95results about How to "Reduce the risk of drug resistance" patented technology

The invention provides a bactericidal composition comprising active components of fluopicolide and copper calcium sulfate with a weight ratio of 1:100-100:1. According to the invention, fluopicolide and copper calcium sulfate are subjected to binary compounding, such that the composition has a significant synergistic effect in controlling crop diseases caused by fungi and bacteria. With binary compounding, bactericidal spectrum is expanded; the doses of the two components are reduced; and the risk of pathogen drug resistance is reduced.

A pesticide composition containing 2-cyano-3-amino-3-phenylacrylic acetate and hymexazol belongs to the technical field of pesticide compounds. The pesticide composition contains the 2-cyano-3-amino-3-phenylacrylic acetate and the hymexazol, which are at a weight ratio of (1:90)-(90:1). According to the pesticide composition containing the 2-cyano-3-amino-3-phenylacrylic acetate and the hymexazol, the 2-cyano-3-amino-3-phenylacrylic acetate and the hymexazol are reasonably and effectively compouned, as a result, the defects that the broad-spectrum performance of the 2-cyano-3-amino-3-phenylacrylic acetate is poor and the hymexazol has a poor effect on fusarium can be overcome, the pesticide efficacy can be remarkably improved, risks caused by pesticide resistance can be lowered, and a remarkable synergy effect is realized.

The invention provides a method for protecting and restoring germplasm of citrus-Hunglongbing-infected citrus according to a two-step method. The method comprises the steps of soaking seeds into alcohol with concentration of 70% for one minute, soaking the seeds into NaOH with concentration of 5% for eliminating pectin, then soaking the seeds into sodium hypochlorite solution with concentration of 3% for 20 minutes, cleaning with sterile water by 2-3 times, then immersing the seeds in normal-temperature water for 5-10 hours, then performing thermal treatment on the seeds by means of wet-and-hot air with temperature of 50-55 DEG C for 40-60 minutes, then removing seed shells, sowing the seeds into an MS medium in which enrofloxacin sodium and sulfadimethoxine sodium antibiotic are added, transplanting seedlings into disinfected nutrient soil after the seedlings are grown to a height of 5cm, and grafting the newly grown branch from a nursery stock as a scion on a stock seedling which is grown from a stock seedling which is processed in the same way. According to the method of the invention, the antibiotic composition which comprises the enrofloxacin sodium and the sulfadimethoxine sodium antibiotic is utilized for reasonable mixing; and a two-step method which comprises thermal treatment and adding the antibiotic is firstly utilized for performing sterilization on the citrus-Hunglongbing-infected citrus, thereby realizing higher sterilization effect.

The invention provides a bactericidal composition. The bactericidal composition comprises the active components of Picarbutrazox and at least one amide bactericide, and the weight ratio of the Picarbutrazox to the at least one amide bactericide is 100:1-1:100. According to the bactericidal composition, binary combination is conducted on the Picarbutrazox and the at least one amide bactericide, and therefore the bactericidal composition has an obvious gain effect on prevention and treatment of crop diseases caused by fungi and bacteria; besides, a bactericidal spectrum is expanded through the binary combination, the usage amount of the Picarbutrazox and the usage amount of the at least one amide bactericide are separately reduced, and the risk that pathogenic bacteria have drug resistance is reduced.

The invention discloses a pesticide composition for preventing and treating fungal diseases of plants. The pesticide composition is prepared from the following components in parts by weight: 0.1-1 part of bacillus velezensis HN-2 extract, 45-65 parts of epsilon-polylysine, 10-20 parts of silicon dioxide and 1-5 parts of gamma-aminobutyric acid, wherein the preservation number of the bacillus velezensis HN-2 is CCTCC (China Center For Type Culture Collection) NO: M 2018382. The invention also discloses a preparation method of the pesticide composition. The pesticide composition disclosed by the invention is wide in disease prevention spectrum and has a remarkable prevention and treatment effect on fungal diseases of various plants.

The invention provides new medical application of mogrol and particularly relates to medical application of the mogrol and the related compounds of the mogrol to the treatment or/and prevention of viral infection. The invention further provides application of the mogrol and the related compounds of the mogrol to the preparation of drugs for treating or/and preventing the viral infection and particularly relates to application of the mogrol and the related compounds of the mogrol to the resisting of hepatitis C viruses and HIV viruses. Experiments prove that the mogrol can evidently activates the expression of body TLRs receptors so as to activate the innate immunity system of a human body to bring an antiviral effect into play. Experiment researches show that the mogrol has a high inhibiting and eliminating effect on the hepatitis C viruses and HIV viruses and is a potential drug for resisting the hepatitis C viruses and HIV viruses. The mogrol is prepared from natural plants which are wide in distribution and rich in resource, so that the mogrol is low in industrial preparation cost and capable of being favorably popularized and applied.

The invention discloses an insecticidal composition containing two effective components including HNPC-A8008 and abamectin, wherein the weight ratio of the effective components, namely HNPC-A8008 to abamectin is 1:100 to 100:1, and the weight sum of HNPC-A8008 and abamectin accounts for 10-70% of the weight percentage of the composition. Proved by a great number of indoor and outdoor experiments, The composition disclosed by the invention has the advantages that a remarkable synergistic effect is achieved after HNPC-A8008 and abamectin are mixed, so that the application field of HNPC-A8008 is widened in actual application, the pesticide-resistant risks of pests to abamectin are reduced, and the aims of taking a combined effect on the pests on multiple aspects, widening the prevented and controlled object range, improving the preventing and controlling effects, effectively preventing and controlling lepidoptera and homopteran pests on vegetables, rice, fruit trees and flower crops, and meanwhile reducing the dosage of a pesticide in a field, agricultural cost and environment pollution caused by the pesticide are achieved.

The invention relates to the technical field of pesticides, and in particular relates to an insecticidal composition for preventing and treating macadamia nut aphids. The invention relates to the insecticidal composition for preventing and treating macadamia nut aphids. The effective component of the insecticidal composition is prepared by binary compounding of propylene glycol alginate, afidopyropen, butene-fipronil or guadipyr. When the two effective components in the insecticidal composition are compounded according to a certain mass ratio, a synergistic effect is shown, compared with a single effective component, the control effect on macadamia nut aphids can be improved, on the basis, the application dosage of the pesticide can be reduced, and the control cost can be reduced; and meanwhile, pesticide residues and environmental pressure can be reduced.

The invention relates to the field of disease prevention and control, in particular to a group of strains and microbial inoculum for preventing and controlling crop diseases as well as a preparation method and application of the strains and the microbial inoculum. The invention provides one group of strains for preventing and treating crop diseases, wherein the strains comprise bacillus subtilis T122F, trichoderma longibrachiatum T202006 and paecilomyces lilacinus; the preservation number of the bacillus subtilis T122F is CGMCC (China General Microbiological Culture Collection Center) No.3043; and the preservation number of the trichoderma longibrachiatum T202006 is CGMCC (China General Microbiological Culture Collection Center) No. 21462. The strains provided by the invention can effectively prevent and treat crop diseases, and are environment-friendly chemical pesticide and chemical fertilizer reduction use substitutes.

The invention relates to a captan and imazalil compound composition, which is excellent in environmental compatibility, high in efficiency and low in toxicity and residue, and application thereof, in particular to application researches on prevention and treatment of apple ring spot, apple anthracnose, grape white rot and grape bitter rot. The weight ratio of the active ingredients, captan and imazalil, in the compound composition is (1: 2)-(16: 1). The captan and imazalil compound composition can be used for preventing and treating major diseases of fruit trees and particularly is excellent in preventing and treating apple ring spot, apple anthracnose, grape white rot and grape bitter rot.

The invention provides a double-component insecticide composition and application thereof to prevention and control of pests. The active component of the double-component insecticide composition is formed by compounding two components, namely a 1,3-dioxolane compound containing a 4-p-phenoxy phenoxy methyl structure (the compound as shown in a structural formula (I)) as well as any one of butene-fipronil, chlorfenapyr, indoxacarb and bifenazate; furthermore, through experiment detection, the medicine effect of the double-component insecticide composition is obviously higher than the preventioneffect of a single insecticide product/component, so that the dosage (the application total amount) of the composition is reduced, the disease-resistant risk of pests is effectively reduced, the useefficiency of the composition is improved and environmental pollution is obviously reduced. Therefore, the double-component insecticide composition has good market potential and wide application prospect in the aspect of preventing and controlling the pests.

The invention discloses a treatment device and method for fermentation dregs of polymyxin sulfate. The method comprises the steps that firstly, original moor mud is provided, the original moor mud is mixed with an SRB enriched medium, a supernatant is discharged every day, fresh and equal-volume SRB enriched medium is supplemented, and the operation is conducted cyclically for cultivation for 3-10 d, so that SRB sludge is obtained; then the fermentation dregs of the polymyxin sulfate are mixed with the SRB sludge, the mixture is placed into a pretreatment tank for airtight cultivation, and the pretreated fermentation dregs of the polymyxin sulfate are obtained; and finally, the pretreated fermentation dregs of the polymyxin sulfate are pumped into an anaerobic jar for an anaerobic reaction, and the fermentation dregs of the polymyxin sulfate are degraded. The treatment method can be used for treatment for the fermentation dregs of the polymyxin sulfate, the treatment period is short, and the degrading effect is remarkable.

The invention provides a bactericidal composition. The bactericidal composition contains active components of Picarbutrazox and bellkute, and the weight ratio of the Picarbutrazox to the bellkute is 10:1-1:50. According to the bactericidal composition, binary combination is conducted on the Picarbutrazox and the bellkute, so that the bactericidal composition has an obvious gain effect on preventing and curing diseases caused by fungi and bacteria on crops; besides, the bactericidal spectrum can be broadened through the binary combination, the usage amount of the Picarbutrazox and the usage amount of the bellkute are separately reduced, and the risk that pathogenic bacteria generate drug resistance is reduced.

The invention discloses a broad-spectrum fungicide for preventing and treating plant viruses and diseases. The broad-spectrum fungicide is prepared by combining two medicaments including cytosinpeptidemycin and amino-oligosaccharin. The broad-spectrum fungicide has the advantages that after cytosinpeptidemycin and amino-oligosaccharin are mixed in a certain proportion, the broad-spectrum fungicide has multiple effects of induction, prevention and treatment and has a remarkable synergistic effect; the broad-spectrum fungicide has a wide disease prevention spectrum and can be used for treating multiple diseases of host plants; the broad-spectrum fungicide is capable of inducing the plants to develop immunity, and the defense capability of the plants can be adequately utilized, so that the use of a chemical pesticide is reduced, the risk of generating the drug resistance is reduced, the ecological environment is protected, and the broad-spectrum fungicide can meet the requirements on green plant protection and ecological civilization construction.

The invention provides a bactericidal composition. The bactericidal composition comprises the active components of Picarbutrazox and captan, and the weight ratio of the Picarbutrazox to the captan is 10:1-1:100. According to the bactericidal composition, binary combination is conducted on the Picarbutrazox and the captan, and therefore the bactericidal composition has an obvious gain effect on prevention and treatment of crop diseases caused by fungi and bacteria; besides, a bactericidal spectrum is expanded through the binary combination, the usage amount of the Picarbutrazox and the usage amount of the captan are separately reduced, and the risk that pathogenic bacteria have drug resistance is reduced.

The invention discloses an insecticidal composition containing effective insecticidal components such as HNPC-A8008 and dinotefuran and used for preventing and controlling lepidoptera pests and homoptera pests. The weight ratio of the HNPC-A8008 to the dinotefuran is (1 to 120)-(120 to 1); the total mass fraction percentage of the HNPC-A8008 and the dinotefuran in the composition is 10%-70%. The insecticidal composition comprises the following dose forms: a suspending agent or a water emulsion, a microemulsion, wettable powder and a water dispersible granule. A plurality of indoor and outdoor tests prove that a mixture of the HNPC-A8008 and the dinotefuran has an obvious synergistic effect, multi-aspect common actions to the pests are achieved, prevention and control objects are expanded, the prevention and controlling effects are improved, the pests are effectively prevented and controlled, meanwhile, the resistance risk of the pests to the dinotefuran is reduced, the use filed of the HNPC-A8008 is broadened, the consumption of the insecticidal composition in a field is reduced, the agricultural cost is lowered, and the environmental pollution caused by the insecticidal composition is reduced; the insecticidal composition has excellent effects to the prevention and the controlling of the lepidoptera pests and the homoptera pests of greenstuffs, rice, fruit trees and flower crops.

The invention relates to a virus delivery culture medium. The virus delivery culture medium contains the following components in concentration: Hank'S equilibrium liquid, 0.2-2 g/L of amino acid, 5-50% of glycerol, 0.02-0.2% of a ProClin preservative and 2-15 g/L of bovine serum albumin. The virus delivery culture medium has the beneficial effects that the virus delivery culture medium is based on the Hank's equilibrium liquid, amino acid is added as a virus protein shell protection component, glycerol is added, the protection of the complete form of a virus in a long-term low-temperature stored virus sample is facilitated, the antigen activity of a virus shell is facilitated, and the virus delivery culture medium is suitable for antigen detection and nucleic acid detection of the virus; and meanwhile, the preservative is added, so that the virus delivery culture medium is suitable for virus transportation and long-term preservation. The virus delivery culture medium has no interference on the detection of an in-vitro diagnostic reagent, avoids the abuse of antibiotics, and reduces the drug resistance risk of pathogenic bacteria.

The invention relates to a long-acting breast injection agent for treating cow mastitis in dry period and a preparation method of the long-acting breast injection agent. The long-acting breast injection agent is prepared from the following raw materials: cefalonium, a tanshinone extract, a slow-release agent, an emulsifier, an antioxidant and an oily solvent. The breast injection agent provided by the invention is mainly used for preventing and treating clinical mastitis and subclinical mastitis caused by staphylococcus aureus, streptococcus, Escherichia coli and the like, has the characteristics of long-lasting property, high stability and high efficiency, and has good clinical application value and market prospects.

The invention provides dimer ester micromolecule PROTACs for inducing MDM2 to self-degrade E3 ubiquitin ligase. The structure of the PROTACs is shown in the specification, wherein in a compound (I), L1 is C1-C30 linear or branched alkyl with or without a substituent group, and any carbon atom in L1 is optionally replaced by heteroatom; R1, R2, R3 and R4 are C1-C30 linear or branched alkyl with orwithout a substituent group, C1-C30 aryl with or a without substituent group, C1-C30 linear or branched alkylaryl with or without a substituent group or C1-C30 linear or branched aryl alkyl with or without a substituent group respectively and independently; X1, X2, X3 and X4 are halogen respectively and independently.

The invention discloses a bactericide composition. The composition is prepared from the following ingredients in parts by weight: 0.1 to 1 part of bacillus velezensis HAB-2 extract, 35 to 55 parts of epsilon-polylysine, 25 to 35 parts of glycine and 4 to 10 parts of alginate oligosaccharide. The preservation number of the bacillus velezensis HAB-2 is CCTCC NO:M 2015070. The invention also discloses a preparation method of the bactericide composition. The bactericide composition disclosed by the invention is wide in disease prevention spectrum and has a remarkable prevention and treatment effect on fungal diseases of various plants.

The invention provides a compound pesticide containing Zhongshengmycin and copper hydroxide and an application of the compound pesticide, and belongs to the technical field of compound pesticides. The compound pesticide contains an effective constituent A and an effective constituent B, wherein the effective constituent A is the Zhongshengmycin; the effective constituent B is the copper hydroxide; and the weight ratio of the effective A to the effective B is 1:10-10:1. Mechanisms of action of the Zhongshengmycin and the copper hydroxide are different, after the Zhongshengmycin and the copper hydroxide are compounded, synergism can be achieved, and risks of pesticide resistance of pathogenic bacteria are reduced. Seeds are soaked with a compound agent of the Zhongshengmycin and the copper hydroxide, the shortcoming that the Zhongshengmycin and the copper hydroxide have poor preventing effect on part of fungi pathogens can be avoided, and borne diseases of good seeds can be prevented. By pesticide spraying in a heading period of rice, requirements of the rice to copper during growing can be met. By one-time pesticide spraying, various rice bacteria and fungi diseases can be prevented and treated, and labor and materials are greatly saved.