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Glucan-based transparent hydrogel dressing and preparation method thereof

A technology of glucan and hydrogel is applied in the field of industrial textiles to achieve the effects of promoting collagen production, improving regeneration ability and good biocompatibility

Inactive Publication Date: 2016-10-26
深圳市菩安科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The characteristics of hydrogel dressings are close to the requirements of ideal dressings, so research on hydrogel dressings is in the ascendant at home and abroad

Method used

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  • Glucan-based transparent hydrogel dressing and preparation method thereof
  • Glucan-based transparent hydrogel dressing and preparation method thereof
  • Glucan-based transparent hydrogel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] like image 3 As shown, a dextran-based transparent hydrogel dressing includes a polyurethane film 1 and a dextran-based transparent hydrogel 2 disposed on the polyurethane film 1, and in the dextran-based transparent hydrogel 2 Contains antibacterial medicines.

[0033] The preparation method of above-mentioned dextran-based transparent hydrogel dressing is:

[0034] a) Preparation of amino-functionalized small molecule monomers containing ethylene glycol segments and carbon-carbon double bonds:

[0035] like figure 1 As shown, di-tert-butyl dicarbonate (2g, 0.00918mol, structural formula is figure 1 Chinese formula (2)) was dissolved in dichloromethane (50ml), then added dropwise to dissolved 1,8-diamino-3,6 dioxahoctane (8.151g, 0.055mol, structural formula: figure 1 In the dichloromethane (50ml) solution of Chinese formula (1), react at 0 ℃ for 24 hours, remove the dichloromethane with a rotary evaporator, then wash with saturated brine, then extract three times...

Embodiment 2

[0048] like image 3 As shown, a dextran-based transparent hydrogel dressing includes a polyurethane film 1 and a dextran-based transparent hydrogel 2 disposed on the polyurethane film 1, and in the dextran-based transparent hydrogel 2 Contains antibacterial medicines.

[0049] The preparation method of the above-mentioned dextran-based transparent hydrogel dressing is similar to Example 1, the difference is:

[0050] Described step b) is:

[0051] 2,3-Epoxypropyltrimethylammonium chloride is ring-opened and grafted onto dextran to obtain dextran quaternary ammonium salt derivatives: such as figure 2 As shown, under the protection of nitrogen, dextran (5g, molecular weight is (20000), structural formula is figure 2 Chinese formula (7)) was dissolved in DMSO (45ml), and 4-dimethylaminopyridine (1g) was added. After fully dissolving, 2,3-epoxypropyltrimethylammonium chloride (4.68g,, structural formula for figure 2 Chinese formula (8)), after reacting at normal temperatu...

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Abstract

The invention provides a glucan-based transparent hydrogel dressing and a preparation method thereof. The preparation method of the glucan-based transparent hydrogel dressing comprises the following steps: conducting a reaction between a glucan quaternary ammonium salt derivative and succinic anhydride; then promoting an obtained product to react with small molecules of amination, so that a macromonomer which contains illuminated cross-linking double bonds is obtained; mixing the macromonomer which contains illuminated cross-linking double bonds with an antibacterial agent and an initiating agent; conducting photo initiation so as to prepare a glucan-based transparent hydrogel; and combining the glucan-based transparent hydrogel with a polyurethane film by virtue of a bonding agent, so that the glucan-based transparent hydrogel dressing is prepared. The finished product (the glucan-based transparent hydrogel dressing) prepared by the invention not only can absorb a great amount of wound exudates so as to keep a wound surface wet, but also can avoid wound adhesion, so that the probability of wound infection is reduced and wound surface healing is promoted.

Description

technical field [0001] The invention belongs to the technical field of industrial textiles, in particular to a novel dextran-based transparent hydrogel composite dressing. Background technique [0002] In 1962, Winter’s moist therapy theory was proposed and confirmed, which marked the beginning of the revolution of “wet dressing”. Since then, many scholars have conducted long-term research on dressings for many shortcomings of gauze dressings, hoping to research and develop dressings with better therapeutic effects. . Film dressing can prevent bacterial infection, provide gas exchange, and has good mechanical properties, etc., but its water vapor transmission rate is too small, and its water absorption performance is not good, it is easy to cause the accumulation of exudate under the membrane, which may induce or aggravate infection. Therefore, it is only suitable for wounds with less exudate. Foam dressings have good absorbency and good water vapor permeability, but the w...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/26A61L15/42A61L15/44C08B37/02C07C231/12C07C233/20
CPCA61L15/26A61L15/28A61L15/42A61L15/46A61L2300/216A61L2300/404C07C231/12C08B37/0006C08L5/02C08L75/04C07C233/20
Inventor 吴德群吴飞飞张俊芝徐海玲俞建勇
Owner 深圳市菩安科技有限公司
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