40results about How to "Excellent anti-protein adsorption performance" patented technology

The invention discloses a lecithin self-assembly cross-linking bionic modified polymer membrane material and a preparation method thereof. The preparation method disclosed by the invention comprises the following steps: dissolving natural lecithin, a cross-linking agent and a photoinitiator into ethanol to prepare a lecithin modified ethanol solution; carrying out constant-pressure medium barrierdischarge plasma processing on a polymer membrane material; soaking the polymer membrane material into the lecithin modified ethanol solution; and after carrying out ultraviolet light radiation for 1-40 minutes, washing with deionized water and drying at room temperature. In the invention, the self-assembly can be carried out on natural lecithin molecules containing unsaturated alkyl chains on the surface of a lyophobic polymer; and the cross-linking is carried out on the natural lecithin molecules containing the unsaturated alkyl chains by combining a sulfydryl-alkenyl click reaction, thereby forming a uniform, durable and stable lecithin bionic layer on the surface of a lyophobic polymer membrane material and endowing the lyophobic polymer membrane with excellent protein-absorption-resistant performance. According to the invention, the process is simple, the processing effect is good, the cost is low, no environmental pollution exists, and high efficiency and energy conservation areachieved.

The invention relates to a surface plasma resonator chip based on modification of hyaluronic acid assisted by dopamine, and a preparation method of the chip. The chip comprises a structure consisting of a glass layer, a chromium layer, a sensing layer, and a dopamine and hyaluronic acid mixed layer in sequence. The preparation method comprises: firstly, coating a BK7 glass substrate with the chromium layer through vacuum sputtering, and then coating the chromium layer with the sensing layer to obtain a sensing chip; immersing the sensing chip in a solution mixed by concentrated sulfuric acid and hydrogen peroxide; and immersing the obtained chip into a hyaluronic acid solution of dopamine to form the dopamine and hyaluronic acid mixed layer. The surface plasma resonator chip based on hyaluronic acid is high in stability, and is unchangeable in pollution resistance after stored for 4 months in a dry state or for 7 days in a phosphate buffer with the pH of 7.4. The chip can be recyclable for reuse, and after ten times recycling, the chip can also keep good pollution resistance. The preparation method is simple in operation and has good economic practicability.

The invention discloses a multienzyme cleaning agent for medical appliances, and belongs to the technical field of medical treatment. According to the multienzyme cleaning agent, 4-formylbenzeneboronic acid is added to effectively inhibit the protease activity during storage, and protease activity is prevented from being reduced; beta cyclodextrin and nonionic surfactant Pluronic-F88 in an aqueoussolution are subjected to host-guest recognition, a hydrogen bond is formed from adjacent beta-cyclodextrins through cavity peripheral cyclodextrin, and functions of other cleaning activators cannotbe influenced; polymethylhydrosiloxane, hexamethyldisiloxane and like are used as raw materials, tert-amino in intermediate and sodium chloroacetate perform a quaternization reaction, the appliance surface is protected from secondary pollution; and baicalin and bacterium prodigiosum polysaccharides are added to reduce rejection and pyrogen reaction caused by over-high load of microorganisms, and the use safety of medical appliances can be improved. The multienzyme cleaning agent can solve the problems of low bioenzyme activity and poor cleaning effect in an enzyme cleaning agent since proteasein current multi-enzyme cleaning agent can decompose other bioenzyme in a solution.

The invention discloses a synthetic method and application of a catechol derivative and a biomimetic polymer, which belongs to the field of macromolecule biological materials and functional materials.Catechol, formaldehyde and secondary amine, which are low in price and easy to acquire, are used as raw materials to obtain 4-amine methyl substituted catechol derivative and 3-amine methyl substituted catechol derivative by virtue of mannich reaction. The biomimetic polymer is the biomimetic polymer comprising catechol polyurethane or the biomimetic polymer comprising catechol polyacrylate, andpolymer monomers are prepared into the biomimetic polymer comprising a catechol structure by virtue of addition polymerization or radical polymerization. The catechol derivative obtained by the methodprovided by the invention can be used for synthesizing the biomimetic polymer comprising the catechol structural unit; and the biomimetic polymer synthesized from the catechol derivative has excellent coating forming capability, protein adsorption resistant capability and hydrogel forming capability and has application value in the aspects such as medical adhesive, medical hydrogel, and coating materials.

The invention relates to the technical field of amphiphilic polymers, in particular to a multi-block copolymer, a multi-block amphiphilic copolymer, a multi-block amphiphilic polymer and a preparationmethod thereof. The multi-block copolymer comprises a polydimethylsiloxane repeating unit and a polyethylene glycol dimethacrylate repeating unit. The invention also provides the preparation method of the multi-block copolymer, the multi-block amphiphilic copolymer prepared from the multi-block copolymer, and the multi-block amphiphilic polymer. The multi-block copolymer and a coating prepared from the polymer provided by the invention have good hydrophobicity and oleophobicity, and also have excellent protein adsorption resistance and diatom adsorption resistance, and the copolymer after entering a quaternary ammonium salt group also has antibacterial ability under the condition of maintaining the properties. The performance defects of the coating are enhanced to a certain extent, and the coating has a wide market application prospect.

The invention discloses colloidal gold partly modified by polyethylene glycol and a preparation method thereof. The preparation method comprises the following steps of (1) preparing the colloidal gold; (2) fixing nanogold on a glass solid phase carrier; (3) modifying the colloidal gold by using the polyethylene glycol; and (4) preparing a solution of the colloidal gold partly modified by the polyethylene glycol. 80-95% of the surface region of the colloidal gold prepared by the method is covered by the polyethylene glycol, and the other 5-20% of the surface region is still a bare gold surface. The stability of the colloidal gold partly modified by the polyethylene glycol prepared by the preparation method in complex mediums and the selective recognition of the colloidal gold to target proteins are obviously enhanced. Through asymmetrically modifying the colloidal gold, directional adjustment and control of reactions can be realized, and the uncontrollable agglomeration and sedimentation problems caused by isotropic colloidal gold in traditional method are also solved; and the colloidal gold partly modified by the polyethylene glycol is expected to be widely used in nano-assembling and biosensing fields.

The invention discloses a preparation method of a zwitter-ion peptide type polymer. The preparation method comprises the following steps: S1, performing a cation open-loop polymerization reaction so as to prepare hydroxyl-terminated poly(2-oxazoline) with double bonds on side chains; S2, performing a reaction on the side chains of poly(2-oxazoline), namely performing photocatalytic addition on sulfydryl-olefin double bonds and an open-loop addition reaction on tertiary amine and cyclic lactone so as to prepare a zwitter-ion peptide type polymer; and S3, hydrolyzing a part of the main chain ofthe zwitter-ion peptide type polymer, so as to prepare the zwitter-ion peptide type polymer with a secondary amine structure in the main chain. The zwitter-ion peptide type polymer which is partiallyhydrolyzed is synthesized, a zwitter-ion peptide type polymer anti-fouling coating is rapidly prepared in a mode of blending deposition of the zwitter-ion peptide type polymer with dopamine in an alkali solution of CuSO4/H2O2, and by adopting the method, the preparation time of the coating can be shortened to a large extent, and the preparation efficiency and the stability of the coating can be improved.

The invention discloses polycaprolactone-base diethylsulfopropyl betaine, a preparation method thereof, and a construction method with same as a medicine release carrier, wherein the carrier is prepared through self-assembling of the polycaprolactone-base diethylsulfopropyl betaine (PCL-SB), wherein the hydrophobic PCL section is the inner core of the carrier while the hydrophilic hydroxyethyl diethylsulfopropyl betaine is a shell layer. The carrier has excellent biocompatibility and is free of cytotoxicity, can load various hydrophobic medicines (e.g. DOX), wherein the loading quantity and release speed are controlled through the molecular weight of the PCL section; what is more, the PCL-SB carrier has excellent anti-protein adsorption performance, so that stability on structure and properties are maintained even in a complex protein medium, thus significantly prolonging circulating time of the medicine in human body by 5-16 times than a conventional amphipathic micelle.

The invention provides polyurethane with increased modulus after water absorption as well as a preparation method and application of the polyurethane. Main chains of the polyurethane are all hard segments, and hydrophilic soft segments are all located on side chains. The polyurethane is soft and low in modulus in a dry state. After the polyurethane absorbs water, the polyurethane hardens, and the modulus is obviously increased. The polyurethane material with the increased modulus after water absorption has a wide application prospect in the aspect of medical implant materials. When the polyurethane material is applied to the medical implant materials, the polyurethane material has the advantages of being soft during implantation, easy to implant and capable of absorbing water to be hardened after implantation, and meets the requirement for high modulus during use. The polyurethane material provided by the invention has a wide application prospect in the field of implantable medical materials such as lumen stents.

The invention discloses a hydrogel artificial blood vessel and a preparation method thereof, the artificial blood vessel is of a double-layer structure, the inner layer is zwitterionic hydrogel, and the outer layer is poly (N-acryloylglycinamide) (PNAGA) hydrogel; zwitterions of the zwitterionic hydrogel are selected from one or more of methacryloyloxyethyl sulphobetaine, 2-methacryloyloxyethyl phosphorylcholine, methacryloyloxyethyl carboxylic acid betaine and methacryloyloxyethyl trifluoropropyl carboxylic acid betaine. According to the technical scheme, the problems of blood compatibility, compliance, biocompatibility, mechanical performance and the like of the artificial blood vessel in the using process can be effectively solved, and the artificial blood vessel is expected to be widely applied to the field of vascular surgery.

The invention discloses a preparation method and application of stimuli-responsive poly-zwitter-ion nanogel, which comprises the following steps: modifying double bonds by hyaluronic acid or derivatives and analogues thereof, and then forming a compound with a positively charged drug, or modifying double bonds by polyethyleneimine, and then forming a compound with a negatively charged drug, so as to prepare the stimuli-responsive poly-zwitter-ion nanogel. And forming a poly-zwitterionic nanogel through double bonds, zwitterions with double-bond structures at one end and a response type cross-linking agent with double-bond structures at two ends in an in-situ free radical polymerization manner, so as to obtain the poly-zwitterionic nanocage coated with protein polypeptide drugs or nucleic acid drugs. The nanogel has excellent anti-fouling performance, can resist adsorption of non-specific biomacromolecules and remarkably prolong the blood circulation time, and can be split under specific stimulation of tumors, so that targeted delivery of therapeutic drugs is realized. The carrier has the characteristics of good biocompatibility, high drug loading rate, efficient enrichment of tumor sites, controllable drug release and the like, and achieves the purpose of efficiently treating tumors.