CoQ capable of quickly relieving high altitude reaction 10 Method for preparing O2 explosive beads and application thereof

Abstract

The present application relates to the technical field of food raw material production, especially to the mild burst release of oxygen, more particularly to a CoQ 10 / O2 burst bead preparation method and application. In the present application, through four steps of glue preparation, bead making, secondary oxygen charging and drying, a CoQ 10 / O2 burst bead is prepared, which can quickly relieve the plateau reaction. 10 The CoQ 10 / O2 burst bead in the present application has moderate ball diameter and is convenient to carry, which not only widens the application field of coenzyme Q 10 , but also can effectively replace oxygen bag and breathing machine, and can greatly bring convenience to plateau travelers.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of food raw material production, in particular to the mild burst release of oxygen, more particularly to a CoQ 10 / O2 burst bead preparation method and application. BACKGROUND

[0002] Altitude sickness is a series of functional metabolic changes caused by the rapid change of blood oxygen content of human body after reaching a certain altitude (generally above 2700 meters), superimposed with environmental factors such as air temperature drop, air dryness, low air pressure and ultraviolet radiation. The main symptoms are headache, dizziness, blurred vision, tinnitus, fatigue, and severe cases can also have chest tightness, shortness of breath, nausea, vomiting, palpitation and edema, etc. In medicine, the specific clinical manifestations of patients with altitude sickness are generally treated according to symptoms: mild symptoms are generally treated with oxygen therapy; moderate and severe patients use high-flow nasal cannula or mask intermittent oxygen therapy; for patients with severe altitude sickness such as cerebral edema and pulmonary edema, immediate rescue is usually used, and breathing machine assisted ventilation is used.

[0003] Although patients with mild altitude sickness can recover on their own, even if the symptoms are mild, they should be diagnosed and treated as soon as possible after discovery to prevent the disease from further developing. If not treated in time, it not only may prolong the time of altitude sickness, but also may cause secondary high altitude pulmonary edema and high altitude cerebral edema, and even endanger life.

[0004] Using VOSviewer software to perform co-occurrence analysis of publications extracted from journals indexed in Scopus, it was found that articles related to high altitude reaction were mostly published in the journal "High Altitude Medicine and Biology", and research focused on adaptation mechanisms (37.1%, mainly hypoxia and respiratory function), acute high altitude reaction (18.4%) and pulmonary edema (14.7%). Among the top ten institutions, "University of Colorado" and "Universidad Catolica San Pablo" contributed more than 100 publications, but there are no mature products on the market that can be used to quickly relieve high altitude reaction developed by these two universities. (Zila-Velasque, J.P., et al. (2023). Adaptation and altitudesickness: A 40-year bibliometric analysis and collaborative networks. Front Public Health 11: 1069212.) At present, the scientific research results on high altitude reaction continue to grow, but most of them are still at the academic research level, and there are few products that can effectively prevent and treat high altitude reaction. It is not difficult to explain why many tourists have to take oxygen bags or even oxygen bottles to travel and study in high altitude areas such as Tibet.

[0005] Based on the foregoing, the current development of a portable, affordable and effective product to prevent and treat high altitude reaction is of great significance to drive the local economy of high altitude areas and protect the life and health of people living in high altitude areas. SUMMARY

[0006] In order to solve the problems in the prior art, the present application provides a CoQ 10 / O2 explosive bead preparation method, which comprises the following steps: glue preparation, bead making, secondary oxygenation and drying.

[0007] Specifically, the glue preparation is to configure the wall material rubber of the explosive bead, and the main components are edible gelatin, food grade plasticizer, food grade water-soluble CoQ 10 and purified water.

[0008] Specifically, the glue preparation is completed in a glue preparation kettle. First, the food grade water-soluble CoQ 10 is completely dissolved with purified water to obtain a CoQ 10 liquid, and then edible gelatin and food grade plasticizer are added at one time to the CoQ 10 liquid (the order of adding edible gelatin and food grade plasticizer is not specially required).

[0009] Specifically, the manufacturer of the edible gelatin is Anhui Fengyuan Gelatin Co., Ltd., the chemical name of the food-grade plasticizer is sorbitol, and the manufacturer is Zhejiang Huakang Pharmaceutical Co., Ltd. 10 The purified water is a self-made product of the company.

[0010] Specifically, the amount of sorbitol is 0.2-0.7 times the mass of edible gelatin. The lower the amount, the harder the wall material of the blasting bead, and vice versa. In order to obtain better oxygen explosion effect,

[0011] Specifically, the amount of sorbitol is preferably 0.3 times the mass of edible gelatin. Other amounts do not achieve good oxygen explosion effect.

[0012] Specifically, the food-grade embedding water-soluble CoQ 10 , namely food-grade embedding water-soluble coenzyme Q 10 , the amount of which is 0.001 times the mass of edible gelatin, can improve heart blood supply and oxygen supply and prevent myocardial cell and brain cell damage caused by ischemia and hypoxia. The recommended daily CoQ 10 for people over 65 years old by the American College of Cardiologists is used as a reference to obtain the recommended amount of taking. 10 In order to make the CoQ 10 in each blasting bead wall material evenly dispersed, it is necessary to use embedding water-soluble CoQ 10 . Because of the water-soluble property of CoQ 10 , it can be completely dissolved in the purified water involved in the gelatin preparation process.

[0013] Specifically, the amount of purified water is 0.8-1.2 times the mass of food-grade gelatin, which can be adjusted according to the specific gelatin preparation effect, and the preferred amount is 0.9 times the mass of food-grade gelatin.

[0014] More specifically, the gelatin preparation kettle is made of 316L stainless steel, equipped with a screw vacuum pump containing a condenser and a receiving tank, and the equipment is commonly used on the market, and the manufacturer is not specially limited.

[0015] More specifically, the glue mixing temperature is 60-65℃, too high temperature will make gelatin hydrolysis, too low temperature is not conducive to the uniform mixing and dispersion of materials. After the glue mixing, the vacuum degassing (-0.05-0.08 MPa) is started, which is started from all components added to the glue mixing kettle, the vacuum degree is from small to large, to prevent the glue liquid from boiling. The vacuum degassing is considered to be completed when there is no obvious bubble release on the surface of the glue liquid and the surface of the glue liquid is honeycomb flow. The completion of the glue mixing is considered to be completed, and the glue liquid obtained after the completion of the glue mixing needs to be stored at a temperature of 50-55℃ for later use. If the temperature of the glue liquid is lower than 50℃, the flowability of the glue liquid will be poor, which is not conducive to the bead making. The moisture content of the glue liquid is controlled at 20-25%, too low moisture content will affect the glue stitching in the next engagement process, and too high moisture content will cause the glue liquid to be unable to be shaped, resulting in the next engagement process unable to proceed normally.

[0016] Specifically, the bead making process is that two hollow engagement gears solidify the glue liquid distributed on the same side of the hollow engagement gears into beads at the moment of engagement, and the engagement environment is pure oxygen environment. The burst beads generated by engagement are spherical, and the ball diameter is determined by the size of the engagement gear, which is 5-15 mm, preferably 8-10 mm (the size of the burst bead is convenient to take and the oxygen storage amount is always). The material of the engagement gear is 316L stainless steel, and cooling water flows in the hollow of the engagement gear. The inlet temperature of the cooling water is set at 10-15℃. The pure oxygen environment is created by 99.999% oxygen. The 99.999% oxygen is obtained from the conventional cylinder gas on the market, and the manufacturer does not make special limitation.

[0017] More specifically, the engagement speed affects the thickness of the wall material of the burst bead, which is generally controlled at 0.9-1.2 mm. If it is lower than 0.9 mm, it will affect the ability of the burst bead to resist the pressure of the wrapped oxygen, and if it is higher than 1.2 mm, it will affect the oxygen release efficiency.

[0018] Specifically, the secondary oxygenation is to inject oxygen again into the burst bead obtained in the previous bead making process by using a fine needle, so that the burst bead cavity contains 1800-2500 Pa of oxygen. The burst bead wall material prepared according to the foregoing bead making process parameters has a certain elasticity, and the oxygen in the burst bead cavity will not leak after the fine needle is pulled out. The material of the fine needle is 316L stainless steel. The secondary oxygenation uses 99.999% oxygen. The 99.999% oxygen is obtained from the conventional cylinder gas on the market, and the manufacturer does not make special limitation.

[0019] Specifically, the secondary oxygenation temperature is room temperature.

[0020] Specifically, the drying is static drying, the drying equipment involved in the static drying is a drying rotating cage, and the manufacturer is Zhejiang Jiangnan Pharmaceutical Machinery Co., Ltd. The drying endpoint is to reduce the moisture content of the bead wall material to 5-10%, at which the soft capsule shape is basically set, and less than 5% will make the bead wall material brittle and form cracks, and more than 10% will make the bead wall material soft and prone to mildew.

[0021] Specifically, the drying temperature is 80-90 DEG C, the drying environment is moderately lower than 60% RH, and the drying time is subject to the drying endpoint.

[0022] Specifically, the CoQ 10 The preparation instrument of the / O2 bead is a bead preparation machine, which specifically comprises a glue preparation device, a bead forming device, a secondary oxygenation device and a drying device; the glue preparation device, the bead forming device, the secondary oxygenation device and the drying device are sequentially connected from top to bottom.

[0023] Specifically, the glue preparation device is provided with a screw vacuum pump.

[0024] Specifically, the bead forming device specifically comprises a sealed bead forming structure and a cold water circulation structure, and the cold water circulation structure is arranged inside the sealed bead forming structure.

[0025] Specifically, the meshing gear is rotatably installed at the center of the sealed bead forming structure; wherein the meshing gear is a hollow structure at the middle position, and the number of the meshing gears is two.

[0026] Specifically, the sealed bead forming structure is a pure oxygen sealed space, and a glue liquid adding structure is fixedly installed above the sealed bead forming structure.

[0027] Specifically, double-sided condensate water conveying pipes are arranged on the two sides below the glue liquid adding structure, and the confluence of the double-sided condensate water conveying pipes is located in the direction of the meshing lines of the two meshing gears.

[0028] Specifically, the double-sided condensate water conveying pipes specifically comprise water inlets and water outlets, and cooling water is conveyed in the hollow structure through the water inlets and the water outlets.

[0029] Specifically, the secondary oxygenation device specifically comprises a hexagonal turntable and a fine needle, wherein the hexagonal turntable is a hollow structure at the middle position, and the number of the hexagonal turntables is two.

[0030] Specifically, the hexagonal turntable is coincident with the meshing line of the first meshing gear, and the fine needle is located in the direction of the meshing lines of the two hexagonal turntables.

[0031] Specifically, the hexagonal turntable comprises a hexagonal left turntable and a hexagonal right turntable; wherein the top corner of the hexagonal right turntable is in contact with the edge of the hexagonal left turntable.

[0032] Beneficial effects

[0033] The application relates to a CoQ 10 / O2 explosive bead capable of quickly relieving high altitude reaction 10 The application broadens the application field of coenzyme Q 10 , is expected to bring a new profit growth point for coenzyme Q 10 related manufacturers, and is expected to have considerable economic benefits. The explosive bead wall material prepared by the preparation method has coenzyme Q 10 which can improve heart blood supply and oxygen supply and prevent ischemia and hypoxia caused myocardial cell and brain cell damage, and the explosive bead cavity contains proper compressed oxygen; when the explosive bead is put into the oral cavity, oxygen can be released within 2 seconds, thereby effectively relieving high altitude reaction. More importantly, the explosive bead prepared by the preparation method has a moderate ball diameter, is convenient to carry, can effectively replace oxygen bags and breathing machines, and can greatly bring convenience to plateau residents.

[0034] The application relates to a CoQ 10 / O2 explosive bead capable of quickly relieving high altitude reaction 10 The preparation instrument of the CoQ / O2 explosive bead capable of quickly relieving high altitude reaction is an explosive bead preparation machine, a bead making device and a secondary oxygen charging device are arranged, so that batch production and manufacturing of the product which is convenient to carry and can efficiently supplement oxygen can be realized; the produced explosive bead can supplement oxygen while being eaten, is convenient to carry, and overcomes the problem of additional physical consumption. BRIEF DESCRIPTION OF DRAWINGS

[0035] Figure 1 It is a schematic view of the inside of the bead making instrument.

[0036] Figure 2 It is a product diagram of the CoQ 10 / O2 explosive bead capable of quickly relieving high altitude reaction.

[0037] Figure 3 It is a whole structure diagram of the explosive bead preparation machine capable of quickly relieving high altitude reaction.

[0038] Figure 4 It is a production structure diagram of the explosive bead preparation machine capable of quickly relieving high altitude reaction after the glue solution is added to the glue solution adding structure.

[0039] Figure 5 It is a bead making device structure diagram of the explosive bead preparation machine capable of quickly relieving high altitude reaction.

[0040] Figure 6 It is a secondary oxygen charging device structure diagram of the explosive bead preparation machine capable of quickly relieving high altitude reaction.

[0041] 101, glue preparation device; 201, bead making device; 202, sealed bead making structure; 203, cold water circulation structure; 204, meshing gear; 205, hollow structure; 206, glue solution adding structure; 207, water inlet; 208, water outlet; 301, secondary oxygenation device; 302, hexagonal turntable; 303, fine needle; 401, drying device. DETAILED DESCRIPTION

[0042] Example 1

[0043] First, purified water (90.00 kg) and food-grade water-soluble CoQ 10 (0.10 kg) were put into a glue preparation kettle (316L stainless steel, 500L, equipped with a screw vacuum pump unit containing a condenser and a receiving tank), and stirring was started. When the material system became a light yellow clear transparent homogeneous liquid, food-grade water-soluble CoQ 10 was dissolved. Then, edible gelatin (100.00 kg) and food-grade plasticizer (30.00 kg) were added, and the temperature was raised to 60-65°C and continued to be kept at this temperature interval for 1 h, obtaining a light yellow slightly viscous homogeneous liquid.

[0044] Food-grade water-soluble CoQ 10 was a self-made product of the company. The manufacturer of edible gelatin was Anhui Fengyuan Gelatin Co., Ltd. The chemical name of the food-grade plasticizer was sorbitol, and the manufacturer was Zhejiang Huakang Pharmaceutical Co., Ltd.

[0045] After the temperature was kept and stirring was completed, vacuum degassing was started at 60-65°C (-0.06±0.02 MPa). The vacuum degree in the kettle was gradually increased. Initially, too high a vacuum degree would cause the glue solution to boil. The vacuum degassing was considered complete when there were no obvious bubbles released from the surface of the glue solution and the surface of the glue solution showed a honeycomb flow. The completion of the degassing was considered as the completion of the glue preparation.

[0046] The glue solution obtained after the completion of the glue preparation needed to be stored at a temperature of 50-55°C for later use.

[0047] After the glue preparation was completed, the pressure in the kettle was returned to normal pressure by nitrogen, and the sample was sent for inspection. The moisture content of the glue solution was 22.15%. Bead making was started. The bead making process was that two hollow meshing gears solidified the glue solution distributed on the same side of the hollow meshing gears into beads at the moment of engagement. The engagement environment was a pure oxygen environment. The burst beads produced by the engagement were spherical, with a diameter of 10 mm and a wall thickness of 1.0 mm.

[0048] The material of the meshing gear was 316L stainless steel. Cooling water flowed through the hollow of the meshing gear. The inlet temperature of the cooling water was set at 10-15°C. The pure oxygen environment was created by 99.999% oxygen, which was obtained from conventional steel cylinders on the market without special limitation of the manufacturer.

[0049] After the beading, the second oxygenation is started. The second oxygenation is to inject oxygen into the beading cavity containing a certain amount of pure oxygen obtained in the previous beading process by using a fine needle at room temperature. When the beading cavity contains 1952 Pa of oxygen, the fine needle is pulled out.

[0050] The material of the fine needle is 316L stainless steel. The 99.999% oxygen used in the second oxygenation is obtained from a conventional cylinder gas on the market, and the manufacturer does not make special limitations.

[0051] After the second oxygenation, the drying is started by using a drying tumbler to stand and dry at an environmental humidity of 55% RH and a drying temperature of 80-90°C to obtain the CoQ 10 The / O2 beaded product (186.35 kg, a light yellow translucent hollow elastic sphere), the moisture of the beaded wall material is 6.82%, and the CoQ 10 The product diagram of the / O2 beaded product is shown in Figure 2 .

[0052] The production factory of the drying tumbler is Zhejiang Jiangnan Pharmaceutical Machinery Co., Ltd.

[0053] The CoQ 10 The preparation instrument of the / O2 beaded product is a beaded preparation machine, which specifically comprises a glue preparation device 101, a beading device 201, a second oxygenation device 301, and a drying device 401.

[0054] The glue preparation device 101 comprises a screw vacuum pump, a condenser, and a receiving tank fixedly installed in the screw vacuum pump. The condenser and the receiving tank are used to transport and collect the condensed water, so as to realize the circulation of the condensed water.

[0055] The beading device 201 comprises a sealed beading structure 202, a cold water circulation structure 203, and double-sided condensed water delivery pipes. The sealed beading structure 202 comprises engaging gears 204 and a glue liquid adding structure 206. The cold water circulation structure 203 comprises a water inlet 207 and a water outlet 208.

[0056] The second oxygenation device 301 comprises a hexagonal turntable 302 and a second glue liquid adding structure 206. The second glue liquid adding structure 206 comprises a fine needle 303. The hexagonal turntable 302 comprises a hexagonal left turntable and a hexagonal right turntable.

[0057] In an embodiment, the structure connection mode of the rapid high altitude reaction relief burst bead preparation machine is as follows: the glue preparation device 101 is communicated with the bead making device 201, the bead making device 201 is communicated with the secondary oxygenation device 301, and the secondary oxygenation device 301 is communicated with the drying device 401; the center of the sealing bead making structure 202 is rotatably provided with the meshing gear 204, the middle position of the meshing gear 204 is a hollow structure 205, the number of the meshing gear 204 is two, and the sealing bead making structure 202 and the cold water circulation structure 203 are two independent structures and are not communicated. The glue liquid adding structure 206 is fixedly installed above the sealing bead making structure 202, and both sides of the glue liquid adding structure 206 are provided with double-sided condensate water conveying pipes, and the convergence of the double-sided condensate water conveying pipes is located in the meshing line direction of the two meshing gears 204; the double-sided condensate water conveying pipes convey cooling water in the hollow structure 205 through the water inlet 207 and the water outlet 208, in the secondary oxygenation device 301, the middle position of the hexagonal turntable 302 is a hollow structure 205, the number of the hexagonal turntable 302 is two, and in the hexagonal turntable 302, the meshing line of the hexagonal turntable 302 coincides with the meshing line of the first meshing gear 204, and the fine needle 303 is located in the meshing line direction of the two hexagonal turntables 302.

[0058] In an embodiment, the working principle of the rapid high altitude reaction relief burst bead preparation machine is as follows: CoQ 10The glue mixing operation of the O2 balloon wall material rubber skin is carried out in the glue mixing device 101 after glue mixing. After vacuum degassing, the glue liquid is transferred to the glue liquid adding structure 206 of the bead making device 201. In the sealed bead making structure 202, the glue liquid is instantaneously solidified into a bead at the meshing line position through the meshing rotation of the two meshing gears 204. At the same time, since the hollow structure 205 is in the middle position of the meshing gear 204, the cooling water circulation is carried out through the cooperation of the hollow structure 205 with the water inlet 207 and the water outlet 208 in the cold water circulation structure 203, so as to carry out the glue liquid cooling and solidification operation. At the same time of solidification into a bead, since the sealed bead making structure 202 is a pure oxygen sealed space, the oxygen in the sealed bead making structure 202 can be sealed into the balloon rubber film. At the same time, the fixedly installed glue liquid adding structure 206 in the patent is a negative pressure push rod structure, which is sealed with a specified volume of glue liquid inside. When the oxygen in the sealed bead making structure 202 is consumed and negative pressure is generated, the push rod in the glue liquid adding structure 206 will automatically push downward and carry out the glue liquid supplement operation. The solidified balloon is transferred to the secondary oxygenation device 301. In the secondary oxygenation device 301, the balloon is supplemented with oxygen through the fine needle 303. Since the balloon wall material has a certain elasticity, the oxygen in the balloon cavity will not leak after the fine needle 303 is pulled out of the balloon cavity. At the same time, the balloon supplemented with oxygen is transported by the two hexagonal turntables 302, and is transported to the drying device 401, and the drying cage in the drying device 401 is used for the standing drying treatment of the balloon.

Claims

1. A CoQ that can quickly alleviate altitude sickness. 10 / O2 burst bead preparation method, characterized in that Includes the following steps: The process involves four steps: glue preparation, bead making, secondary oxygenation, and drying. The aforementioned adhesive, which is the wall material adhesive containing the popping beads, mainly consists of edible gelatin, food-grade plasticizer, and food-grade water-soluble CoQ encapsulation. 10 and purified water; The gel preparation is completed in a gel preparation tank. First, food-grade water-soluble CoQ is encapsulated in purified water. 10 Completely dissolve to obtain CoQ 10 Liquid, then into CoQ 10 Edible gelatin and food-grade plasticizer are added to the liquid in one step. The bead-making process involves two hollow meshing gears solidifying the adhesive distributed on the same side of the hollow meshing gears into beads at the moment of meshing, with the meshing environment being a pure oxygen environment. The secondary oxygenation refers to injecting oxygen again into the popping beads that already contain a certain amount of pure oxygen obtained from the previous bead-making process using a fine needle. The drying process is static drying, and the drying equipment involved is a rotary drying drum; the chemical name of the food-grade plasticizer is sorbitol; the amount of sorbitol used is 0.2 to 0.7 times the mass of edible gelatin; the food-grade encapsulated water-soluble CoQ... 10 Food-grade encapsulated water-soluble coenzyme Q 10 The amount used is 0.001 times the mass of edible gelatin; the thickness of the popping bead wall material is 0.9 to 1.2 mm.

2. The CoQ solution for rapidly alleviating altitude sickness according to claim 1. 10 / O2 burst bead preparation method, characterized in that The amount of purified water used is 0.8-1.2 times the mass of food-grade gelatin.

3. The CoQ that can rapidly alleviate altitude sickness according to claim 1. 10 / O2 burst bead preparation method, characterized in that The resulting adhesive solution, after being prepared, needs to be stored at a controlled temperature of 50–55°C until use.

4. The CoQ that can rapidly alleviate altitude sickness according to claim 1 10 / O2 burst bead preparation method, characterized in that The secondary oxygenation temperature is room temperature.

5. The CoQ that can rapidly alleviate altitude sickness according to claim 1. 10 / O2 burst bead preparation method, characterized in that The drying temperature is 80–90°C.

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