Alginic acid-chitosan composite fiber for tranma repairing and preparation method thereof

A composite fiber, wound repair technology, applied in the direction of fiber chemical characteristics, conjugated rayon, textiles and papermaking, etc., can solve problems such as poor mechanical strength, achieve good hemostasis performance, improve hemostasis efficiency, and good production feasibility. Effect

Inactive Publication Date: 2013-12-25
山东颐诺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In Zhou Lixin's patent "A Treatment Method for Alginate Fibers Used in Nonwovens for Medical Dressings (CN103147302A)", he proposed a method to obtain emulsified alginate fibers by chopping alginate fibers and treating them with an emulsifier, thereby Fibers with ideal strength and excellent toughness are obtained, effectively solving the problem of poor mechanical strength of pure alginate fibers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation steps of the alginic acid-chitosan composite fiber used for wound repair of the present invention are as follows:

[0023] Sodium alginate and carboxymethyl chitosan are used as raw materials to prepare composite fibers, and the coagulation liquid is calcium chloride solution.

[0024] (1) Weigh an appropriate amount of sodium alginate powder and prepare a 5% (w / v) solution with deionized water. The molecular weight of the sodium alginate is about 15KD, and the M / G ratio is about 0.65;

[0025] (2) Weigh an appropriate amount of carboxymethyl chitosan powder, and prepare a 3.5% (w / v) solution with deionized water. The molecular weight of the carboxymethyl chitosan is about 35KD, and the degree of substitution is about 1.0;

[0026] (3) Mix the above two solutions at a ratio of 9:1, stir gently to mix them evenly, and vacuum degas to prepare a spinning solution;

[0027] (4) Extrude the spinning solution into a 4.5% (w / v) calcium chloride solution throug...

Embodiment 2

[0031] The preparation steps of the alginic acid-chitosan composite fiber used for wound repair of the present invention are as follows:

[0032] Sodium alginate and carboxymethyl chitosan are used as raw materials to prepare composite fibers, and the coagulation liquid is calcium chloride solution.

[0033] (1) The concentration of alginic acid solution is 4% (w / v), and the rest are the same as in Example 1;

[0034] (2) Same as embodiment 1;

[0035] (3) Mix the above two solutions at a ratio of 8.5:1.5, stir gently to mix, and vacuum degas to prepare spinning solution;

[0036] (4) Squeeze the spinning solution into a 5% (w / v) calcium chloride solution through a spinneret hole with a diameter of 300 μm, and obtain alginic acid-chitosan composite fibers at 25°C;

[0037] (5) After washing with water to remove the residual coagulation liquid, immerse the obtained fiber in 5% (w / v) zinc chloride solution, and treat at 35°C for 3 minutes;

[0038] (6) Same as embodiment 1. ...

Embodiment 3

[0040] The preparation steps of the alginic acid-chitosan composite fiber used for wound repair of the present invention are as follows:

[0041]Sodium alginate and hydroxyethyl chitosan are used as raw materials to prepare composite fibers, and the coagulation liquid is calcium chloride solution.

[0042] (1) Same as embodiment 1;

[0043] (2) Weigh an appropriate amount of hydroxyethyl chitosan powder, and prepare a 3.5% (w / v) solution with deionized water. The molecular weight of the hydroxyethyl chitosan is about 30KD, and the degree of substitution is about 0.8;

[0044] (3) Same as embodiment 1;

[0045] (4) Same as embodiment 2;

[0046] (5) Same as embodiment 2;

[0047] (6) Same as embodiment 1.

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Abstract

The invention belongs to the field of biomedical materials, and particularly discloses an alginic acid-chitosan composite fiber for tranma repairing and a preparation method thereof. The alginic acid-chitosan composite fiber for the tranma repairing is characterized by comprising an alginic acid component of which the mass fraction is 50-95%, and a chitosan component of which the mass fraction is 5-50%. The processing technique disclosed by the invention is not involved with an organic reagent or an organic chemical reaction, so that the preparation method is mild in reaction system and controllable in condition; the residue problems of a toxic crosslinking agent or an assistant and the like do not exist; used materials, reagents and the like have good biosecurity; the security risk of clinical applications is greatly reduced. In addition, the technology disclosed by the invention is simple and controllable, and has the good product transformation feasibility; the difficulty of risk management in the preparation process is greatly reduced.

Description

(1) Technical field [0001] The invention belongs to the field of biomedical materials, in particular to an alginic acid-chitosan composite fiber for wound repair and a preparation method thereof. (2) Background technology [0002] Controlling bleeding, preventing infection, accelerating healing, and regenerative repair are the main issues related to the success or failure of various clinical operations, and they are also the problems that medical workers are most concerned about and have been working hard to improve. Hemostasis, anti-inflammation, healing, and repair are several key steps in postoperative body repair, and are directly related to the quality of clinical treatment after recovery. In the early 1970s, the U.S. FDA recognized alginic acid as a "recognized safe substance" food and drug additive, and alginic acid-based biomaterials as wound dressings, temporary ureteral drainage stents, and bone graft substitutes have been approved by the FDA. Approved above. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F8/18A61L15/28A61L15/44
Inventor 位晓娟顾其胜奚廷斐王庆生
Owner 山东颐诺生物科技有限公司
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