionic acid is cheap and easy to obtain, can be produced in large scale, is beneficial to development into a medicine for treating blood-borne infection and has good application value.