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Split type blood vessel coating support

A technology of covered stents and blood vessels, which is applied in the field of medical devices, can solve the problems of threatening the life of patients, dissection rupture, bifurcation stent disengagement, etc., and achieve the effects of good controllability, high water absorption rate and stable structure

Active Publication Date: 2019-01-29
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Among them, type I endoleaks may cause dissection rupture, and type III endoleaks may directly lead to disengagement of the bifurcation stent, threatening the life of the patient.

Method used

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  • Split type blood vessel coating support
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] In a 25ml round bottom flask, add 2.0g (0.01mol) of polyethylene glycol diacrylate (PEGDA-200) with a molecular weight of 200, 0.144g of acrylic acid (AA) (molar ratio PEGDA-200:AA=5:1), 0.5ml of methanol, magnetically stirred and mixed, then added azobisisobutyronitrile (AIBN) (molar ratio PEGDA-200:AIBN=1:0.8‰), magnetically stirred to dissolve. The round bottom flask was sealed with a rubber stopper, and vacuum-filled with nitrogen was repeated 5 times. Magnetic stirring was carried out at 60°C for 2.5 hours, the reactant was precipitated with tetrahydrofuran and washed with methanol three times, and dried in a vacuum oven at 60°C to obtain a prepolymer.

[0041] The prepolymer, pentaerythritol tetramercaptoacetate (1wt%), and photoinitiator DMPA (2wt‰) were fully dissolved and mixed in 1ml of methanol, and cured by ultraviolet light (365nm) for 1 minute to obtain the stent port covering material. The water absorption rate of the material can reach 300% in 24 hours....

Embodiment 2

[0043] Others are the same as in Example 1, except that the reaction time is changed to 1.5 hours. The 24-hour water absorption rate of the obtained stent port covering material was 400%.

Embodiment 3

[0045] Others are the same as in Example 1, except that polyethylene glycol diacrylate (PEGDA-1000) with a molecular weight of 1000 is used instead. The 24-hour water absorption rate of the obtained stent port covering material was 200%.

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Abstract

The invention discloses a split type blood vessel coating support which comprises a main support and a trouser leg support connected with the main support. Water-absorbing self-expansion material layers are attached to the outer walls of one or all of a connecting part between the main support and the trouser leg support, other ends of the main support and other ends of the trouser leg support. Water-absorbent resin materials covering ports of the support have good biological compatibility and excellent protein-adsorption-resistance performance. The covering materials can quickly expand by absorbing water in a blood environment, are stable in structure after expansion and have a controllable water absorbing rate. The materials used for the support have no damage and side effect on human body blood vessels, the success rate of aortic aneurysm endovascular graft exclusion is increased, and the safety and curing effect of the aortic aneurysm endovascular graft exclusion are further improved.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to a split-type blood vessel covered stent. Background technique [0002] Endovascular aortic repair has become one of the recognized treatment methods for Stanford type B aortic dissection. It has the advantages of high success rate and low mortality, but it will have some complications, mainly stent graft migration and internal Leaks appear. [0003] Endoleak is a special complication associated with EVAR (Endoluminal Aortic Aneurysm Repair) that is different from open vessel surgery, that is, the graft fails to completely seal off the lesion so that blood flow can still enter the lesion area (aneurysm lumen ). The corresponding English expression is endoleak. After the occurrence of endoleak, due to the disturbance of hemodynamic stability, the direction and velocity of blood flow are changed, and the pressure of the graft on the vessel wall causes local edema, inflamm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/07A61L31/14A61L31/10A61L31/02
CPCA61F2/07A61F2002/075A61F2210/0061A61L31/022A61L31/10A61L31/14C08L51/08
Inventor 刘震杰顾政陈枫张祥满
Owner ZHEJIANG UNIV
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