864results about How to "Reduce the chance of infection" patented technology

The invention discloses a CRISPR Cas9 system for Bacillus subtilis genome edition and an establishment method thereof, belonging to the technical field of gene engineering. A knock-out plasmid PHY300dsrf is established; and the plasmid comprises sgRNA and cas9 genes of the specific targeted target gene, a homologous restoration arm, and replication initial points and tolerance screening markers of Escherichia coli and Bacillus subtilis. The sgRNA of the specific targeted srfA-C gene can guide the cas9 protein to cut double strands at the specific site of the srfA-C gene, and can be used for accurate homologous recombination on the genome under the guide of the homologous restoration arm, thereby introducing the XhoI enzyme digestion site at the rupture. When the tank feed fermentation culture is carried out on the Bacillus subtilis of which the srfA-C gene is successfully knocked out, the foam is obviously reduced, which proves that the CRISPR/Cas9 gene editing system can effectively perform gene edition on the Bacillus subtilis genome.

The invention provides a novel biological-material complex patch which is of a laminated structure comprising a basic layer and an additional layer. The novel biological-material complex patch is characterized in that the basic layer is an patch made from an artificial synthetic material; the additional layer is a biological patch made from an extracellular matrix/acellular tissue matrix material, or a synthetic-material patch made from an artificial synthetic biological material or the artificial synthetic biological material and an artificial synthetic degradable material; and the basic layer and the additional layer are integrated through a surgical suture or a medical adhesive or other methods. The biological-material complex patch has the advantages of easiness for peripheral tissue growth and angiogenesis, adhesion prevention, degradability, good infection resistance and the like of the biological material and the advantages of easiness for tissue growth by of a big mesh, excellent infection resistance, difficulty for generating hydrops, non-degradability, high late mechanical strength and durability of the artificial-synthetic-material patch, adopts a simple production method, is more effective after being applied in clinic, and ensures recent and late relapse and infection rates to be lower.

The invention discloses an intelligent supervision system for medical hand hygiene compliance. The data transmission is conducted between the front-end processor of a software monitoring platform and an AP based on a TCP/IP interface. The data communication of the AP is realized based on the connection with name tags based on 433M/2.4G signals. The types of equipment and the fixed IDs of equipment can be preset by an identifying device. The identifying device and name tags are in communication based on 125K radio frequency signals. The position identifying and the positioning of name tags are realized based on 125K radio frequency signals. A name tag reader is respectively in communication with the front-end processor, the AP and name tags based on 433M/2.4G signals. According to the technical scheme of the invention, the probability of nosocomial infection due to the unfulfillment of hand hygiene during the medical activity procedure can be reduced.

The invention provides a repair material for biological derivative tendon. The material takes homogeneous or heterogeneous tendon as a raw material and is formed through disinfection, degreasing, deproteinization, decellularization, freeze drying, depolymerization, devillication recombination and secondary disinfection. A method for preparing a tendon scaffold material comprises the following steps that: on one hand, a periphery structure of a tendon tissue is destructed through treatment processes of removing soft tissues, the disinfecting, the degreasing and the decellularization, and the repellency of a transplantation receipt to the tendon is reduced; on the other hand, a basic mechanism, partial enzyme activity of the tendon tissue and the continuity of the tendon tissue are further maintained through a freeze drying process so as to provide a good scaffold structure for the revascularization and cell tissue of the tendon.

The invention provides a device for subpackaging culture mediums. According to the device for subpackaging the culture mediums, culture dishes comprising dish covers and dish bottoms descend along a first pushing rod, a clamping part retracts inwards to clamp the dish covers tightly, the dish bottoms continue to descend to a horizontal rotating tray of culture dish separating equipment, and the first pushing rod continues to descend to the position below the horizontal rotating tray; the dish bottoms and the dish covers rotate together along with the culture dish separating equipment, and the horizontal rotating tray rotates to the position above a second pushing rod; after the culture mediums are injected, the second pushing rod pushes the dish bottoms upwards, so that the dish bottoms are made to make contact with the dish covers; the clamping part is loosened, the dish bottoms are covered with the dish covers, and the culture dishes injected with the culture mediums are recovered. According to the device for subpackaging the culture mediums, the continuity, speediness, quantification and the automation of subpackaging can be achieved, and the compatibility to the outlines, the diameter sizes and heights of the culture dishes is good; particularly, the device can be used for subpackaging novel culture dishes of which the diameter of dish bottoms is larger than the diameter of dish covers.

The invention relates to medical equipment, in particular to simple automatic peritoneal dialysis equipment. The equipment comprises a raw water filter, an EDI electric deionizater and a raw water processing device composed of I and II class reverse osmosis units, a peritoneal dialysis liquid confecting device composed of a dual-cavity proportioning pump, a peritoneal dialysis liquid confecting three-way solenoid valve and a peritoneal dialysis liquid container, a peritoneal dialysis treating device composed of a peritoneal dialysis treating three-way solenoid valve, an abdominal cavity inner guide coupling, a waste liquid container and a negative pressure pump as well as an automatic control system composed of an ARM singlechip which carries out finishing and programming on the collected signal; wherein the signal input interface of the ARM singlechip is respectively connected with the raw water processing program module, a treating program module, a correction treating program module and a safe monitoring program module, and the signal output interface thereof is connected with a power driver which controls the external parts under the instruction of the ARM singlechip. The invention integrates water treatment, peritoneal dialysis liquid confecting and automatic peritoneal dialysis treatment, totally closed type one machine treatment is realized, and treating expense can be greatly reduced.

The invention provides a glucan-based transparent hydrogel dressing and a preparation method thereof. The preparation method of the glucan-based transparent hydrogel dressing comprises the following steps: conducting a reaction between a glucan quaternary ammonium salt derivative and succinic anhydride; then promoting an obtained product to react with small molecules of amination, so that a macromonomer which contains illuminated cross-linking double bonds is obtained; mixing the macromonomer which contains illuminated cross-linking double bonds with an antibacterial agent and an initiating agent; conducting photo initiation so as to prepare a glucan-based transparent hydrogel; and combining the glucan-based transparent hydrogel with a polyurethane film by virtue of a bonding agent, so that the glucan-based transparent hydrogel dressing is prepared. The finished product (the glucan-based transparent hydrogel dressing) prepared by the invention not only can absorb a great amount of wound exudates so as to keep a wound surface wet, but also can avoid wound adhesion, so that the probability of wound infection is reduced and wound surface healing is promoted.

The invention relates to a medical rubbish bin dumping device which is characterized in that the medical rubbish bin dumping device comprises a fixing frame, a support shaft supported at the upper end of the fixing frame, and a slowdown motor which is installed at one lateral end of the fixing frame and is in transmission connection with the support shaft. An overturning box consisting of a bottom support part, a left support part, a right support part and a back support part is arranged inside the fixing frame; clamping devices are arranged at the upper ends of the left and right support parts; and the part of the back support part, which is close to the upper end, is fixedly connected with the support shaft. The medical rubbish bin dumping device realizes automatic dumping of the medical rubbish, and an operator only needs to mount a medical rubbish bin on the medical rubbish bin dumping device and then demount the emptied medical rubbish bin from the dumping device. Compared with the conventional manual dumping manner, the medical rubbish bin dumping device has the advantages of lightening the work intensity, and improving the dumping efficiency. Moreover, in the dumping process, the operator can be far away from the medical rubbish bin, so direct contact between the operator and the medical rubbish is avoided. Therefore, the medical rubbish bin dumping device is safe and hygienic, and reduces the probability of iatrogenic infection of the operator.

The invention discloses a drug-delivery absorbable hemostatic sponge, which belongs to the technical field of novel hemostatic materials and comprises drug-loaded chitosan microsphere and collagen protein, wherein the drug-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The weight ratios of the medicinal grade chitosan to the medicinal grade tranexamic acid are (0.01-100):1 respectively. The invention also discloses a method for preparing the drug-delivery absorbable hemostatic sponge. By selecting collagen with good hemostatic function and biocompatibility as the main hemostatic substrate, compounding the drug-delivery chitosan microsphere and the medicinal grade tranexamic acid, and making use of the special properties of the chitosan including hemostatic function and drug-delivery function, a novel hemostatic sponge with rapid hemostasis and lasting and steady drug delivery in a period of time can be prepared, and has considerable economic and social benefits.

The invention relates to washable negative pressure drainage dressing which comprises a sponge body, a drainage catheter and a washing catheter, wherein a double-cavity catheter is inserted in the sponge body, a plurality of through holes are evenly arranged on the wall of the double-cavity catheter inserted in the sponge body, and the outer end of the double-cavity catheter is connected with the drainage catheter and the washing catheter through a tee joint. A washing cavity channel and a drainage cavity channel are arranged in the double-cavity catheter. According to the washable negative pressure drainage dressing, the medical sponge body can be repeatedly washed in the treatment process, so that phenomena such as unsmooth drainage caused by drying and blocking of the sponge body in the wound negative pressure treating process are avoided. The washable negative pressure drainage dressing is reasonable in structure and convenient to operate and use, and reduces dressing change times and risk of clinical infection. In addition, the clinical operation is safe and convenient.

The invention provides a microbial deodorant and strain for eliminating waste odor of municipal landfill and waste transfer station, and the preparation and application method thereof. The preparation method comprises the following steps: culturing Saccharomyces cerevisiae with the conservation number of CGMCC No.5183 in a PDA culture medium, and culturing Lactobacillus casei (CGMCC No.5182) in an MRS culture medium to obtain the seed liquid; and fermenting in a fermentation tank to obtain the microbial deodorant. The microbial deodorant is prepared by a mixed culture manner so as to lower the fermentation cost, reduce the generation of mixed bacteria and stabilize the product quality. The microbial deodorant prepared by the method can effectively eliminate the waste odor of the municipallandfill so as to achieve good deodorant effect.

The present invention relates to biodegradable antibacterial composite fibers, which comprise polylactic acid, nanoparticles and a surfactant, wherein the nanoparticles are nanometer zinc oxide or nanometer titanium oxide, and a weight ratio of the polylactic acid to the nanoparticles to the surfactant is 100:2-10:0.08-1.2. The present invention further provides a preparation method of the biodegradable antibacterial composite fibers, wherein the preparation method comprises a polylactic acid solution preparation step. The preparation method specifically comprises: dissolving polylactic acid in a mixed solvent, wherein the polylactic acid concentration is 10-15 g/L; adding nanoparticles and a surfactant to the polylactic acid solution, and completely mixing to form a mixed solution; carrying out an ultrasonic dispersion treatment on the mixed solution; and placing the stable suspension solution after being subjected to the ultrasonic dispersion treatment in a preset syringe, and carrying out a spinning treatment on the suspension solution according to the preset injection speed. According to the present invention, the preparation method is simple and feasible, and the prepared composite fibers have a certain strength, good biological safety, and good antibacterial property.

The invention provides an eyelid massager which comprises a binding part used for being bound with the head of a user, a fixing part arranged at the front end of the binding part, a driving part installed on the fixing part in a rotation mode, a massaging part arranged by corresponding to the eyes, connected with the driving part and used for massaging the eyes under the drive of the driving part and a switch used for starting or stopping the driving part. The massaging part comprises upper eyelid massaging balls corresponding to the upper eyelids of the eyes and lower eyelid massaging balls corresponding to the lower eyelids of the eyes. The driving part is used for driving the upper eyelid massaging balls to extrude and massage the upper eyelids from top to bottom repeatedly and at the same time, driving the lower eyelid massaging balls to extrude and massage the lower eyelids from bottom to top repeatedly. The upper eyelids and the lower eyelids of the user are massaged specifically. The manner of increasing the pressure is used for discharging thick and dense secreta in the meibomian glands so as to eliminate jamming of the meibomian glands and achieve the aim of promoting smooth secretion of the meibomian glands.

The invention discloses an antimicrobial coated resin lens and a manufacturing method thereof. The manufacturing method of the antimicrobial coated resin lens is characterized by including steps: 1, manufacturing a wear-resistant hardening layer on the surface of a resin lens by adopting dip-coating technology; 2, plating an antireflection film layer on the surface of the wear-resistant hardening layer by adopting vacuum sputtering coating technology and ion source assisted coating technology; 3, plating an antimicrobial layer on the surface of the antireflection film layer by adopting the vacuum sputtering coating technology and the ion source assisted coating technology; 4, plating an adhesive layer on the surface of the antimicrobial layer by adopting the vacuum sputtering coating technology and the ion source assisted coating technology; 5, continuing adopting the vacuum sputtering coating technology for plating a top wear-resistant layer on the surface of the adhesive layer. The manufacturing method of the antimicrobial coated resin lens adopts the vacuum sputtering coating technology and the ion source assisted coating technology, and thereby increases adhesion stress among all the film layers, and achieves the purpose of enabling obtained glasses products to not only keep original performance of the antireflection film layer, but also have long-term effective excellent antibacterial performance.